ADAM2

Summary

ADAM2 (ADAM metallopeptidase domain 2, HGNC:198) is a protein-coding gene on chromosome 8p11.22, encoding Disintegrin and metalloproteinase domain-containing protein 2 (Q99965). Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization.

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 2515 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 116 total — 1 pathogenic
• MANE Select transcript: NM_001464

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:198
Approved symbol	ADAM2
Name	ADAM metallopeptidase domain 2
Location	8p11.22
Locus type	gene with protein product
Status	Approved
Aliases	PH-30b, PH30, CT15
Ensembl gene	ENSG00000104755
Ensembl biotype	protein_coding
OMIM	601533
Entrez	2515

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000265708, ENST00000347580, ENST00000379853, ENST00000520434, ENST00000521880, ENST00000523181

RefSeq mRNA: 3 — MANE Select: NM_001464 NM_001278113, NM_001278114, NM_001464

CCDS: CCDS34884, CCDS64882, CCDS64883

Canonical transcript exons

ENST00000265708 — 21 exons

Exon	Start	End
ENSE00000689500	39788085	39788251
ENSE00000689502	39786974	39787055
ENSE00000689504	39777025	39777161
ENSE00000689518	39755728	39755911
ENSE00000689522	39749667	39749744
ENSE00000689527	39749312	39749450
ENSE00001040070	39746472	39746631
ENSE00001196410	39761176	39761281
ENSE00001196413	39766848	39767043
ENSE00001305886	39744830	39744893
ENSE00001330826	39809410	39809466
ENSE00001382689	39788669	39788740
ENSE00002111556	39743735	39744064
ENSE00002122139	39838131	39838227
ENSE00003523790	39821586	39821662
ENSE00003532519	39821002	39821170
ENSE00003617320	39769392	39769575
ENSE00003619233	39824819	39824897
ENSE00003623490	39767153	39767251
ENSE00003649906	39837136	39837212
ENSE00003671343	39833944	39833999

Expression profiles

Bgee: expression breadth broad, 34 present calls, max score 88.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1659 / max 106.9071, expressed in 50 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92780	0.0926	3
92779	0.0550	47
92781	0.0183	3

Top tissues by expression

96 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
testis	UBERON:0000473	88.08	gold quality
left testis	UBERON:0004533	87.87	gold quality
right testis	UBERON:0004534	87.30	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	61.15	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
placenta	UBERON:0001987	37.15	gold quality
granulocyte	CL:0000094	37.11	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
bone marrow cell	CL:0002092	36.16	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
monocyte	CL:0000576	34.45	silver quality
leukocyte	CL:0000738	34.41	silver quality
right coronary artery	UBERON:0001625	34.11	gold quality
endometrium	UBERON:0001295	33.72	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
prostate gland	UBERON:0002367	33.00	gold quality
bone marrow	UBERON:0002371	31.74	gold quality
muscle tissue	UBERON:0002385	31.06	gold quality
vermiform appendix	UBERON:0001154	30.93	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
tonsil	UBERON:0002372	30.23	gold quality
ectocervix	UBERON:0012249	30.22	gold quality
liver	UBERON:0002107	30.13	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.43	silver quality
metanephros cortex	UBERON:0010533	29.24	silver quality
hypothalamus	UBERON:0001898	29.21	gold quality
kidney	UBERON:0002113	29.13	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AHR, AP1, AR, ATF2, ATF4, BARX1, BCL6, CDX2, CEBPA, CEBPB, CEBPD, CEBPG, CREB1, CREM, CRX, CTNNB1, CUX1, DNMT1, E2F1, E2F6, EGR1, EGR2, ESR1, ESR2, ESRRA, ETS1, ETS2, EZH2, FLI1, FOS, FOSB, FOXA1, FOXA2, FOXC2, FOXH1, FOXM1, FOXO1, FOXP3, GABPA, GATA1

miRNA regulators (miRDB)

