ABCC10

Summary

ABCC10 (ATP binding cassette subfamily C member 10, HGNC:52) is a protein-coding gene on chromosome 6p21.1, encoding ATP-binding cassette sub-family C member 10 (Q5T3U5). ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. In precision oncology, ABCC10 Overexpression is associated with resistance to Paclitaxel in Lung Non-small Cell Carcinoma (CIViC Level D).

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 89845 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 292 total
• Druggable target: yes
• Precision-oncology evidence (CIViC): 1 curated variant–drug association
• MANE Select transcript: NM_001198934

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52
Approved symbol	ABCC10
Name	ATP binding cassette subfamily C member 10
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	EST182763, MRP7, SIMRP7
Ensembl gene	ENSG00000124574
Ensembl biotype	protein_coding
OMIM	612509
Entrez	89845

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 9 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000244533, ENST00000372512, ENST00000372515, ENST00000372530, ENST00000437104, ENST00000443426, ENST00000463024, ENST00000469856, ENST00000502549, ENST00000505344, ENST00000854259, ENST00000854260, ENST00000921385, ENST00000952098, ENST00000952099

RefSeq mRNA: 3 — MANE Select: NM_001198934 NM_001198934, NM_001350518, NM_033450

CCDS: CCDS4896, CCDS56430

Canonical transcript exons

ENST00000372530 — 22 exons

Exon	Start	End
ENSE00001137768	43427541	43427757
ENSE00001172893	43443933	43444010
ENSE00001172921	43438624	43438795
ENSE00001172943	43435751	43435907
ENSE00001172952	43434621	43434848
ENSE00001284152	43437934	43438013
ENSE00001284325	43442970	43443159
ENSE00001353357	43432142	43433360
ENSE00002084667	43449929	43450427
ENSE00003464807	43445125	43445314
ENSE00003482501	43447248	43447408
ENSE00003493911	43449422	43449534
ENSE00003502377	43448881	43449026
ENSE00003535524	43436138	43436247
ENSE00003550420	43447684	43447937
ENSE00003564297	43444788	43444938
ENSE00003589156	43445599	43445942
ENSE00003604784	43446277	43446446
ENSE00003606120	43449107	43449204
ENSE00003621785	43444159	43444353
ENSE00003639568	43441862	43441960
ENSE00003674831	43427968	43428139

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 93.77.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.1384 / max 62.1597, expressed in 1789 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
67901	4.5750	1695
67903	3.7899	1677
67902	2.2088	1294
67904	0.5647	281

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	93.77	gold quality
cerebellar hemisphere	UBERON:0002245	93.30	gold quality
cerebellar cortex	UBERON:0002129	93.16	gold quality
cervix squamous epithelium	UBERON:0006922	92.52	gold quality
cerebellum	UBERON:0002037	92.22	gold quality
granulocyte	CL:0000094	91.47	gold quality
right ovary	UBERON:0002118	91.18	gold quality
pituitary gland	UBERON:0000007	90.84	gold quality
lower esophagus mucosa	UBERON:0035834	90.82	gold quality
adenohypophysis	UBERON:0002196	90.36	gold quality
metanephros cortex	UBERON:0010533	90.15	gold quality
right adrenal gland cortex	UBERON:0035827	90.14	gold quality
apex of heart	UBERON:0002098	89.87	gold quality
right adrenal gland	UBERON:0001233	89.81	gold quality
left ovary	UBERON:0002119	89.68	gold quality
epithelium of nasopharynx	UBERON:0001951	89.51	gold quality
right frontal lobe	UBERON:0002810	89.38	gold quality
right lobe of thyroid gland	UBERON:0001119	88.94	gold quality
body of pancreas	UBERON:0001150	88.92	gold quality
pylorus	UBERON:0001166	88.87	gold quality
adrenal cortex	UBERON:0001235	88.74	gold quality
endothelial cell	CL:0000115	88.56	gold quality
left adrenal gland cortex	UBERON:0035825	88.29	gold quality
body of uterus	UBERON:0009853	88.27	gold quality
pancreatic ductal cell	CL:0002079	88.24	silver quality
left adrenal gland	UBERON:0001234	88.14	gold quality
cortical plate	UBERON:0005343	88.04	gold quality
Brodmann (1909) area 23	UBERON:0013554	88.04	gold quality
mucosa of transverse colon	UBERON:0004991	88.03	gold quality
primary visual cortex	UBERON:0002436	87.90	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.01
E-GEOD-81608	no	7.24

