ADGRG5

Summary

ADGRG5 (adhesion G protein-coupled receptor G5, HGNC:19010) is a protein-coding gene on chromosome 16q21, encoding Adhesion G-protein coupled receptor G5 (Q8IZF4). Orphan adhesion G-protein coupled receptor (aGPCR).

This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 221188 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 112 total
• Druggable target: yes
• MANE Select transcript: NM_001304376

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19010
Approved symbol	ADGRG5
Name	adhesion G protein-coupled receptor G5
Location	16q21
Locus type	gene with protein product
Status	Approved
Aliases	PGR27
Ensembl gene	ENSG00000159618
Ensembl biotype	protein_coding
OMIM	616965
Entrez	221188

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 4 protein_coding, 2 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000340339, ENST00000349457, ENST00000394361, ENST00000564607, ENST00000564983, ENST00000569839, ENST00000615867, ENST00000897109

RefSeq mRNA: 3 — MANE Select: NM_001304376 NM_001304376, NM_001318481, NM_153837

CCDS: CCDS10785

Canonical transcript exons

ENST00000349457 — 12 exons

Exon	Start	End
ENSE00002603680	57575438	57577189
ENSE00002615744	57542643	57542701
ENSE00003493065	57562384	57562459
ENSE00003506551	57563091	57563247
ENSE00003531290	57566599	57566751
ENSE00003570835	57565034	57565150
ENSE00003603608	57567470	57567591
ENSE00003617022	57563848	57563979
ENSE00003623453	57567856	57568124
ENSE00003679996	57562056	57562157
ENSE00003680329	57574815	57575092
ENSE00003693458	57570418	57570535

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 92.24.

FANTOM5 (CAGE): breadth broad, TPM avg 3.1848 / max 253.7774, expressed in 261 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154379	2.9651	253
154380	0.2197	88

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	92.24	gold quality
lymph node	UBERON:0000029	79.44	gold quality
blood	UBERON:0000178	79.36	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.74	gold quality
islet of Langerhans	UBERON:0000006	78.19	gold quality
spleen	UBERON:0002106	77.90	gold quality
bone marrow cell	CL:0002092	77.46	gold quality
vermiform appendix	UBERON:0001154	76.13	gold quality
epithelium of nasopharynx	UBERON:0001951	71.35	silver quality
leukocyte	CL:0000738	71.11	gold quality
tonsil	UBERON:0002372	70.53	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.63	gold quality
monocyte	CL:0000576	69.56	gold quality
mucosa of transverse colon	UBERON:0004991	69.40	gold quality
duodenum	UBERON:0002114	69.32	gold quality
gall bladder	UBERON:0002110	69.31	gold quality
caecum	UBERON:0001153	68.43	gold quality
jejunal mucosa	UBERON:0000399	67.41	silver quality
palpebral conjunctiva	UBERON:0001812	67.31	gold quality
adult mammalian kidney	UBERON:0000082	67.29	gold quality
body of stomach	UBERON:0001161	67.22	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.35	gold quality
small intestine	UBERON:0002108	66.16	gold quality
pancreas	UBERON:0001264	66.09	gold quality
stomach	UBERON:0000945	65.84	gold quality
bone marrow	UBERON:0002371	65.67	gold quality
rectum	UBERON:0001052	64.33	gold quality
buccal mucosa cell	CL:0002336	63.01	gold quality
colonic epithelium	UBERON:0000397	61.56	gold quality
fundus of stomach	UBERON:0001160	61.41	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-MTAB-9067	yes	12.95
E-ENAD-27	yes	8.52
E-ANND-3	yes	7.70

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

43 targeting ADGRG5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-3663-3P	99.84	70.39	798
HSA-MIR-11181-3P	99.75	66.38	2205
HSA-MIR-10393-5P	99.65	68.01	1368
HSA-MIR-1260A	99.61	66.67	1098
HSA-MIR-1260B	99.61	66.67	1098
HSA-MIR-4452	99.50	68.45	1493
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-4677-3P	99.49	67.91	1246
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-6878-3P	99.24	64.23	920
HSA-MIR-6744-3P	99.22	64.41	972
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-4757-5P	99.12	64.51	981
HSA-MIR-4254	99.11	65.15	1315
HSA-MIR-485-5P	99.10	64.78	1889
HSA-MIR-6884-5P	99.10	64.50	1987
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-4297	98.77	66.95	2013
HSA-MIR-548Q	98.71	65.35	563
HSA-MIR-7155-5P	98.65	66.14	1290
HSA-MIR-6754-5P	98.60	65.54	1627
HSA-MIR-4726-3P	98.49	63.89	1385

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Adgrg5	ENSMUSG00000061577
rattus_norvegicus	Adgrg5	ENSRNOG00000039891

