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ABHD4

gene
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Also known as FLJ12816

Summary

ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B, HGNC:20154) is a protein-coding gene on chromosome 14q11.2, encoding (Lyso)-N-acylphosphatidylethanolamine lipase (Q8TB40). Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE).

Predicted to enable lysophosphatidic acid acyltransferase activity and lysophospholipase activity. Predicted to be involved in N-acylphosphatidylethanolamine metabolic process; lipid homeostasis; and phosphatidic acid biosynthetic process. Predicted to act upstream of or within N-acylethanolamine metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in lipid droplet and mitochondrion.

Source: NCBI Gene 63874 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 76 total — 9 pathogenic, 1 likely-pathogenic
  • MANE Select transcript: NM_022060

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:20154
Approved symbolABHD4
Nameabhydrolase domain containing 4, N-acyl phospholipase B
Location14q11.2
Locus typegene with protein product
StatusApproved
AliasesFLJ12816
Ensembl geneENSG00000100439
Ensembl biotypeprotein_coding
OMIM619728
Entrez63874

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000216327, ENST00000418446, ENST00000428304, ENST00000489928, ENST00000537243, ENST00000539344, ENST00000541962, ENST00000542041, ENST00000544562, ENST00000545034, ENST00000870569, ENST00000919857

RefSeq mRNA: 2 — MANE Select: NM_022060 NM_001392009, NM_022060

CCDS: CCDS9572

Canonical transcript exons

ENST00000428304 — 7 exons

ExonStartEnd
ENSE000016650362261085922612963
ENSE000022822782259830022598329
ENSE000034817272260166722601755
ENSE000035244082260972422609910
ENSE000035666992260339022603762
ENSE000036764122260642222606533
ENSE000036852782260392522604079

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 94.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.2880 / max 256.5482, expressed in 1794 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
13881225.30721794
1388110.6548405
1388140.3260146

Top tissues by expression

272 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
lower esophagus mucosaUBERON:003583494.52gold quality
stromal cell of endometriumCL:000225594.15gold quality
adrenal tissueUBERON:001830392.96gold quality
right testisUBERON:000453492.89gold quality
popliteal arteryUBERON:000225092.68gold quality
tibial arteryUBERON:000761092.66gold quality
esophagus mucosaUBERON:000246992.51gold quality
left testisUBERON:000453392.48gold quality
aortaUBERON:000094792.36gold quality
right adrenal gland cortexUBERON:003582792.21gold quality
ascending aortaUBERON:000149692.14gold quality
thoracic aortaUBERON:000151592.06gold quality
right adrenal glandUBERON:000123391.70gold quality
ectocervixUBERON:001224991.52gold quality
left adrenal glandUBERON:000123491.50gold quality
esophagusUBERON:000104391.47gold quality
gall bladderUBERON:000211091.46gold quality
ventricular zoneUBERON:000305391.41gold quality
right lobe of thyroid glandUBERON:000111991.31gold quality
right coronary arteryUBERON:000162591.17gold quality
testisUBERON:000047391.05gold quality
body of stomachUBERON:000116191.04gold quality
left lobe of thyroid glandUBERON:000112090.94gold quality
descending thoracic aortaUBERON:000234590.90gold quality
body of uterusUBERON:000985390.67gold quality
left adrenal gland cortexUBERON:003582590.57gold quality
adrenal glandUBERON:000236990.45gold quality
lower esophagusUBERON:001347390.34gold quality
lower esophagus muscularis layerUBERON:003583390.30gold quality
hindlimb stylopod muscleUBERON:000425290.28gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-MTAB-9067yes11.39
E-ANND-3no0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

  • Lysophospholipase/phospholipase B (EC 3.1.1.5) specific for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the biosynthesis of N-acyl ethanolamines including the endocannabinoid anandamide. (PMID:16818490)
  • ABHD4 is a novel genetic regulator of anoikis sensitivity. (PMID:22488300)
  • ABHD4-dependent developmental anoikis safeguards the embryonic brain. (PMID:32868797)

