A2ML1-AS1

Summary

A2ML1-AS1 (A2ML1 antisense RNA 1, HGNC:41022) is a long non-coding RNA gene on chromosome 12p13.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41022
Approved symbol	A2ML1-AS1
Name	A2ML1 antisense RNA 1
Location	12p13.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256661
Ensembl biotype	lncRNA
Entrez	100874108
RNAcentral	URS00026A22E0 — lncRNA, 819 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000537288

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000537288 — 2 exons

Exon	Start	End
ENSE00002229439	8776219	8776384
ENSE00002275055	8830662	8830947

Expression profiles

Bgee: expression breadth broad, 79 present calls, max score 86.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0394 / max 17.9137, expressed in 12 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
129372	0.0240	7
129371	0.0154	5

Top tissues by expression

79 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	86.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.33	gold quality
tonsil	UBERON:0002372	74.78	gold quality
sural nerve	UBERON:0015488	70.56	gold quality
uterine cervix	UBERON:0000002	63.76	gold quality
prefrontal cortex	UBERON:0000451	61.51	gold quality
liver	UBERON:0002107	57.17	silver quality
ectocervix	UBERON:0012249	55.01	gold quality
esophagus	UBERON:0001043	54.79	gold quality
esophagus mucosa	UBERON:0002469	54.77	gold quality
right lobe of thyroid gland	UBERON:0001119	53.76	gold quality
blood	UBERON:0000178	52.89	gold quality
lower esophagus mucosa	UBERON:0035834	52.71	gold quality
vagina	UBERON:0000996	52.22	gold quality
endometrium	UBERON:0001295	52.05	silver quality
gastrocnemius	UBERON:0001388	51.75	gold quality
saliva-secreting gland	UBERON:0001044	51.19	gold quality
minor salivary gland	UBERON:0001830	50.84	gold quality
placenta	UBERON:0001987	50.61	gold quality
calcaneal tendon	UBERON:0003701	49.83	silver quality
left coronary artery	UBERON:0001626	48.46	gold quality
heart left ventricle	UBERON:0002084	47.55	gold quality
zone of skin	UBERON:0000014	46.51	gold quality
skin of abdomen	UBERON:0001416	46.49	gold quality
multicellular organism	UBERON:0000468	46.27	gold quality
stomach	UBERON:0000945	46.25	gold quality
cerebellar cortex	UBERON:0002129	46.18	silver quality
body of pancreas	UBERON:0001150	46.09	silver quality
spleen	UBERON:0002106	46.09	gold quality
body of stomach	UBERON:0001161	46.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.37

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.