26 targeting ADAM2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-3660	99.68	67.33	1149
HSA-MIR-4526	99.68	67.07	1136
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-203A-3P	99.49	70.56	2806
HSA-MIR-194-5P	99.01	69.65	1465
HSA-MIR-3145-3P	98.85	69.07	2031
HSA-MIR-6840-3P	98.68	65.95	1923
HSA-MIR-934	98.49	70.44	581
HSA-MIR-2681-3P	98.18	65.28	577
HSA-MIR-6884-3P	98.05	65.32	750
HSA-MIR-96-3P	97.47	68.03	839
HSA-MIR-517-5P	97.13	68.43	781
HSA-MIR-624-5P	96.00	68.88	728
HSA-MIR-5684	93.17	64.85	454

Literature-anchored findings (GeneRIF, showing 14)

• CG17836/Xrp1 is involved in the regulation of cell proliferation in eye discs and affects disc identity specification. (PMID:23391928)
• Xrp1 induction in Rp mutant cells depends on a particular Rp with regulatory effects (PMID:30078730)
• Xrp1 knockdown substantially rescued the motor deficits and life span of flies expressing ALS mutant FUS in motor neurons, implicating gene expression dysregulation in ALS-FUS pathogenesis. (PMID:30209068)
• demonstrates that RpS12, Xrp1, and Dilp8 form an independent regulatory module that ensures intra- and inter-organ growth coordination during development (PMID:31006647)
• Findings provide clear molecular and genetic evidence that RpS12 plays a central and early role in generating multiple aspects of the Ribosomal Protein (Rp)+/- phenotype in imaginal discs by activating Xrp1 expression and activity. (PMID:31841522)
• Roles of C/EBP class bZip proteins in the growth and cell competition of Rp (‘Minute’) mutants in Drosophila. (PMID:31909714)
• The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction in Drosophila. (PMID:34605405)
• Cell competition is driven by Xrp1-mediated phosphorylation of eukaryotic initiation factor 2alpha. (PMID:34871307)
• Xrp1 and Irbp18 trigger a feed-forward loop of proteotoxic stress to induce the loser status. (PMID:34914692)
• Xrp1 governs the stress response program to spliceosome dysfunction. (PMID:38303573)
• The fertilin beta contributes not only to successful fertilization, but may has an important impact in development of preimplantation embryos. (PMID:18292840)
• ADAM2, CALR3 and SAGE1 cancer/testis antigens are not promising targets for immunotherapy of breast and lung cancer. (PMID:26252478)
• Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection. (PMID:30463455)
• Is there a relationship between infertility and fertilin beta protein distribution? (PMID:35933293)

Cross-species orthologs

9 orthologs

Organism	Symbol	Gene ID
danio_rerio	adam10b	ENSDARG00000015502
danio_rerio	adam10a	ENSDARG00000053468
danio_rerio	adam9b	ENSDARG00000057138
mus_musculus	Adam2	ENSMUSG00000022039
rattus_norvegicus	Adam2	ENSRNOG00000017027
drosophila_melanogaster	mmd	FBGN0259110
drosophila_melanogaster	kuz	FBGN0259984
caenorhabditis_elegans	sup-17	WBGENE00006324
caenorhabditis_elegans		WBGENE00006804

Paralogs (20): ADAM22 (ENSG00000008277), ADAM28 (ENSG00000042980), ADAM7 (ENSG00000069206), ADAM11 (ENSG00000073670), ADAM23 (ENSG00000114948), ADAM20 (ENSG00000134007), ADAMDEC1 (ENSG00000134028), ADAM30 (ENSG00000134249), ADAM19 (ENSG00000135074), ADAM10 (ENSG00000137845), ADAM21 (ENSG00000139985), ADAM15 (ENSG00000143537), ADAM12 (ENSG00000148848), ADAM33 (ENSG00000149451), ADAM8 (ENSG00000151651), ADAM17 (ENSG00000151694), ADAM29 (ENSG00000168594), ADAM9 (ENSG00000168615), ADAM18 (ENSG00000168619), ADAM32 (ENSG00000197140)

Protein

Protein identifiers

Disintegrin and metalloproteinase domain-containing protein 2 — Q99965 (reviewed: Q99965)

Alternative names: Cancer/testis antigen 15, Fertilin subunit beta, PH-30, PH30-beta

All UniProt accessions (3): B4DWY7, Q99965, Q6P2G0

UniProt curated annotations — full annotation on UniProt →

Function. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

Subcellular location. Membrane.