Cross-species orthologs

11 orthologs

OrganismSymbolGene ID
danio_rerioabhd4ENSDARG00000102887
mus_musculusAbhd4ENSMUSG00000040997
rattus_norvegicusAbhd4ENSRNOG00000009244
drosophila_melanogasterpumlFBGN0033226
caenorhabditis_elegansC31H5.1WBGENE00007854
caenorhabditis_elegansWBGENE00017335
caenorhabditis_elegansWBGENE00018077
caenorhabditis_elegansWBGENE00019525
caenorhabditis_elegansWBGENE00022258
caenorhabditis_elegansWBGENE00022259
caenorhabditis_elegansWBGENE00022260

Paralogs (12): ABHD5 (ENSG00000011198), EPHX3 (ENSG00000105131), ABHD11 (ENSG00000106077), MEST (ENSG00000106484), ABHD14B (ENSG00000114779), EPHX2 (ENSG00000120915), ABHD8 (ENSG00000127220), BPHL (ENSG00000137274), ABHD6 (ENSG00000163686), EPHX4 (ENSG00000172031), SERHL2 (ENSG00000183569), ABHD14A (ENSG00000248487)

Protein

Protein identifiers

(Lyso)-N-acylphosphatidylethanolamine lipase — Q8TB40 (reviewed: Q8TB40)

Alternative names: Alpha/beta hydrolase domain-containing protein 4, Alpha/beta-hydrolase 4

All UniProt accessions (6): Q8TB40, F5GZC9, F5H067, F5H6T0, H0YFD5, J3KMW0

UniProt curated annotations — full annotation on UniProt →

Function. Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.

Similarity. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

Isoforms (2)

UniProt IDNamesCanonical?
Q8TB40-11yes
Q8TB40-22

RefSeq proteins (2): NP_001378938, NP_071343* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000073AB_hydrolase_1Domain
IPR029058AB_hydrolase_foldHomologous_superfamily

Pfam: PF00561

Catalyzed reactions (Rhea), 10 shown:

  • N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45384)
  • N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl-sn-glycero-3-phospho-ethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45388)
  • N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-eicosanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45392)
  • N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45396)
  • N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45400)
  • N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) (RHEA:45420)
  • N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+) (RHEA:45424)
  • an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N,1-diacyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+) (RHEA:45460)
  • 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + (9Z)-octadecenoate + H(+) (RHEA:55236)
  • 1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + (9Z)-octadecenoate + H(+) (RHEA:55240)

UniProt features (5 total): splice variant 2, chain 1, domain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8TB40-F188.300.71

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

IDPathway
R-HSA-1482839Acyl chain remodelling of PE
R-HSA-1430728Metabolism
R-HSA-1483206Glycerophospholipid biosynthesis
R-HSA-1483257Phospholipid metabolism
R-HSA-556833Metabolism of lipids

MSigDB gene sets: 206 (showing top): TGGTGCT_MIR29A_MIR29B_MIR29C, AP1_01, GOBP_PHOSPHOLIPID_METABOLIC_PROCESS, KOBAYASHI_EGFR_SIGNALING_24HR_UP, GOBP_PHOSPHATIDYLCHOLINE_METABOLIC_PROCESS, XU_GH1_AUTOCRINE_TARGETS_UP, FISCHER_G1_S_CELL_CYCLE, GOZGIT_ESR1_TARGETS_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, AP4_Q6, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, CAGCTG_AP4_Q5, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_PHOSPHOLIPID_BIOSYNTHETIC_PROCESS

GO Biological Process (7): phosphatidic acid biosynthetic process (GO:0006654), lipid catabolic process (GO:0016042), phosphatidylethanolamine acyl-chain remodeling (GO:0036152), lipid homeostasis (GO:0055088), N-acylphosphatidylethanolamine metabolic process (GO:0070292), lipid metabolic process (GO:0006629), glycerophospholipid metabolic process (GO:0006650)

GO Molecular Function (4): phosphatidylcholine lysophospholipase A1 activity (GO:0004622), hydrolase activity (GO:0016787), lysophosphatidic acid acyltransferase activity (GO:0042171), protein binding (GO:0005515)

GO Cellular Component (2): endoplasmic reticulum membrane (GO:0005789), lipid droplet (GO:0005811)

