ACOXL

Summary

ACOXL (acyl-CoA oxidase like, HGNC:25621) is a protein-coding gene on chromosome 2q13, encoding Acyl-coenzyme A oxidase-like protein (Q9NUZ1).

Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be located in peroxisomal matrix. Predicted to be active in peroxisome.

Source: NCBI Gene 55289 — RefSeq curated summary.

At a glance

• GWAS associations: 92
• Clinical variants (ClinVar): 158 total — 15 pathogenic, 6 likely-pathogenic
• MANE Select transcript: NM_001142807

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25621
Approved symbol	ACOXL
Name	acyl-CoA oxidase like
Location	2q13
Locus type	gene with protein product
Status	Approved
Aliases	FLJ11042, ACOX4
Ensembl gene	ENSG00000153093
Ensembl biotype	protein_coding
Entrez	55289

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 26 protein_coding, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000340561, ENST00000389811, ENST00000417074, ENST00000433706, ENST00000439055, ENST00000441974, ENST00000443586, ENST00000448863, ENST00000461340, ENST00000496981, ENST00000676595, ENST00000903107, ENST00000930157, ENST00000930158, ENST00000930159, ENST00000930160, ENST00000930161, ENST00000930162, ENST00000930163, ENST00000930164, ENST00000957114, ENST00000957115, ENST00000957116, ENST00000957117, ENST00000957118, ENST00000957119, ENST00000957120, ENST00000957121, ENST00000957122

RefSeq mRNA: 3 — MANE Select: NM_001142807 NM_001142807, NM_001365487, NM_001371254

CCDS: CCDS42730, CCDS46389, CCDS92841

Canonical transcript exons

ENST00000439055 — 18 exons

Exon	Start	End
ENSE00001008795	110987108	110987217
ENSE00001008796	110933489	110933642
ENSE00001008797	110841371	110841405
ENSE00001008799	110995893	110996004
ENSE00001008800	111031627	111031714
ENSE00001008801	110805263	110805395
ENSE00001008805	110908789	110908905
ENSE00001146517	110801652	110801724
ENSE00001514654	110732573	110732774
ENSE00001693594	110799014	110799100
ENSE00002444491	110798610	110798724
ENSE00002450006	110794076	110794174
ENSE00002470533	110784732	110784815
ENSE00002519011	110793650	110793736
ENSE00002708869	110768368	110768464
ENSE00003495323	111092865	111092966
ENSE00003541999	111049218	111049288
ENSE00003905097	111117616	111118548

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 82.58.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7201 / max 47.5041, expressed in 190 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21935	0.5531	146
21934	0.0685	40
21937	0.0503	29
202341	0.0256	18
21938	0.0226	19

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.33	gold quality
buccal mucosa cell	CL:0002336	78.40	gold quality
upper lobe of left lung	UBERON:0008952	73.81	gold quality
upper lobe of lung	UBERON:0008948	73.78	gold quality
visceral pleura	UBERON:0002401	73.43	gold quality
lower lobe of lung	UBERON:0008949	72.68	silver quality
apex of heart	UBERON:0002098	71.28	gold quality
right lung	UBERON:0002167	70.83	gold quality
left testis	UBERON:0004533	70.77	gold quality
right testis	UBERON:0004534	70.77	gold quality
lung	UBERON:0002048	69.90	gold quality
testis	UBERON:0000473	68.88	gold quality
urinary bladder	UBERON:0001255	68.80	gold quality
secondary oocyte	CL:0000655	68.62	gold quality
mucosa of stomach	UBERON:0001199	67.82	gold quality
gastrocnemius	UBERON:0001388	67.71	gold quality
muscle of leg	UBERON:0001383	66.47	gold quality
right coronary artery	UBERON:0001625	66.37	gold quality
tibial artery	UBERON:0007610	65.44	gold quality
popliteal artery	UBERON:0002250	65.43	gold quality
prostate gland	UBERON:0002367	65.29	gold quality
cauda epididymis	UBERON:0004360	65.25	gold quality
right atrium auricular region	UBERON:0006631	64.82	gold quality
stromal cell of endometrium	CL:0002255	64.31	gold quality
corpus epididymis	UBERON:0004359	63.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	63.67	gold quality
bone marrow cell	CL:0002092	63.60	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	63.29	gold quality
cardiac atrium	UBERON:0002081	63.28	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	16.28
E-ENAD-27	no	27.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The study identified two proteins, TMEM79 and ACOXL, with potential to differentiate between benign and cancerous prostatic glands in tissue biopsies. (PMID:26237329)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	acoxl	ENSDARG00000020149
mus_musculus	Acoxl	ENSMUSG00000027380
rattus_norvegicus	Acoxl	ENSRNOG00000016179
caenorhabditis_elegans	acox-1.1	WBGENE00008564
caenorhabditis_elegans	acox-1.2	WBGENE00008565
caenorhabditis_elegans	acox-1.3	WBGENE00008566
caenorhabditis_elegans	acox-1.4	WBGENE00008567
caenorhabditis_elegans		WBGENE00015894
caenorhabditis_elegans	acdh-1	WBGENE00016943
caenorhabditis_elegans		WBGENE00019406
caenorhabditis_elegans		WBGENE00020366

Paralogs (14): ACADVL (ENSG00000072778), ACOX3 (ENSG00000087008), GCDH (ENSG00000105607), ACAD10 (ENSG00000111271), ACADL (ENSG00000115361), ACADM (ENSG00000117054), ACADS (ENSG00000122971), IVD (ENSG00000128928), ACAD8 (ENSG00000151498), ACOX1 (ENSG00000161533), ACOX2 (ENSG00000168306), ACAD9 (ENSG00000177646), ACADSB (ENSG00000196177), ACAD11 (ENSG00000240303)

Protein

Protein identifiers

Acyl-coenzyme A oxidase-like protein — Q9NUZ1 (reviewed: Q9NUZ1)

All UniProt accessions (7): Q9NUZ1, A0A0C4DG10, A0A7I2V3X2, C9JQI3, H7C0A6, H7C2M3, H7C345

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the acyl-CoA oxidase family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9NUZ1-1	1	yes
Q9NUZ1-2	2
Q9NUZ1-3	3
Q9NUZ1-4	4

RefSeq proteins (3): NP_001136279, NP_001352416, NP_001358183 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002655	Acyl-CoA_oxidase_C	Domain
IPR006091	AcylCoA_DH/ox_M	Domain
IPR009100	AcylCoA_DH/oxidase_NM_dom_sf	Homologous_superfamily
IPR012258	Acyl-CoA_oxidase	Family
IPR036250	AcylCo_DH-like_C	Homologous_superfamily
IPR046373	Acyl-CoA_Oxase/DH_mid-dom_sf	Homologous_superfamily
IPR055060	ACOX_C_alpha1	Domain

Pfam: PF01756, PF02770, PF22924

UniProt features (10 total): splice variant 4, sequence variant 2, sequence conflict 2, chain 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NUZ1-F1	92.00	0.79

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 350–355

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-389887	Beta-oxidation of pristanoyl-CoA
R-HSA-1430728	Metabolism
R-HSA-390918	Peroxisomal lipid metabolism
R-HSA-556833	Metabolism of lipids
R-HSA-8978868	Fatty acid metabolism

MSigDB gene sets: 103 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, GOBP_LIPID_MODIFICATION, GOBP_FATTY_ACID_CATABOLIC_PROCESS, RORA1_01, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_THE_CH_CH_GROUP_OF_DONORS, GOBP_MONOCARBOXYLIC_ACID_METABOLIC_PROCESS, GOBP_FATTY_ACID_BETA_OXIDATION_USING_ACYL_COA_OXIDASE, GOBP_ORGANIC_ACID_CATABOLIC_PROCESS, GOBP_LIPID_METABOLIC_PROCESS, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, GOBP_SMALL_MOLECULE_CATABOLIC_PROCESS, AACTTT_UNKNOWN, GOBP_MONOCARBOXYLIC_ACID_CATABOLIC_PROCESS, GOBP_LIPID_CATABOLIC_PROCESS, GOBP_LIPID_OXIDATION

GO Biological Process (4): fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540), fatty acid metabolic process (GO:0006631), fatty acid beta-oxidation (GO:0006635), biological_process (GO:0008150)

GO Molecular Function (7): acyl-CoA oxidase activity (GO:0003997), fatty acid binding (GO:0005504), flavin adenine dinucleotide binding (GO:0050660), FAD binding (GO:0071949), molecular_function (GO:0003674), oxidoreductase activity (GO:0016491), oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)

GO Cellular Component (3): peroxisome (GO:0005777), peroxisomal matrix (GO:0005782), cellular_component (GO:0005575)

Reactome top-level categories

Rollup of top-4 pathways:

Category	Pathways
Peroxisomal lipid metabolism	1
Fatty acid metabolism	1
Metabolism	1
Metabolism of lipids	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
fatty acid beta-oxidation	1
lipid metabolic process	1
monocarboxylic acid metabolic process	1
fatty acid catabolic process	1
fatty acid ligase activity	1
fatty acid oxidation	1
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	1
lipid binding	1
monocarboxylic acid binding	1
nucleotide binding	1
anion binding	1
flavin adenine dinucleotide binding	1
catalytic activity	1
oxidoreductase activity	1
microbody	1
peroxisome	1
microbody lumen	1

Protein interactions and networks

STRING

1856 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACOXL	TMEM87B	Q96K49	503
ACOXL	ANAPC1	Q9H1A4	466
ACOXL	CFAP299	Q6V702	464
ACOXL	ZC3H6	P61129	451
ACOXL	C11orf21	Q9P2W6	447
ACOXL	SP140	Q13342	418
ACOXL	LRRC32	Q14392	396
ACOXL	PPARA	Q07869	394
ACOXL	FBLN7	Q53RD9	393
ACOXL	ACACA	Q13085	390
ACOXL	PPARG	P37231	379
ACOXL	FASN	P49327	379
ACOXL	ZC3H8	Q8N5P1	365
ACOXL	ACSL3	O95573	364
ACOXL	BCL2L11	O43521	364

IntAct

2 interactions, top by confidence:

A	B	Type	Score
CUL1	LGALS8	psi-mi:“MI:0914”(association)	0.350

BioGRID (3): ACOXL (Synthetic Lethality), ACOXL (Affinity Capture-MS), ACOXL (Affinity Capture-MS)

ESM2 similar proteins: B1H369, O00764, O35331, O35969, O80526, O95045, P10867, P10868, P11172, P33124, P50554, P58710, P61922, P80404, P81799, Q05B63, Q15124, Q28DS0, Q2KIG0, Q2QNG7, Q2QZ86, Q3SZM9, Q3T067, Q3U129, Q3ZC33, Q4R4U1, Q5I0K3, Q5R5C9, Q5R5F8, Q5RFI8, Q5ZID6, Q6AY30, Q7SXM0, Q8BZF8, Q8HXW0, Q8K183, Q8N0X4, Q8NBX0, Q8R127, Q8R4N0

Diamond homologs: O02767, O15254, O62137, O62138, O62139, O62140, O64894, O65201, O65202, O74934, O74935, O74936, P07872, P34355, P97562, Q15067, Q3SZP5, Q54GQ6, Q5RAU0, Q5RC19, Q63448, Q6FY63, Q7KML2, Q8HYL8, Q99424, Q9EPL9, Q9NUZ1, Q9QXD1, Q9R0H0, Q9Z1N0, Q9ZQP2, P0CZ23, Q20992, Q756A9, Q9DBS4, Q9LMI7, P06598, P08790, Q6BRD5, Q8HXX8

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

158 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	15
Likely pathogenic	6
Uncertain significance	111
Likely benign	9
Benign	0

Top pathogenic / likely-pathogenic (21)

Variant ID	HGVS	Classification
149662	GRCh38/hg38 2q11.2-13(chr2:101710825-110791418)x3	Pathogenic
1705942	GRCh37/hg19 2q13(chr2:111365995-113199850)x3	Pathogenic
219044	GRCh37/hg19 2q13(chr2:111398336-113101220)x1	Pathogenic
252968	GRCh37/hg19 2q13(chr2:111392259-113094793)x1	Pathogenic
253388	GRCh37/hg19 2q12.3-14.3(chr2:109798247-125658380)x1	Pathogenic
253673	GRCh37/hg19 2q12.2-14.1(chr2:106423310-115054828)x1	Pathogenic
3062651	GRCh37/hg19 2q12.2-21.2(chr2:106755586-134302739)x1	Pathogenic
3242293	GRCh37/hg19 2q13(chr2:111394609-112009912)x1	Pathogenic
562655	GRCh37/hg19 2q13(chr2:110980294-113137529)x1	Pathogenic
562679	GRCh37/hg19 2q11.1-13(chr2:96353030-114045463)x3	Pathogenic
625548	GRCh37/hg19 2q13(chr2:111395351-113102594)	Pathogenic
686485	GRCh37/hg19 2q13(chr2:111382460-113137975)x3	Pathogenic
686865	GRCh37/hg19 2q13(chr2:111382460-113115979)x3	Pathogenic
687786	GRCh37/hg19 2q13(chr2:111388619-113199850)x3	Pathogenic
688671	GRCh37/hg19 2q13(chr2:111388619-113137529)x3	Pathogenic
151397	GRCh38/hg38 2q13-14.1(chr2:110684553-112344958)x1	Likely pathogenic
1808613	GRCh37/hg19 2q13(chr2:111397786-113111856)x3	Likely pathogenic
1808680	GRCh37/hg19 2q13(chr2:111365996-113111856)x3	Likely pathogenic
223093	NC_000002.12:g.(?110649261)(112345017_?)del	Likely pathogenic
560135	Single allele	Likely pathogenic
625831	GRCh37/hg19 2q13(chr2:111395603-113251000)	Likely pathogenic

SpliceAI

4740 predictions. Top by Δscore:

Variant	Effect	Δscore
2:110768362:TCACA:T	acceptor_loss	1.0000
2:110768363:CACA:C	acceptor_loss	1.0000
2:110768365:CAG:C	acceptor_loss	1.0000
2:110768366:AGG:A	acceptor_loss	1.0000
2:110768463:TGGTA:T	donor_loss	1.0000
2:110768465:G:GG	donor_gain	1.0000
2:110768465:GT:G	donor_loss	1.0000
2:110793644:TTCCA:T	acceptor_loss	1.0000
2:110793645:TCCA:T	acceptor_loss	1.0000
2:110793646:CCA:C	acceptor_loss	1.0000
2:110793647:CA:C	acceptor_loss	1.0000
2:110793648:A:AG	acceptor_gain	1.0000
2:110793648:AGTGC:A	acceptor_gain	1.0000
2:110793649:G:GA	acceptor_gain	1.0000
2:110793649:GT:G	acceptor_gain	1.0000
2:110793649:GTGC:G	acceptor_gain	1.0000
2:110793649:GTGCG:G	acceptor_gain	1.0000
2:110793732:TCCAG:T	donor_loss	1.0000
2:110793733:CCAG:C	donor_loss	1.0000
2:110793734:CAG:C	donor_loss	1.0000
2:110793735:AGGTA:A	donor_loss	1.0000
2:110793736:GG:G	donor_loss	1.0000
2:110793737:GT:G	donor_loss	1.0000
2:110793738:T:A	donor_loss	1.0000
2:110794060:ATCT:A	acceptor_gain	1.0000
2:110798609:GGA:G	acceptor_gain	1.0000
2:110798713:G:GT	donor_gain	1.0000
2:110798720:TCAAG:T	donor_loss	1.0000
2:110798721:CAAG:C	donor_loss	1.0000
2:110798722:AAGGT:A	donor_loss	1.0000

AlphaMissense

3799 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:110799032:T:A	V160D	0.987
2:110794097:T:C	F90L	0.983
2:110794099:T:A	F90L	0.983
2:110794099:T:G	F90L	0.983
2:110798613:T:C	F117L	0.982
2:110798615:T:A	F117L	0.982
2:110798615:T:G	F117L	0.982
2:110908799:T:C	F267L	0.979
2:110908801:T:A	F267L	0.979
2:110908801:T:G	F267L	0.979
2:110799096:G:C	K181N	0.978
2:110799096:G:T	K181N	0.978
2:110793671:T:C	F61L	0.975
2:110793673:T:A	F61L	0.975
2:110793673:T:G	F61L	0.975
2:110799041:G:C	R163P	0.973
2:110801700:T:A	I199K	0.973
2:110798691:T:C	F143L	0.969
2:110798693:T:A	F143L	0.969
2:110798693:T:G	F143L	0.969
2:110798682:G:C	A140P	0.968
2:110794151:G:C	A108P	0.967
2:110794110:A:T	E94V	0.966
2:110805324:T:C	F228L	0.965
2:110805326:C:A	F228L	0.965
2:110805326:C:G	F228L	0.965
2:110793696:G:A	G69E	0.963
2:110801684:T:C	F194L	0.959
2:110801686:T:A	F194L	0.959
2:110801686:T:G	F194L	0.959

dbSNP variants (sampled 300 via entrez): RS1000011218 (2:111019897 A>G), RS1000011771 (2:111100043 A>T), RS1000013537 (2:111036268 A>G), RS1000017590 (2:111099129 A>G), RS1000017799 (2:110876546 A>G), RS1000027810 (2:110907265 G>A,T), RS1000028159 (2:111088626 A>G,T), RS1000030538 (2:110732428 C>G), RS1000038969 (2:110960493 A>T), RS1000045769 (2:110754034 G>A), RS1000051414 (2:110883482 G>A,C), RS1000059422 (2:110844926 T>C), RS1000070769 (2:110844704 C>A,T), RS1000071385 (2:110968975 T>C), RS1000071924 (2:111010956 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

92 associations (top):

Study	Trait	p-value
GCST000224_2	Chronic lymphocytic leukemia	2.000000e-10
GCST001134_10	White blood cell types	4.000000e-07
GCST001364_7	IgA nephropathy	4.000000e-07
GCST001515_15	Economic and political preferences (immigration/crime)	4.000000e-06
GCST001765_39	Red blood cell traits	4.000000e-11
GCST002073_11	Chronic lymphocytic leukemia	4.000000e-17
GCST002073_9	Chronic lymphocytic leukemia	2.000000e-18
GCST002299_7	Chronic lymphocytic leukemia	5.000000e-15
GCST002318_128	Rheumatoid arthritis	9.000000e-09
GCST002318_2	Rheumatoid arthritis	3.000000e-08
GCST002415_12	Colorectal cancer (diet interaction)	1.000000e-06
GCST003025_20	Attention function in attention deficit hyperactive disorder	3.000000e-07
GCST003025_9	Attention function in attention deficit hyperactive disorder	2.000000e-06
GCST003468_2	Chronic lymphocytic leukemia	5.000000e-20
GCST004146_2	Chronic lymphocytic leukemia	2.000000e-27
GCST004601_28	Red blood cell count	8.000000e-20
GCST004601_29	Red blood cell count	3.000000e-15
GCST004602_90	Mean corpuscular volume	8.000000e-25
GCST004602_91	Mean corpuscular volume	2.000000e-27
GCST004608_55	Granulocyte percentage of myeloid white cells	5.000000e-25
GCST004608_56	Granulocyte percentage of myeloid white cells	1.000000e-21
GCST004608_57	Granulocyte percentage of myeloid white cells	9.000000e-24
GCST004609_141	Monocyte percentage of white cells	1.000000e-31
GCST004609_142	Monocyte percentage of white cells	3.000000e-25
GCST004609_143	Monocyte percentage of white cells	2.000000e-21
GCST004625_49	Monocyte count	7.000000e-20
GCST004625_50	Monocyte count	3.000000e-27
GCST004625_51	Monocyte count	1.000000e-18
GCST004627_79	Lymphocyte count	1.000000e-19
GCST004627_80	Lymphocyte count	4.000000e-11

EFO canonical traits (28, from GWAS)

EFO ID	Trait name
EFO:0005091	monocyte count
EFO:0004827	economic and social preference
EFO:0008111	diet measurement
EFO:0007636	attention function measurement
EFO:0004305	erythrocyte count
EFO:0007997	granulocyte percentage of myeloid white cells
EFO:0007989	monocyte percentage of leukocytes
EFO:0004587	lymphocyte count
EFO:0004527	mean corpuscular hemoglobin
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0007990	neutrophil percentage of leukocytes
EFO:0005128	albumin:globulin ratio measurement
EFO:0006336	diastolic blood pressure
EFO:0006527	smoking status measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0004574	total cholesterol measurement
EFO:0008039	BMI-adjusted hip circumference
EFO:0007778	urinary albumin to creatinine ratio
EFO:0010355	diacylglycerol 36:2 measurement
EFO:0010411	triacylglycerol 50:4 measurement
EFO:0006939	cup-to-disc ratio measurement
EFO:0004614	apolipoprotein A 1 measurement
EFO:0007789	BMI-adjusted waist circumference
EFO:0007991	eosinophil percentage of leukocytes
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0010701	mean reticulocyte volume
EFO:0007984	platelet component distribution width
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

4 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs73954926	ACOXL, BCL2L11		0.00	0
rs72836346	ACOXL, BCL2L11		0.00	0
rs7582030	ACOXL, BCL2L11		0.00	0
rs72836345	ACOXL, BCL2L11		0.00	0

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
entinostat	increases expression, affects cotreatment	2
Benzo(a)pyrene	decreases methylation, affects methylation, decreases expression	2
Aflatoxin B1	decreases methylation, increases methylation	2
methylmercuric chloride	increases expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Arsenic	affects methylation	1
Cadmium	decreases expression, decreases reaction	1
Methyl Methanesulfonate	decreases expression	1
Selenium	decreases expression, decreases reaction	1
Smoke	decreases expression	1
Valproic Acid	increases expression	1
Cyclosporine	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.