ADGRD2

Summary

ADGRD2 (adhesion G protein-coupled receptor D2, HGNC:18651) is a protein-coding gene on chromosome 9q33.3, encoding Adhesion G protein-coupled receptor D2 (Q7Z7M1). Orphan receptor.

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 347088 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 7 total — 4 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001395425

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18651
Approved symbol	ADGRD2
Name	adhesion G protein-coupled receptor D2
Location	9q33.3
Locus type	gene with protein product
Status	Approved
Aliases	PGR24
Ensembl gene	ENSG00000180264
Ensembl biotype	protein_coding
OMIM	620837
Entrez	347088

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 2 protein_coding, 1 retained_intron

ENST00000610875, ENST00000618308, ENST00000622546, ENST00000638310, ENST00000638707, ENST00000639026, ENST00000696331, ENST00000706946

RefSeq mRNA: 1 — MANE Select: NM_001395425 NM_001395425

CCDS: CCDS94480

Canonical transcript exons

ENST00000696331 — 25 exons

Exon	Start	End
ENSE00001232682	124469432	124469547
ENSE00001232691	124469222	124469355
ENSE00001331572	124475446	124475487
ENSE00001331573	124470494	124470614
ENSE00001647646	124454843	124455127
ENSE00001658923	124452510	124452722
ENSE00001679798	124454484	124454569
ENSE00001701177	124468088	124468190
ENSE00001706925	124458113	124458236
ENSE00001722405	124453999	124454097
ENSE00001745047	124458616	124458721
ENSE00001751403	124452091	124452154
ENSE00001754328	124456622	124456733
ENSE00001761329	124453035	124453676
ENSE00001763245	124466258	124466413
ENSE00001783705	124467721	124467824
ENSE00001801652	124468519	124468672
ENSE00003721723	124476679	124476709
ENSE00003741843	124478281	124478580
ENSE00003742335	124476357	124476415
ENSE00003747371	124457472	124457606
ENSE00003967049	124450451	124450510
ENSE00003967050	124451610	124451702
ENSE00003967051	124451305	124451435
ENSE00003997559	124475571	124475615

Expression profiles

Bgee: expression breadth ubiquitous, 168 present calls, max score 92.90.

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gluteal muscle	UBERON:0002000	92.90	silver quality
parotid gland	UBERON:0001831	92.85	silver quality
triceps brachii	UBERON:0001509	92.19	silver quality
tongue squamous epithelium	UBERON:0006919	88.77	silver quality
vena cava	UBERON:0004087	88.44	silver quality
type B pancreatic cell	CL:0000169	88.42	gold quality
heart right ventricle	UBERON:0002080	88.04	silver quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	86.56	gold quality
pituitary gland	UBERON:0000007	86.22	gold quality
adenohypophysis	UBERON:0002196	86.21	gold quality
olfactory bulb	UBERON:0002264	86.17	gold quality
lateral nuclear group of thalamus	UBERON:0002736	85.91	silver quality
inferior olivary complex	UBERON:0002127	85.90	silver quality
cerebellar vermis	UBERON:0004720	85.33	silver quality
buccal mucosa cell	CL:0002336	85.14	gold quality
cervix squamous epithelium	UBERON:0006922	84.50	gold quality
body of tongue	UBERON:0011876	82.77	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	82.65	silver quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	82.14	silver quality
subthalamic nucleus	UBERON:0001906	81.54	silver quality
dorsal plus ventral thalamus	UBERON:0001897	81.37	silver quality
diaphragm	UBERON:0001103	80.96	gold quality
substantia nigra pars compacta	UBERON:0001965	80.77	silver quality
substantia nigra pars reticulata	UBERON:0001966	80.64	silver quality
medial globus pallidus	UBERON:0002477	80.39	silver quality
tongue	UBERON:0001723	80.34	silver quality
globus pallidus	UBERON:0001875	80.17	silver quality
cervix epithelium	UBERON:0004801	79.87	gold quality
medulla oblongata	UBERON:0001896	79.58	silver quality
pons	UBERON:0000988	79.37	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-75367	yes	78.34
E-ANND-3	yes	2.91
E-CURD-11	no	9.97

Regulation

Is transcription factor: no

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
danio_rerio	adgrd2	ENSDARG00000103067

