ADAMTS9-AS2

Summary

ADAMTS9-AS2 (ADAMTS9 antisense RNA 2, HGNC:42435) is a long non-coding RNA gene on chromosome 3p14.1.

Implicated in diabetic retinopathy.

Source: NCBI Gene 100507098 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42435
Approved symbol	ADAMTS9-AS2
Name	ADAMTS9 antisense RNA 2
Location	3p14.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000241684
Ensembl biotype	lncRNA
Entrez	100507098
RNAcentral	URS000075C89F — lncRNA, 2258 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 39 — 39 lncRNA

ENST00000460833, ENST00000474768, ENST00000481312, ENST00000485174, ENST00000650103, ENST00000691998, ENST00000692372, ENST00000702102, ENST00000702331, ENST00000770413, ENST00000770414, ENST00000770415, ENST00000770416, ENST00000770417, ENST00000770418, ENST00000770419, ENST00000770420, ENST00000770421, ENST00000770422, ENST00000770423, ENST00000770424, ENST00000770425, ENST00000770426, ENST00000770427, ENST00000770428, ENST00000770429, ENST00000770430, ENST00000770431, ENST00000770432, ENST00000770433, ENST00000770434, ENST00000770435, ENST00000770436, ENST00000770448, ENST00000770449, ENST00000770450, ENST00000770451, ENST00000770452, ENST00000770453

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000460833 — 2 exons

Exon	Start	End
ENSE00004132496	64684879	64685338
ENSE00004132508	64799465	64802725

Expression profiles

Bgee: expression breadth ubiquitous, 198 present calls, max score 91.63.

FANTOM5 (CAGE): breadth broad, TPM avg 4.1993 / max 303.9588, expressed in 711 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
37176	2.2672	611
37174	1.5069	275
37175	0.2594	106
37177	0.0991	46
37173	0.0667	33

Top tissues by expression

236 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.63	gold quality
renal medulla	UBERON:0000362	88.62	gold quality
calcaneal tendon	UBERON:0003701	88.60	gold quality
left ovary	UBERON:0002119	88.55	gold quality
cauda epididymis	UBERON:0004360	87.69	gold quality
buccal mucosa cell	CL:0002336	86.72	silver quality
right ovary	UBERON:0002118	86.26	gold quality
ovary	UBERON:0000992	85.16	gold quality
popliteal artery	UBERON:0002250	84.77	gold quality
tibial artery	UBERON:0007610	84.75	gold quality
tibial nerve	UBERON:0001323	84.18	gold quality
endocervix	UBERON:0000458	83.27	gold quality
descending thoracic aorta	UBERON:0002345	83.23	gold quality
aorta	UBERON:0000947	83.22	gold quality
body of uterus	UBERON:0009853	82.98	gold quality
colonic epithelium	UBERON:0000397	82.68	gold quality
uterine cervix	UBERON:0000002	82.45	gold quality
seminal vesicle	UBERON:0000998	82.25	gold quality
urinary bladder	UBERON:0001255	82.19	gold quality
cartilage tissue	UBERON:0002418	81.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	81.34	gold quality
thoracic aorta	UBERON:0001515	81.23	gold quality
ascending aorta	UBERON:0001496	81.07	gold quality
right coronary artery	UBERON:0001625	80.83	gold quality
mucosa of stomach	UBERON:0001199	80.79	gold quality
left coronary artery	UBERON:0001626	80.70	gold quality
tibia	UBERON:0000979	80.45	gold quality
coronary artery	UBERON:0001621	80.32	gold quality
dorsal root ganglion	UBERON:0000044	80.01	gold quality
left uterine tube	UBERON:0001303	79.71	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	38.62
E-HCAD-35	yes	11.88
E-ANND-3	yes	5.94

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 19)

• Low ADAMTS9-AS2 expression is associated with progression of lung cancer. (PMID:29707897)
• ADAMTS9-AS2 promotes migration and invasion in SACC by competing with miR-143-3p. This sheds a new insight into the regulation mechanism of ADAMTS9-AS2, and it provides a possible application for the SACC treatment. (PMID:30217729)
• lncRNA ADAMTS9-AS2 decreased OC progression by regulating miR-182-5p/FOXF2 axis (PMID:30268751)
• Our results demonstrate an explicit oncogenic role of ADAMTS9-AS2 in tongue squamous cell carcinoma tumorigenesis. (PMID:30970517)
• Identification and development of long non-coding RNA-associated regulatory network in colorectal cancer. (PMID:31144439)
• LncRNA ADAMTS9-AS2 inhibits cell proliferation and decreases chemoresistance in clear cell renal cell carcinoma via the miR-27a-3p/FOXO1 axis. (PMID:31400752)
• ADAMTS9-AS2 overexpression in colorectal cancer cells inhibited cell proliferation, migration, and invasion, while suppression of ADAMTS9-AS2 showed opposite effects (PMID:31413211)
• Overexpressed ADAMTS9-AS2 aids in the suppression of esophageal cancer development, which is achieved via inducing CDH3 promoter methylation. (PMID:31621118)
• LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP. (PMID:32160650)
• high LINC00460 expression and low ADAMTS9-AS1 expression in bladder cancer as compared with normal bladder tissues; Differential expression results of ADAMTS9-AS1 suggests it may be correlated with a worse prognosis and a shorter survival time (PMID:32277695)
• LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis. (PMID:32516127)
• ADAMTS9-AS2 and CADM2 expression and association with the prognosis in esophageal squamous cell carcinoma. (PMID:32892630)
• Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway. (PMID:33345447)
• Long-Chain Noncoding RNA ADAMTS9-AS2 Regulates Proliferation, Migration, and Apoptosis in Bladder Cancer Cells Through Regulating miR-182-5p. (PMID:33621133)
• ADAMTS9-AS2: A Functional Long Non-coding RNA in Tumorigenesis. (PMID:33823762)
• The diagnostic significance of circulating lncRNA ADAMTS9-AS2 tumor biomarker in non-small cell lung cancer among the Egyptian population. (PMID:34312940)
• ADAMTS9-AS2 Promotes Angiogenesis of Brain Microvascular Endothelial Cells Through Regulating miR-185-5p/IGFBP-2 Axis in Ischemic Stroke. (PMID:35098480)
• A review on the role of ADAMTS9-AS2 in different disorders. (PMID:36746036)
• LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin. (PMID:37957805)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.