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

28 targeting ABCC10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-3175	99.65	66.30	2031
HSA-MIR-4672	99.50	71.58	2893
HSA-MIR-4426	99.17	66.74	1949
HSA-MIR-4784	99.15	67.41	1733
HSA-MIR-374A-3P	98.87	67.82	1531
HSA-MIR-3150B-3P	98.81	67.21	1728
HSA-MIR-4700-5P	98.63	67.43	1915
HSA-MIR-4662B	98.33	66.37	1163
HSA-MIR-4647	98.30	66.41	1139
HSA-MIR-5088-3P	98.29	66.63	1310
HSA-MIR-8089	97.74	66.21	1698
HSA-MIR-4667-5P	97.61	66.67	1683
HSA-MIR-4314	97.50	67.30	1369
HSA-MIR-1225-3P	97.29	64.60	876
HSA-MIR-4433B-3P	97.22	63.62	663
HSA-MIR-6895-5P	97.05	64.96	522
HSA-MIR-4323	93.93	63.89	656

Literature-anchored findings (GeneRIF, showing 24)

• First study to describe structure and expression pattern of this transporter. (PMID:11146224)
• First study to describe ABCC10’s ability to transport physiological substrates, confirming that this protein, with low identity to ABCC1, was indeed a efflux pump. (PMID:12527806)
• MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification. (PMID:12527806)
• The genomic organization and gene expression regulation of human multidrug resistance-associated protein 7 and a splicing variant MRP7A were identified (PMID:12566991)
• This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro. (PMID:15256465)
• A non-major histocompatibility complex MRP7 leader peptide ALALVRMLI binds to HLA-E and strongly inhibits natural killer (NK) cell-mediated lysis (PMID:16034073)
• MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma (PMID:17203221)
• ABCC10/MRP7 may confer vinorelbine resistance in non-small cell lung cancer (PMID:19082471)
• Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B. (PMID:19118001)
• Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10) (PMID:19841739)
• Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model. (PMID:21576088)
• Tenofovir is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence tenofovir renal tubular transport and contribute to the development of kidney tubular dysfunction. (PMID:21628669)
• Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations (PMID:22082652)
• Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7. (PMID:22739155)
• This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase sorafenib as an inhibitor of ABCC10. (PMID:23087055)
• the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10 (PMID:24431074)
• ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays. (PMID:24937672)
• BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance. (PMID:26655271)
• The present study shows that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients (PMID:27468921)
• FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells. (PMID:28051999)
• It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. (PMID:28612064)
• In the cancer cell lines, only rs2125739 of ABCC10 gene was significantly associated with docetaxel cytotoxicity, and this was confirmed in the genome-edited cell line. In the non-small cell lung cancer (NSCLC) patients, there were no significant differences related to rs2125739 genotype in terms of response rate, progression free and overall survival. However, this SNP was associated with grade 3/4 neutropenia. (PMID:30890141)
• Exosomal Delivery of FTO Confers Gefitinib Resistance to Recipient Cells through ABCC10 Regulation in an m6A-dependent Manner. (PMID:33563765)
• ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells. (PMID:36297086)

