ADAMTS9-AS1

Summary

ADAMTS9-AS1 (ADAMTS9 antisense RNA 1, HGNC:40625) is a long non-coding RNA gene on chromosome 3p14.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40625
Approved symbol	ADAMTS9-AS1
Name	ADAMTS9 antisense RNA 1
Location	3p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241158
Ensembl biotype	lncRNA
Entrez	101929335
RNAcentral	URS000075D0FD — lncRNA, 3930 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 21 lncRNA

ENST00000466225, ENST00000470447, ENST00000471990, ENST00000474313, ENST00000480831, ENST00000493124, ENST00000594810, ENST00000597944, ENST00000601022, ENST00000625328, ENST00000625396, ENST00000625433, ENST00000625636, ENST00000625832, ENST00000626014, ENST00000626280, ENST00000627227, ENST00000628461, ENST00000630336, ENST00000631269, ENST00000647631

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000466225 — 2 exons

Exon	Start	End
ENSE00001899511	64586761	64587221
ENSE00003004076	64583151	64583511

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 97.08.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4025 / max 127.9628, expressed in 92 samples.

FANTOM5 promoters (12 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37166	0.1074	27
37167	0.0602	33
37172	0.0589	29
37169	0.0458	31
37162	0.0351	16
37170	0.0327	21
37168	0.0190	8
37163	0.0144	8
37171	0.0118	5
37165	0.0089	3

Top tissues by expression

249 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
metanephros cortex	UBERON:0010533	97.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.52	gold quality
lower esophagus	UBERON:0013473	93.50	gold quality
left uterine tube	UBERON:0001303	93.37	gold quality
adult mammalian kidney	UBERON:0000082	92.23	gold quality
left ovary	UBERON:0002119	91.95	gold quality
right ovary	UBERON:0002118	91.57	gold quality
sural nerve	UBERON:0015488	91.47	gold quality
cortex of kidney	UBERON:0001225	91.46	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.71	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	90.35	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.29	gold quality
kidney	UBERON:0002113	89.11	gold quality
omental fat pad	UBERON:0010414	87.97	gold quality
peritoneum	UBERON:0002358	87.85	gold quality
lower esophagus mucosa	UBERON:0035834	86.96	gold quality
kidney epithelium	UBERON:0004819	86.66	silver quality
body of uterus	UBERON:0009853	85.77	gold quality
adipose tissue of abdominal region	UBERON:0007808	85.63	gold quality
ovary	UBERON:0000992	85.53	gold quality
smooth muscle tissue	UBERON:0001135	85.50	gold quality
left coronary artery	UBERON:0001626	85.03	gold quality
tibial artery	UBERON:0007610	83.99	gold quality
popliteal artery	UBERON:0002250	83.95	gold quality
colonic epithelium	UBERON:0000397	83.67	gold quality
esophagus	UBERON:0001043	82.63	gold quality
coronary artery	UBERON:0001621	82.58	gold quality
right atrium auricular region	UBERON:0006631	80.98	gold quality
right coronary artery	UBERON:0001625	80.64	gold quality
endocervix	UBERON:0000458	80.56	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	51.76
E-ANND-3	yes	30.00
E-MTAB-9543	yes	6.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• Long non-coding RNA ADAMTS9-AS1 suppresses colorectal cancer by inhibiting the Wnt/beta-catenin signalling pathway and is a potential diagnostic biomarker. (PMID:32889785)
• Long non-coding RNA ADAMTS9-AS1 inhibits the progression of prostate cancer by modulating the miR-142-5p/CCND1 axis. (PMID:33704879)
• lncRNA ADAMTS9-AS1 promotes bladder cancer cell invasion, migration, and inhibits apoptosis and autophagy through PI3K/AKT/mTOR signaling pathway. (PMID:34428588)
• LncRNA ADAMTS9-AS1 knockdown suppresses cell proliferation and migration in glioma through downregulating Wnt/beta-catenin signaling pathway. (PMID:34923953)
• Long non-coding RNA ADAMTS9-AS1 attenuates ferroptosis by Targeting microRNA-587/solute carrier family 7 member 11 axis in epithelial ovarian cancer. (PMID:35311457)
• lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy. (PMID:35401927)
• ADAMTS9-AS1 Long Non-coding RNA Sponges miR-128 and miR-150 to Regulate Ras/MAPK Signaling Pathway in Glioma. (PMID:36449154)
• LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis. (PMID:36870548)
• The lncRNA ADAMTS9-AS1/miR-185-5p/KAT7 ceRNA network inhibits cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy. (PMID:37258203)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.