ACTN1-DT

Summary

ACTN1-DT (ACTN1 divergent transcript, HGNC:20131) is a long non-coding RNA gene on chromosome 14q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20131
Approved symbol	ACTN1-DT
Name	ACTN1 divergent transcript
Location	14q24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259062
Ensembl biotype	lncRNA
Entrez	161159
RNAcentral	URS00001D1FF7 — lncRNA, 599 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000553944, ENST00000553961, ENST00000749507

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000553944 — 4 exons

Exon	Start	End
ENSE00002458435	68981226	68981562
ENSE00002514173	68979928	68980187
ENSE00004093216	68978862	68978896
ENSE00004093218	68978974	68979060

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 83.78.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2464 / max 45.6813, expressed in 83 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140321	0.2464	83

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
quadriceps femoris	UBERON:0001377	83.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.93	gold quality
cerebellar vermis	UBERON:0004720	77.54	gold quality
bone marrow	UBERON:0002371	73.77	gold quality
bone marrow cell	CL:0002092	71.81	silver quality
myometrium	UBERON:0001296	69.46	gold quality
smooth muscle tissue	UBERON:0001135	68.70	gold quality
muscle tissue	UBERON:0002385	68.09	gold quality
body of uterus	UBERON:0009853	68.08	gold quality
ventricular zone	UBERON:0003053	67.38	gold quality
skeletal muscle tissue	UBERON:0001134	67.10	gold quality
descending thoracic aorta	UBERON:0002345	66.91	gold quality
lymph node	UBERON:0000029	66.81	gold quality
thymus	UBERON:0002370	66.74	silver quality
lower esophagus	UBERON:0013473	66.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.35	gold quality
ascending aorta	UBERON:0001496	66.21	gold quality
thoracic aorta	UBERON:0001515	66.10	gold quality
left coronary artery	UBERON:0001626	65.04	gold quality
urinary bladder	UBERON:0001255	65.02	gold quality
ganglionic eminence	UBERON:0004023	64.97	gold quality
right coronary artery	UBERON:0001625	64.78	gold quality
blood	UBERON:0000178	64.51	gold quality
tibial artery	UBERON:0007610	63.86	gold quality
popliteal artery	UBERON:0002250	63.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.69	gold quality
prostate gland	UBERON:0002367	63.37	gold quality
thoracic mammary gland	UBERON:0005200	63.04	gold quality
lower esophagus mucosa	UBERON:0035834	62.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.96

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.