ACTR3C

Summary

ACTR3C (actin related protein 3C, HGNC:37282) is a protein-coding gene on chromosome 7q36.1, encoding Actin-related protein 3C (Q9C0K3). May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Predicted to enable ATP binding activity and actin binding activity. Predicted to contribute to actin filament binding activity. Located in extracellular exosome.

Source: NCBI Gene 653857 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 45 total — 2 pathogenic
• MANE Select transcript: NM_001164458

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37282
Approved symbol	ACTR3C
Name	actin related protein 3C
Location	7q36.1
Locus type	gene with protein product
Status	Approved
Aliases	ARP11
Ensembl gene	ENSG00000106526
Ensembl biotype	protein_coding
Entrez	653857

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 25 protein_coding

ENST00000252071, ENST00000477367, ENST00000477871, ENST00000478393, ENST00000539352, ENST00000683684, ENST00000865059, ENST00000865060, ENST00000865061, ENST00000865062, ENST00000865063, ENST00000865064, ENST00000865065, ENST00000865066, ENST00000865067, ENST00000865068, ENST00000865069, ENST00000865070, ENST00000916821, ENST00000944427, ENST00000944428, ENST00000944429, ENST00000944430, ENST00000944431, ENST00000944432

RefSeq mRNA: 2 — MANE Select: NM_001164458 NM_001164458, NM_001164459

CCDS: CCDS47744

Canonical transcript exons

ENST00000683684 — 8 exons

Exon	Start	End
ENSE00001403670	150248948	150249054
ENSE00002468905	150286367	150286540
ENSE00002491228	150284753	150284845
ENSE00002512088	150289450	150289593
ENSE00003665482	150295252	150295347
ENSE00003786250	150293312	150293419
ENSE00003918085	150323469	150323545
ENSE00003918770	150247212	150247569

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 85.11.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.2429 / max 60.4568, expressed in 921 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
86769	2.0879	736
86770	0.5533	262
86768	0.3971	207
86771	0.1591	73
86767	0.0311	14
204998	0.0142	5

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	85.11	gold quality
liver	UBERON:0002107	81.74	gold quality
islet of Langerhans	UBERON:0000006	81.58	gold quality
body of pancreas	UBERON:0001150	81.41	gold quality
right adrenal gland cortex	UBERON:0035827	81.22	gold quality
left adrenal gland cortex	UBERON:0035825	80.94	gold quality
right adrenal gland	UBERON:0001233	80.56	gold quality
pancreas	UBERON:0001264	80.37	gold quality
left adrenal gland	UBERON:0001234	80.26	gold quality
metanephros cortex	UBERON:0010533	79.78	gold quality
adult mammalian kidney	UBERON:0000082	79.61	gold quality
adrenal cortex	UBERON:0001235	79.53	gold quality
adrenal gland	UBERON:0002369	79.26	gold quality
kidney epithelium	UBERON:0004819	78.87	gold quality
rectum	UBERON:0001052	77.74	gold quality
bone marrow cell	CL:0002092	77.09	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.01	gold quality
esophagus mucosa	UBERON:0002469	75.28	gold quality
kidney	UBERON:0002113	75.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.12	gold quality
adrenal tissue	UBERON:0018303	74.94	gold quality
cortex of kidney	UBERON:0001225	74.08	gold quality
mucosa of transverse colon	UBERON:0004991	73.94	gold quality
gall bladder	UBERON:0002110	73.36	gold quality
oviduct epithelium	UBERON:0004804	73.18	gold quality
adenohypophysis	UBERON:0002196	72.90	gold quality
body of stomach	UBERON:0001161	72.45	gold quality
pituitary gland	UBERON:0000007	72.28	gold quality
minor salivary gland	UBERON:0001830	71.87	gold quality
colonic epithelium	UBERON:0000397	71.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.33

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting ACTR3C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-6892-3P	99.68	66.40	1178
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-216A-5P	99.50	68.02	1288
HSA-MIR-7849-3P	99.47	68.17	1224
HSA-MIR-122B-5P	99.46	70.81	1457
HSA-MIR-372-5P	99.41	69.11	2299
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-4721	99.26	66.05	818
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-4758-3P	99.12	63.96	869
HSA-MIR-10524-5P	99.05	66.08	963

