ACTR1B

Summary

ACTR1B (actin related protein 1B, HGNC:168) is a protein-coding gene on chromosome 2q11.2, encoding Beta-centractin (P42025). Component of a multi-subunit complex involved in microtubule based vesicle motility.

This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex.

Source: NCBI Gene 10120 — RefSeq curated summary.

At a glance

• GWAS associations: 10
• Clinical variants (ClinVar): 85 total — 3 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_005735

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:168
Approved symbol	ACTR1B
Name	actin related protein 1B
Location	2q11.2
Locus type	gene with protein product
Status	Approved
Aliases	Arp1B
Ensembl gene	ENSG00000115073
Ensembl biotype	protein_coding
OMIM	605144
Entrez	10120

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 2 retained_intron

ENST00000289228, ENST00000451664, ENST00000460427, ENST00000855773, ENST00000855774, ENST00000855775, ENST00000855776, ENST00000855777, ENST00000855778, ENST00000936775, ENST00000936776, ENST00000936777, ENST00000936778

RefSeq mRNA: 1 — MANE Select: NM_005735 NM_005735

CCDS: CCDS2033

Canonical transcript exons

ENST00000289228 — 11 exons

Exon	Start	End
ENSE00000771300	97658427	97658643
ENSE00000771302	97657943	97658117
ENSE00000771304	97657152	97657192
ENSE00000804145	97655939	97656960
ENSE00001346652	97663843	97664044
ENSE00002449288	97657448	97657509
ENSE00002463641	97658879	97659003
ENSE00003508567	97659352	97659477
ENSE00003575161	97661882	97661946
ENSE00003635234	97660571	97660646
ENSE00003656694	97658224	97658316

Expression profiles

Bgee: expression breadth ubiquitous, 294 present calls, max score 97.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.1656 / max 88.9980, expressed in 1803 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29820	15.1656	1803

Top tissues by expression

300 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right frontal lobe	UBERON:0002810	97.39	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.38	gold quality
prefrontal cortex	UBERON:0000451	96.94	gold quality
cerebellar hemisphere	UBERON:0002245	96.94	gold quality
cerebellar cortex	UBERON:0002129	96.90	gold quality
body of pancreas	UBERON:0001150	96.61	gold quality
apex of heart	UBERON:0002098	96.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.28	gold quality
right uterine tube	UBERON:0001302	96.24	gold quality
left adrenal gland cortex	UBERON:0035825	96.21	gold quality
right adrenal gland	UBERON:0001233	96.20	gold quality
left adrenal gland	UBERON:0001234	96.15	gold quality
cerebellum	UBERON:0002037	96.11	gold quality
body of uterus	UBERON:0009853	96.09	gold quality
metanephros cortex	UBERON:0010533	96.06	gold quality
right adrenal gland cortex	UBERON:0035827	96.05	gold quality
body of stomach	UBERON:0001161	95.89	gold quality
right lobe of thyroid gland	UBERON:0001119	95.81	gold quality
adrenal cortex	UBERON:0001235	95.79	gold quality
left ovary	UBERON:0002119	95.79	gold quality
muscle layer of sigmoid colon	UBERON:0035805	95.73	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	95.64	gold quality
lower esophagus	UBERON:0013473	95.63	gold quality
right ovary	UBERON:0002118	95.62	gold quality
ascending aorta	UBERON:0001496	95.61	gold quality
thoracic aorta	UBERON:0001515	95.61	gold quality
left uterine tube	UBERON:0001303	95.59	gold quality
frontal cortex	UBERON:0001870	95.57	gold quality
frontal lobe	UBERON:0016525	95.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	9.12

