ACTR3B

Summary

ACTR3B (actin related protein 3B, HGNC:17256) is a protein-coding gene on chromosome 7q36.1-q36.2, encoding Actin-related protein 3B (Q9P1U1). Plays a role in the organization of the actin cytoskeleton.

This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms.

Source: NCBI Gene 57180 — RefSeq curated summary.

At a glance

• GWAS associations: 8
• Clinical variants (ClinVar): 58 total — 7 pathogenic, 1 likely-pathogenic
• MANE Select transcript: NM_020445

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17256
Approved symbol	ACTR3B
Name	actin related protein 3B
Location	7q36.1-q36.2
Locus type	gene with protein product
Status	Approved
Aliases	ARP11, ARP3beta
Ensembl gene	ENSG00000133627
Ensembl biotype	protein_coding
Entrez	57180

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000256001, ENST00000377776, ENST00000397282, ENST00000479402, ENST00000488782, ENST00000885354, ENST00000885355, ENST00000885356, ENST00000885357, ENST00000919241, ENST00000919242, ENST00000919243, ENST00000965408

RefSeq mRNA: 9 — MANE Select: NM_020445 NM_001040135, NM_001350940, NM_001350941, NM_001350942, NM_001350943, NM_001350944, NM_001350945, NM_001350946, NM_020445

CCDS: CCDS34782, CCDS5934, CCDS87568

Canonical transcript exons

ENST00000256001 — 12 exons

Exon	Start	End
ENSE00000827618	152854458	152855378
ENSE00003432239	152816481	152816588
ENSE00003462962	152825030	152825122
ENSE00003470665	152852126	152852251
ENSE00003477818	152814550	152814645
ENSE00003501039	152801621	152801731
ENSE00003537700	152783187	152783242
ENSE00003543124	152853494	152853577
ENSE00003602821	152800531	152800655
ENSE00003605728	152823342	152823515
ENSE00003632132	152820299	152820442
ENSE00003850575	152759752	152759926

Expression profiles

Bgee: expression breadth ubiquitous, 232 present calls, max score 96.23.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 15.6918 / max 187.1984, expressed in 1777 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
82145	14.5887	1766
82144	0.7596	447
82146	0.2671	122
82147	0.0764	33

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	96.23	gold quality
nucleus accumbens	UBERON:0001882	93.87	gold quality
secondary oocyte	CL:0000655	93.17	gold quality
ventricular zone	UBERON:0003053	92.66	gold quality
parotid gland	UBERON:0001831	92.59	gold quality
prefrontal cortex	UBERON:0000451	92.50	gold quality
caudate nucleus	UBERON:0001873	91.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.87	gold quality
putamen	UBERON:0001874	91.30	gold quality
neocortex	UBERON:0001950	91.03	gold quality
frontal cortex	UBERON:0001870	90.99	gold quality
anterior cingulate cortex	UBERON:0009835	90.96	gold quality
cingulate cortex	UBERON:0003027	90.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	90.74	gold quality
telencephalon	UBERON:0001893	90.62	gold quality
right frontal lobe	UBERON:0002810	90.60	gold quality
cerebral cortex	UBERON:0000956	90.55	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.04	gold quality
forebrain	UBERON:0001890	89.55	gold quality
Ammon’s horn	UBERON:0001954	89.52	gold quality
primary visual cortex	UBERON:0002436	89.42	gold quality
amygdala	UBERON:0001876	88.93	gold quality
occipital lobe	UBERON:0002021	88.77	gold quality
middle temporal gyrus	UBERON:0002771	88.70	gold quality
ganglionic eminence	UBERON:0004023	88.58	gold quality
brain	UBERON:0000955	88.50	gold quality
temporal lobe	UBERON:0001871	88.07	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.99	gold quality
superior frontal gyrus	UBERON:0002661	86.97	gold quality
orbitofrontal cortex	UBERON:0004167	86.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75140	yes	215.53
E-ANND-3	yes	5.25

