Vitamin E

Summary

Vitamin E (CHEMBL3989727) is an approved unknown (ATC A11HA03); indicated across 75 conditions including chronic obstructive pulmonary disease and myocardial infarction.

At a glance

• Status: Approved (max clinical phase 4)
• Modality: Unknown
• ATC class: A11HA03
• Indications: 75 conditions
• Clinical trials: 169

Identifiers

Drug identity and classification

Field	Value
ChEMBL ID	CHEMBL3989727
Name	Vitamin E
Type	Unknown
Max phase	4
ATC	A11HA03

Also known as: .alpha.-tocopherol, .alpha.-tocopherol acetate, dl-, .alpha.-tocopherol succinate, d-, .alpha.-tocopheryl acetate, .alpha.-tocopheryl succinate, All-rac-alfa-tocopheryl acetate, All-rac-alpha-tocopheryl acetate, Alpha tocopherol, Alpha-tocopherol, Alpha-tocopherol acetate

Targets

Targets

No target linkage available.

Bioactivity

No ChEMBL bioactivity rows at pChembl ≥ 5 (expected for biologics / antibodies).

Target pathways

No target-pathway data for this drug (no mapped target genes).

Indications & clinical

Indications

75 indications (0 at ChEMBL trial phase 4). Phase below is the highest clinical-trial phase recorded for this drug against each disease — not the molecule’s overall approval status (that is in the Summary).

Indication	Trial phase	MONDO	EFO
chronic obstructive pulmonary disease	3	MONDO:0005002	EFO:0000341
myocardial infarction	3	MONDO:0005068	EFO:0000612
liver disorder	3	MONDO:0005154	EFO:0001421
cirrhosis of liver	3	MONDO:0005155	EFO:0001422
kidney disorder	3	MONDO:0005240	EFO:0003086
metabolic dysfunction-associated steatotic liver disease	3	MONDO:0013209	EFO:0003095
cerebrovascular disorder	3	MONDO:0011057	EFO:0003763
breast neoplasm	3	MONDO:0021100	EFO:0003869
upper aerodigestive tract neoplasm	3	MONDO:0005398	EFO:0004284
head and neck cancer	3	MONDO:0005627	EFO:0006859
delirium	3	MONDO:0045057	EFO:0009267
myocardial ischemia	3	MONDO:0024644	EFO:1001375
fatty liver disease	3	MONDO:0004790	HP:0001397
macular degeneration	3	MONDO:0003004	EFO:0009606
osteonecrosis	3	MONDO:0005380	MONDO:0018373
rectal cancer	3	MONDO:0006519	EFO:1000657
metabolic dysfunction-associated steatohepatitis	3	MONDO:0007027	EFO:1001249
depressive disorder	3	MONDO:0002050	MONDO:0002050
Alzheimer disease	3	MONDO:0004975	MONDO:0004975
amyotrophic lateral sclerosis	3	MONDO:0004976	MONDO:0004976
cataract	3	MONDO:0005129	MONDO:0005129
Parkinson disease	3	MONDO:0005180	MONDO:0005180
migraine disorder	3	MONDO:0005277	MONDO:0005277
hypobetalipoproteinemia	3	MONDO:0017774	MONDO:0017774
retinitis pigmentosa	3	MONDO:0019200	MONDO:0019200
psoriasis	3	MONDO:0005083	EFO:1001494
glaucoma	3	MONDO:0005041	MONDO:0005041
coronary artery disorder	3	MONDO:0005010	EFO:0001645
vascular disorder	3	MONDO:0005385	EFO:0004264
colorectal neoplasm	3	MONDO:0005335	MONDO:0005575
Gaucher disease	3	MONDO:0018150	MONDO:0018150
cardiovascular disorder	2	MONDO:0004995	EFO:0000319
injury	2	MONDO:0021178	EFO:0000546
polycystic ovary syndrome	2	MONDO:0008487	EFO:0000660
endometriosis	2	MONDO:0005133	EFO:0001065
ischemia reperfusion injury	2	MONDO:0005203	EFO:0002687
peripheral neuropathy	2	MONDO:0005244	EFO:0003100
heart failure	2	MONDO:0005252	EFO:0003144
nicotine dependence	2	MONDO:0008575	EFO:0003768
heart disorder	2	MONDO:0005267	EFO:0003777
carotid artery disorder	2	MONDO:0005269	EFO:0003781
chronic kidney disease	2	MONDO:0005300	EFO:0003884
atherosclerosis	2	MONDO:0005311	EFO:0003914
brain disorder	2	MONDO:0005560	EFO:0005774
burn	2	MONDO:0043519	EFO:0009516
cerebral atherosclerosis	2	MONDO:0006694	EFO:1000860
heavy metal poisoning	2	MONDO:0023305	EFO:1001518
neuromuscular disease	2	MONDO:0019056	EFO:1001902
stomatitis	2	MONDO:0004842	EFO:1001904
acute kidney injury	2	MONDO:0002492	HP:0001919
lung neoplasm	2	MONDO:0021117	MONDO:0008903
male infertility	2	MONDO:0005372	EFO:0004248
type 2 diabetes mellitus	2	MONDO:0005148	MONDO:0005148
adrenoleukodystrophy	2	MONDO:0018544	MONDO:0015339
Friedreich ataxia	2	MONDO:0100339	MONDO:0100339
neoplasm	2	MONDO:0005070	MONDO:0004992
rheumatoid arthritis	1	MONDO:0008383	EFO:0000685
exocrine pancreatic carcinoma	1	MONDO:0005192	EFO:0002618
pancreatic neoplasm	1	MONDO:0021040	EFO:0003860
anemia	1	MONDO:0002280	EFO:0004272
ovarian cancer	1	MONDO:0008170	MONDO:0008170
asthma	1	MONDO:0004979	MONDO:0004979
infertility disorder	0	MONDO:0005047	EFO:0000545

12 further indication records had no mapped disease name (EFO/MeSH-only) or were duplicates, and are omitted.

Clinical trials

Total trials: 169.

Phase distribution

Phase	Trials
Not specified	51
PHASE3	44
PHASE2	29
PHASE4	20
PHASE1	13
PHASE2/PHASE3	5
PHASE1/PHASE2	5
EARLY_PHASE1	2

Top trials by phase / activity

NCT	Phase	Status	Title
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT06926712	PHASE4	NOT_YET_RECRUITING	The Effect of Vitamin E Supplementation on Hospital Stay Duration in Non-cyanotic Heart Disease Children With Lower Respiratory Tract Infections
NCT00004637	PHASE4	COMPLETED	Double-Blind, Placebo-Controlled Trial of Vitamin E as Add-on Therapy for Children With Epilepsy
NCT00384618	PHASE4	TERMINATED	Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study
NCT00817622	PHASE4	COMPLETED	Effects of EPA and Vitamin E on Leptin, Adiponectin and Enzymatic Antioxidants in Type 2 DM
NCT01002547	PHASE4	COMPLETED	Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) in Hispanics With Diabetes Mellitus Type 2 (T2DM) and Role of Treatment
NCT01148576	PHASE4	UNKNOWN	Influence of Hepatic Steatosis on the Therapeutic Effect of Entecavir in Chronic Hepatitis B Patients
NCT01418378	PHASE4	COMPLETED	Sigma CR150 Versus Sigma CR Knee RCT
NCT01720719	PHASE4	UNKNOWN	Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease
NCT01743742	PHASE4	COMPLETED	First-day High Dose Vitamin C, E in Severe Birth Asphyxia
NCT02011906	PHASE4	UNKNOWN	The Effects of Omega 3 and Vitamin E Supplementation on the Serum Antioxidant Enzymes and Gene Expressions of PGC-1a, h TERT, FOXOs and SIRTs in CAD Patients
NCT02019186	PHASE4	COMPLETED	Effects of Vitamin C and E on Endothelial Function in Adolescent Diabetes
NCT03176966	PHASE4	COMPLETED	Ropinirole for the Treatment of Muscle Cramps in Patients With Cirrhosis
NCT03228238	PHASE4	TERMINATED	ANti-Oxidant in Variant Angina (ANOVA) Trial
NCT03358524	PHASE4	COMPLETED	Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia
NCT03903133	PHASE4	COMPLETED	Endothelial Monocyte-activating Polypeptide-II in Egyptian Sickle Patients
NCT04977661	PHASE4	COMPLETED	Comparing the Effects of Vitamin E, Ursodeoxycholic Acid and Pentoxyfylline on Egyptian Non-alcoholic Steatohepatitis (NASH) Patients
NCT05488925	PHASE4	COMPLETED	Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.
NCT05616442	PHASE4	COMPLETED	Ketotifen in Non-Alcoholic Fatty Liver Disease Patients
NCT05711810	PHASE4	COMPLETED	Medicine-induced Cardiac Hemodialysis on COVID-19
NCT00000114	PHASE3	COMPLETED	Randomized Trial of Vitamin A and Vitamin E Supplementation for Retinitis Pigmentosa
NCT00000161	PHASE3	UNKNOWN	Randomized Trials of Vitamin Supplements and Eye Disease
NCT00000173	PHASE3	COMPLETED	Memory Impairment Study (Mild Cognitive Impairment Study)
NCT00000479	PHASE3	COMPLETED	Women’s Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer
NCT00000539	PHASE3	COMPLETED	Arterial Disease Multifactorial Intervention Trial (ADMIT)
NCT00000555	PHASE3	COMPLETED	Women’s Angiographic Vitamin and Estrogen Trial (WAVE)
NCT00003367	PHASE3	COMPLETED	Diet and PSA Levels in Patients With Prostate Cancer
NCT00006349	PHASE3	COMPLETED	Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer
NCT00006392	PHASE3	COMPLETED	S0000 Selenium and Vitamin E in Preventing Prostate Cancer
NCT00054561	PHASE3	COMPLETED	Isotretinoin, Interferon Alfa, and Vitamin E in Treating Patients With Stage III or Stage IV Head and Neck Cancer
NCT00056329	PHASE3	UNKNOWN	Vitamin E in Aging Persons With Down Syndrome
NCT00063453	PHASE3	COMPLETED	Supplemental Selenium and Vitamin E and Pulmonary Function
NCT00063622	PHASE3	COMPLETED	Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis (PIVENS)
NCT00063635	PHASE3	COMPLETED	Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)
NCT00064194	PHASE3	COMPLETED	Vitamin E, Selenium, and Soy Protein in Preventing Cancer in Patients With High-Grade Prostate Neoplasia
NCT00135707	PHASE3	COMPLETED	Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)
NCT00169845	PHASE3	COMPLETED	Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
NCT00272428	PHASE3	COMPLETED	Primary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
NCT00311116	PHASE2/PHASE3	COMPLETED	Vitamin E to Prevent Mucositis in Children With Cancer
NCT00314379	PHASE2/PHASE3	COMPLETED	Endothelial Function in a Sample Group of Patients From the ICARE Study

Clinical evidence (CIViC)

No CIViC predictive evidence (expected for non-precision-medicine drugs).

Pharmacology

Pharmacogenomics

No PharmGKB pharmacogenomic data curated for this drug.

Related molecules

Related molecules

No competitor molecules sharing a primary target (ChEMBL phase ≥2 or PubChem drug-class).