Tissue specificity. Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.

Post-translational modifications. The prodomain and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.

Domain organisation. A tripeptide motif (FEE) within disintegrin-like domain could be involved in the binding to egg integrin receptor and thus could mediate sperm/egg binding.

Miscellaneous. In mammals, exists as a heterodimer composed of an alpha and beta subunits. In human, fertilin subunit alpha is a pseudogene.

Isoforms (2)

UniProt ID	Names	Canonical?
Q99965-1	1	yes
Q99965-2	2

RefSeq proteins (3): NP_001265042, NP_001265043, NP_001455* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001590	Peptidase_M12B	Domain
IPR001762	Disintegrin_dom	Domain
IPR002870	Peptidase_M12B_N	Domain
IPR006586	ADAM_Cys-rich	Domain
IPR018358	Disintegrin_CS	Conserved_site
IPR024079	MetalloPept_cat_dom_sf	Homologous_superfamily
IPR034027	Reprolysin_adamalysin	Domain
IPR036436	Disintegrin_dom_sf	Homologous_superfamily

Pfam: PF00200, PF01421, PF01562, PF08516

UniProt features (40 total): sequence conflict 16, disulfide bond 7, glycosylation site 5, domain 3, topological domain 2, signal peptide 1, propeptide 1, chain 1, splice variant 1, sequence variant 1, transmembrane region 1, modified residue 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99965-F1	81.05	0.47

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 729

Disulfide bonds (7): 287–370, 329–354, 331–336, 445–465, 616–627, 621–633, 635–644

Glycosylation sites (5): 122, 220, 353, 459, 566

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-2534343	Interaction With Cumulus Cells And The Zona Pellucida
R-HSA-1187000	Fertilization
R-HSA-1474165	Reproduction

MSigDB gene sets: 103 (showing top): GOBP_SINGLE_FERTILIZATION, GOBP_COGNITION, GOBP_BEHAVIOR, GOMF_METALLOPEPTIDASE_ACTIVITY, GOBP_ADULT_BEHAVIOR, GOBP_ASSOCIATIVE_LEARNING, GOBP_MEMBRANE_FUSION, GOBP_PLASMA_MEMBRANE_ORGANIZATION, GOCC_CELL_SURFACE, PID_INTEGRIN_A9B1_PATHWAY, GOBP_REPRODUCTIVE_SYSTEM_DEVELOPMENT, GOBP_LEARNING, GOBP_SPERM_EGG_RECOGNITION, MODULE_99, GOBP_RESPONSE_TO_RADIATION

GO Biological Process (10): proteolysis (GO:0006508), cell adhesion (GO:0007155), binding of sperm to zona pellucida (GO:0007339), fusion of sperm to egg plasma membrane involved in single fertilization (GO:0007342), visual learning (GO:0008542), male gonad development (GO:0008584), gene expression (GO:0010467), positive regulation of gene expression (GO:0010628), adult behavior (GO:0030534), integrin-mediated signaling pathway (GO:0007229)

GO Molecular Function (3): metalloendopeptidase activity (GO:0004222), integrin binding (GO:0005178), metallopeptidase activity (GO:0008237)

GO Cellular Component (4): plasma membrane (GO:0005886), cell surface (GO:0009986), protein-containing complex (GO:0032991), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Fertilization	1
Reproduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein metabolic process	1
cellular process	1
sperm-egg recognition	1
single fertilization	1
cellular process involved in reproduction in multicellular organism	1
visual behavior	1
associative learning	1
gonad development	1
development of primary male sexual characteristics	1
macromolecule biosynthetic process	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
behavior	1
cell surface receptor signaling pathway	1
endopeptidase activity	1
metallopeptidase activity	1
signaling receptor binding	1
protein-containing complex binding	1
cell adhesion molecule binding	1
peptidase activity	1
membrane	1
cell periphery	1
cellular_component	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

2 interactions, top by confidence:

A	B	Type	Score
ADAM2	ADAMTS2	psi-mi:“MI:0914”(association)	0.350

BioGRID (13): ASPHD2 (Affinity Capture-MS), C6orf120 (Affinity Capture-MS), ADAMTS2 (Affinity Capture-MS), LRRC3 (Affinity Capture-MS), TTN (Affinity Capture-MS), LCLAT1 (Affinity Capture-MS), ADAM2 (Affinity Capture-Western), ASPHD2 (Affinity Capture-MS), LRRC3 (Affinity Capture-MS), C6orf120 (Affinity Capture-MS), ADAMTS2 (Affinity Capture-MS), ADAM9 (Negative Genetic), EEF2 (Cross-Linking-MS (XL-MS))

ESM2 similar proteins: F8VQ03, O15072, O15204, O35227, O77780, P58397, P59509, P59510, P70505, P97776, P97857, Q1EHB3, Q28475, Q28478, Q28483, Q28660, Q3TTE0, Q5BK84, Q60411, Q60472, Q60718, Q60813, Q63180, Q63202, Q68SA9, Q811B3, Q811Q4, Q8C9W3, Q8K410, Q8N2E2, Q8R534, Q8TC27, Q8TE59, Q99965, Q9H2U9, Q9JI76, Q9JLN6, Q9R0X2, Q9R157, Q9R158

Diamond homologs: A2CJE2, A2CJE3, A2CJE4, A8QL59, C0LZJ5, C5FUK3, D4B1G0, D4DCV9, E9NW26, F8VQ03, G5EFD5, J3S830, O13766, O35227, O42596, O73795, O75077, O75078, O77780, O93515, O93517, O93518, P0C6B6, P0C6E3, P0C6R9, P0C7B0, P0DJ87, P0DM87, P17497, P23323, P31989, P83912, Q05910, Q0NZX6, Q0NZX7, Q0NZX8, Q0NZX9, Q0NZY0, Q13443, Q13444

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

116 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	102
Likely benign	7
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
59783	GRCh38/hg38 8p11.22-q11.21(chr8:39830633-49209461)x3	Pathogenic

SpliceAI

3963 predictions. Top by Δscore:

Variant	Effect	Δscore
8:39744828:A:AC	donor_gain	1.0000
8:39744829:C:CC	donor_gain	1.0000
8:39761174:A:AC	donor_gain	1.0000
8:39761175:C:CC	donor_gain	1.0000
8:39761175:CTCAG:C	donor_gain	1.0000
8:39761179:G:C	donor_gain	1.0000
8:39767151:A:AC	donor_gain	1.0000
8:39767152:C:CC	donor_gain	1.0000
8:39767152:CTAGA:C	donor_gain	1.0000
8:39786986:T:TA	donor_gain	1.0000
8:39790750:T:TA	donor_gain	1.0000
8:39817967:T:TA	donor_gain	1.0000
8:39817968:C:A	donor_gain	1.0000
8:39833942:A:AC	donor_gain	1.0000
8:39833943:C:CC	donor_gain	1.0000
8:39834012:CACAG:C	acceptor_gain	1.0000
8:39834016:G:GC	acceptor_gain	1.0000
8:39834022:A:AC	acceptor_gain	1.0000
8:39834022:A:C	acceptor_gain	1.0000
8:39837130:CATTA:C	donor_loss	1.0000
8:39837131:ATTAC:A	donor_loss	1.0000
8:39837132:TTACC:T	donor_loss	1.0000
8:39837133:TAC:T	donor_loss	1.0000
8:39837134:A:C	donor_loss	1.0000
8:39837152:T:TA	donor_gain	1.0000
8:39837213:C:CC	acceptor_gain	1.0000
8:39838129:A:AC	donor_gain	1.0000
8:39838130:C:CC	donor_gain	1.0000
8:39838130:CTA:C	donor_gain	1.0000
8:39744065:C:CC	acceptor_gain	0.9900

AlphaMissense

4895 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:39749446:C:G	C627S	0.998
8:39749447:A:T	C627S	0.998
8:39766868:C:G	C496S	0.998
8:39766869:A:T	C496S	0.998
8:39749680:C:G	C621S	0.997
8:39749681:A:T	C621S	0.997
8:39755900:C:G	C542S	0.997
8:39755901:A:T	C542S	0.997
8:39761185:C:G	C535S	0.997
8:39761186:A:T	C535S	0.997
8:39766982:C:G	C458S	0.997
8:39766983:A:T	C458S	0.997
8:39749428:C:G	C633S	0.996
8:39749429:A:T	C633S	0.996
8:39749740:C:G	C601S	0.996
8:39749741:A:T	C601S	0.996
8:39755741:C:G	C595S	0.996
8:39755742:A:T	C595S	0.996
8:39755810:C:G	C572S	0.996
8:39755811:A:T	C572S	0.996
8:39755885:C:G	C547S	0.996
8:39755886:A:T	C547S	0.996
8:39761257:C:G	C511S	0.996
8:39761258:A:T	C511S	0.996
8:39766889:C:G	C489S	0.996
8:39766890:A:T	C489S	0.996
8:39766904:C:G	C484S	0.996
8:39766905:A:T	C484S	0.996
8:39766961:C:G	C465S	0.996
8:39766962:A:T	C465S	0.996

dbSNP variants (sampled 300 via entrez): RS1000032713 (8:39760758 G>T), RS1000096148 (8:39785831 T>A), RS1000146245 (8:39800621 T>G), RS1000148409 (8:39828868 C>T), RS1000178366 (8:39800892 C>T), RS1000183252 (8:39754303 C>T), RS1000205684 (8:39780264 C>A,T), RS1000213683 (8:39794739 C>T), RS1000224262 (8:39783794 TACAA>T), RS1000273591 (8:39837737 G>C), RS1000278017 (8:39765338 T>C), RS1000303318 (8:39838034 G>A), RS1000319684 (8:39754620 T>C), RS1000383705 (8:39831561 G>C), RS1000410405 (8:39806257 G>T)

Disease associations

OMIM: gene MIM:601533 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): breast ductal adenocarcinoma (MONDO:0005590)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST005042_10	Restless legs syndrome	2.000000e-34

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D018270	Carcinoma, Ductal, Breast	C04.557.470.200.025.232.500; C04.557.470.615.132.500; C04.588.180.390; C17.800.090.500.390

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — M12: Astacin/Adamalysin

CTD chemical–gene interactions

9 total (human), top 9 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation, increases methylation	2
zinc chloride	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Calcitriol	decreases expression, affects cotreatment	1
Folic Acid	decreases expression	1
Testosterone	affects cotreatment, decreases expression	1
Zinc	decreases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

11 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT03414970	PHASE3	ACTIVE_NOT_RECRUITING	Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer
NCT00461344	PHASE2	TERMINATED	Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer
NCT07499999	PHASE2	NOT_YET_RECRUITING	Randomized Double-Blind Phase II Trial of Baby Exemestane Versus Baby Tamoxifen in Post-Menopausal Women at High Risk for Breast Cancer
NCT00637364	PHASE1/PHASE2	SUSPENDED	High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain
NCT02779855	PHASE1/PHASE2	COMPLETED	Talimogene Laherparepvec in Combination With Neoadjuvant Chemotherapy in Triple Negative Breast Cancer
NCT01753908	EARLY_PHASE1	COMPLETED	Broccoli Sprout Extract in Treating Patients With Breast Cancer
NCT01796041	EARLY_PHASE1	COMPLETED	Intraoperative Imaging of Breast Cancer With Indocyanine Green
NCT01208974	Not specified	ACTIVE_NOT_RECRUITING	Nipple-Areola Complex (NAC) Irradiation After Nipple-Sparing Mastectomy and Reconstruction
NCT01875198	Not specified	TERMINATED	Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected Left-sided Pancreatic Cancer
NCT03543397	Not specified	UNKNOWN	MRI in Ductal Carcinoma in Situ (DCIS)
NCT03834532	Not specified	COMPLETED	Living Well After Breast Surgery