AAMP

Summary

AAMP (angio associated migratory cell protein, HGNC:18) is a protein-coding gene on chromosome 2q35, encoding Angio-associated migratory cell protein (Q13685). Plays a role in angiogenesis and cell migration. It is a common-essential gene (DepMap: required in 92.4% of cancer cell lines).

The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion.

Source: NCBI Gene 14 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 72 total — 8 pathogenic, 2 likely-pathogenic
• Cancer dependency (DepMap): dependent in 92.4% of screened cell lines (common-essential)
• MANE Select transcript: NM_001087

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18
Approved symbol	AAMP
Name	angio associated migratory cell protein
Location	2q35
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000127837
Ensembl biotype	protein_coding
OMIM	603488
Entrez	14

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 16 protein_coding, 5 retained_intron

ENST00000248450, ENST00000420660, ENST00000422731, ENST00000444053, ENST00000447885, ENST00000461911, ENST00000465442, ENST00000475678, ENST00000489767, ENST00000494720, ENST00000896971, ENST00000896972, ENST00000896973, ENST00000912377, ENST00000912378, ENST00000952043, ENST00000952044, ENST00000952045, ENST00000952046, ENST00000952047, ENST00000952048

RefSeq mRNA: 2 — MANE Select: NM_001087 NM_001087, NM_001302545

CCDS: CCDS33378, CCDS77530

Canonical transcript exons

ENST00000248450 — 11 exons

Exon	Start	End
ENSE00000785678	218265579	218265682
ENSE00000876140	218265831	218265946
ENSE00001721960	218264129	218264608
ENSE00001852820	218269966	218270137
ENSE00003486562	218266443	218266587
ENSE00003553930	218265371	218265461
ENSE00003607332	218265020	218265174
ENSE00003619314	218266847	218266986
ENSE00003621040	218266064	218266147
ENSE00003671189	218269382	218269534
ENSE00003687437	218267494	218267613

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 97.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 60.6162 / max 537.5614, expressed in 1826 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33939	59.8701	1826
33937	0.4629	250
33938	0.2832	132

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of stomach	UBERON:0001161	97.85	gold quality
mucosa of transverse colon	UBERON:0004991	97.83	gold quality
left ovary	UBERON:0002119	97.61	gold quality
right ovary	UBERON:0002118	97.49	gold quality
adenohypophysis	UBERON:0002196	97.15	gold quality
mucosa of stomach	UBERON:0001199	97.07	gold quality
transverse colon	UBERON:0001157	97.06	gold quality
skin of leg	UBERON:0001511	96.96	gold quality
stromal cell of endometrium	CL:0002255	96.94	gold quality
left lobe of thyroid gland	UBERON:0001120	96.85	gold quality
skin of abdomen	UBERON:0001416	96.77	gold quality
endocervix	UBERON:0000458	96.76	gold quality
gall bladder	UBERON:0002110	96.74	gold quality
body of pancreas	UBERON:0001150	96.73	gold quality
apex of heart	UBERON:0002098	96.73	gold quality
left uterine tube	UBERON:0001303	96.71	gold quality
stomach	UBERON:0000945	96.70	gold quality
ectocervix	UBERON:0012249	96.69	gold quality
right lobe of thyroid gland	UBERON:0001119	96.65	gold quality
body of uterus	UBERON:0009853	96.63	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.58	gold quality
islet of Langerhans	UBERON:0000006	96.55	gold quality
right adrenal gland	UBERON:0001233	96.49	gold quality
pituitary gland	UBERON:0000007	96.48	gold quality
right uterine tube	UBERON:0001302	96.48	gold quality
left adrenal gland	UBERON:0001234	96.47	gold quality
metanephros cortex	UBERON:0010533	96.46	gold quality
omental fat pad	UBERON:0010414	96.44	gold quality
right adrenal gland cortex	UBERON:0035827	96.43	gold quality
peritoneum	UBERON:0002358	96.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting AAMP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-3153	99.55	67.59	2337
HSA-MIR-3609	99.52	69.89	2587
HSA-MIR-548AH-5P	99.52	69.73	2626
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-5584-5P	99.49	68.22	2814
HSA-MIR-4284	99.36	65.25	1293
HSA-MIR-4311	99.31	70.47	3041
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-3692-5P	99.29	67.04	1421
HSA-MIR-1253	99.12	67.08	1688
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-4709-3P	98.88	68.04	1594
HSA-MIR-12126	98.09	64.82	637
HSA-MIR-634	97.74	67.11	818
HSA-MIR-1226-3P	97.51	66.32	1063
HSA-MIR-939-5P	97.10	65.80	1579
HSA-MIR-1343-5P	96.48	66.06	1506