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting ACTR1B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-3912-5P	99.95	66.11	925
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-6132	99.60	65.83	1554
HSA-MIR-6836-5P	99.60	65.62	1538
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-6722-3P	99.45	67.62	1919
HSA-MIR-580-5P	99.28	70.94	1776
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-1909-3P	99.03	66.56	1662
HSA-MIR-4742-5P	98.89	68.41	1542
HSA-MIR-760	98.81	66.65	1392
HSA-MIR-6761-5P	98.71	68.03	1504
HSA-MIR-1301-3P	98.64	68.27	1071
HSA-MIR-5047	98.64	68.62	1035
HSA-MIR-6873-5P	98.45	66.14	1417
HSA-MIR-6826-3P	98.19	66.32	1153
HSA-MIR-4660	97.79	67.44	1328
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-7154-3P	97.65	65.02	985

Literature-anchored findings (GeneRIF, showing 2)

• Down-regulation of beta-centractin is associated with hepatocellular carcinoma immune escape (PMID:17619203)
• Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp. (PMID:19996280)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Actr1b	ENSMUSG00000037351
rattus_norvegicus	Actr1b	ENSRNOG00000016789

Paralogs (26): ACTR6 (ENSG00000075089), ACTB (ENSG00000075624), ACTL6B (ENSG00000077080), ACTR5 (ENSG00000101442), ACTR3C (ENSG00000106526), ACTA2 (ENSG00000107796), ACTR8 (ENSG00000113812), ACTR3 (ENSG00000115091), ACTL8 (ENSG00000117148), ACTRT1 (ENSG00000123165), ACTR10 (ENSG00000131966), ACTR3B (ENSG00000133627), ACTL6A (ENSG00000136518), ACTR2 (ENSG00000138071), ACTR1A (ENSG00000138107), ACTA1 (ENSG00000143632), ACTL7B (ENSG00000148156), ACTC1 (ENSG00000159251), ACTG2 (ENSG00000163017), ACTBL2 (ENSG00000169067), ACTRT2 (ENSG00000169717), ACTL9 (ENSG00000181786), ACTG1 (ENSG00000184009), ACTRT3 (ENSG00000184378), ACTL7A (ENSG00000187003), ACTL10 (ENSG00000288649)

Protein

Protein identifiers

Beta-centractin — P42025 (reviewed: P42025)

Alternative names: Actin-related protein 1B

All UniProt accessions (1): P42025

UniProt curated annotations — full annotation on UniProt →

Function. Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Subcellular location. Cytoplasm. Cytoskeleton. Microtubule organizing center. Centrosome.

Similarity. Belongs to the actin family. ARP1 subfamily.

RefSeq proteins (1): NP_005726* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004000	Actin	Family
IPR004001	Actin_CS	Conserved_site
IPR020902	Actin/actin-like_CS	Conserved_site
IPR043129	ATPase_NBD	Homologous_superfamily

Pfam: PF00022

UniProt features (5 total): modified residue 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P42025-F1	93.34	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 1, 4

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-2132295	MHC class II antigen presentation
R-HSA-6798695	Neutrophil degranulation
R-HSA-1280218	Adaptive Immune System
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System

MSigDB gene sets: 144 (showing top): TAATAAT_MIR126, REACTOME_INNATE_IMMUNE_SYSTEM, REACTOME_ADAPTIVE_IMMUNE_SYSTEM, GOCC_SECRETORY_GRANULE, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOCC_MICROTUBULE_ORGANIZING_CENTER, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, BROWNE_HCMV_INFECTION_48HR_DN, GOCC_CENTROSOME, MODULE_98, LEE_AGING_MUSCLE_UP, GOCC_SECRETORY_VESICLE, GOCC_VESICLE_LUMEN, MODULE_438, BLALOCK_ALZHEIMERS_DISEASE_DN

GO Biological Process (0):

GO Molecular Function (3): ATP binding (GO:0005524), nucleotide binding (GO:0000166), protein binding (GO:0005515)

GO Cellular Component (11): extracellular region (GO:0005576), cytoplasm (GO:0005737), centrosome (GO:0005813), cytosol (GO:0005829), dynactin complex (GO:0005869), membrane (GO:0016020), secretory granule lumen (GO:0034774), extracellular exosome (GO:0070062), ficolin-1-rich granule lumen (GO:1904813), microtubule organizing center (GO:0005815), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Immune System	2
Adaptive Immune System	1
Innate Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
intracellular anatomical structure	1
centriole	1
microtubule organizing center	1
cytoplasm	1
microtubule associated complex	1
actin cytoskeleton	1
secretory granule	1
cytoplasmic vesicle lumen	1
extracellular vesicle	1
intracellular organelle lumen	1
ficolin-1-rich granule	1
microtubule cytoskeleton	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

