ACTL9

Summary

ACTL9 (actin like 9, HGNC:28494) is a protein-coding gene on chromosome 19p13.2, encoding Actin-like protein 9 (Q8TC94). Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.

Predicted to be a structural constituent of cytoskeleton. Involved in acrosome assembly and fertilization. Located in acrosomal vesicle; perinuclear theca; and sperm head. Implicated in spermatogenic failure 53.

Source: NCBI Gene 284382 — automated summary from GO annotations (Alliance of Genome Resources).

At a glance

• Gene–disease (curated): spermatogenic failure 53 (Strong, GenCC) — +1 more curated relationship
• GWAS associations: 23
• Clinical variants (ClinVar): 76 total — 3 pathogenic
• Phenotypes (HPO): 3
• Constraint (gnomAD): pLI 0.19 (intermediate), LOEUF 1.57 (unconstrained)
• MANE Select transcript: NM_178525

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28494
Approved symbol	ACTL9
Name	actin like 9
Location	19p13.2
Locus type	gene with protein product
Status	Approved
Aliases	MGC33407
Ensembl gene	ENSG00000181786
Ensembl biotype	protein_coding
OMIM	619251
Entrez	284382

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

MANE Select: ENST00000324436

ENST00000324436

RefSeq mRNA: 1 — MANE Select: NM_178525 NM_178525

CCDS: CCDS12207

Canonical transcript exons

ENST00000324436 — 1 exons

Exon	Start	End
ENSE00001227362	8697400	8698795

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 96.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1494 / max 146.6026, expressed in 3 samples.

Highest expression (Bgee): male germ line stem cell (sensu Vertebrata) in testis, sperm, testis, adult organism, quadriceps femoris.

Genetic regulation across tissues (GTEx eQTL / sQTL)

ACTL9 is not an eGene in any GTEx v10 tissue: no tissue shows a variant significantly associated with its expression or splicing (q < 0.05).

FANTOM5 promoters

3 alternative TSS:

Promoter ID	TPM avg	Samples expressed
178973	0.0914	3
178972	0.0511	3
178971	0.0068	3