Cross-species orthologs

19 orthologs

Organism	Symbol	Gene ID
danio_rerio	abcc6a	ENSDARG00000016750
danio_rerio	abcc10	ENSDARG00000077988
danio_rerio	abcc6b.2	ENSDARG00000094901
danio_rerio	abcc6b.1	ENSDARG00000105403
mus_musculus	Abcc10	ENSMUSG00000032842
rattus_norvegicus	Abcc10	ENSRNOG00000018863
drosophila_melanogaster	l(2)03659	FBGN0010549
drosophila_melanogaster	CG7627	FBGN0032026
drosophila_melanogaster	MRP	FBGN0032456
drosophila_melanogaster	CG9270	FBGN0032908
drosophila_melanogaster	CG10505	FBGN0034612
drosophila_melanogaster	Mrp5	FBGN0038740
drosophila_melanogaster	rdog	FBGN0039644
drosophila_melanogaster	CG11898	FBGN0039645
drosophila_melanogaster	CG31792	FBGN0051792
drosophila_melanogaster	CG31793	FBGN0051793
drosophila_melanogaster	Mrp4	FBGN0263316
caenorhabditis_elegans		WBGENE00000477
caenorhabditis_elegans		WBGENE00003413

Paralogs (11): CFTR (ENSG00000001626), ABCC8 (ENSG00000006071), ABCC2 (ENSG00000023839), ABCC9 (ENSG00000069431), ABCC6 (ENSG00000091262), ABCC1 (ENSG00000103222), ABCC3 (ENSG00000108846), ABCC5 (ENSG00000114770), ABCC11 (ENSG00000121270), ABCC4 (ENSG00000125257), ABCC12 (ENSG00000140798)

Protein

Protein identifiers

ATP-binding cassette sub-family C member 10 — Q5T3U5 (reviewed: Q5T3U5)

Alternative names: Multidrug resistance-associated protein 7

All UniProt accessions (3): D6R9B3, Q5T3U5, H0Y904

UniProt curated annotations — full annotation on UniProt →

Function. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May regulate the transport of organic compounds in testes across the blood-testis-barrier. Mediates intercellular propagation of antiviral immune signaling in early stages of infection. In RNA virus-infected cells, oligoadenylate synthase senses viral dsRNA and generates 2’,5’-oligoadenylates (2-5A) which act as second messengers to activate RNASEL and type I interferon signaling to inhibit viral replication. This innate signaling pathway is locally extended and amplified by ABCC10, which exports 2-5A from virus-infected cells to cross-activates RNASEL in uninfected neighboring cells and confers protection against viral infection. Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.

Subcellular location. Cell membrane. Basolateral cell membrane. Basal cell membrane.

Tissue specificity. In testis, localized to peritubular myoid cells, Leydig cells, along the basal membrane of Sertoli cells, moderately in the adluminal compartment of the seminiferous tubules, and in vascular endothelial cells. Specifically expressed in spleen. Widely expressed.

Similarity. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q5T3U5-1	1, Mrp7	yes
Q5T3U5-2	2, Mrp7A

RefSeq proteins (3): NP_001185863, NP_001337447, NP_258261 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003439	ABC_transporter-like_ATP-bd	Domain
IPR003593	AAA+_ATPase	Domain
IPR011527	ABC1_TM_dom	Domain
IPR017871	ABC_transporter-like_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR036640	ABC1_TM_sf	Homologous_superfamily
IPR050173	ABC_transporter_C-like	Family

Pfam: PF00005, PF00664

Enzyme classification (BRENDA):

• EC 7.6.2.2 — ABC-type xenobiotic transporter (BRENDA: 49 organisms, 716 substrates, 471 inhibitors, 280 Km, 31 kcat entries)

Substrate kinetics (BRENDA)

68 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
ATP	0.0009–9	105
VERAPAMIL/IN	0.0006–0.0058	11
VINBLASTINE/IN	0.0002–0.1455	11
ESTRADIOL 17-BETA-D-GLUCURONIDE/IN	0.013–0.17	7
LEUKOTRIENE C4/IN	—	7
METHOTREXATE/IN	0.24–0.776	6
NICARDIPINE/IN	0.0004–0.0026	6
PROGESTERONE/IN	0.0038–0.0207	6
CYCLIC GUANOSINE MONOPHOSPHATE/IN	0.36–2	5
VERAPAMIL	0.0022–0.0115	5
COLCHICINE/IN	0.037–0.72	4
FOLIC ACID/IN	0.13–0.26	4
PACLITAXEL/IN	0.0007–0.0009	4
RHODAMINE 123/IN	0.0118–0.0354	4
DEXAMETHASONE	0.394–0.826	3