Paralogs (42): CALCR (ENSG00000004948), GIPR (ENSG00000010310), ADGRA2 (ENSG00000020181), CALCRL (ENSG00000064989), GLP2R (ENSG00000065325), ADGRF5 (ENSG00000069122), ADGRL1 (ENSG00000072071), ADCYAP1R1 (ENSG00000078549), SCTR (ENSG00000080293), VIPR2 (ENSG00000106018), CRHR2 (ENSG00000106113), GHRHR (ENSG00000106128), ADGRD1 (ENSG00000111452), GLP1R (ENSG00000112164), ADGRG6 (ENSG00000112414), VIPR1 (ENSG00000114812), ADGRL2 (ENSG00000117114), CRHR1 (ENSG00000120088), ADGRB2 (ENSG00000121753), ADGRE5 (ENSG00000123146), ADGRE2 (ENSG00000127507), ADGRE3 (ENSG00000131355), ADGRB3 (ENSG00000135298), PTH2R (ENSG00000144407), ADGRG7 (ENSG00000144820), ADGRL3 (ENSG00000150471), ADGRA3 (ENSG00000152990), ADGRF1 (ENSG00000153292), ADGRF4 (ENSG00000153294), ADGRG4 (ENSG00000156920), ADGRG5 (ENSG00000159618), PTH1R (ENSG00000160801), ADGRL4 (ENSG00000162618), EVA1C (ENSG00000166979), ADGRF3 (ENSG00000173567), ADGRG2 (ENSG00000173698), ADGRE1 (ENSG00000174837), ADGRB1 (ENSG00000181790), ADGRG3 (ENSG00000182885), ADGRA1 (ENSG00000197177)

Protein

Protein identifiers

Adhesion G protein-coupled receptor D2 — Q7Z7M1 (reviewed: Q7Z7M1)

Alternative names: G-protein coupled receptor 144, G-protein coupled receptor PGR24

All UniProt accessions (5): A0A087WWT7, A0A1W2PRP3, A0A1W2PSD9, A0A8Q3SIF2, A0A9L9PY34

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor.

Subcellular location. Membrane.

Similarity. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

RefSeq proteins (1): NP_001382354* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000203	GPS	Conserved_site
IPR000832	GPCR_2_secretin-like	Family
IPR001759	PTX_dom	Domain
IPR013320	ConA-like_dom_sf	Homologous_superfamily
IPR017981	GPCR_2-like_7TM	Domain
IPR046338	GAIN_dom_sf	Homologous_superfamily
IPR057244	GAIN_B	Domain

Pfam: PF00002, PF00354, PF01825

UniProt features (26 total): topological domain 8, transmembrane region 7, domain 2, region of interest 2, glycosylation site 2, disulfide bond 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z7M1-F1	72.98	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 146–212, 619–633

Glycosylation sites (2): 271, 634

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): WHITEHURST_PACLITAXEL_SENSITIVITY, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, HATADA_METHYLATED_IN_LUNG_CANCER_UP, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12, RATTENBACHER_BOUND_BY_CELF1, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, CTIP_DN.V1_DN, KRAS.BREAST_UP.V1_UP, ZNF563_TARGET_GENES, ZHANG_FH_DEFICIENT_RCC_C2_VS_OTHERS_UP, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GSE3982_MAC_VS_BASOPHIL_DN, GSE3982_NEUTROPHIL_VS_BASOPHIL_DN

GO Biological Process (2): cell surface receptor signaling pathway (GO:0007166), G protein-coupled receptor signaling pathway (GO:0007186)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), transmembrane signaling receptor activity (GO:0004888)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signal transduction	2
G protein-coupled receptor activity	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
signaling receptor activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

438 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ADGRD2	ADGRA1	Q86SQ6	595
ADGRD2	ADGRA3	Q8IWK6	496
ADGRD2	NOSTRIN	Q8IVI9	426
ADGRD2	ZNF541	Q9H0D2	400
ADGRD2	PSMB7	Q99436	397
ADGRD2	GOLGA6L6	A8MZA4	394
ADGRD2	NR6A1	Q15406	385
ADGRD2	ODF4	Q2M2E3	376
ADGRD2	AP1G1	O43747	360
ADGRD2	PI15	O43692	356
ADGRD2	CDC42EP3	Q9UKI2	352
ADGRD2	IMPG1	Q17R60	349
ADGRD2	DTHD1	Q6ZMT9	347
ADGRD2	PRUNE2	Q8WUY3	336
ADGRD2	PRDM6	Q9NQX0	336

IntAct

0 interactions, top by confidence:

