ACVR2B-AS1

Summary

ACVR2B-AS1 (ACVR2B antisense RNA 1, HGNC:44161) is a long non-coding RNA gene on chromosome 3p22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44161
Approved symbol	ACVR2B-AS1
Name	ACVR2B antisense RNA 1
Location	3p22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229589
Ensembl biotype	lncRNA
Entrez	100128640
RNAcentral	URS00004374A2 — lncRNA, 2517 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000441531

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441531 — 2 exons

Exon	Start	End
ENSE00001596750	38451027	38453225
ENSE00001697123	38454503	38454820

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 98.34.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2109 / max 9.1332, expressed in 98 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41712	0.2109	98

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	98.34	gold quality
hindlimb stylopod muscle	UBERON:0004252	78.73	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	76.19	gold quality
muscle of leg	UBERON:0001383	76.11	gold quality
gastrocnemius	UBERON:0001388	76.09	gold quality
muscle organ	UBERON:0001630	72.71	gold quality
ganglionic eminence	UBERON:0004023	69.98	gold quality
tibialis anterior	UBERON:0001385	69.75	silver quality
left adrenal gland cortex	UBERON:0035825	69.46	gold quality
left adrenal gland	UBERON:0001234	69.44	gold quality
right adrenal gland cortex	UBERON:0035827	68.36	gold quality
right adrenal gland	UBERON:0001233	67.86	gold quality
adrenal cortex	UBERON:0001235	67.21	gold quality
adrenal gland	UBERON:0002369	66.44	gold quality
ventricular zone	UBERON:0003053	66.41	gold quality
left ovary	UBERON:0002119	66.40	gold quality
cortical plate	UBERON:0005343	66.09	gold quality
diaphragm	UBERON:0001103	66.02	gold quality
mucosa of stomach	UBERON:0001199	65.21	gold quality
ovary	UBERON:0000992	64.83	gold quality
body of pancreas	UBERON:0001150	64.35	gold quality
colonic epithelium	UBERON:0000397	63.76	silver quality
body of uterus	UBERON:0009853	63.73	gold quality
skeletal muscle tissue	UBERON:0001134	63.54	gold quality
quadriceps femoris	UBERON:0001377	63.46	gold quality
right ovary	UBERON:0002118	63.40	gold quality
vastus lateralis	UBERON:0001379	63.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.00	gold quality
lower esophagus	UBERON:0013473	62.93	gold quality
muscle tissue	UBERON:0002385	62.74	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.28

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• work suggests that the lncRNA ACVR2B-AS1 could be a candidate biomarker for liver cancer prognosis. (PMID:31886217)
• LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity. (PMID:39254854)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.