Catalyzed reactions (Rhea), 4 shown:

• an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+) (RHEA:19121)
• leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+) (RHEA:38963)
• 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+) (RHEA:60128)
• 5’-triphosphoadenylyl-(2’->5’)-adenylyl-(2’->5’)-adenosine(in) + ATP + H2O = 5’-triphosphoadenylyl-(2’->5’)-adenylyl-(2’->5’)-adenosine(out) + ADP + phosphate + H(+) (RHEA:85015)

UniProt features (44 total): transmembrane region 17, sequence conflict 12, domain 4, splice variant 3, binding site 2, modified residue 2, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T3U5-F1	81.32	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (2): 633–640; 1280–1287

Post-translational modifications (2): 463, 467

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-382556	ABC-family protein mediated transport
R-HSA-382551	Transport of small molecules

MSigDB gene sets: 123 (showing top): GOCC_VACUOLAR_MEMBRANE, BILD_SRC_ONCOGENIC_SIGNATURE, GOBP_ORGANIC_ACID_TRANSPORT, KEGG_ABC_TRANSPORTERS, PUJANA_CHEK2_PCC_NETWORK, BLALOCK_ALZHEIMERS_DISEASE_UP, BILD_E2F3_ONCOGENIC_SIGNATURE, GOBP_ORGANIC_ANION_TRANSPORT, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP, RYTTCCTG_ETS2_B, GOBP_LIPID_LOCALIZATION, MILI_PSEUDOPODIA_CHEMOTAXIS_DN, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_LEUKOTRIENE_METABOLIC_PROCESS

GO Biological Process (7): leukotriene metabolic process (GO:0006691), lipid transport (GO:0006869), obsolete organic anion transport (GO:0015711), transmembrane transport (GO:0055085), leukotriene transport (GO:0071716), xenobiotic transport (GO:0042908), monoatomic anion transmembrane transport (GO:0098656)

GO Molecular Function (8): ATP binding (GO:0005524), ABC-type xenobiotic transporter activity (GO:0008559), ABC-type glutathione S-conjugate transporter activity (GO:0015431), ATP hydrolysis activity (GO:0016887), obsolete ATPase-coupled inorganic anion transmembrane transporter activity (GO:0043225), ABC-type transporter activity (GO:0140359), nucleotide binding (GO:0000166), xenobiotic transmembrane transporter activity (GO:0042910)

GO Cellular Component (5): lysosomal membrane (GO:0005765), plasma membrane (GO:0005886), basal plasma membrane (GO:0009925), basolateral plasma membrane (GO:0016323), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
ABC-type transporter activity	2
plasma membrane region	2
icosanoid metabolic process	1
lipid localization	1
cellular process	1
icosanoid transport	1
monoatomic anion transport	1
monoatomic ion transmembrane transport	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
xenobiotic transmembrane transporter activity	1
sulfur compound transmembrane transporter activity	1
ribonucleoside triphosphate phosphatase activity	1
ATP-dependent activity	1
ATPase-coupled transmembrane transporter activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
transmembrane transporter activity	1
xenobiotic transport	1
lysosome	1
lytic vacuole membrane	1
membrane	1
cell periphery	1
basal part of cell	1
basal plasma membrane	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1150 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ABCC10	MRPS7	Q9Y2R9	592
ABCC10	E2F1	Q01094	525
ABCC10	ABCE1	P61221	499
ABCC10	ABCG4	Q9H172	490
ABCC10	ABCF1	Q8NE71	489
ABCC10	ABCF2	Q9UG63	481
ABCC10	ABCF3	Q9NUQ8	452
ABCC10	HLA-E	P13747	449
ABCC10	ABCB1	P08183	440
ABCC10	ABCB5	Q2M3G0	430
ABCC10	ABCG5	Q9H222	426
ABCC10	ZNF318	Q5VUA4	417
ABCC10	ABCG1	P45844	401
ABCC10	SLC22A6	Q4U2R8	377
ABCC10	ABCG2	Q9UNQ0	371