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

45 targeting ACTR3B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-576-5P	99.84	70.46	2582
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-4255	99.72	67.70	1541
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-12124	99.68	69.17	2700
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-7106-5P	99.53	67.47	3574
HSA-MIR-5571-5P	99.49	66.99	1764
HSA-MIR-142-5P	99.48	70.92	2416
HSA-MIR-5590-3P	99.48	70.91	2429
HSA-MIR-4666A-5P	99.41	69.72	1887

Literature-anchored findings (GeneRIF, showing 1)

• Thus, overexpression of Arp11 may suppress tumorigenicity in nude mice. (PMID:14651955)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	actr3b	ENSDARG00000008790
mus_musculus	Actr3b	ENSMUSG00000056367
rattus_norvegicus	Actr3b	ENSRNOG00000031855

Paralogs (26): ACTR6 (ENSG00000075089), ACTB (ENSG00000075624), ACTL6B (ENSG00000077080), ACTR5 (ENSG00000101442), ACTR3C (ENSG00000106526), ACTA2 (ENSG00000107796), ACTR8 (ENSG00000113812), ACTR1B (ENSG00000115073), ACTR3 (ENSG00000115091), ACTL8 (ENSG00000117148), ACTRT1 (ENSG00000123165), ACTR10 (ENSG00000131966), ACTL6A (ENSG00000136518), ACTR2 (ENSG00000138071), ACTR1A (ENSG00000138107), ACTA1 (ENSG00000143632), ACTL7B (ENSG00000148156), ACTC1 (ENSG00000159251), ACTG2 (ENSG00000163017), ACTBL2 (ENSG00000169067), ACTRT2 (ENSG00000169717), ACTL9 (ENSG00000181786), ACTG1 (ENSG00000184009), ACTRT3 (ENSG00000184378), ACTL7A (ENSG00000187003), ACTL10 (ENSG00000288649)

Protein

Protein identifiers

Actin-related protein 3B — Q9P1U1 (reviewed: Q9P1U1)

Alternative names: ARP3-beta, Actin-like protein 3B, Actin-related protein ARP4

All UniProt accessions (1): Q9P1U1

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.

Subunit / interactions. Interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular location. Cytoplasm. Cytoskeleton. Cell projection.

Tissue specificity. Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.

Similarity. Belongs to the actin family. ARP3 subfamily.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9P1U1-1	1	yes
Q9P1U1-2	2
Q9P1U1-3	3

RefSeq proteins (9): NP_001035225, NP_001337869, NP_001337870, NP_001337871, NP_001337872, NP_001337873, NP_001337874, NP_001337875, NP_065178* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004000	Actin	Family
IPR020902	Actin/actin-like_CS	Conserved_site
IPR043129	ATPase_NBD	Homologous_superfamily

Pfam: PF00022

UniProt features (4 total): splice variant 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P1U1-F1	93.40	0.90

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 121 (showing top): MCLACHLAN_DENTAL_CARIES_DN, GOBP_ACTIN_FILAMENT_ORGANIZATION, GOMF_ACTIN_BINDING, ZHANG_BREAST_CANCER_PROGENITORS_UP, GOBP_ARP2_3_COMPLEX_MEDIATED_ACTIN_NUCLEATION, GOBP_ACTIN_NUCLEATION, MODULE_207, GOCC_LAMELLIPODIUM, GOCC_ARP2_3_PROTEIN_COMPLEX, GAVIN_FOXP3_TARGETS_CLUSTER_P3, BLALOCK_ALZHEIMERS_DISEASE_DN, GOCC_CELL_LEADING_EDGE, GOMF_CYTOSKELETAL_PROTEIN_BINDING, GOMF_ADENYL_NUCLEOTIDE_BINDING, WONG_ADULT_TISSUE_STEM_MODULE

GO Biological Process (0):