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	actr3b	ENSDARG00000008790
mus_musculus	Actr3b	ENSMUSG00000056367
rattus_norvegicus	Actr3b	ENSRNOG00000031855

Paralogs (26): ACTR6 (ENSG00000075089), ACTB (ENSG00000075624), ACTL6B (ENSG00000077080), ACTR5 (ENSG00000101442), ACTA2 (ENSG00000107796), ACTR8 (ENSG00000113812), ACTR1B (ENSG00000115073), ACTR3 (ENSG00000115091), ACTL8 (ENSG00000117148), ACTRT1 (ENSG00000123165), ACTR10 (ENSG00000131966), ACTR3B (ENSG00000133627), ACTL6A (ENSG00000136518), ACTR2 (ENSG00000138071), ACTR1A (ENSG00000138107), ACTA1 (ENSG00000143632), ACTL7B (ENSG00000148156), ACTC1 (ENSG00000159251), ACTG2 (ENSG00000163017), ACTBL2 (ENSG00000169067), ACTRT2 (ENSG00000169717), ACTL9 (ENSG00000181786), ACTG1 (ENSG00000184009), ACTRT3 (ENSG00000184378), ACTL7A (ENSG00000187003), ACTL10 (ENSG00000288649)

Protein

Protein identifiers

Actin-related protein 3C — Q9C0K3 (reviewed: Q9C0K3)

Alternative names: Actin-related protein 11

All UniProt accessions (5): Q9C0K3, A0A0A0MTI9, C9IZN3, C9J580, H7C4J1

UniProt curated annotations — full annotation on UniProt →

Function. May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Tissue specificity. Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.

Similarity. Belongs to the actin family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9C0K3-1	1	yes
Q9C0K3-2	2

RefSeq proteins (2): NP_001157930, NP_001157931 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004000	Actin	Family
IPR043129	ATPase_NBD	Homologous_superfamily

Pfam: PF00022

UniProt features (4 total): signal peptide 1, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9C0K3-F1	87.32	0.78

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 50 (showing top): GOMF_ACTIN_BINDING, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, GOMF_CYTOSKELETAL_PROTEIN_BINDING, GOMF_ADENYL_NUCLEOTIDE_BINDING, GRYDER_PAX3FOXO1_ENHANCERS_KO_DOWN, ATF6_TARGET_GENES, FOXJ2_TARGET_GENES, FOXN3_TARGET_GENES, H1_6_TARGET_GENES, HOXB4_TARGET_GENES, HOXC6_TARGET_GENES, MAFG_TARGET_GENES, MEF2D_TARGET_GENES, NFE2L1_TARGET_GENES, NKX2_3_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (4): actin binding (GO:0003779), ATP binding (GO:0005524), nucleotide binding (GO:0000166), actin filament binding (GO:0051015)

GO Cellular Component (1): extracellular exosome (GO:0070062)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoskeletal protein binding	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
actin binding	1
protein-containing complex binding	1
extracellular vesicle	1

Protein interactions and networks

STRING

2027 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ACTR3C	ACTR2	P61160	976
ACTR3C	DCTN2	Q13561	912
ACTR3C	DCTN4	Q9UJW0	864
ACTR3C	DCTN5	Q9BTE1	858
ACTR3C	TPPP	O94811	847
ACTR3C	CAPZA2	P47755	822
ACTR3C	CAPZA1	P52907	808
ACTR3C	DCTN6	O00399	803
ACTR3C	DCTN1	Q14203	799
ACTR3C	ARPC2	O15144	712
ACTR3C	ARPC5	O15511	706
ACTR3C	ARPC3	O15145	686
ACTR3C	ACTB	P02570	678
ACTR3C	WAS	P42768	588
ACTR3C	LRRC61	Q9BV99	584

IntAct

8 interactions, top by confidence:

A	B	Type	Score
STN1	SMCO3	psi-mi:“MI:0914”(association)	0.530
ITGB8	GET1	psi-mi:“MI:0914”(association)	0.530
DUSP21	A2ML1	psi-mi:“MI:0914”(association)	0.350
DND1	ATXN3	psi-mi:“MI:0914”(association)	0.350
MALL	GPR89A	psi-mi:“MI:0914”(association)	0.350
HCRTR2	FADS1	psi-mi:“MI:0914”(association)	0.350

BioGRID (12): ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-RNA), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS), ACTR3C (Affinity Capture-MS)

ESM2 similar proteins: A0A1L8EV45, C9WPN6, F1QGW6, F6RQL9, O73723, O77676, P00516, P0C605, P20461, P23258, P23330, P31321, P32392, P35250, P41091, P53033, P61157, P61158, P62482, P62483, P81795, P83887, P83888, Q05B83, Q0VCD2, Q13126, Q13303, Q13976, Q27955, Q2KHU8, Q2KJ81, Q2VIR3, Q32KM1, Q4V7C7, Q5R797, Q5R8R1, Q5ZHS1, Q5ZMS3, Q641P0, Q641W4

Diamond homologs: A0A1L8EV45, A2BDB0, A2X6S3, O16808, O17320, O18840, O73723, P02576, P02578, P04752, P04829, P07829, P0DM41, P0DM42, P10984, P10986, P10988, P10990, P12716, P13363, P17126, P17128, P22132, P26183, P27131, P30162, P30163, P32390, P32392, P35432, P41112, P41339, P42528, P43239, P45886, P47117, P53458, P53461, P53468, P53470

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	0
Uncertain significance	35
Likely benign	0
Benign	2

Top pathogenic / likely-pathogenic (2)

Variant ID	HGVS	Classification
3391897	GRCh37/hg19 7q31.32-36.1(chr7:122190535-149944340)x1	Pathogenic
57185	GRCh38/hg38 7q35-36.1(chr7:147345844-150426340)x1	Pathogenic

SpliceAI

2316 predictions. Top by Δscore:

Variant	Effect	Δscore
7:150284842:CAAA:C	acceptor_gain	1.0000
7:150284846:C:CC	acceptor_gain	1.0000
7:150284851:T:C	acceptor_gain	1.0000
7:150284851:T:TC	acceptor_gain	1.0000
7:150284853:G:C	acceptor_gain	1.0000
7:150284853:G:GC	acceptor_gain	1.0000
7:150284855:A:AC	acceptor_gain	1.0000
7:150284855:A:C	acceptor_gain	1.0000
7:150284859:CAA:C	acceptor_gain	1.0000
7:150284860:A:T	acceptor_gain	1.0000
7:150284861:A:AC	acceptor_gain	1.0000
7:150284861:A:C	acceptor_gain	1.0000
7:150284863:A:C	acceptor_gain	1.0000
7:150286361:CCTTA:C	donor_loss	1.0000
7:150286362:CTTA:C	donor_loss	1.0000
7:150286363:TTA:T	donor_loss	1.0000
7:150286364:TA:T	donor_loss	1.0000
7:150286365:A:AT	donor_loss	1.0000
7:150286365:ACCT:A	donor_gain	1.0000
7:150286366:C:CG	donor_loss	1.0000
7:150286366:CCT:C	donor_gain	1.0000
7:150286366:CCTC:C	donor_gain	1.0000
7:150295246:TTTTA:T	donor_loss	1.0000
7:150295247:TTTA:T	donor_loss	1.0000
7:150295248:TTA:T	donor_loss	1.0000
7:150295249:TA:T	donor_loss	1.0000
7:150295250:A:AG	donor_loss	1.0000
7:150295251:CCTG:C	donor_loss	1.0000
7:150295344:CTGT:C	acceptor_gain	1.0000
7:150295346:GTCT:G	acceptor_loss	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000002215 (7:150127353 C>G), RS1000014160 (7:150032693 C>A), RS1000027285 (7:150278144 G>A,T), RS1000028133 (7:150230241 A>C), RS1000030712 (7:150174702 C>A,G), RS1000045177 (7:150032538 C>T), RS1000049177 (7:149981999 A>G), RS1000051010 (7:150082634 C>A), RS1000052030 (7:149882416 C>T), RS1000063409 (7:150324086 G>T), RS1000072646 (7:149886488 C>T), RS1000119052 (7:150084128 T>G), RS1000120777 (7:149937584 C>T), RS1000135859 (7:149989072 C>T), RS1000142761 (7:150277993 G>A)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004389_3	Circulating chemerin levels	8.000000e-14

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004573	chemerin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases methylation	2
Cadmium Chloride	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
ethyl-p-hydroxybenzoate	increases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
beta-lapachone	increases expression	1
butyraldehyde	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	decreases methylation	1
cupric oxide	decreases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Methapyrilene	increases methylation	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Valproic Acid	decreases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.