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 92.4% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 10)

• Drosophila miR-14 regulates context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2). (PMID:25306920)
• The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes. (PMID:35950495)
• important functional role of AAMP in the migration of smooth muscle cells (SMCs), identifying AAMP as a potential target to limit lesion formation after injury. (PMID:18634987)
• Data support a new function of AAMP in regulating innate immune responses initiated by the NLR protein Nod2. (PMID:19535145)
• angio-associated migratory cell protein was identified as a novel interacting partner of both TPalpha and TPbeta isoforms of the thromboxane A2 receptor (PMID:21172430)
• High levels of AAMP levels were associated with breast cancer progression and metastasis (PMID:23564791)
• AAMP Regulates Endothelial Cell Migration and Angiogenesis Through RhoA/Rho Kinase Signaling. (PMID:26350504)
• Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells. (PMID:31075398)
• Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. (PMID:33279622)
• A crucial exosome-related gene pair (AAMP and ABAT) is associated with inflammatory cells in intervertebral disc degeneration. (PMID:37122729)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	aamp	ENSDARG00000045019
mus_musculus	Aamp	ENSMUSG00000006299
rattus_norvegicus	Aamp	ENSRNOG00000014399
drosophila_melanogaster	CG5114	FBGN0036460
caenorhabditis_elegans		WBGENE00013735

Paralogs (1): NWD2 (ENSG00000174145)

Protein

Protein identifiers

Angio-associated migratory cell protein — Q13685 (reviewed: Q13685)

All UniProt accessions (5): Q13685, C9JEH3, C9JG97, C9JTS3, H7C0R2

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway.

Subcellular location. Cell membrane. Cytoplasm.

Tissue specificity. Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics.

RefSeq proteins (2): NP_001078, NP_001289474 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR051179	WD_repeat_multifunction	Family

Pfam: PF00400

UniProt features (13 total): repeat 8, chain 1, compositionally biased region 1, modified residue 1, sequence variant 1, region of interest 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q13685-F1	84.55	0.75

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 20

Function

Pathways and Gene Ontology

Reactome pathways

12 pathways

ID	Pathway
R-HSA-168638	NOD1/2 Signaling Pathway
R-HSA-177929	Signaling by EGFR
R-HSA-194138	Signaling by VEGF
R-HSA-428930	Thromboxane signalling through TP receptor
R-HSA-109582	Hemostasis
R-HSA-162582	Signal Transduction
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System
R-HSA-168643	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-392518	Signal amplification
R-HSA-76002	Platelet activation, signaling and aggregation
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases

MSigDB gene sets: 174 (showing top): REACTOME_INNATE_IMMUNE_SYSTEM, PAX4_01, REACTOME_NOD1_2_SIGNALING_PATHWAY, REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS, REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, GOCC_CELL_SURFACE, HSIAO_HOUSEKEEPING_GENES, AACYNNNNTTCCS_UNKNOWN, TGACCTY_ERR1_Q2, GGGTGGRR_PAX4_03, AACWWCAANK_UNKNOWN, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, IRF7_01, CEBP_Q2

GO Biological Process (4): angiogenesis (GO:0001525), positive regulation of endothelial cell migration (GO:0010595), smooth muscle cell migration (GO:0014909), cell differentiation (GO:0030154)

GO Molecular Function (2): heparin binding (GO:0008201), protein binding (GO:0005515)