IntAct

33 interactions, top by confidence:

A	B	Type	Score
ECSIT	NDUFS8	psi-mi:“MI:0914”(association)	0.530
SLC30A2	RER1	psi-mi:“MI:0914”(association)	0.530
TEX264	PER1	psi-mi:“MI:0914”(association)	0.530
CHRND	TPST2	psi-mi:“MI:0914”(association)	0.530
	DENND11	psi-mi:“MI:0914”(association)	0.350
ATP2B2	ESYT2	psi-mi:“MI:0914”(association)	0.350
TTMP	TMEM223	psi-mi:“MI:0914”(association)	0.350
TTYH1	TMEM223	psi-mi:“MI:0914”(association)	0.350
CHRNA4	TMEM223	psi-mi:“MI:0914”(association)	0.350
CMTM5	TMEM120B	psi-mi:“MI:0914”(association)	0.350
ZDHHC12	NBAS	psi-mi:“MI:0914”(association)	0.350
CHRNB2	TMEM131L	psi-mi:“MI:0914”(association)	0.350
AVPR1B	KLRG2	psi-mi:“MI:0914”(association)	0.350
OPRL1	METTL15	psi-mi:“MI:0914”(association)	0.350
RXFP1	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
KCNMB3	UPK3BL1	psi-mi:“MI:0914”(association)	0.350
PCDHGC4		psi-mi:“MI:0914”(association)	0.350
NKAIN1	GPR89A	psi-mi:“MI:0914”(association)	0.350
GPR12	TLCD2	psi-mi:“MI:0914”(association)	0.350
MARCHF4	C2CD2L	psi-mi:“MI:0914”(association)	0.350
MS4A15	ABCD4	psi-mi:“MI:0914”(association)	0.350
SLC17A2	ABCD4	psi-mi:“MI:0914”(association)	0.350
OR10H2	ABCD4	psi-mi:“MI:0914”(association)	0.350
OR10H1	NRP1	psi-mi:“MI:0914”(association)	0.350
CHRM4	TNPO2	psi-mi:“MI:0914”(association)	0.350
DPM2	WDR46	psi-mi:“MI:0914”(association)	0.350
OR4N2	EMC8	psi-mi:“MI:0914”(association)	0.350
PIGH	ILVBL	psi-mi:“MI:0914”(association)	0.350
ECSIT	NDUFA2	psi-mi:“MI:0914”(association)	0.350
SLC39A8	CEBPZOS	psi-mi:“MI:0914”(association)	0.350

BioGRID (46): ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-RNA), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS), ABCC10 (Affinity Capture-MS)

ESM2 similar proteins: A0A8C2M425, A1L1J9, B0BNF0, B0BNG2, B6CZ46, B6CZ56, C1BKZ7, F1RMN2, O88269, O95255, P86243, Q03518, Q28433, Q32L10, Q32LM8, Q3MHQ7, Q3T0W0, Q497J1, Q499P8, Q49LS7, Q4VV71, Q5KR61, Q5R8F6, Q5REM8, Q5T3U5, Q61672, Q6AZ83, Q6NVG1, Q6UW68, Q767L9, Q7TPN3, Q86VD9, Q8AVI9, Q8C0T0, Q8C3X8, Q8K0H7, Q8N2M4, Q8N661, Q8R1J1, Q8R4P9

Diamond homologs: A0A0D1CZ63, A0A1U8QTJ9, A2XCD4, A7KVC2, B2RX12, E7F6F7, E9Q236, F1M3J4, G5EFD4, H2LNR5, J9VQH1, O15438, O15439, O15440, O35379, O60706, O88269, O88563, O95255, P0AAG5, P0AAG6, P0AAG7, P0CE69, P14772, P32386, P33527, P38735, P39109, P70170, P75094, P82451, P91660, Q09427, Q09428, Q09429, Q10185, Q10RX7, Q28689, Q42093, Q4HVU7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 54 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
monoatomic ion transmembrane transport	5	23.6×	8e-04

