ADD3-AS1

Summary

ADD3-AS1 (ADD3 antisense RNA 1, HGNC:48682) is a long non-coding RNA gene on chromosome 10q25.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48682
Approved symbol	ADD3-AS1
Name	ADD3 antisense RNA 1
Location	10q25.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000203876
Ensembl biotype	lncRNA
Entrez	100505933
RNAcentral	URS0000759A44 — lncRNA, 1280 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 12 lncRNA, 1 retained_intron

ENST00000369655, ENST00000369657, ENST00000625954, ENST00000627565, ENST00000631276, ENST00000767402, ENST00000767403, ENST00000767404, ENST00000767405, ENST00000767406, ENST00000767407, ENST00000767408, ENST00000767409

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000369655 — 6 exons

Exon	Start	End
ENSE00001450550	109947196	109947276
ENSE00001450560	109953756	109953891
ENSE00002458988	109951844	109951965
ENSE00004126889	109945572	109946295
ENSE00004126897	110005957	110006081
ENSE00004126910	110008181	110008390

Expression profiles

Bgee: expression breadth ubiquitous, 183 present calls, max score 95.77.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3929 / max 77.5866, expressed in 144 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
111375	0.2483	109
111374	0.0552	26
111376	0.0451	4
111377	0.0442	5

Top tissues by expression

269 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	95.77	gold quality
male germ cell	CL:0000015	94.58	gold quality
right testis	UBERON:0004534	91.77	gold quality
left testis	UBERON:0004533	91.59	gold quality
testis	UBERON:0000473	88.72	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.60	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	81.42	gold quality
type B pancreatic cell	CL:0000169	78.18	gold quality
olfactory bulb	UBERON:0002264	77.99	gold quality
amygdala	UBERON:0001876	74.19	gold quality
adult organism	UBERON:0007023	72.77	gold quality
calcaneal tendon	UBERON:0003701	72.55	gold quality
right frontal lobe	UBERON:0002810	71.16	gold quality
cingulate cortex	UBERON:0003027	70.73	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.46	gold quality
anterior cingulate cortex	UBERON:0009835	70.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.75	gold quality
biceps brachii	UBERON:0001507	68.40	gold quality
prefrontal cortex	UBERON:0000451	68.25	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	68.17	gold quality
tibial nerve	UBERON:0001323	68.09	gold quality
sural nerve	UBERON:0015488	67.94	silver quality
endothelial cell	CL:0000115	67.85	silver quality
Ammon’s horn	UBERON:0001954	67.73	gold quality
temporal lobe	UBERON:0001871	67.69	gold quality
nucleus accumbens	UBERON:0001882	67.51	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.50	gold quality
triceps brachii	UBERON:0001509	67.20	gold quality
cerebral cortex	UBERON:0000956	67.02	gold quality
neocortex	UBERON:0001950	67.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Role of long non-coding RNA-adducin 3 antisense RNA1 in liver fibrosis of biliary atresia. (PMID:35246014)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.