Reactome top-level categories

Rollup of top-4 pathways:

CategoryPathways
Glycerophospholipid biosynthesis1
Phospholipid metabolism1
Metabolism of lipids1
Metabolism1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
phosphatidic acid metabolic process1
glycerophospholipid biosynthetic process1
lipid metabolic process1
catabolic process1
phosphatidylcholine metabolic process1
chemical homeostasis1
phosphatidylethanolamine metabolic process1
primary metabolic process1
phospholipid metabolic process1
glycerolipid metabolic process1
lysophospholipase A1 activity1
catalytic activity1
lysophospholipid acyltransferase activity1
binding1
organelle membrane1
nuclear outer membrane-endoplasmic reticulum membrane network1
endoplasmic reticulum subcompartment1
intracellular membraneless organelle1

Protein interactions and networks

STRING

1374 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
ABHD4GDE1Q9NZC3864
ABHD4NAPEPLDQ6IQ20852
ABHD4ABHD12Q8N2K0739
ABHD4ABHD6Q9BV23735
ABHD4MGLLQ99685721
ABHD4FAAHO00519720
ABHD4DAGLAQ9Y4D2714
ABHD4DAGLBQ8NCG7678
ABHD4NAAAQ02083658
ABHD4FAAH2Q6GMR7623
ABHD4ABHD3Q8WU67612
ABHD4GPR55Q9Y2T6546
ABHD4ABHD2P08910545
ABHD4GDPD1Q8N9F7543
ABHD4ABHD16AO95870542

IntAct

40 interactions, top by confidence:

ABTypeScore
BNIP2ABHD4psi-mi:“MI:0915”(physical association)0.560
ABHD4CMTM5psi-mi:“MI:0915”(physical association)0.560
REEP5ABHD4psi-mi:“MI:0915”(physical association)0.560
PLIN3ABHD4psi-mi:“MI:0915”(physical association)0.560
DGAT2L6ABHD4psi-mi:“MI:0915”(physical association)0.560
IGFBP5ABHD4psi-mi:“MI:0915”(physical association)0.560
ABHD4HTATIP2psi-mi:“MI:0915”(physical association)0.560
COL4A5ABHD4psi-mi:“MI:0915”(physical association)0.560
ABHD4DERL1psi-mi:“MI:0915”(physical association)0.560
ABHD4AURKAIP1psi-mi:“MI:0915”(physical association)0.560
ABHD4RABAC1psi-mi:“MI:0915”(physical association)0.560
ABHD4INSIG2psi-mi:“MI:0915”(physical association)0.560
ABHD4CSNK2Bpsi-mi:“MI:0915”(physical association)0.370
ABHD4TK1psi-mi:“MI:0915”(physical association)0.370
NEK4E2F8psi-mi:“MI:0914”(association)0.350
ABHD4CMTM5psi-mi:“MI:0915”(physical association)0.000
ABHD4DGAT2L6psi-mi:“MI:0915”(physical association)0.000
ABHD4REEP5psi-mi:“MI:0915”(physical association)0.000
ABHD4PLIN3psi-mi:“MI:0915”(physical association)0.000
IGFBP5ABHD4psi-mi:“MI:0915”(physical association)0.000
COL4A5ABHD4psi-mi:“MI:0915”(physical association)0.000
DERL1ABHD4psi-mi:“MI:0915”(physical association)0.000
INSIG2ABHD4psi-mi:“MI:0915”(physical association)0.000
HTATIP2ABHD4psi-mi:“MI:0915”(physical association)0.000

BioGRID (16): PLIN3 (Two-hybrid), RABAC1 (Two-hybrid), HTATIP2 (Two-hybrid), IGFBP5 (Two-hybrid), INSIG2 (Two-hybrid), REEP5 (Two-hybrid), DERL1 (Two-hybrid), BNIP2 (Two-hybrid), CMTM5 (Two-hybrid), AURKAIP1 (Two-hybrid), DGAT2L6 (Two-hybrid), COL4A5 (Two-hybrid), ABHD4 (Affinity Capture-MS), ABHD4 (Proximity Label-MS), ABHD4 (Two-hybrid)