Top tissues by expression

showing 100 of 215 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	96.80	gold quality
sperm	CL:0000019	96.51	gold quality
left testis	UBERON:0004533	94.88	gold quality
right testis	UBERON:0004534	94.84	gold quality
testis	UBERON:0000473	91.73	gold quality
adult organism	UBERON:0007023	90.98	gold quality
quadriceps femoris	UBERON:0001377	60.42	gold quality
vastus lateralis	UBERON:0001379	60.41	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	58.52	gold quality
biceps brachii	UBERON:0001507	57.22	gold quality
cardiac muscle of right atrium	UBERON:0003379	54.34	gold quality
left ventricle myocardium	UBERON:0006566	54.23	gold quality
kidney epithelium	UBERON:0004819	53.93	gold quality
upper arm skin	UBERON:0004263	53.52	gold quality
epithelial cell of pancreas	CL:0000083	53.37	gold quality
deltoid	UBERON:0001476	53.18	gold quality
tibialis anterior	UBERON:0001385	53.12	silver quality
ileal mucosa	UBERON:0000331	52.70	silver quality
myocardium	UBERON:0002349	50.25	gold quality
amniotic fluid	UBERON:0000173	49.55	silver quality
pancreatic ductal cell	CL:0002079	49.44	silver quality
skeletal muscle tissue	UBERON:0001134	47.83	gold quality
nasal cavity epithelium	UBERON:0005384	47.03	gold quality
muscle tissue	UBERON:0002385	46.66	gold quality
jejunum	UBERON:0002115	45.69	gold quality
cauda epididymis	UBERON:0004360	45.59	silver quality
layer of synovial tissue	UBERON:0007616	43.55	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
epithelium of nasopharynx	UBERON:0001951	42.73	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
substantia nigra pars reticulata	UBERON:0001966	42.38	gold quality
upper leg skin	UBERON:0004262	42.01	silver quality
buccal mucosa cell	CL:0002336	41.65	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
Brodmann (1909) area 23	UBERON:0013554	41.01	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
tongue	UBERON:0001723	40.79	gold quality
cartilage tissue	UBERON:0002418	40.77	gold quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
bone marrow cell	CL:0002092	40.34	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
epithelium of mammary gland	UBERON:0003244	40.14	gold quality
oviduct epithelium	UBERON:0004804	40.03	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
oocyte	CL:0000023	39.80	gold quality
urethra	UBERON:0000057	39.80	gold quality
heart right ventricle	UBERON:0002080	39.79	gold quality
pericardium	UBERON:0002407	39.77	gold quality
endothelial cell	CL:0000115	39.75	gold quality
synovial joint	UBERON:0002217	39.70	gold quality
dorsal root ganglion	UBERON:0000044	39.68	gold quality
nipple	UBERON:0002030	39.68	gold quality
bronchial epithelial cell	CL:0002328	39.65	gold quality
decidua	UBERON:0002450	39.65	gold quality
penis	UBERON:0000989	39.64	gold quality
gingiva	UBERON:0001828	39.64	gold quality
bronchus	UBERON:0002185	39.64	gold quality
mammalian vulva	UBERON:0000997	39.63	gold quality
trigeminal ganglion	UBERON:0001675	39.63	gold quality
tendon of biceps brachii	UBERON:0008188	39.60	gold quality
inferior vagus X ganglion	UBERON:0005363	39.57	gold quality
superior surface of tongue	UBERON:0007371	39.56	gold quality
pylorus	UBERON:0001166	39.55	gold quality
renal medulla	UBERON:0000362	39.53	gold quality
colonic mucosa	UBERON:0000317	39.51	gold quality
pons	UBERON:0000988	39.51	gold quality
thymus	UBERON:0002370	39.50	gold quality
medulla oblongata	UBERON:0001896	39.48	gold quality
superior vestibular nucleus	UBERON:0007227	39.47	gold quality
cardia of stomach	UBERON:0001162	39.46	gold quality
parietal pleura	UBERON:0002400	39.45	gold quality
dorsal plus ventral thalamus	UBERON:0001897	39.38	gold quality
cerebellar vermis	UBERON:0004720	39.37	gold quality
oral cavity	UBERON:0000167	39.35	gold quality
subthalamic nucleus	UBERON:0001906	39.35	gold quality
ventral tegmental area	UBERON:0002691	39.35	gold quality
trachea	UBERON:0003126	39.33	gold quality
parietal lobe	UBERON:0001872	39.32	gold quality
vena cava	UBERON:0004087	39.31	gold quality
pharyngeal mucosa	UBERON:0000355	39.27	gold quality
substantia nigra pars compacta	UBERON:0001965	39.23	gold quality
visceral pleura	UBERON:0002401	39.23	gold quality
postcentral gyrus	UBERON:0002581	39.23	gold quality
body of tongue	UBERON:0011876	39.22	gold quality
medial globus pallidus	UBERON:0002477	39.18	gold quality
trabecular bone tissue	UBERON:0002483	39.18	gold quality
globus pallidus	UBERON:0001875	39.15	gold quality
entorhinal cortex	UBERON:0002728	39.05	gold quality
lateral nuclear group of thalamus	UBERON:0002736	39.00	gold quality
corpus epididymis	UBERON:0004359	38.98	gold quality
tibia	UBERON:0000979	38.93	gold quality
lateral globus pallidus	UBERON:0002476	38.81	gold quality
seminal vesicle	UBERON:0000998	38.75	gold quality
caput epididymis	UBERON:0004358	38.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

HPA expression

RNA tissue specificity: Tissue enriched

2 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM
Testis	tissue	25.5
Frontal cortex	tissue	0.1

Regulation

Is transcription factor: no

Functional genomics

gnomAD constraint: pLI 0.187, LOEUF 1.57, missense Z -0.551 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000324436 — one region, missense o/e 1.05.