Disease & clinical

Cancer significance

Clinical variants and AI predictions

ClinVar

292 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	238
Likely benign	18
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

4328 predictions. Top by Δscore:

Variant	Effect	Δscore
6:43433346:G:GT	donor_gain	1.0000
6:43433357:TAAG:T	donor_loss	1.0000
6:43433358:AAGGT:A	donor_loss	1.0000
6:43433359:AG:A	donor_loss	1.0000
6:43433360:GG:G	donor_loss	1.0000
6:43433361:G:A	donor_loss	1.0000
6:43434616:CCTA:C	acceptor_loss	1.0000
6:43434619:A:AG	acceptor_gain	1.0000
6:43434619:AGCT:A	acceptor_loss	1.0000
6:43434619:AGCTT:A	acceptor_gain	1.0000
6:43434620:G:GG	acceptor_gain	1.0000
6:43434620:GC:G	acceptor_gain	1.0000
6:43434620:GCT:G	acceptor_gain	1.0000
6:43434620:GCTT:G	acceptor_gain	1.0000
6:43434620:GCTTG:G	acceptor_gain	1.0000
6:43435799:A:AG	acceptor_gain	1.0000
6:43435808:T:TA	acceptor_gain	1.0000
6:43435809:G:A	acceptor_gain	1.0000
6:43437932:AG:A	acceptor_gain	1.0000
6:43437933:GG:G	acceptor_gain	1.0000
6:43438009:CACAG:C	donor_loss	1.0000
6:43438010:ACAG:A	donor_loss	1.0000
6:43438012:AGG:A	donor_loss	1.0000
6:43438014:G:T	donor_loss	1.0000
6:43438757:G:GT	donor_gain	1.0000
6:43438792:CAGT:C	donor_gain	1.0000
6:43438794:GT:G	donor_gain	1.0000
6:43438794:GTGT:G	donor_loss	1.0000
6:43438795:TGTG:T	donor_loss	1.0000
6:43438796:G:GG	donor_gain	1.0000

AlphaMissense

9439 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:43441913:A:C	S727R	0.996
6:43441915:C:A	S727R	0.996
6:43441915:C:G	S727R	0.996
6:43449438:A:T	E1407V	0.994
6:43443024:G:C	A761P	0.993
6:43443034:T:C	L764P	0.993
6:43447832:G:A	G1285D	0.993
6:43447835:A:T	K1286M	0.993
6:43435770:T:C	L543P	0.992
6:43447816:G:C	G1280R	0.992
6:43443013:A:T	D757V	0.991
6:43447836:G:C	K1286N	0.991
6:43447836:G:T	K1286N	0.991
6:43433184:T:A	W402R	0.990
6:43433184:T:C	W402R	0.990
6:43435754:T:C	F538L	0.990
6:43435756:C:A	F538L	0.990
6:43435756:C:G	F538L	0.990
6:43447811:T:A	I1278N	0.990
6:43447835:A:C	K1286T	0.990
6:43447838:C:T	S1287F	0.990
6:43448905:G:C	Q1328H	0.990
6:43448905:G:T	Q1328H	0.990
6:43449438:A:C	E1407A	0.990
6:43449961:T:C	L1450P	0.990
6:43441932:G:C	R733P	0.989
6:43441944:C:A	A737D	0.989
6:43447721:T:C	F1248S	0.989
6:43447817:G:T	G1280V	0.989
6:43447834:A:G	K1286E	0.989

dbSNP variants (sampled 300 via entrez): RS1000144165 (6:43443353 T>C), RS1000429626 (6:43437011 G>A), RS1000434065 (6:43430759 G>C,T), RS1000534219 (6:43441629 A>G), RS1000885104 (6:43436746 C>G), RS1001166463 (6:43435455 C>T), RS1001424006 (6:43447570 T>C), RS1001539913 (6:43435022 C>T), RS1001542947 (6:43437518 C>T), RS1001773157 (6:43431093 A>C), RS1002056152 (6:43429901 C>G,T), RS1002185185 (6:43447970 G>A,C), RS1002501591 (6:43439561 C>A,T), RS1002670716 (6:43426014 A>G), RS1002722221 (6:43432831 G>T)