GO Molecular Function (4): actin binding (GO:0003779), ATP binding (GO:0005524), nucleotide binding (GO:0000166), actin filament binding (GO:0051015)

GO Cellular Component (5): cytoskeleton (GO:0005856), lamellipodium (GO:0030027), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cytoskeletal protein binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
actin binding	1
protein-containing complex binding	1
intracellular membraneless organelle	1
cell leading edge	1
plasma membrane bounded cell projection	1
extracellular vesicle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

2189 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACTR3B	ACTR2	P61160	976
ACTR3B	DCTN2	Q13561	907
ACTR3B	TPPP	O94811	844
ACTR3B	DCTN5	Q9BTE1	838
ACTR3B	CAPZA2	P47755	810
ACTR3B	CAPZA1	P52907	798
ACTR3B	DCTN1	Q14203	794
ACTR3B	DCTN6	O00399	791
ACTR3B	DCTN4	Q9UJW0	767
ACTR3B	ARPC5	O15511	737
ACTR3B	ARPC5L	Q9BPX5	732
ACTR3B	ARPC2	O15144	727
ACTR3B	ARPC3	O15145	691
ACTR3B	ACTB	P02570	675
ACTR3B	WAS	P42768	589

IntAct

57 interactions, top by confidence:

A	B	Type	Score
ARPC1B	ARPC2	psi-mi:“MI:0914”(association)	0.920
ARPC4	ARPC1B	psi-mi:“MI:0914”(association)	0.910
ARPC1A	ARPC2	psi-mi:“MI:0914”(association)	0.900
ARPC5	ARPC1B	psi-mi:“MI:0914”(association)	0.890
SEPTIN9	SEPTIN6	psi-mi:“MI:0914”(association)	0.800
ARPC5	ARPC3	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
ENO1	ENO2	psi-mi:“MI:0914”(association)	0.710
ACTR3B	ARPC2	psi-mi:“MI:0914”(association)	0.670
ARPC3	ARPC2	psi-mi:“MI:0914”(association)	0.640
STK4	STRN	psi-mi:“MI:0914”(association)	0.610
ACTR3B	EXOC5	psi-mi:“MI:0915”(physical association)	0.370
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
ACTR2		psi-mi:“MI:0914”(association)	0.350
ARPC2		psi-mi:“MI:0914”(association)	0.350
ARPC3		psi-mi:“MI:0914”(association)	0.350
CALD1		psi-mi:“MI:0914”(association)	0.350
CAPZB	ENAH	psi-mi:“MI:0914”(association)	0.350
ACTR3B	SBNO1	psi-mi:“MI:0914”(association)	0.350
PAAT	HIP1	psi-mi:“MI:0914”(association)	0.350
FAM133A	DNM1L	psi-mi:“MI:0914”(association)	0.350
NCKIPSD	GAS7	psi-mi:“MI:0914”(association)	0.350
NDP	MYCBP2	psi-mi:“MI:0914”(association)	0.350
TUBD1	FLOT1	psi-mi:“MI:0914”(association)	0.350
MSC	TCF3	psi-mi:“MI:0914”(association)	0.350
TFAP4	PRKCA	psi-mi:“MI:0914”(association)	0.350
SLC25A41	TMOD1	psi-mi:“MI:0914”(association)	0.350
ACADL	RAP1B	psi-mi:“MI:0914”(association)	0.350

BioGRID (128): ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR3B (Co-fractionation), ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ACTR2 (Affinity Capture-MS), ACTR3B (Affinity Capture-MS), ARPC2 (Affinity Capture-MS), CHURC1 (Affinity Capture-MS), OSBPL3 (Affinity Capture-MS), ACTR3 (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8EV45, C9WPN6, F1QGW6, F6RQL9, O73723, O77676, P00516, P0C605, P20461, P23258, P23330, P31321, P32392, P35250, P41091, P53033, P61157, P61158, P62482, P62483, P81795, P83887, P83888, Q05B83, Q0VCD2, Q13126, Q13303, Q13976, Q27955, Q2KHU8, Q2KJ81, Q2VIR3, Q32KM1, Q4V7C7, Q5R797, Q5R8R1, Q5ZHS1, Q5ZMS3, Q641P0, Q641W4