Paralogs (42): CALCR (ENSG00000004948), GIPR (ENSG00000010310), ADGRA2 (ENSG00000020181), CALCRL (ENSG00000064989), GLP2R (ENSG00000065325), ADGRF5 (ENSG00000069122), ADGRL1 (ENSG00000072071), ADCYAP1R1 (ENSG00000078549), SCTR (ENSG00000080293), VIPR2 (ENSG00000106018), CRHR2 (ENSG00000106113), GHRHR (ENSG00000106128), ADGRD1 (ENSG00000111452), GLP1R (ENSG00000112164), ADGRG6 (ENSG00000112414), VIPR1 (ENSG00000114812), ADGRL2 (ENSG00000117114), CRHR1 (ENSG00000120088), ADGRB2 (ENSG00000121753), ADGRE5 (ENSG00000123146), ADGRE2 (ENSG00000127507), ADGRE3 (ENSG00000131355), ADGRB3 (ENSG00000135298), PTH2R (ENSG00000144407), ADGRG7 (ENSG00000144820), ADGRL3 (ENSG00000150471), ADGRA3 (ENSG00000152990), ADGRF1 (ENSG00000153292), ADGRF4 (ENSG00000153294), ADGRG4 (ENSG00000156920), PTH1R (ENSG00000160801), ADGRL4 (ENSG00000162618), EVA1C (ENSG00000166979), ADGRF3 (ENSG00000173567), ADGRG2 (ENSG00000173698), ADGRE1 (ENSG00000174837), ADGRD2 (ENSG00000180264), ADGRB1 (ENSG00000181790), ADGRG3 (ENSG00000182885), ADGRA1 (ENSG00000197177)

Protein

Protein identifiers

Adhesion G-protein coupled receptor G5 — Q8IZF4 (reviewed: Q8IZF4)

Alternative names: G-protein coupled receptor 114, G-protein coupled receptor PGR27

All UniProt accessions (2): Q8IZF4, A0A087WZA0

UniProt curated annotations — full annotation on UniProt →

Function. Orphan adhesion G-protein coupled receptor (aGPCR). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG5 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity.

Subunit / interactions. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

Subcellular location. Cell membrane.

Tissue specificity. Expressed in immune cells. Primarily found in granulocytes. Found in eosinophils.

Post-translational modifications. Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. N-glycsylated.

Activity regulation. Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain. In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling. The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor.

Domain organisation. The Stachel sequence (also named stalk) in the C-terminal part of the extracellular domain (ECD) functions as a tethered agonist. In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling.

Similarity. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

RefSeq proteins (3): NP_001291305, NP_001305410, NP_722579 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000203	GPS	Conserved_site
IPR000832	GPCR_2_secretin-like	Family
IPR003910	GPR1/GPR3/GPR5	Family
IPR017981	GPCR_2-like_7TM	Domain
IPR046338	GAIN_dom_sf	Homologous_superfamily
IPR057244	GAIN_B	Domain

Pfam: PF00002, PF01825

UniProt features (56 total): helix 13, topological domain 8, glycosylation site 8, transmembrane region 7, chain 3, disulfide bond 3, sequence conflict 3, turn 3, region of interest 2, mutagenesis site 2, signal peptide 1, domain 1, site 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7EQ1	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IZF4-F1	82.51	0.42

Antibody-complex structures (SAbDab): 1 — 7EQ1

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 226–227 (cleavage; by autolysis)

Disulfide bonds (3): 189–221, 209–223, 314–404

Glycosylation sites (8): 58, 65, 146, 147, 173, 179, 394, 400

Mutagenesis-validated functional residues (2):

Position	Phenotype
225	abolished autoproteolytically processing.
230	impaired g protein-coupled receptor activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 101 (showing top): GOBP_ADENYLATE_CYCLASE_MODULATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, chr16q21, GOBP_ADENYLATE_CYCLASE_ACTIVATING_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, ROYLANCE_BREAST_CANCER_16Q_COPY_NUMBER_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GSE13762_CTRL_VS_125_VITAMIND_DAY12_DC_DN, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, LI_INDUCED_T_TO_NATURAL_KILLER_UP, MARTENS_BOUND_BY_PML_RARA_FUSION, WIERENGA_STAT5A_TARGETS_UP, WIERENGA_STAT5A_TARGETS_GROUP1, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, BAKKER_FOXO3_TARGETS_DN, DELACROIX_RAR_BOUND_ES, GSE14699_NAIVE_VS_ACT_CD8_TCELL_DN

GO Biological Process (4): cell surface receptor signaling pathway (GO:0007166), G protein-coupled receptor signaling pathway (GO:0007186), adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189), signal transduction (GO:0007165)