Disease associations

OMIM: gene MIM:612509 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST004521_164	Autism spectrum disorder or schizophrenia	3.000000e-08
GCST005196_100	Coronary artery disease	1.000000e-06
GCST006259_53	Systolic blood pressure	5.000000e-09
GCST007576_192	Chronotype	3.000000e-09
GCST012227_10	Hip circumference adjusted for BMI	4.000000e-08
GCST012227_11	Hip circumference adjusted for BMI	6.000000e-09
GCST012442_48	Age-related hearing impairment	3.000000e-11
GCST90011900_185	Serum alkaline phosphatase levels	2.000000e-10

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0008328	chronotype measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0004533	alkaline phosphatase measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2073687 (SINGLE PROTEIN)

Clinical evidence (CIViC)

Drug × variant × indication: 1 predictive associations from 1 curated evidence items.

Variant	Therapy	Indication	Effect	Level	CIViC
ABCC10 Overexpression	Paclitaxel	Lung Non-small Cell Carcinoma	Resistance	CIViC D	EID952

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB clinical annotations

3 annotations.

Variant	Type	Level	Drugs	Phenotypes
rs2125739	Metabolism/PK	3	nevirapine	HIV infectious disease
rs9349256	Toxicity	3	tenofovir
rs9349256	Toxicity	3	tenofovir disoproxil fumarate	HIV infectious disease;Nephrotoxicity

PharmGKB variants

7 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs1214763	ABCC10		0.00	0
rs2125739	ABCC10	3	2.00	1	nevirapine
rs2185631	ABCC10		0.00	0
rs2487663	ABCC10		0.00	0
rs9349256	ABCC10	3	2.50	2	tenofovir disoproxil fumarate;tenofovir
rs9394952	ABCC10		0.00	0
rs4714684	ABCC10		0.00	0

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: transporter — ABCC subfamily

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	2
Paclitaxel	decreases abundance, increases secretion, decreases response to substance, decreases reaction, increases expression	2
aristolochic acid I	increases expression	1
trichostatin A	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
potassium chromate(VI)	decreases expression, affects cotreatment	1
N,N,N’,N’-tetrakis(2-pyridylmethyl)ethylenediamine	decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
nilotinib	decreases abundance, decreases reaction, increases secretion, decreases response to substance	1
jinfukang	increases expression	1
(+)-JQ1 compound	increases expression	1
Imatinib Mesylate	decreases abundance, decreases reaction, increases secretion, decreases response to substance	1
Docetaxel	decreases expression, decreases response to substance	1
Sunitinib	increases expression	1
Arsenic	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Rifampin	increases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Vincristine	decreases response to substance, decreases reaction	1
2-Acetylaminofluorene	increases expression	1
Zidovudine	increases expression	1
Cyclosporine	decreases expression	1
Asbestos, Crocidolite	decreases expression	1
Zinc Sulfate	increases expression	1
Acrylamide	decreases expression	1

ChEMBL screening assays

30 unique, capped per target: 24 functional, 6 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2076521	Functional	TP_TRANSPORTER: uptake in membrane vesicles from MRP7-expressing HEK293 cells	Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). — Mol Pharmacol
CHEMBL3382975	Binding	Inhibition of ABCC10 (unknown origin) assessed as reduction in BeFx-sensitive ATPase activity at 12.5 uM incubated over 20 mins by inorganic phosphate release assay	Synthesis and biological evaluation of pentacyclic strychnos alkaloids as selective modulators of the ABCC10 (MRP7) efflux pump. — J Med Chem

Cellosaurus cell lines

5 cell lines: 3 transformed cell line, 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3Q0	SKOV3/MRP7	Cancer cell line	Female
CVCL_B3Q1	HEK293-MRP7	Transformed cell line	Female
CVCL_B6A0	C2BBe1 MRP7 KO	Cancer cell line	Male
CVCL_B7SA	HEK293-MRP7-C17	Transformed cell line	Female
CVCL_B7SB	HEK293-MRP7-C18	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.