Diamond homologs: A0A1L8EV45, A2BDB0, A2X6S3, O16808, O17320, O18840, O73723, P02576, P02578, P04752, P04829, P07829, P0DM41, P0DM42, P10984, P10986, P10988, P10990, P12716, P13363, P17126, P17128, P22132, P26183, P27131, P30162, P30163, P32390, P32392, P35432, P41112, P41339, P42528, P43239, P45886, P47117, P53458, P53461, P53468, P53470

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 57 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
RHO GTPases Activate WASPs and WAVEs	9	77.2×	4e-13
Parasite infection	8	74.8×	9e-12
Leishmania phagocytosis	8	74.8×	9e-12
Fcgamma receptor (FCGR) dependent phagocytosis	8	60.2×	3e-11
EPHB-mediated forward signaling	8	57.4×	4e-11
FCGR3A-mediated phagocytosis	9	45.5×	2e-11
Regulation of actin dynamics for phagocytic cup formation	9	44.8×	2e-11
Leishmania infection	8	35.3×	2e-09

GO biological processes:

GO term	Partners	Fold	FDR
Arp2/3 complex-mediated actin nucleation	8	165.2×	2e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	7
Likely pathogenic	1
Uncertain significance	34
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (8)

Variant ID	HGVS	Classification
147806	GRCh38/hg38 7q36.2-36.3(chr7:152807205-159325876)x1	Pathogenic
150933	GRCh38/hg38 7q36.1-36.3(chr7:152428852-159335865)x3	Pathogenic
1808403	GRCh37/hg19 7q36.1-36.2(chr7:151581341-153599029)x1	Pathogenic
3236546	GRCh37/hg19 7q36.1-36.2(chr7:151935482-154215665)x1	Pathogenic
442820	GRCh37/hg19 7q36.1-36.3(chr7:151566053-159119707)x3	Pathogenic
443708	GRCh37/hg19 7q36.1-36.3(chr7:151167135-159119707)x1	Pathogenic
60314	GRCh38/hg38 7q36.1-36.3(chr7:152332476-159296617)x1	Pathogenic
443611	GRCh37/hg19 7q36.1-36.2(chr7:151387196-154070094)x1	Likely pathogenic

SpliceAI

3797 predictions. Top by Δscore:

Variant	Effect	Δscore
7:152801618:CA:C	acceptor_loss	1.0000
7:152801619:A:AG	acceptor_gain	1.0000
7:152801619:AGT:A	acceptor_gain	1.0000
7:152801619:AGTG:A	acceptor_gain	1.0000
7:152801620:G:GA	acceptor_gain	1.0000
7:152801620:GT:G	acceptor_gain	1.0000
7:152801620:GTG:G	acceptor_gain	1.0000
7:152801620:GTGG:G	acceptor_gain	1.0000
7:152801620:GTGGC:G	acceptor_gain	1.0000
7:152801727:TAATG:T	donor_gain	1.0000
7:152801729:ATG:A	donor_gain	1.0000
7:152801730:TG:T	donor_gain	1.0000
7:152801731:GG:G	donor_gain	1.0000
7:152801732:G:GG	donor_gain	1.0000
7:152801732:GT:G	donor_loss	1.0000
7:152801733:T:A	donor_loss	1.0000
7:152814549:GACA:G	acceptor_gain	1.0000
7:152819347:ACTTG:A	acceptor_gain	1.0000
7:152819350:T:TA	acceptor_gain	1.0000
7:152823513:G:GT	donor_gain	1.0000
7:152823514:AGG:A	donor_loss	1.0000
7:152823516:G:GA	donor_loss	1.0000
7:152823517:T:G	donor_loss	1.0000
7:152825011:ATATT:A	acceptor_gain	1.0000
7:152825012:T:G	acceptor_gain	1.0000
7:152825013:A:AG	acceptor_gain	1.0000
7:152825013:ATT:A	acceptor_gain	1.0000
7:152825014:T:G	acceptor_gain	1.0000
7:152825015:T:A	acceptor_gain	1.0000
7:152825019:A:AG	acceptor_gain	1.0000

