A2M-AS1

Summary

A2M-AS1 (A2M antisense RNA 1, HGNC:27057) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27057
Approved symbol	A2M-AS1
Name	A2M antisense RNA 1
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000245105
Ensembl biotype	lncRNA
Entrez	144571
RNAcentral	URS00001F234A — lncRNA, 2187 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000499762, ENST00000648157, ENST00000667950, ENST00000670582, ENST00000839574, ENST00000839575

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499762 — 3 exons

Exon	Start	End
ENSE00001959179	9065826	9066060
ENSE00001968487	9065177	9065228
ENSE00001981674	9066156	9068060

Expression profiles

Bgee: expression breadth ubiquitous, 204 present calls, max score 81.79.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4734 / max 25.0367, expressed in 247 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
124031	0.4734	247

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	81.79	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.27	silver quality
upper lobe of left lung	UBERON:0008952	77.64	gold quality
body of uterus	UBERON:0009853	76.22	gold quality
lower esophagus muscularis layer	UBERON:0035833	76.19	gold quality
right lung	UBERON:0002167	76.14	gold quality
lower esophagus	UBERON:0013473	76.13	gold quality
metanephros cortex	UBERON:0010533	76.04	gold quality
apex of heart	UBERON:0002098	76.03	gold quality
upper lobe of lung	UBERON:0008948	75.90	gold quality
right coronary artery	UBERON:0001625	75.86	gold quality
thoracic aorta	UBERON:0001515	75.54	gold quality
ascending aorta	UBERON:0001496	75.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	75.53	gold quality
left coronary artery	UBERON:0001626	75.37	gold quality
descending thoracic aorta	UBERON:0002345	75.28	gold quality
aorta	UBERON:0000947	75.22	gold quality
tibial artery	UBERON:0007610	75.21	gold quality
popliteal artery	UBERON:0002250	75.19	gold quality
mucosa of stomach	UBERON:0001199	74.76	gold quality
right atrium auricular region	UBERON:0006631	74.72	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.61	gold quality
heart left ventricle	UBERON:0002084	74.51	gold quality
tendon of biceps brachii	UBERON:0008188	74.46	silver quality
cardiac ventricle	UBERON:0002082	74.01	gold quality
left adrenal gland cortex	UBERON:0035825	74.00	gold quality
buccal mucosa cell	CL:0002336	73.82	silver quality
coronary artery	UBERON:0001621	73.81	gold quality
tibial nerve	UBERON:0001323	73.73	gold quality
cardiac atrium	UBERON:0002081	73.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.59

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer. (PMID:32352014)
• LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2. (PMID:33057899)
• LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3. (PMID:35920801)
• Overexpression of lncRNA A2M-AS1 inhibits cell growth and aggressiveness via regulating the miR-587/bone morphogenetic protein 3 axis in lung adenocarcinoma. (PMID:36461613)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.