GO Cellular Component (7): cytosol (GO:0005829), plasma membrane (GO:0005886), cell surface (GO:0009986), microtubule cytoskeleton (GO:0015630), intercellular bridge (GO:0045171), cytoplasm (GO:0005737), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-8 pathways:

Category	Pathways
Signaling by Receptor Tyrosine Kinases	2
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	1
Signal amplification	1
Immune System	1
Innate Immune System	1
Platelet activation, signaling and aggregation	1
Hemostasis	1
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
regulation of endothelial cell migration	1
positive regulation of cell migration	1
endothelial cell migration	1
muscle cell migration	1
cellular developmental process	1
glycosaminoglycan binding	1
sulfur compound binding	1
binding	1
cytoplasm	1
membrane	1
cell periphery	1
cytoskeleton	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1614 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AAMP	NOD2	Q9HC29	542
AAMP	TBXA2R	P21731	525
AAMP	PUM1	Q14671	509
AAMP	ARPC2	O15144	494
AAMP	SMIM9	A6NGZ8	445
AAMP	ERBIN	Q96RT1	445
AAMP	ZNF48	Q96MX3	430
AAMP	LSG1	Q9H089	419
AAMP	RAB29	O14966	405
AAMP	NMD3	Q96D46	388
AAMP	MRTO4	Q9UKD2	374
AAMP	DRGX	A6NNA5	363
AAMP	RWDD1	Q9H446	362
AAMP	ZNF428	Q96B54	358
AAMP	GRWD1	Q9BQ67	353

IntAct

31 interactions, top by confidence:

A	B	Type	Score
S100B	S100A4	psi-mi:“MI:0914”(association)	0.870
AAMP	AEN	psi-mi:“MI:0915”(physical association)	0.670
AEN	AAMP	psi-mi:“MI:0915”(physical association)	0.570
AAMP	GABARAPL2	psi-mi:“MI:0915”(physical association)	0.550
PTPRU	GOLIM4	psi-mi:“MI:0914”(association)	0.530
MKLN1	HTRA2	psi-mi:“MI:0914”(association)	0.510
VPS52	AAMP	psi-mi:“MI:0915”(physical association)	0.370
BHLHE40	AAMP	psi-mi:“MI:0915”(physical association)	0.370
C8orf33	AAMP	psi-mi:“MI:0915”(physical association)	0.370
MAP1LC3B	AAMP	psi-mi:“MI:0915”(physical association)	0.370
AAMP	TK1	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
KSR1	FBLL1	psi-mi:“MI:0914”(association)	0.350
AAMP	RPL10	psi-mi:“MI:0914”(association)	0.350
FXR2	RPS21	psi-mi:“MI:0914”(association)	0.350
GABARAPL2		psi-mi:“MI:0914”(association)	0.350
AAMP	PRPF40A	psi-mi:“MI:0914”(association)	0.350
DKC1	U2SURP	psi-mi:“MI:0914”(association)	0.350
AAMP	ASAH1	psi-mi:“MI:0914”(association)	0.350
C1orf54	QSOX1	psi-mi:“MI:0914”(association)	0.350
PCDHGB4	AAMP	psi-mi:“MI:0914”(association)	0.350
PMFBP1	AAMP	psi-mi:“MI:0915”(physical association)	0.000
AAMP	MMADHC	psi-mi:“MI:0915”(physical association)	0.000
AAMP	MKLN1	psi-mi:“MI:0915”(physical association)	0.000
AEN	AAMP	psi-mi:“MI:0915”(physical association)	0.000
melB1	AAMP	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (106): VPS52 (Two-hybrid), BHLHE40 (Two-hybrid), AEN (Two-hybrid), AAMP (Two-hybrid), AAMP (Affinity Capture-MS), AAMP (Affinity Capture-MS), RPL10 (Affinity Capture-MS), DICER1 (Affinity Capture-MS), WNK1 (Affinity Capture-MS), PPP2R2D (Affinity Capture-MS), PTPRU (Affinity Capture-MS), ASAH1 (Affinity Capture-MS), ACE2 (Affinity Capture-MS), TCF25 (Affinity Capture-MS), INPP5K (Affinity Capture-MS)

ESM2 similar proteins: A1L112, A4IHS2, A8NZM5, B2ZZS9, O00423, O80775, O95834, P93107, P97452, Q05BC3, Q0DYP5, Q13216, Q13610, Q13685, Q15269, Q1JQD2, Q2HJ56, Q32KQ2, Q32P44, Q3SZK1, Q4V8C3, Q562C2, Q58DT8, Q5BIM8, Q5F3K4, Q5R9T6, Q5RCG7, Q5RFQ3, Q5VU92, Q5XI13, Q5ZK69, Q6DRF9, Q6P6T4, Q6PFM9, Q7TNG5, Q7YR70, Q810D6, Q8BH57, Q8BHB4, Q8BU03

Diamond homologs: A0A1P8AW69, F4HTH8, F4KB17, O61585, Q13685, Q3SZK1, Q4V7Y7, Q5RCG7, Q5ZIU8, Q6NVM2, Q7YR70, Q7ZUV2, Q8BG40, Q8H0T9, Q9BVA0, O14301, O93277, O94620, P39706, P46680, P54686, P90587, Q11176, Q6DIF4, Q6PAX7, Q9LV35, Q9VU68, Q9W7F2, Q9ZU34, A0CH87, A0DB19, B3MRC6, B4JWS7, C5FWH1, D4AZ50, D4DG66, O14727, O88879, P41838, P49026

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

72 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	8
Likely pathogenic	2
Uncertain significance	52
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (10)

Variant ID	HGVS	Classification
1526950	GRCh37/hg19 2q34-36.1(chr2:215108009-221679980)	Pathogenic
2580353	GRCh37/hg19 2q32.1-36.1(chr2:186698504-223918111)x3	Pathogenic
2685875	GRCh37/hg19 2q35-37.3(chr2:218376403-242783384)x3	Pathogenic
4682551	GRCh37/hg19 2q33.3-37.3(chr2:206965837-242783384)x3	Pathogenic
562677	GRCh37/hg19 2q33.3-35(chr2:205169148-219149293)x3	Pathogenic
59158	GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3	Pathogenic
638100	GRCh37/hg19 2q34-37.3(chr2:210779657-239879183)x3	Pathogenic
816573	GRCh37/hg19 2q35(chr2:216883237-220953003)x3	Pathogenic
625776	GRCh37/hg19 2q35(chr2:218271898-219825640)	Likely pathogenic
980004	GRCh37/hg19 2q34-35(chr2:215122019-220397907)x1	Likely pathogenic

SpliceAI

1861 predictions. Top by Δscore:

Variant	Effect	Δscore
2:218265015:CTTA:C	donor_gain	1.0000
2:218265017:TA:T	donor_loss	1.0000
2:218265018:A:AC	donor_gain	1.0000
2:218265018:ACTTG:A	donor_gain	1.0000
2:218265019:C:CT	donor_gain	1.0000
2:218265019:CT:C	donor_gain	1.0000
2:218265019:CTT:C	donor_gain	1.0000
2:218265019:CTTG:C	donor_gain	1.0000
2:218265019:CTTGC:C	donor_gain	1.0000
2:218265170:CCCGA:C	acceptor_gain	1.0000
2:218265171:CCGA:C	acceptor_gain	1.0000
2:218265171:CCGAC:C	acceptor_gain	1.0000
2:218265172:CGAC:C	acceptor_gain	1.0000
2:218265175:C:CC	acceptor_gain	1.0000
2:218265181:C:CT	acceptor_gain	1.0000
2:218265181:C:T	acceptor_gain	1.0000
2:218265182:G:T	acceptor_gain	1.0000
2:218265467:C:CT	acceptor_gain	1.0000
2:218265573:A:AC	donor_gain	1.0000
2:218265574:C:CC	donor_gain	1.0000
2:218265578:CA:C	donor_gain	1.0000
2:218265578:CACA:C	donor_gain	1.0000
2:218265827:TCACC:T	donor_loss	1.0000
2:218265828:CACC:C	donor_loss	1.0000
2:218265829:A:AC	donor_gain	1.0000
2:218265829:A:T	donor_loss	1.0000
2:218265830:C:CC	donor_gain	1.0000
2:218265830:C:CT	donor_loss	1.0000
2:218265830:CCTTG:C	donor_gain	1.0000
2:218266087:C:A	donor_gain	1.0000

