ACTA2-AS1

Summary

ACTA2-AS1 (ACTA2 antisense RNA 1, HGNC:45169) is a long non-coding RNA gene on chromosome 10q23.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45169
Approved symbol	ACTA2-AS1
Name	ACTA2 antisense RNA 1
Location	10q23.31
Locus type	RNA, long non-coding
Status	Approved
Aliases	uc001kfo.1, ZXF1, UC001kfo
Ensembl gene	ENSG00000180139
Ensembl biotype	lncRNA
Entrez	100132116
RNAcentral	URS00007E505A — lncRNA, 2043 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000437930, ENST00000596007, ENST00000625277, ENST00000627669

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437930 — 5 exons

Exon	Start	End
ENSE00001408856	88939395	88940340
ENSE00001423870	88938212	88938476
ENSE00002237620	88932643	88932959
ENSE00002495163	88934898	88935573
ENSE00002534019	88933641	88933886

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 99.10.

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right coronary artery	UBERON:0001625	99.10	gold quality
popliteal artery	UBERON:0002250	98.96	gold quality
tibial artery	UBERON:0007610	98.96	gold quality
body of uterus	UBERON:0009853	98.63	gold quality
aorta	UBERON:0000947	98.28	gold quality
mucosa of stomach	UBERON:0001199	98.19	gold quality
ascending aorta	UBERON:0001496	97.96	gold quality
thoracic aorta	UBERON:0001515	97.94	gold quality
smooth muscle tissue	UBERON:0001135	97.88	gold quality
left coronary artery	UBERON:0001626	97.75	gold quality
lower esophagus muscularis layer	UBERON:0035833	97.43	gold quality
lower esophagus	UBERON:0013473	97.41	gold quality
descending thoracic aorta	UBERON:0002345	97.30	gold quality
left uterine tube	UBERON:0001303	97.21	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	97.07	gold quality
coronary artery	UBERON:0001621	95.53	gold quality
endocervix	UBERON:0000458	95.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.92	gold quality
lower esophagus mucosa	UBERON:0035834	91.44	gold quality
colonic epithelium	UBERON:0000397	91.34	gold quality
right uterine tube	UBERON:0001302	91.31	gold quality
rectum	UBERON:0001052	91.10	gold quality
tibial nerve	UBERON:0001323	91.06	gold quality
ectocervix	UBERON:0012249	90.18	gold quality
skin of leg	UBERON:0001511	89.35	gold quality
esophagus	UBERON:0001043	89.16	gold quality
right ovary	UBERON:0002118	88.88	gold quality
prostate gland	UBERON:0002367	88.61	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	87.90	gold quality
right atrium auricular region	UBERON:0006631	87.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	14.71

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• mRNAs were differentially expressed in the HepG2 cell line after the down-regulation of long noncoding rna-UC001kfo. (PMID:28786067)
• Downregulation of ACTA2AS1:4 affects a number of key mechanisms involved in liver cancer progression. These data may be important for the future of liver cancer diagnosis and subsequent treatments. (PMID:30664183)
• Downregulation of long non-coding RNA ZXF1 restricts cell survival by targeting miR-634-GRB2 in lung adenocarcinoma. (PMID:32160453)
• Enhanced expression of lncRNA ZXF1 promotes cisplatin resistance in lung cancer cell via MAPK axis. (PMID:32533982)
• ACTA2-AS1 suppresses lung adenocarcinoma progression via sequestering miR-378a-3p and miR-4428 to elevate SOX7 expression. (PMID:32808728)
• Long non-coding RNA ACTA2-AS1 inhibits the cisplatin resistance of non-small cell lung cancer cells through inhibiting autophagy by suppressing TSC2. (PMID:34985374)
• Overexpression of long non-coding RNA ACTA2-AS1 inhibits the viability, proliferation, migration and invasion of colorectal cancer cells. (PMID:35325674)
• Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a. (PMID:35412951)
• lncRNA ACTA2-AS1 predicts malignancy and poor prognosis of triple-negative breast cancer and regulates tumor progression via modulating miR-532-5p. (PMID:35896973)
• Long Noncoding RNA ACTA2-AS1 Inhibits Cell Growth and Facilitates Apoptosis in Gastric Cancer by Binding with miR-6720-5p to Regulate ESRRB. (PMID:37222961)
• Long non-coding RNA ACTA2-AS1 suppresses metastasis of papillary thyroid cancer via regulation of miR-4428/KLF9 axis. (PMID:38195623)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.