3261 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACTR1B	DCTN2	Q13561	726
ACTR1B	MYO1A	Q9UBC5	715
ACTR1B	OTP	Q5XKR4	665
ACTR1B	DCTN4	Q9UJW0	649
ACTR1B	DCTN1	Q14203	634
ACTR1B	CAPZA2	P47755	559
ACTR1B	CAPZA1	P52907	548
ACTR1B	CAPZB	P47756	538
ACTR1B	PITX1	P78337	507
ACTR1B	RNF181	Q9P0P0	506
ACTR1B	DCTN3	O75935	502
ACTR1B	OTX1	P32242	490
ACTR1B	ARHGDIA	P52565	452
ACTR1B	PITX2	Q99697	451
ACTR1B	DCTN6	O00399	441

IntAct

110 interactions, top by confidence:

A	B	Type	Score
DCTN1	DCTN6	psi-mi:“MI:0914”(association)	0.780
DCTN2	DCTN6	psi-mi:“MI:0914”(association)	0.730
DCTN2	DCTN3	psi-mi:“MI:0914”(association)	0.730
DCTN1	DCTN3	psi-mi:“MI:0914”(association)	0.710
DYNC1I2	DYNC1LI2	psi-mi:“MI:0914”(association)	0.680
ACTR1B	DCTN1	psi-mi:“MI:0915”(physical association)	0.650
MIS18A	DCTN6	psi-mi:“MI:0914”(association)	0.640
CCT2	PPP6C	psi-mi:“MI:0914”(association)	0.640
CAPZB	CNOT1	psi-mi:“MI:0914”(association)	0.640
CAPZA2	CNOT1	psi-mi:“MI:0914”(association)	0.640
DCTN5	DCTN6	psi-mi:“MI:0914”(association)	0.640
PDCL3	PEX7	psi-mi:“MI:0914”(association)	0.640
Dctn2	DCTN6	psi-mi:“MI:0914”(association)	0.560
ACTR1B	HTT	psi-mi:“MI:0915”(physical association)	0.560
UQCRH	DCTN6	psi-mi:“MI:0914”(association)	0.530
GPS2	DCTN6	psi-mi:“MI:0914”(association)	0.530
RPS19BP1	DCTN6	psi-mi:“MI:0914”(association)	0.530
BMERB1	DCTN6	psi-mi:“MI:0914”(association)	0.530
DEFB127	DCTN6	psi-mi:“MI:0914”(association)	0.530
DCTN6	ZBTB43	psi-mi:“MI:0914”(association)	0.530

BioGRID (210): ACTR1B (Two-hybrid), ACTR1B (Affinity Capture-MS), ACTR1B (Affinity Capture-MS), ACTR1B (Affinity Capture-MS), ACTR1B (Affinity Capture-MS), DCTN3 (Affinity Capture-MS), CCT4 (Affinity Capture-MS), DCTN4 (Affinity Capture-MS), ACTR1A (Affinity Capture-MS), ACTR10 (Affinity Capture-MS), DCTN5 (Affinity Capture-MS), CCT3 (Affinity Capture-MS), DCTN6 (Affinity Capture-MS), SCCPDH (Affinity Capture-MS), CCT7 (Affinity Capture-MS)

ESM2 similar proteins: A2WNB0, A2XMK6, A2YUL5, A3ANB5, A4FUX8, A4IFE3, F2Z5G5, O94241, O94630, O94805, O96019, O96621, P02583, P32381, P38673, P42025, P45888, P45889, P45890, P45891, P47117, P51775, P53489, P85515, P86173, Q09443, Q09849, Q0IEG8, Q2TA43, Q4R333, Q4R6J9, Q54I79, Q5BL41, Q5NBI2, Q61JZ2, Q6AY16, Q6C982, Q6Z256, Q74ZV8, Q7ZTP2