AlphaMissense

2847 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:218266578:A:G	W182R	1.000
2:218266578:A:T	W182R	1.000
2:218264557:A:C	F427L	0.999
2:218264557:A:T	F427L	0.999
2:218264558:A:G	F427S	0.999
2:218264559:A:G	F427L	0.999
2:218265096:A:G	W385R	0.999
2:218265096:A:T	W385R	0.999
2:218265447:G:T	A333D	0.999
2:218266129:C:T	G233D	0.999
2:218266521:A:G	W201R	0.999
2:218266521:A:T	W201R	0.999
2:218266547:C:T	G192D	0.999
2:218266576:C:A	W182C	0.999
2:218266576:C:G	W182C	0.999
2:218266587:A:G	W179R	0.999
2:218266587:A:T	W179R	0.999
2:218266914:C:T	G156D	0.999
2:218266932:G:T	A150D	0.999
2:218266955:G:C	F142L	0.999
2:218266955:G:T	F142L	0.999
2:218266956:A:G	F142S	0.999
2:218266957:A:G	F142L	0.999
2:218266971:A:T	V137E	0.999
2:218266974:G:A	S136F	0.999
2:218267551:C:G	D113H	0.999
2:218267559:C:T	G110E	0.999
2:218267560:C:A	G110W	0.999
2:218267603:A:C	F95L	0.999
2:218267603:A:T	F95L	0.999

dbSNP variants (sampled 300 via entrez): RS1000339013 (2:218271072 C>T), RS1000370456 (2:218270761 C>G,T), RS1000827608 (2:218266319 C>A,G), RS1000880141 (2:218264730 G>A), RS1001583154 (2:218271878 A>G), RS1001648395 (2:218268434 G>C), RS1002430778 (2:218263853 G>A), RS1002832194 (2:218269002 T>C,G), RS1003484082 (2:218264988 C>T), RS1003589612 (2:218271032 G>A,C,T), RS1003641757 (2:218270677 G>A,T), RS1003944149 (2:218264672 A>T), RS1004219663 (2:218270477 C>A), RS1004243535 (2:218264598 G>A), RS1004791945 (2:218271542 C>G)

Disease associations

OMIM: gene MIM:603488 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST000964_14	Ulcerative colitis	1.000000e-10
GCST001896_9	Smooth-surface caries	2.000000e-06
GCST004131_76	Inflammatory bowel disease	2.000000e-07
GCST90002379_33	Basophil count	2.000000e-12
GCST90002398_115	Neutrophil count	1.000000e-14
GCST90013407_19	Liver enzyme levels (gamma-glutamyl transferase)	6.000000e-24

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0005090	basophil count
EFO:0004833	neutrophil count
EFO:0004532	serum gamma-glutamyl transferase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
potassium perchlorate	decreases expression	1
beta-lapachone	increases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
bicalutamide	increases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	decreases expression	1
2-amino-14,16-dimethyloctadecan-3-ol	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Oxaliplatin	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Arsenic Trioxide	affects binding, decreases reaction	1
Air Pollutants	affects expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Cadmium	increases abundance, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylstilbestrol	increases expression	1
Doxorubicin	increases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Indomethacin	affects cotreatment, increases expression	1
Ketoconazole	increases expression	1
Nickel	decreases expression	1
Ozone	affects expression, increases abundance	1
Plant Extracts	affects cotreatment, increases expression	1
Progesterone	increases expression	1
Rotenone	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.