ESM2 similar proteins: A5GFX0, A8Y5H7, F7B909, O59707, P35200, P49675, P51557, P59095, P59096, P70114, Q03606, Q04006, Q05776, Q0V9N0, Q14849, Q16KN5, Q28996, Q29JQ0, Q4R5S9, Q54G07, Q54VC7, Q58DB0, Q5BKH5, Q5EA59, Q5RBI4, Q61542, Q6GM21, Q6NTS7, Q6P9U4, Q6TMK8, Q8GXB1, Q8TB40, Q8VD66, Q8VE85, Q8WTS1, Q92503, Q96N28, Q9CYY7, Q9DE06, Q9DEB4

Diamond homologs: A1VUV0, A4JPX5, A5I3F5, A8YWL3, B2JQW2, C0ZKI1, C3K630, C7TMK0, D5H0J3, O52866, O83041, P17548, P46541, P46542, P46544, P47229, P52278, P52279, P96084, Q03NE0, Q184M8, Q1G8L9, Q49KF8, Q52011, Q52036, Q59324, Q5EA59, Q5FMT1, Q76KX0, Q87DF8, Q890D8, Q8KZP5, Q8TB40, Q8VD66, Q97A76, Q97UA2, Q9KWQ6, Q9PD69, Q9S2L4, A1AGT6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic9
Likely pathogenic1
Uncertain significance58
Likely benign0
Benign0

Top pathogenic / likely-pathogenic (10)

Variant IDHGVSClassification
1703540GRCh37/hg19 14q11.2-21.3(chr14:20511672-47481203)Pathogenic
253659GRCh37/hg19 14q11.2-12(chr14:19794561-27768254)x3Pathogenic
3391854GRCh37/hg19 14q11.2(chr14:20875269-23659582)x3Pathogenic
57246GRCh38/hg38 14q11.2(chr14:20151149-23442195)x3Pathogenic
57743GRCh38/hg38 14q11.2(chr14:19755249-22741281)x1Pathogenic
59932GRCh38/hg38 14q11.2-21.1(chr14:20000611-38984415)x3Pathogenic
625814GRCh37/hg19 14q11.2-12(chr14:19100682-28730087)Pathogenic
815628GRCh37/hg19 14q11.2-21.2(chr14:20511672-44829030)x3Pathogenic
815629GRCh37/hg19 14q11.2(chr14:21143933-23297667)x1Pathogenic
666446GRCh37/hg19 14q11.2(chr14:21717093-24027220)x3Likely pathogenic

SpliceAI

1068 predictions. Top by Δscore:

VariantEffectΔscore
14:22598327:GCA:Gdonor_gain1.0000
14:22598330:G:GGdonor_gain1.0000
14:22601663:CCA:Cacceptor_loss1.0000
14:22601754:GT:Gdonor_gain1.0000
14:22601755:TG:Tdonor_loss1.0000
14:22601756:G:GAdonor_loss1.0000
14:22601756:G:GGdonor_gain1.0000
14:22601757:T:Gdonor_loss1.0000
14:22603386:CCA:Cacceptor_loss1.0000
14:22603388:A:ACacceptor_loss1.0000
14:22603641:GA:Gdonor_gain1.0000
14:22606419:CAG:Cacceptor_loss1.0000
14:22606420:A:ACacceptor_loss1.0000
14:22606420:A:AGacceptor_gain1.0000
14:22606420:AG:Aacceptor_gain1.0000
14:22606420:AGG:Aacceptor_gain1.0000
14:22606421:G:GGacceptor_gain1.0000
14:22606421:GG:Gacceptor_gain1.0000
14:22606421:GGG:Gacceptor_gain1.0000
14:22606421:GGGC:Gacceptor_gain1.0000
14:22606421:GGGCC:Gacceptor_gain1.0000
14:22606530:CCAG:Cdonor_loss1.0000
14:22606531:CAGG:Cdonor_loss1.0000
14:22606532:AGGTG:Adonor_loss1.0000
14:22606533:GGTGA:Gdonor_loss1.0000
14:22606534:G:GAdonor_loss1.0000
14:22606535:T:Adonor_loss1.0000
14:22609719:GACA:Gacceptor_loss1.0000
14:22609721:CA:Cacceptor_loss1.0000
14:22609722:A:AGacceptor_gain1.0000

AlphaMissense

2245 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
14:22603527:T:AW84R1.000
14:22603527:T:CW84R1.000
14:22603587:G:CG104R1.000
14:22603590:T:CF105L1.000
14:22603592:C:AF105L1.000
14:22603592:C:GF105L1.000
14:22603668:T:AW131R1.000
14:22603668:T:CW131R1.000
14:22603672:G:CR132P1.000
14:22604071:G:AG211E1.000
14:22601726:T:CL28P0.999
14:22603510:G:AG78E0.999
14:22603579:A:CD101A0.999
14:22603579:A:TD101V0.999
14:22603588:G:AG104D0.999
14:22603588:G:TG104V0.999
14:22603593:G:TG106W0.999
14:22603594:G:AG106E0.999
14:22603599:A:CS108R0.999
14:22603600:G:TS108I0.999
14:22603601:C:AS108R0.999
14:22603601:C:GS108R0.999
14:22603606:G:TR110M0.999
14:22603707:G:TG144W0.999
14:22603708:G:AG144E0.999
14:22603708:G:TG144V0.999
14:22603719:G:AG148R0.999
14:22603719:G:CG148R0.999
14:22603720:G:AG148E0.999
14:22603720:G:TG148V0.999

dbSNP variants (sampled 300 via entrez): RS1000184763 (14:22600513 C>T), RS1000362752 (14:22607530 G>A,C), RS1000403768 (14:22602402 C>T), RS1000652725 (14:22597270 C>A), RS1001284841 (14:22600841 T>G), RS1001289504 (14:22612462 T>C), RS1001637172 (14:22608947 G>A,T), RS1001853342 (14:22610300 G>A), RS1001919628 (14:22609173 T>A,C), RS1002069663 (14:22604471 C>A,T), RS1002276874 (14:22598467 G>A,T), RS1002507771 (14:22600404 C>T), RS1002734384 (14:22598751 G>T), RS1002921238 (14:22608697 T>C), RS1002959981 (14:22602697 C>T)

Disease associations

OMIM: gene MIM:619728 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST003253_7Microalbuminuria4.000000e-06
GCST009391_702Metabolite levels2.000000e-06

EFO canonical traits (1, from GWAS)

EFO IDTrait name
EFO:0010356lysophosphatidylcholine 14:0 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — 2-Acylglycerol ester turnover

CTD chemical–gene interactions

51 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyreneincreases expression4
sodium arseniteincreases expression, decreases expression, affects cotreatment, increases abundance3
Cisplatinincreases expression3
Cyclosporineincreases expression3
bisphenol Aaffects expression, increases expression2
sulforaphaneincreases expression2
Cadmium Chlorideincreases expression2
aristolochic acid Iincreases expression1
chloroacetaldehydeaffects expression1
triphenyl phosphateaffects expression1
pirinixic acidaffects binding, increases activity, increases expression1
tris(1,3-dichloro-2-propyl)phosphateincreases expression1
cobaltous chlorideincreases expression1
manganese chlorideaffects cotreatment, increases abundance, increases expression1
potassium chromate(VI)decreases expression1
cupric chlorideincreases expression1
S-(1,2-dichlorovinyl)cysteinedecreases reaction, decreases expression1
perfluorooctane sulfonic acidincreases expression1
clothianidindecreases expression1
nutlin 3affects cotreatment, increases expression1
NSC 689534affects binding, increases expression1
1-(2-trifluoromethoxyphenyl)-2-nitroethanoneincreases expression1
Dasatinibincreases expression1
Cidofovirincreases expression1
Arsenicaffects cotreatment, increases abundance, increases expression1
Azathioprineincreases expression1
Copperaffects binding, increases expression1
Dactinomycinaffects cotreatment, increases expression1
Dichlorodiphenyl Dichloroethylenedecreases expression1
Clodronic Acidincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 76

This page pulls from 76 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot