ACOT1

Summary

ACOT1 (acyl-CoA thioesterase 1, HGNC:33128) is a protein-coding gene on chromosome 14q24.3, encoding Acyl-coenzyme A thioesterase 1 (Q86TX2). Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels.

Enables fatty acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol.

Source: NCBI Gene 641371 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 234 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001037161

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33128
Approved symbol	ACOT1
Name	acyl-CoA thioesterase 1
Location	14q24.3
Locus type	gene with protein product
Status	Approved
Aliases	ACH2, CTE-1, LACH2
Ensembl gene	ENSG00000184227
Ensembl biotype	protein_coding
OMIM	614313
Entrez	641371

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000311148, ENST00000557556

RefSeq mRNA: 1 — MANE Select: NM_001037161 NM_001037161

CCDS: CCDS32117

Canonical transcript exons

ENST00000311148 — 3 exons

Exon	Start	End
ENSE00000911930	73543050	73543796
ENSE00001197558	73537143	73537878
ENSE00001763751	73541493	73541695

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 88.05.

FANTOM5 (CAGE): breadth broad, TPM avg 0.8434 / max 111.2100, expressed in 358 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140539	0.4449	195
140541	0.1344	62
140538	0.1229	32
140540	0.0731	31
140542	0.0680	29

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.82	gold quality
right lobe of liver	UBERON:0001114	87.48	gold quality
smooth muscle tissue	UBERON:0001135	85.63	gold quality
heart left ventricle	UBERON:0002084	84.96	gold quality
gastrocnemius	UBERON:0001388	84.42	gold quality
liver	UBERON:0002107	84.40	gold quality
muscle of leg	UBERON:0001383	84.11	gold quality
apex of heart	UBERON:0002098	83.83	gold quality
mucosa of stomach	UBERON:0001199	83.05	gold quality
heart	UBERON:0000948	82.98	gold quality
adult mammalian kidney	UBERON:0000082	82.69	gold quality
right adrenal gland	UBERON:0001233	82.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.95	gold quality
lower esophagus	UBERON:0013473	81.94	gold quality
left coronary artery	UBERON:0001626	81.77	gold quality
hindlimb stylopod muscle	UBERON:0004252	81.67	gold quality
subcutaneous adipose tissue	UBERON:0002190	81.60	gold quality
right atrium auricular region	UBERON:0006631	81.33	gold quality
popliteal artery	UBERON:0002250	81.28	gold quality
left adrenal gland cortex	UBERON:0035825	81.27	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.25	gold quality
tibial artery	UBERON:0007610	81.23	gold quality
left adrenal gland	UBERON:0001234	81.19	gold quality
right adrenal gland cortex	UBERON:0035827	80.86	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.76	gold quality
adipose tissue	UBERON:0001013	80.44	gold quality
omental fat pad	UBERON:0010414	78.93	gold quality
adrenal gland	UBERON:0002369	78.85	gold quality
duodenum	UBERON:0002114	78.53	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	17.45
E-MTAB-6142	no	166.67

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

19 targeting ACOT1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-4271	99.88	68.32	2244
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-466	99.67	70.85	2863
HSA-MIR-664A-3P	99.22	71.08	2696
HSA-MIR-3688-5P	99.12	69.67	1091
HSA-MIR-603	98.58	68.28	1603
HSA-MIR-4717-5P	98.19	67.97	894
HSA-MIR-665	97.60	65.64	1781
HSA-MIR-4670-3P	97.37	68.35	1378
HSA-MIR-6734-5P	95.70	65.56	950

Literature-anchored findings (GeneRIF, showing 4)

• that increased expression of ACOT1 is correlated with pivotal clinicopathological parameters and poor prognosis in gastric adenocarcinoma through increased expression of the potential tumor-promoting protein GLI3 (PMID:29555575)
• The Thioesterase ACOT1 as a Regulator of Lipid Metabolism in Type 2 Diabetes Detected in a Multi-Omics Study of Human Liver. (PMID:34520261)
• Acyl-Coa Thioesterases: A Rheostat That Controls Activated Fatty Acids Modulates Dengue Virus Serotype 2 Replication. (PMID:35215835)
• Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as highly absent genes in gastric cancer population. (PMID:36109518)

Cross-species orthologs

16 orthologs

Organism	Symbol	Gene ID
danio_rerio	acot20	ENSDARG00000042510
danio_rerio	acot21	ENSDARG00000042513
danio_rerio	acot22	ENSDARG00000058945
mus_musculus	Acot2	ENSMUSG00000021226
mus_musculus	Acot3	ENSMUSG00000021228
mus_musculus	Acot5	ENSMUSG00000042540
mus_musculus	Acot1	ENSMUSG00000072949
rattus_norvegicus	Acot2	ENSRNOG00000010134
rattus_norvegicus	Acot3	ENSRNOG00000027960
rattus_norvegicus	Acot5	ENSRNOG00000032508
rattus_norvegicus	Acot5	ENSRNOG00000053460
rattus_norvegicus	Acot1	ENSRNOG00000055221
caenorhabditis_elegans	C31H5.6	WBGENE00007857
caenorhabditis_elegans		WBGENE00019404
caenorhabditis_elegans	T05E7.1	WBGENE00020258
caenorhabditis_elegans	W03D8.8	WBGENE00020989

Paralogs (4): ACOT2 (ENSG00000119673), BAAT (ENSG00000136881), ACOT4 (ENSG00000177465), ACOT6 (ENSG00000205669)

Protein

Protein identifiers

Acyl-coenzyme A thioesterase 1 — Q86TX2 (reviewed: Q86TX2)

Alternative names: CTE-I, CTE-Ib, Inducible cytosolic acyl-coenzyme A thioester hydrolase, Long chain acyl-CoA thioester hydrolase, Palmitoyl-coenzyme A thioesterase

All UniProt accessions (3): E9KL42, G3V4F2, Q86TX2

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).

Subunit / interactions. Monomer.

Subcellular location. Cytoplasm. Cytosol.

Pathway. Lipid metabolism; fatty acid metabolism.

Similarity. Belongs to the C/M/P thioester hydrolase family.

RefSeq proteins (1): NP_001032238* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006862	Thio_Ohase/aa_AcTrfase	Domain
IPR014940	BAAT_C	Domain
IPR016662	Acyl-CoA_thioEstase_long-chain	Family
IPR029058	AB_hydrolase_fold	Homologous_superfamily
IPR042490	Thio_Ohase/BAAT_N	Homologous_superfamily

Pfam: PF04775, PF08840

Enzyme classification (BRENDA):

• EC 3.1.2.2 — palmitoyl-CoA hydrolase (BRENDA: 40 organisms, 184 substrates, 159 inhibitors, 142 Km, 46 kcat entries)

Substrate kinetics (BRENDA)

34 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
HEXADECANOYL-COA	—	26
DODECANOYL-COA	0.0018–0.325	12
LAUROYL-COA	0.0385–0.185	10
OLEOYL-COA	0.0014–0.0088	8
TETRADECANOYL-COA	0.0016–0.024	8
ARACHIDONOYL-COA	0.0004–0.0092	6
DECANOYL-COA	0.0027–0.067	6
P-NITROPHENYL BUTYRATE	0.61–1.88	6
PALMITOLEOYL-COA	0.0014–0.058	6
N-CARBOBENZOXY-L-TYROSINE P-NITROPHENYL ESTER	0.043–0.174	5
OCTADECANOYL-COA	0.0004–0.034	5
OCTANOYL-COA	0.007–0.118	5
EICOSANOYL-COA	0.0004–0.0048	3
HEXANOYL-COA	0.0055–0.077	3
PALMITOYL-COA	0.0033–0.023	3

Catalyzed reactions (Rhea), 9 shown:

• hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+) (RHEA:16645)
• dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+) (RHEA:30135)
• octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+) (RHEA:30139)
• decanoyl-CoA + H2O = decanoate + CoA + H(+) (RHEA:40059)
• tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+) (RHEA:40119)
• (9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+) (RHEA:40131)
• (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+) (RHEA:40139)
• eicosanoyl-CoA + H2O = eicosanoate + CoA + H(+) (RHEA:40147)
• (9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+) (RHEA:40723)

UniProt features (6 total): active site 3, initiator methionine 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86TX2-F1	96.65	0.96

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (3): 232 (charge relay system); 326 (charge relay system); 360 (charge relay system)

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-77289	Mitochondrial Fatty Acid Beta-Oxidation
R-HSA-1430728	Metabolism
R-HSA-556833	Metabolism of lipids
R-HSA-8978868	Fatty acid metabolism

MSigDB gene sets: 77 (showing top): GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, KEGG_BIOSYNTHESIS_OF_UNSATURATED_FATTY_ACIDS, LA_MEN1_TARGETS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, chr14q24, GOBP_AMIDE_METABOLIC_PROCESS, FUJIWARA_PARK2_HEPATOCYTE_PROLIFERATION_DN, SCHAEFFER_PROSTATE_DEVELOPMENT_12HR_UP, GOBP_VERY_LONG_CHAIN_FATTY_ACID_METABOLIC_PROCESS, SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP, MCBRYAN_PUBERTAL_BREAST_5_6WK_UP, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS

GO Biological Process (6): very long-chain fatty acid metabolic process (GO:0000038), long-chain fatty acid metabolic process (GO:0001676), fatty acid metabolic process (GO:0006631), acyl-CoA metabolic process (GO:0006637), lipid metabolic process (GO:0006629), monocarboxylic acid metabolic process (GO:0032787)

GO Molecular Function (5): fatty acyl-CoA hydrolase activity (GO:0047617), carboxylic ester hydrolase activity (GO:0052689), protein binding (GO:0005515), hydrolase activity (GO:0016787), thiolester hydrolase activity (GO:0016790)

GO Cellular Component (3): mitochondrion (GO:0005739), cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Fatty acid metabolism	1
Metabolism	1
Metabolism of lipids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
fatty acid metabolic process	2
hydrolase activity, acting on ester bonds	2
cytoplasm	2
cellular anatomical structure	2
lipid metabolic process	1
monocarboxylic acid metabolic process	1
nucleoside phosphate metabolic process	1
sulfur compound metabolic process	1
purine-containing compound metabolic process	1
primary metabolic process	1
carboxylic acid metabolic process	1
acyl-CoA hydrolase activity	1
binding	1
catalytic activity	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

938 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACOT1	ACOT8	O14734	951
ACOT1	PPARA	Q07869	796
ACOT1	ACOT7	O00154	775
ACOT1	EHHADH	Q08426	596
ACOT1	HEATR4	Q86WZ0	588
ACOT1	ACOT13	Q9NPJ3	567
ACOT1	ACOX1	Q15067	538
ACOT1	RBM8A	Q9Y5S9	521
ACOT1	ACOT11	Q8WXI4	476
ACOT1	FABP5	Q01469	475
ACOT1	ACOT9	Q9Y305	465
ACOT1	PDK4	Q16654	455
ACOT1	CD4	P01730	448
ACOT1	CPT2	P23786	446
ACOT1	HMGCS2	P54868	440

IntAct

36 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
SLC35A5	TNKS	psi-mi:“MI:0914”(association)	0.640
TFAP2A	ACOT1	psi-mi:“MI:0915”(physical association)	0.560
PCNA	POM121C	psi-mi:“MI:0914”(association)	0.550
ACOT2	ACOT1	psi-mi:“MI:0914”(association)	0.530
KCNA10	GAPDHS	psi-mi:“MI:0914”(association)	0.530
AIFM1	HAX1	psi-mi:“MI:2364”(proximity)	0.420
HHATL	ACOT1	psi-mi:“MI:0915”(physical association)	0.400
PATZ1	ACOT1	psi-mi:“MI:0915”(physical association)	0.400
Chmp4b	BDP1	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
ZFP69B	CNP	psi-mi:“MI:0914”(association)	0.350
TMPRSS11E	RAB4A	psi-mi:“MI:0914”(association)	0.350
TFAP2A	TFAP2D	psi-mi:“MI:0914”(association)	0.350
CNP	UBB	psi-mi:“MI:0914”(association)	0.350
SPG7	TUBA4A	psi-mi:“MI:0914”(association)	0.350
FECH	GTPBP10	psi-mi:“MI:0914”(association)	0.350
AIFM1	NUDT19	psi-mi:“MI:2364”(proximity)	0.270
AURKAIP1	VWA8	psi-mi:“MI:2364”(proximity)	0.270
	VWA8	psi-mi:“MI:2364”(proximity)	0.270
HSPD1	VWA8	psi-mi:“MI:2364”(proximity)	0.270
COX14	NUDT19	psi-mi:“MI:2364”(proximity)	0.270
COX4I1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
MGST3	VWA8	psi-mi:“MI:2364”(proximity)	0.270
PDK1	VWA8	psi-mi:“MI:2364”(proximity)	0.270
SCO1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
SFXN1	HAX1	psi-mi:“MI:2364”(proximity)	0.270
TRMT61B	VWA8	psi-mi:“MI:2364”(proximity)	0.270
IMMP2L	MRPL45	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (142): ACOT1 (Affinity Capture-MS), ACOT1 (Affinity Capture-MS), ACOT1 (Affinity Capture-MS), ACOT1 (Affinity Capture-MS), ACOT1 (Affinity Capture-MS), ACOT1 (Affinity Capture-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS), ACOT1 (Proximity Label-MS)

ESM2 similar proteins: A0A1D5PJB7, A1A4Q9, A5YM72, A6NLP5, D3KCC4, I3L5V6, O43292, P10938, Q00973, Q05B52, Q09200, Q10468, Q14623, Q148G5, Q16586, Q2V8X7, Q3SZV0, Q561R2, Q5E9M9, Q5M868, Q5ZL13, Q66H45, Q69ZF3, Q6P3D0, Q6P7A1, Q6P9Z4, Q6SZW1, Q6TEC1, Q6ZPS2, Q7TMC8, Q864R5, Q86TX2, Q8IXI1, Q8N0W3, Q8N3Y3, Q8N6R0, Q8NF37, Q8NI29, Q8TCD5, Q8VBW8

Diamond homologs: A2AKK5, O55137, O55171, O88267, P49753, Q14032, Q32Q92, Q3I5F7, Q5FVR5, Q63276, Q6Q2Z6, Q86TX2, Q8BGG9, Q8BWN8, Q8N9L9, Q91X34, Q9QYR7, Q9QYR9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 47 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial protein degradation	6	21.4×	1e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

234 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	184
Likely benign	24
Benign	4

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
375394	NM_001037161.2(ACOT1):c.410_423del (p.Glu137fs)	Pathogenic

SpliceAI

939 predictions. Top by Δscore:

Variant	Effect	Δscore
14:73539729:G:GT	donor_gain	1.0000
14:73541230:T:A	acceptor_gain	1.0000
14:73541479:T:TA	acceptor_gain	1.0000
14:73541489:CAAG:C	acceptor_loss	1.0000
14:73541490:A:AG	acceptor_gain	1.0000
14:73541491:A:G	acceptor_gain	1.0000
14:73541491:A:T	acceptor_loss	1.0000
14:73541492:G:A	acceptor_loss	1.0000
14:73541492:G:GC	acceptor_gain	1.0000
14:73541492:GA:G	acceptor_gain	1.0000
14:73541492:GAA:G	acceptor_gain	1.0000
14:73541492:GAAC:G	acceptor_gain	1.0000
14:73541492:GAACC:G	acceptor_gain	1.0000
14:73541691:CTGAG:C	donor_gain	1.0000
14:73541692:TGAG:T	donor_gain	1.0000
14:73541693:GAG:G	donor_gain	1.0000
14:73541693:GAGG:G	donor_gain	1.0000
14:73541694:AG:A	donor_gain	1.0000
14:73541694:AGGT:A	donor_loss	1.0000
14:73541695:GG:G	donor_gain	1.0000
14:73541696:G:GA	donor_loss	1.0000
14:73541696:G:GG	donor_gain	1.0000
14:73539718:G:GT	donor_gain	0.9900
14:73539817:GGG:G	donor_gain	0.9900
14:73539818:GGG:G	donor_gain	0.9900
14:73541494:A:AG	acceptor_gain	0.9900
14:73541494:ACCT:A	acceptor_gain	0.9900
14:73541494:ACCTG:A	acceptor_gain	0.9900
14:73541495:C:G	acceptor_gain	0.9900
14:73543045:CTCA:C	acceptor_loss	0.9900

AlphaMissense

2700 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:73543366:A:C	D326A	0.983
14:73543380:A:C	S331R	0.983
14:73543382:T:A	S331R	0.983
14:73543382:T:G	S331R	0.983
14:73537557:T:C	F46L	0.982
14:73537559:C:A	F46L	0.982
14:73537559:C:G	F46L	0.982
14:73543365:G:C	D326H	0.982
14:73543469:C:A	H360Q	0.982
14:73543469:C:G	H360Q	0.982
14:73543584:T:A	W399R	0.982
14:73543584:T:C	W399R	0.982
14:73543366:A:T	D326V	0.981
14:73537635:T:C	F72L	0.980
14:73537637:C:A	F72L	0.980
14:73537637:C:G	F72L	0.980
14:73543467:C:G	H360D	0.980
14:73541561:A:C	S176R	0.979
14:73541563:T:A	S176R	0.979
14:73541563:T:G	S176R	0.979
14:73543367:C:A	D326E	0.977
14:73543367:C:G	D326E	0.977
14:73537575:T:G	Y52D	0.976
14:73543154:C:A	N255K	0.974
14:73543154:C:G	N255K	0.974
14:73543586:G:C	W399C	0.973
14:73543586:G:T	W399C	0.973
14:73543374:T:A	W329R	0.972
14:73543374:T:C	W329R	0.972
14:73537706:G:C	K95N	0.970

dbSNP variants (sampled 300 via entrez): RS1000028636 (14:73517976 C>T), RS1000042399 (14:73496632 T>C), RS1000135040 (14:73524860 A>G), RS1000190326 (14:73543268 G>A), RS1000326850 (14:73497772 A>G), RS1000343396 (14:73502024 A>C,G), RS1000390861 (14:73510014 C>T), RS1000414511 (14:73491297 C>A,G), RS1000468253 (14:73491491 C>G,T), RS1000524285 (14:73530368 T>C), RS1000552373 (14:73529764 C>T), RS1000764213 (14:73490900 C>A,G,T), RS1000801752 (14:73493195 C>T), RS1000947156 (14:73497511 C>T), RS1001148371 (14:73516853 G>T)

Disease associations

OMIM: gene MIM:614313 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2189136 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs758109	ACOT1, HEATR4, RIOX1		0.00	0

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, increases methylation, decreases expression	2
Acetaminophen	decreases expression	2
bisphenol F	increases expression	1
lasiocarpine	decreases expression	1
methyleugenol	decreases expression	1
chlortoluron	decreases expression	1
deoxynivalenol	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	increases expression	1
ochratoxin A	decreases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
nivalenol	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
GW 4064	decreases expression, affects cotreatment	1
GW 7647	increases expression	1
6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime	increases expression	1
nutlin 3	affects cotreatment, increases secretion	1
bisphenol B	increases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	decreases expression	1
Cadmium	increases abundance, increases expression	1
Caffeine	decreases phosphorylation	1
Catechin	affects cotreatment, increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL2209148	Binding	Inhibition of ACOT1 binding to FP-biotin in [12C][14N]-lysine, arginine and [13C6][15N2]-lysine, arginine labeled HEK293T cells at 20 uM after 1 hr by isotopic activity-based protein profiling-MudPIT assay	Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. — J Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.