ESM2 similar proteins: A0A140LHF2, A0EQL2, D3YZF7, D7PDD4, O15533, O55237, O70394, O70540, O95866, P04278, P05111, P07994, P08689, P0C6B3, P0DP72, P15196, P17490, P18627, P40238, P55101, P60882, P97497, Q00657, Q08351, Q14393, Q14773, Q16671, Q3SWY4, Q5BK54, Q5NKT8, Q5TJE4, Q61790, Q61826, Q62588, Q6PZD2, Q6UVK1, Q6UWB1, Q7Z7M0, Q7Z7M1, Q86VR7

Diamond homologs: A0A1D5NSM8, A0JNA2, A2AVA0, A2AX52, D3YXF5, O02839, O19063, O35764, O43405, O70340, O76536, O89029, O95502, O96530, P02741, P02743, P06205, P06206, P06207, P06681, P07202, P07629, P08607, P09871, P0C6B8, P10643, P12246, P13944, P14151, P14847, P15697, P18337, P23680, P32018, P47970, P47971, P47972, P48199, P49254, P49262

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

7 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	4
Likely pathogenic	0
Uncertain significance	1
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
1341250	GRCh37/hg19 9q33.1-33.3(chr9:120045175-127335905)x1	Pathogenic
153090	GRCh38/hg38 9q33.2-33.3(chr9:123095598-126693843)x1	Pathogenic
1808695	GRCh37/hg19 9q33.2-33.3(chr9:124018736-129995568)x1	Pathogenic
3063098	GRCh37/hg19 9q33.2-33.3(chr9:122755951-127551056)x1	Pathogenic

SpliceAI

4141 predictions. Top by Δscore:

Variant	Effect	Δscore
9:124452718:GAGGC:G	donor_gain	1.0000
9:124452721:GC:G	donor_gain	1.0000
9:124468084:CCA:C	acceptor_loss	1.0000
9:124468086:A:AC	acceptor_loss	1.0000
9:124468086:A:AG	acceptor_gain	1.0000
9:124468086:AG:A	acceptor_gain	1.0000
9:124468086:AGG:A	acceptor_gain	1.0000
9:124468087:G:A	acceptor_gain	1.0000
9:124468087:G:GT	acceptor_gain	1.0000
9:124468087:GGG:G	acceptor_gain	1.0000
9:124468087:GGGT:G	acceptor_gain	1.0000
9:124468087:GGGTC:G	acceptor_gain	1.0000
9:124468168:GCGA:G	donor_gain	1.0000
9:124468182:GCCAA:G	donor_gain	1.0000
9:124468188:GAG:G	donor_gain	1.0000
9:124468188:GAGG:G	donor_loss	1.0000
9:124468189:AG:A	donor_loss	1.0000
9:124468190:GG:G	donor_loss	1.0000
9:124468192:T:G	donor_loss	1.0000
9:124469221:GGC:G	acceptor_gain	1.0000
9:124469356:G:GG	donor_gain	1.0000
9:124452723:G:GG	donor_gain	0.9900
9:124455124:TG:T	donor_gain	0.9900
9:124455125:G:GT	donor_gain	0.9900
9:124455128:G:GG	donor_gain	0.9900
9:124466285:A:G	acceptor_gain	0.9900
9:124466411:CAGGT:C	donor_loss	0.9900
9:124466415:T:G	donor_loss	0.9900
9:124468084:CCAGG:C	acceptor_gain	0.9900
9:124468085:CAGGG:C	acceptor_gain	0.9900

AlphaMissense

6261 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000024490 (9:124478070 G>A), RS1000073264 (9:124456557 C>A,T), RS1000207727 (9:124472667 T>A,C), RS1000223936 (9:124475440 C>T), RS1000288800 (9:124469826 T>A), RS1000371458 (9:124465254 C>T), RS1000390213 (9:124458557 G>A), RS1000433063 (9:124467927 A>T), RS1000491234 (9:124472888 G>C,T), RS1000507818 (9:124453566 C>T), RS1000541933 (9:124473875 A>G,T), RS1000660606 (9:124469968 C>T), RS1000717647 (9:124478270 T>C), RS1000718624 (9:124469006 C>T), RS1000719643 (9:124469284 G>A,T)

Disease associations

OMIM: gene MIM:620837 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523880 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Adhesion Class GPCRs

CTD chemical–gene interactions

7 total (human), top 7 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	affects cotreatment, decreases methylation	1
ethyl-p-hydroxybenzoate	decreases expression	1
sodium arsenite	affects methylation	1
excavatolide B	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Benzo(a)pyrene	increases methylation	1
Endosulfan	increases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883414	Binding	PRESTO-Tango GPCRome screening (GPR144)	Data for DCP probe UCSF924

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.