AlphaMissense

2750 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:152759923:C:T	T14I	1.000
7:152783196:G:C	K18N	1.000
7:152783196:G:T	K18N	1.000
7:152783222:C:A	P27H	1.000
7:152800618:G:A	G63E	1.000
7:152801637:G:A	G81E	1.000
7:152801651:T:A	W86R	1.000
7:152801651:T:C	W86R	1.000
7:152814582:A:C	R123S	1.000
7:152814582:A:T	R123S	1.000
7:152816541:G:T	G165W	1.000
7:152816542:G:A	G165E	1.000
7:152816556:A:C	S170R	1.000
7:152816558:C:A	S170R	1.000
7:152816558:C:G	S170R	1.000
7:152816560:G:A	G171E	1.000
7:152816560:G:T	G171V	1.000
7:152852142:G:A	G323E	1.000
7:152852142:G:T	G323V	1.000
7:152853548:T:A	W378R	1.000
7:152853548:T:C	W378R	1.000
7:152853555:G:A	G380E	1.000
7:152853558:G:A	G381D	1.000
7:152759913:G:C	D11H	0.999
7:152759919:G:C	G13R	0.999
7:152759919:G:T	G13C	0.999
7:152759920:G:A	G13D	0.999
7:152759920:G:T	G13V	0.999
7:152759926:G:A	G15E	0.999
7:152783194:A:G	K18E	0.999

dbSNP variants (sampled 300 via entrez): RS1000059767 (7:152797709 G>A), RS1000075994 (7:152789475 G>A), RS1000135654 (7:152810857 T>C), RS1000163740 (7:152834432 G>A), RS1000273946 (7:152781272 A>G,T), RS1000293394 (7:152781493 A>G,T), RS1000326392 (7:152829161 C>T), RS1000381615 (7:152774664 T>C,G), RS1000451963 (7:152822725 G>T), RS1000501394 (7:152775113 G>A), RS1000511896 (7:152842782 C>G,T), RS1000574185 (7:152847926 G>A,C), RS1000580593 (7:152790064 C>A,T), RS1000646620 (7:152768642 A>G), RS1000667606 (7:152817314 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

8 associations (top):

Study	Trait	p-value
GCST001762_195	Obesity-related traits	9.000000e-06
GCST002548_5	Ulcerative colitis	5.000000e-07
GCST003657_2	Attention deficit hyperactivity disorder symptom score	2.000000e-06
GCST004251_8	Paneth cell defects in Crohn’s disease	4.000000e-06
GCST004640_7	Western dietary pattern	2.000000e-06
GCST006446_6	Ulna and radius bone mineral density	7.000000e-06
GCST008154_4	Trunk fat mass	2.000000e-07
GCST008157_36	Body fat mass	1.000000e-07

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004338	body weight
EFO:0007860	ADHD symptom measurement
EFO:0007963	abnormal paneth cell measurement
EFO:0008111	diet measurement
EFO:0007933	radius bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases abundance, increases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
triphenyl phosphate	affects expression	1
bisphenol A	affects cotreatment, increases methylation, decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
cupric oxide	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	increases reaction, affects binding	1
Fulvestrant	affects cotreatment, increases methylation	1
Amiodarone	increases expression	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Estradiol	increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Thiram	decreases expression	1
Valproic Acid	decreases methylation	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases methylation	1
Copper Sulfate	decreases expression	1
tert-Butylhydroperoxide	decreases expression	1
Vitamin K 3	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.