Literature-anchored findings (GeneRIF, showing 4)

• Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients (PMID:23278845)
• KIF3A and OVOL1, but not ACTL9, are involved in the development of Atopic dermatitis in the Chinese pediatric population. (PMID:26127003)
• Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. (PMID:33626338)
• Identification of a new mutation in the ACTL9 gene in men with unexplained infertility. (PMID:38769899)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Actl9	ENSMUSG00000092519
rattus_norvegicus	Actl9b	ENSRNOG00000026033
rattus_norvegicus	Actl9	ENSRNOG00000049571

Paralogs (26): ACTR6 (ENSG00000075089), ACTB (ENSG00000075624), ACTL6B (ENSG00000077080), ACTR5 (ENSG00000101442), ACTR3C (ENSG00000106526), ACTA2 (ENSG00000107796), ACTR8 (ENSG00000113812), ACTR1B (ENSG00000115073), ACTR3 (ENSG00000115091), ACTL8 (ENSG00000117148), ACTRT1 (ENSG00000123165), ACTR10 (ENSG00000131966), ACTR3B (ENSG00000133627), ACTL6A (ENSG00000136518), ACTR2 (ENSG00000138071), ACTR1A (ENSG00000138107), ACTA1 (ENSG00000143632), ACTL7B (ENSG00000148156), ACTC1 (ENSG00000159251), ACTG2 (ENSG00000163017), ACTBL2 (ENSG00000169067), ACTRT2 (ENSG00000169717), ACTG1 (ENSG00000184009), ACTRT3 (ENSG00000184378), ACTL7A (ENSG00000187003), ACTL10 (ENSG00000288649)

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:1916731) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 6 distinct phenotype terms.

Mouse phenotype (MP)	Records
impaired fertilization	1
abnormal spermatid morphology	1
abnormal acrosome morphology	1
detached acrosome	1
abnormal acrosome assembly	1
abnormal proacrosomal vesicle fusion	1

Additional cross-species homologs

Sequence homologs in species beyond Ensembl Compara’s model organisms, by Diamond local protein alignment (% sequence identity; best hit per species). Lower-identity rows are more distant homologs. The matched accessions’ gene symbols aren’t in biobtree yet, so each row shows the UniProt accession.

Organism	UniProt	Identity	Method
Bos taurus	Q2T9W4	81.0%	Diamond
Debaryomyces hansenii CBS767	Q6BXN0	73.9%	Diamond
Saccharomyces cerevisiae S288C	Q12509	63.2%	Diamond
Dictyostelium discoideum	Q54KZ7	42.6%	Diamond
Schizosaccharomyces pombe 972h-	Q9UTQ7	34.5%	Diamond

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
NFILZ	protein-coding	105372267
ZNF558	protein-coding	148156
OR2Z1	protein-coding	284383
MBD3L1	protein-coding	85509
MUC16	protein-coding	94025
MYO1F	protein-coding	4542
ADAMTS10	protein-coding	81794
ZNF414	protein-coding	84330

Protein

Protein identifiers

Actin-like protein 9 — Q8TC94 (reviewed: Q8TC94)

All UniProt accessions (1): Q8TC94

UniProt curated annotations — full annotation on UniProt →

Function. Testis-specic protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.

Subunit / interactions. Interacts with ACTL7A.

Subcellular location. Cytoplasmic vesicle. Secretory vesicle. Acrosome. Cytoplasm. Cytoskeleton. Perinuclear theca.

Tissue specificity. Testis-specific.

Disease relevance. Spermatogenic failure 53 (SPGF53) [MIM:619258] An autosomal recessive infertility disorder characterized by impaired oocyte fertilization due to oocyte activation failure, in association with structural anomalies in sperm heads. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the actin family.

RefSeq proteins (1): NP_848620* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004000	Actin	Family
IPR043129	ATPase_NBD	Homologous_superfamily

Pfam: PF00022

UniProt features (11 total): sequence variant 8, chain 1, region of interest 1, sequence conflict 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TC94-F1	87.56	0.74

Human Protein Atlas

Protein class: Predicted intracellular proteins, Disease related genes, Human disease related genes

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): acrosome; equatorial segment

Antibody reliability (HPA): IH uncertain · IF supported

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 54 (showing top): GOBP_SINGLE_FERTILIZATION, GOCC_SECRETORY_GRANULE, GOBP_VESICLE_ORGANIZATION, GOBP_MALE_GAMETE_GENERATION, GOBP_SECRETORY_GRANULE_ORGANIZATION, GOBP_CELLULAR_COMPONENT_ASSEMBLY_INVOLVED_IN_MORPHOGENESIS, GOBP_ACROSOME_ASSEMBLY, GOBP_ORGANELLE_ASSEMBLY, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_FERTILIZATION, GOCC_SECRETORY_VESICLE, GOCC_ACROSOMAL_VESICLE, chr19p13

GO Biological Process (4): acrosome assembly (GO:0001675), single fertilization (GO:0007338), fertilization (GO:0009566), cytoskeleton organization (GO:0007010)

GO Molecular Function (2): structural constituent of cytoskeleton (GO:0005200), protein binding (GO:0005515)

GO Cellular Component (5): acrosomal vesicle (GO:0001669), actin cytoskeleton (GO:0015629), perinuclear theca (GO:0033011), sperm head (GO:0061827), cytoplasmic vesicle (GO:0031410)

GO top-level categories

19 GO namespaces:

Category	Terms
cytoskeleton	3
developmental process involved in reproduction	1
spermatid development	1
cellular component assembly involved in morphogenesis	1
cellular process involved in reproduction in multicellular organism	1
secretory granule organization	1
organelle assembly	1
fertilization	1
sexual reproduction	1
reproductive process	1
organelle organization	1
structural molecule activity	1
cytoskeleton organization	1
binding	1
secretory granule	1
perinuclear region of cytoplasm	1
cellular anatomical structure	1
cytoplasm	1
intracellular vesicle	1

Experimentally-supported GO annotations

GO terms backed by direct experimental evidence (ECO experimental codes) — 5 of 11 annotations. The rest are phylogenetic / computational / electronic (IEA).

5 experimentally-supported GO terms:

GO term	NS	Evidence
acrosome assembly	BP	mutant phenotype
fertilization	BP	direct assay
acrosomal vesicle	CC	direct assay
perinuclear theca	CC	direct assay
sperm head	CC	direct assay

Protein interactions and networks

STRING

showing 15 of 1,631 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACTL9	PLCZ1	Q86YW0	643
ACTL9	OVOL1	O14753	570
ACTL9	TLE6	Q9H808	551
ACTL9	DNAH17	Q9UFH2	539
ACTL9	WEE2	P0C1S8	531
ACTL9	OR2Z1	Q8NG97	492
ACTL9	OR10A3	P58181	469
ACTL9	TMEM232	C9JQI7	461
ACTL9	KIF3A	Q9Y496	441
ACTL9	NLRP5	P59047	432
ACTL9	EMSY	Q7Z589	430
ACTL9	ZGPAT	Q8N5A5	385
ACTL9	ROPN1B	Q9BZX4	360
ACTL9	IQCN	Q9H0B3	359
ACTL9	SLC25A46	Q96AG3	352

IntAct

BioGRID (3 interactions; top human partners by supporting records): CUL3 (Affinity Capture-MS), POLI (Reconstituted Complex), QRICH1 (Two-hybrid)

Disease & clinical

Genetic variants

Variant evidence for ACTL9: 76 ClinVar records (3 pathogenic / likely pathogenic); 23 GWAS associations. Per-variant detail is on Sugi Variant.

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	0
Uncertain significance	67
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (3)

Showing all 3 pathogenic / likely-pathogenic ClinVar records, ranked by ClinVar review status (expert panel → multiple submitters → single submitter), then by number of submitting labs.

Variant ID	HGVS	Classification	Review	Submitters
1048625	NM_178525.5(ACTL9):c.1034C>T (p.Ser345Leu)	Pathogenic	no assertion criteria provided	1
1048626	NM_178525.5(ACTL9):c.1138G>T (p.Val380Leu)	Pathogenic	no assertion criteria provided	1
1048627	NM_178525.5(ACTL9):c.1209C>G (p.Tyr403Ter)	Pathogenic	no assertion criteria provided	1

Per-variant reference — Sugi Variant

Explore ACTL9’s pathogenic and likely-pathogenic variants individually — each with its ClinVar classification and conditions, applied ACMG criteria (ClinGen expert panel, where curated), the calibrated in-silico predictors (AlphaMissense, REVEL, SaProt, conservation), gnomAD frequency, and the predictor-disagreement QC signal — on Sugi Variant.

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 19 predictions of 51):

Position(s)	Effect	Δscore	Sites
19:8698178	donor_gain	0.5200
19:8698174	donor_gain	0.4000
19:8697714	donor_gain	0.3600
19:8698072–8698073	acceptor_loss	0.3400	6
19:8698074	acceptor_loss	0.3300
19:8697925	donor_gain	0.3200
19:8697730	donor_gain	0.3100
19:8697829	donor_gain	0.3100
19:8698354	acceptor_gain	0.2600
19:8698514–8698515	donor_loss	0.2600	5

HPA cancer prognostics

RNA cancer specificity: Not detected

Disease associations

OMIM: gene MIM:619251 | disease phenotypes: MIM:619258

GenCC curated gene-disease

2 curated gene-disease records:

Disease	Classification	Inheritance	Records
spermatogenic failure 53	Strong	Autosomal recessive	2
non-syndromic male infertility due to sperm motility disorder	Supportive	Autosomal recessive

Mondo (2): spermatogenic failure 53 (MONDO:0030989), (MONDO:0017173)

HPO phenotypes

3 phenotypes (HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0003251	Male infertility
HP:0032562	Tapered sperm head

GWAS associations

23 associations:

Study	Trait	p-value
GCST008363_8	Offspring birth weight	2e-25
GCST008363_129	Offspring birth weight	6e-25
GCST004861_30	Itch intensity from mosquito bite	4e-15
GCST003184_11	Atopic dermatitis	5e-12
GCST004862_191	Itch intensity from mosquito bite adjusted by bite size	8e-12
GCST003184_1	Atopic dermatitis	2e-11
GCST010984_45	Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis)	5e-11
GCST010985_49	Allergic disease (asthma, hay fever and/or eczema) (age of onset)	5e-11
GCST007800_56	Asthma (childhood onset)	5e-10
GCST003995_5	Tonsillectomy	1e-9
GCST004865_20	Itch intensity from mosquito bite adjusted by bite size	1e-9
GCST005014_100	Tonsillectomy	1e-9
GCST004862_157	Itch intensity from mosquito bite adjusted by bite size	5e-9
GCST001363_2	Atopic dermatitis	7e-9
GCST008362_12	Birth weight	1e-8
GCST008362_124	Birth weight	1e-8
GCST005146_51	Birth weight	2e-8
GCST90007329_1	circulating leptin levels adjusted for BMI	2e-7
GCST90007323_1	circulating leptin levels adjusted for BMI	4e-7
GCST90007326_1	circulating leptin levels adjusted for BMI	7e-7
GCST007798_3	Asthma	9e-7
GCST90007320_1	circulating leptin levels adjusted for BMI	9e-7
GCST004523_10	Resting metabolic rate	9e-6

EFO canonical traits (from GWAS)

8 canonical traits:

EFO ID	Trait name
EFO:0007924	tonsillectomy risk measurement
EFO:0008004	resting metabolic rate measurement
EFO:0008377	mosquito bite reaction itch intensity measurement
EFO:0008378	mosquito bite reaction size measurement
EFO:0004344	birth weight
EFO:0005939	parental genotype effect measurement
EFO:0004847	age at onset
EFO:0007793	BMI-adjusted leptin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
terbufos	increases methylation	1
Resveratrol	affects cotreatment, decreases expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Fonofos	increases methylation	1
Parathion	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.

12 trials:

NCT	Phase	Status	Title
NCT03414970	Phase 3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	Phase 2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	Phase 2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	Phase 1/2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	Phase 1/2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	Early Phase 1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	Early Phase 1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT07628634	Early Phase 1	RECRUITING	Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
NCT01208974	Not specified	COMPLETED	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery