AATBC

Summary

AATBC (apoptosis associated transcript in bladder cancer, HGNC:51526) is a long non-coding RNA gene on chromosome 21q22.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:51526
Approved symbol	AATBC
Name	apoptosis associated transcript in bladder cancer
Location	21q22.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000215458
Ensembl biotype	lncRNA
Entrez	284837
RNAcentral	URS000075DB22 — lncRNA, 4622 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000400385, ENST00000437258, ENST00000448247, ENST00000808738, ENST00000808739, ENST00000808740

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000400385 — 2 exons

Exon	Start	End
ENSE00001542670	43805758	43806588
ENSE00001542671	43808801	43812567

Expression profiles

Bgee: expression breadth ubiquitous, 184 present calls, max score 95.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3196 / max 20.0881, expressed in 114 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190723	0.2090	79
190724	0.0905	39
190725	0.0200	8

Top tissues by expression

241 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	95.09	silver quality
buccal mucosa cell	CL:0002336	93.06	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.62	gold quality
monocyte	CL:0000576	88.06	gold quality
granulocyte	CL:0000094	87.75	gold quality
leukocyte	CL:0000738	87.60	gold quality
mammalian vulva	UBERON:0000997	87.07	gold quality
endothelial cell	CL:0000115	82.84	silver quality
upper leg skin	UBERON:0004262	81.65	gold quality
nipple	UBERON:0002030	81.44	gold quality
tendon of biceps brachii	UBERON:0008188	80.27	silver quality
skin of abdomen	UBERON:0001416	79.04	gold quality
blood	UBERON:0000178	78.82	gold quality
lower esophagus mucosa	UBERON:0035834	78.22	gold quality
esophagus squamous epithelium	UBERON:0006920	77.19	silver quality
zone of skin	UBERON:0000014	77.05	gold quality
gingival epithelium	UBERON:0001949	76.39	silver quality
skin of leg	UBERON:0001511	75.67	gold quality
mucosa of transverse colon	UBERON:0004991	74.02	gold quality
gingiva	UBERON:0001828	72.44	silver quality
esophagus mucosa	UBERON:0002469	72.21	gold quality
thymus	UBERON:0002370	72.03	gold quality
skin of hip	UBERON:0001554	71.27	gold quality
bone marrow cell	CL:0002092	69.94	silver quality
spleen	UBERON:0002106	69.59	gold quality
left testis	UBERON:0004533	67.95	gold quality
penis	UBERON:0000989	67.92	gold quality
right testis	UBERON:0004534	67.67	gold quality
colonic epithelium	UBERON:0000397	67.51	silver quality
testis	UBERON:0000473	66.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. (PMID:32364663)
• LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p. (PMID:36420764)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.