GO Molecular Function (2): G protein-coupled receptor activity (GO:0004930), transmembrane signaling receptor activity (GO:0004888)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signal transduction	2
G protein-coupled receptor activity	1
adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1
adenylate cyclase activator activity	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
signaling receptor activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

630 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ADGRG5	ADGRA1	Q86SQ6	639
ADGRG5	ADGRA3	Q8IWK6	580
ADGRG5	ADGRD1	Q6QNK2	488
ADGRG5	RELL1	Q8IUW5	380
ADGRG5	ADGRG3	Q86Y34	378
ADGRG5	ADGRF1	Q5T601	378
ADGRG5	GPR174	Q9BXC1	371
ADGRG5	ADGRF2P	Q8IZF7	367
ADGRG5	ADGRG4	Q8IZF6	339
ADGRG5	ADGRV1	Q8WXG9	333
ADGRG5	ADGRF4	Q8IZF3	332
ADGRG5	AMDHD1	Q96NU7	317
ADGRG5	ADGRG7	Q96K78	314
ADGRG5	ADGRL1	O94910	313
ADGRG5	SPINK14	Q6IE38	305

IntAct

11 interactions, top by confidence:

A	B	Type	Score
ADGRG5	KLRG2	psi-mi:“MI:0914”(association)	0.530
ADGRG5	SRPK2	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
ADGRG5	RAMP1	psi-mi:“MI:0915”(physical association)	0.400
ADGRG5	RAMP2	psi-mi:“MI:0915”(physical association)	0.400
RAMP3	ADGRG5	psi-mi:“MI:0915”(physical association)	0.400
ADGRG5	RAMP3	psi-mi:“MI:0915”(physical association)	0.400
ADGRG5	SLC33A1	psi-mi:“MI:0914”(association)	0.350

BioGRID (152): LPPR3 (Affinity Capture-MS), TSPAN10 (Affinity Capture-MS), TMEM68 (Affinity Capture-MS), SEC11C (Affinity Capture-MS), GJC1 (Affinity Capture-MS), FZD3 (Affinity Capture-MS), SLC6A6 (Affinity Capture-MS), EPHB3 (Affinity Capture-MS), FZD2 (Affinity Capture-MS), REEP6 (Affinity Capture-MS), TMX4 (Affinity Capture-MS), GPM6B (Affinity Capture-MS), GJA1 (Affinity Capture-MS), BMPR1A (Affinity Capture-MS), GRAMD1B (Affinity Capture-MS)

ESM2 similar proteins: C3VPR6, G1T469, G1T7E7, G1TR84, O00590, O08707, O09027, O14843, O15529, P11609, P11610, P15151, P20701, P20702, P32506, P38570, P46094, P97583, Q13349, Q2Q421, Q2Q426, Q3V0T4, Q3V3Z3, Q50DM5, Q50DM6, Q50DM7, Q50DM8, Q5Y4N8, Q61549, Q6E804, Q6ZSA7, Q7RTX1, Q80T32, Q86Y34, Q8BYC4, Q8IZF4, Q8K209, Q8K3V3, Q8R0T6, Q91ZV8

Diamond homologs: B7ZCC9, C6KFA3, G5ECX0, G5EDW2, O88917, O94910, O97817, O97827, O97831, Q2Q421, Q2Q426, Q3V3Z3, Q50DM5, Q50DM6, Q50DM7, Q50DM8, Q6F3F9, Q6QNK2, Q7SY09, Q80TR1, Q80TS3, Q86SQ3, Q86SQ4, Q86Y34, Q8CJ11, Q8CJ12, Q8IZF4, Q8IZF6, Q8IZP9, Q8JZZ7, Q8K209, Q8SQA4, Q923X1, Q9BY15, Q9ESC1, Q9HAR2, Q9HBW9, Q9HCU4, Q9QYP2, Q9R0M0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

112 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	87
Likely benign	8
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1869 predictions. Top by Δscore:

Variant	Effect	Δscore
16:57562158:G:GC	donor_loss	1.0000
16:57562159:T:A	donor_loss	1.0000
16:57563844:GCAG:G	acceptor_loss	1.0000
16:57563846:A:AG	acceptor_gain	1.0000
16:57563846:AG:A	acceptor_gain	1.0000
16:57563847:G:GG	acceptor_gain	1.0000
16:57563847:GG:G	acceptor_gain	1.0000
16:57563847:GGCA:G	acceptor_gain	1.0000
16:57563976:CAAGG:C	donor_loss	1.0000
16:57563978:AG:A	donor_gain	1.0000
16:57563979:GG:G	donor_gain	1.0000
16:57563980:G:GG	donor_gain	1.0000
16:57563980:GTCA:G	donor_loss	1.0000
16:57565146:GCCTG:G	donor_gain	1.0000
16:57542697:CTCAG:C	donor_loss	0.9900
16:57542698:TCAG:T	donor_loss	0.9900
16:57542699:CAGG:C	donor_loss	0.9900
16:57542700:AGGT:A	donor_loss	0.9900
16:57542701:GG:G	donor_loss	0.9900
16:57542702:G:GA	donor_loss	0.9900
16:57542703:T:G	donor_loss	0.9900
16:57562050:TTTCA:T	acceptor_loss	0.9900
16:57562051:TTCAG:T	acceptor_loss	0.9900
16:57562052:TCAG:T	acceptor_loss	0.9900
16:57562054:A:AG	acceptor_gain	0.9900
16:57562054:A:C	acceptor_loss	0.9900
16:57562054:AG:A	acceptor_gain	0.9900
16:57562055:G:GG	acceptor_gain	0.9900
16:57562055:G:GT	acceptor_loss	0.9900
16:57562055:GG:G	acceptor_gain	0.9900

AlphaMissense

3422 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
16:57566623:T:C	F191L	0.995
16:57566625:C:A	F191L	0.995
16:57566625:C:G	F191L	0.995
16:57566664:G:C	W204C	0.995
16:57566664:G:T	W204C	0.995
16:57566737:T:C	F229L	0.995
16:57566739:T:A	F229L	0.995
16:57566739:T:G	F229L	0.995
16:57563888:T:C	F113S	0.992
16:57563888:T:G	F113C	0.991
16:57566628:G:C	W192C	0.991
16:57566628:G:T	W192C	0.991
16:57566738:T:G	F229C	0.991
16:57566662:T:A	W204R	0.989
16:57566662:T:C	W204R	0.989
16:57566618:G:A	C189Y	0.988
16:57566713:T:A	C221S	0.987
16:57566714:G:C	C221S	0.987
16:57563942:T:C	L131P	0.986
16:57566619:T:G	C189W	0.985
16:57566677:T:A	C209S	0.985
16:57566678:G:C	C209S	0.985
16:57566617:T:C	C189R	0.983
16:57566618:G:T	C189F	0.983
16:57563200:T:C	F84L	0.982
16:57563202:C:A	F84L	0.982
16:57563202:C:G	F84L	0.982
16:57566617:T:A	C189S	0.982
16:57566618:G:C	C189S	0.982
16:57566738:T:C	F229S	0.980

dbSNP variants (sampled 300 via entrez): RS1000082475 (16:57545130 T>A), RS1000134873 (16:57544878 C>A), RS1000301749 (16:57557434 T>C), RS1000508089 (16:57564175 T>C), RS1000596782 (16:57551526 G>A), RS1000604063 (16:57570835 C>T), RS1000678885 (16:57529776 A>G), RS1000781336 (16:57535483 T>G), RS1000789890 (16:57575982 C>T), RS1001094172 (16:57546319 T>C), RS1001128871 (16:57529574 C>T), RS1001222119 (16:57575690 G>A), RS1001263544 (16:57544553 G>T), RS1001397821 (16:57540344 T>C), RS1001421050 (16:57550821 A>G)

Disease associations

OMIM: gene MIM:616965 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST009066_28	Mosaic loss of chromosome Y (Y chromosome dosage)	1.000000e-09
GCST009067_22	Mosaic loss of chromosome Y (Y chromosome dosage)	1.000000e-11
GCST90002390_88	Mean corpuscular hemoglobin	8.000000e-12
GCST90002392_504	Mean corpuscular volume	7.000000e-11
GCST90002396_587	Mean reticulocyte volume	1.000000e-10
GCST90002400_179	Plateletcrit	3.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007783	mosaic loss of chromosome Y measurement
EFO:0004527	mean corpuscular hemoglobin
EFO:0010701	mean reticulocyte volume
EFO:0007985	platelet crit

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523890 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Adhesion Class GPCRs

CTD chemical–gene interactions

13 total (human), top 13 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases methylation, increases mutagenesis	2
Valproic Acid	affects expression, increases expression	2
GSK-J4	decreases expression	1
aminomethylphosphonic acid (AMPA)	decreases expression	1
methylmercuric chloride	increases expression	1
triphenyl phosphate	affects expression	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	increases expression	1
(+)-JQ1 compound	decreases expression	1
Hydrogen Peroxide	increases expression	1
Tretinoin	increases expression	1
2,4-Dichlorophenoxyacetic Acid	decreases expression	1
Aflatoxin B1	increases methylation	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883398	Binding	PRESTO-Tango GPCRome screening (GPR114)	Data for DCP probe UCSF924

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.