Diamond homologs: A2BDB0, A2XLF2, A2XNS1, A3C6D7, A4IFE3, F2Z5G5, O17320, O18840, O65314, O81221, P02578, P04829, P0C539, P0CJ46, P0CJ47, P0DM41, P0DM42, P10981, P10984, P10986, P10990, P17304, P30162, P30163, P30167, P30171, P38673, P42023, P42025, P45885, P45886, P45889, P48465, P48975, P53455, P53456, P53457, P53458, P53470, P53471

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 89 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
COPI-independent Golgi-to-ER retrograde traffic	11	36.2×	2e-12
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	11	33.8×	3e-12
Sensory processing of sound	5	24.5×	9e-05
COPI-mediated anterograde transport	11	19.2×	8e-10
MHC class II antigen presentation	12	17.0×	5e-10
Sensory processing of sound by inner hair cells of the cochlea	6	15.5×	1e-04
Loss of Nlp from mitotic centrosomes	6	15.1×	1e-04
Loss of proteins required for interphase microtubule organization from the centrosome	6	15.1×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
axonogenesis	5	10.6×	8e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

85 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	1
Uncertain significance	56
Likely benign	6
Benign	2

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
394206	GRCh37/hg19 2q11.1-11.2(chr2:95691600-100587394)	Pathogenic
395690	GRCh37/hg19 2q11.1-12.3(chr2:95529039-108518266)	Pathogenic
59145	GRCh38/hg38 2p11.2-q11.2(chr2:91443218-102334856)x3	Pathogenic
2685857	GRCh37/hg19 2q11.1-11.2(chr2:95773428-102550061)x3	Likely pathogenic

SpliceAI

2097 predictions. Top by Δscore:

Variant	Effect	Δscore
2:97656958:CCG:C	acceptor_gain	1.0000
2:97656959:CG:C	acceptor_gain	1.0000
2:97656959:CGC:C	acceptor_gain	1.0000
2:97656961:C:CC	acceptor_gain	1.0000
2:97657442:CCTCA:C	donor_loss	1.0000
2:97657443:CTCAC:C	donor_loss	1.0000
2:97657444:TCA:T	donor_loss	1.0000
2:97657445:CAC:C	donor_loss	1.0000
2:97657446:A:AC	donor_gain	1.0000
2:97657447:C:CC	donor_gain	1.0000
2:97657508:GCC:G	acceptor_loss	1.0000
2:97657509:CCTG:C	acceptor_loss	1.0000
2:97657510:C:CC	acceptor_gain	1.0000
2:97657510:CTGTG:C	acceptor_loss	1.0000
2:97657939:GTA:G	donor_loss	1.0000
2:97657940:TA:T	donor_loss	1.0000
2:97658098:C:CT	acceptor_gain	1.0000
2:97658217:CACTT:C	donor_loss	1.0000
2:97658218:ACTT:A	donor_loss	1.0000
2:97658219:CTT:C	donor_loss	1.0000
2:97658220:TTA:T	donor_loss	1.0000
2:97658221:TACAT:T	donor_loss	1.0000
2:97658222:A:AC	donor_gain	1.0000
2:97658222:ACA:A	donor_loss	1.0000
2:97658223:C:CT	donor_gain	1.0000
2:97658223:CA:C	donor_gain	1.0000
2:97658223:CAT:C	donor_gain	1.0000
2:97658223:CATCA:C	donor_gain	1.0000
2:97658312:GCTCG:G	acceptor_gain	1.0000
2:97658313:CTCG:C	acceptor_gain	1.0000

AlphaMissense

2443 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:97656958:C:T	G344D	1.000
2:97657152:C:T	G343D	1.000
2:97656930:A:C	F353L	0.999
2:97656930:A:T	F353L	0.999
2:97656932:A:G	F353L	0.999
2:97656940:A:G	L350P	0.999
2:97656946:G:T	A348D	0.999
2:97656949:A:G	L347P	0.999
2:97656959:C:G	G344R	0.999
2:97657153:C:A	G343C	0.999
2:97657153:C:G	G343R	0.999
2:97657159:A:G	W341R	0.999
2:97657159:A:T	W341R	0.999
2:97657497:C:G	R313P	0.999
2:97658430:T:A	K218N	0.999
2:97658430:T:G	K218N	0.999
2:97658562:A:C	F174L	0.999
2:97658562:A:T	F174L	0.999
2:97658564:A:G	F174L	0.999
2:97658620:C:T	G155E	0.999
2:97658639:C:G	A149P	0.999
2:97658881:A:C	S146R	0.999
2:97658881:A:T	S146R	0.999
2:97658883:T:G	S146R	0.999
2:97658993:A:G	L109P	0.999
2:97659399:A:G	W90R	0.999
2:97659399:A:T	W90R	0.999
2:97659420:A:G	W83R	0.999
2:97659420:A:T	W83R	0.999
2:97661929:T:A	K22N	0.999

dbSNP variants (sampled 300 via entrez): RS1000420174 (2:97656499 C>G), RS1000524736 (2:97656004 GTTT>G,GTT), RS1000797664 (2:97661564 C>T), RS1000849924 (2:97661282 T>C), RS1001400126 (2:97660905 A>G), RS1001444121 (2:97660712 C>T), RS1001692163 (2:97655610 C>T), RS1002265733 (2:97662953 C>A,T), RS1002564841 (2:97664269 G>A,C), RS1002580055 (2:97658167 C>G,T), RS1002641219 (2:97662643 G>A,T), RS1002791733 (2:97664372 G>A), RS1003007775 (2:97664565 A>G), RS1003220741 (2:97665496 G>A), RS1003579374 (2:97665882 ATCC>A)

Disease associations

OMIM: gene MIM:605144 | disease phenotypes: MIM:126800

GenCC curated gene-disease

Mondo (1): Duane retraction syndrome (MONDO:0007473)

Orphanet (1): Duane retraction syndrome (Orphanet:233)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

10 associations (top):

Study	Trait	p-value
GCST007328_33	Alcohol consumption (drinks per week)	2.000000e-10
GCST008103_128	Bipolar disorder	2.000000e-06
GCST008522_43	Bitter alcoholic beverage consumption	4.000000e-09
GCST010697_1	Cortical surface area (min-P)	6.000000e-12
GCST010698_17	Subcortical volume (min-P)	9.000000e-09
GCST010699_105	Brain morphology (min-P)	2.000000e-11
GCST010700_9	Cortical thickness (MOSTest)	9.000000e-14
GCST010701_54	Cortical surface area (MOSTest)	2.000000e-16
GCST010702_79	Subcortical volume (MOSTest)	5.000000e-09
GCST010703_322	Brain morphology (MOSTest)	1.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0010092	bitter alcoholic beverage consumption measurement
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D004370	Duane Retraction Syndrome	C10.292.562.700.375.500; C11.270.235; C11.590.436.400.500; C16.320.290.235

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, increases abundance, increases expression, decreases expression	4
Arsenic	decreases expression, increases abundance, affects cotreatment	2
ginger extract	decreases expression, increases abundance	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
zinc chromate	increases abundance, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
chromium hexavalent ion	decreases expression, increases abundance	1
CC-8490	decreases expression	1
bisphenol S	affects cotreatment, increases methylation	1
Temozolomide	decreases expression	1
Arsenic Trioxide	decreases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Atrazine	increases expression	1
Diethylhexyl Phthalate	decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Ivermectin	decreases expression	1
Oils, Volatile	decreases expression, increases abundance	1
Phthalic Acids	decreases methylation	1
Quercetin	increases expression	1
Selenium	increases expression	1
Smoke	decreases expression	1
Tamoxifen	decreases expression	1
Valproic Acid	decreases expression	1
Vitamin E	increases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

1 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03059420	Not specified	RECRUITING	Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies