ADGRG7
geneOn this page
Also known as FLJ14454
Summary
ADGRG7 (adhesion G protein-coupled receptor G7, HGNC:19241) is a protein-coding gene on chromosome 3q12.2, encoding Adhesion G-protein coupled receptor G7 (Q96K78). Orphan receptor.
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Source: NCBI Gene 84873 — RefSeq curated summary.
At a glance
- GWAS associations: 1
- Clinical variants (ClinVar): 146 total
- MANE Select transcript:
NM_032787
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:19241 |
| Approved symbol | ADGRG7 |
| Name | adhesion G protein-coupled receptor G7 |
| Location | 3q12.2 |
| Locus type | gene with protein product |
| Status | Approved |
| Aliases | FLJ14454 |
| Ensembl gene | ENSG00000144820 |
| Ensembl biotype | protein_coding |
| OMIM | 612307 |
| Entrez | 84873 |
Gene structure
Transcript identifiers
Ensembl transcripts: 6 — 3 protein_coding, 3 protein_coding_CDS_not_defined
ENST00000273352, ENST00000475887, ENST00000481361, ENST00000481506, ENST00000493081, ENST00000868805
RefSeq mRNA: 2 — MANE Select: NM_032787
NM_001308362, NM_032787
CCDS: CCDS2938, CCDS77778
Canonical transcript exons
ENST00000273352 — 16 exons
| Exon | Start | End |
|---|---|---|
| ENSE00000967307 | 100629598 | 100629711 |
| ENSE00000967309 | 100630705 | 100630809 |
| ENSE00000967311 | 100633265 | 100633377 |
| ENSE00000967313 | 100635677 | 100635826 |
| ENSE00000967318 | 100643526 | 100643633 |
| ENSE00000967320 | 100645945 | 100646108 |
| ENSE00000967321 | 100646569 | 100646724 |
| ENSE00000967322 | 100649695 | 100649807 |
| ENSE00000967323 | 100654835 | 100655181 |
| ENSE00001225265 | 100694744 | 100695479 |
| ENSE00001225273 | 100609601 | 100609971 |
| ENSE00003528101 | 100659688 | 100659843 |
| ENSE00003570251 | 100668949 | 100669105 |
| ENSE00003570753 | 100643266 | 100643405 |
| ENSE00003576823 | 100637302 | 100637402 |
| ENSE00003588830 | 100655899 | 100655995 |
Expression profiles
Bgee: expression breadth ubiquitous, 118 present calls, max score 94.64.
FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1988 / max 105.4681, expressed in 19 samples.
FANTOM5 promoters (6 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 37623 | 0.1256 | 12 |
| 37627 | 0.0264 | 6 |
| 37626 | 0.0207 | 5 |
| 37624 | 0.0096 | 4 |
| 202862 | 0.0086 | 3 |
| 37625 | 0.0081 | 4 |
Top tissues by expression
240 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| jejunal mucosa | UBERON:0000399 | 94.64 | gold quality |
| duodenum | UBERON:0002114 | 90.63 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 81.63 | gold quality |
| right lobe of liver | UBERON:0001114 | 80.50 | gold quality |
| small intestine | UBERON:0002108 | 78.90 | gold quality |
| small intestine Peyer’s patch | UBERON:0003454 | 78.89 | gold quality |
| liver | UBERON:0002107 | 77.73 | gold quality |
| mucosa of transverse colon | UBERON:0004991 | 75.43 | gold quality |
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 74.03 | gold quality |
| rectum | UBERON:0001052 | 71.41 | gold quality |
| jejunum | UBERON:0002115 | 70.42 | gold quality |
| colonic mucosa | UBERON:0000317 | 66.08 | gold quality |
| gall bladder | UBERON:0002110 | 62.55 | gold quality |
| transverse colon | UBERON:0001157 | 62.18 | gold quality |
| smooth muscle tissue | UBERON:0001135 | 61.89 | gold quality |
| vermiform appendix | UBERON:0001154 | 61.08 | gold quality |
| mucosa of sigmoid colon | UBERON:0004993 | 61.06 | silver quality |
| intestine | UBERON:0000160 | 60.49 | gold quality |
| caecum | UBERON:0001153 | 56.51 | gold quality |
| large intestine | UBERON:0000059 | 53.78 | gold quality |
| colon | UBERON:0001155 | 52.80 | gold quality |
| skin of hip | UBERON:0001554 | 51.28 | silver quality |
| upper leg skin | UBERON:0004262 | 49.95 | gold quality |
| seminal vesicle | UBERON:0000998 | 49.61 | gold quality |
| amniotic fluid | UBERON:0000173 | 47.13 | silver quality |
| skeletal muscle tissue of rectus abdominis | UBERON:0004511 | 43.37 | gold quality |
| secondary oocyte | CL:0000655 | 42.57 | gold quality |
| mammary duct | UBERON:0001765 | 42.29 | silver quality |
| endometrium | UBERON:0001295 | 41.76 | gold quality |
| urinary bladder | UBERON:0001255 | 41.72 | gold quality |
Single-cell (SCXA)
Detected in 3 experiment(s), a significant marker in 3.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-GEOD-75140 | yes | 143.27 |
| E-GEOD-76312 | yes | 94.28 |
| E-ANND-3 | yes | 6.23 |
Regulation
Is transcription factor: no
miRNA regulators (miRDB)
37 targeting ADGRG7, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):
| miRNA | Max score | Avg score | miRNA target_count |
|---|---|---|---|
| HSA-MIR-186-5P | 99.99 | 70.83 | 3707 |
| HSA-MIR-1297 | 99.91 | 73.41 | 3162 |
| HSA-MIR-6809-3P | 99.91 | 71.45 | 3814 |
| HSA-MIR-5582-3P | 99.86 | 72.48 | 4221 |
| HSA-MIR-548AR-3P | 99.85 | 71.26 | 3889 |
| HSA-MIR-548AZ-3P | 99.82 | 70.56 | 3549 |
| HSA-MIR-548BC | 99.82 | 70.61 | 3524 |
| HSA-MIR-548E-3P | 99.82 | 70.59 | 3514 |
| HSA-MIR-548F-3P | 99.82 | 70.59 | 3540 |
| HSA-MIR-374C-5P | 99.80 | 72.06 | 2910 |
| HSA-MIR-655-3P | 99.80 | 72.19 | 2909 |
| HSA-MIR-26A-5P | 99.78 | 73.52 | 2303 |
| HSA-MIR-26B-5P | 99.78 | 73.51 | 2305 |
| HSA-MIR-548A-3P | 99.76 | 70.58 | 3524 |
| HSA-MIR-4306 | 99.72 | 70.50 | 3630 |
| HSA-MIR-4465 | 99.71 | 72.56 | 2096 |
| HSA-MIR-561-3P | 99.64 | 70.90 | 3647 |
| HSA-MIR-4762-5P | 99.57 | 68.54 | 1424 |
| HSA-MIR-3915 | 99.45 | 68.49 | 1905 |
| HSA-MIR-297 | 99.40 | 69.58 | 1418 |
| HSA-MIR-185-5P | 99.35 | 68.60 | 2497 |
| HSA-MIR-4644 | 99.35 | 69.12 | 2514 |
| HSA-MIR-6739-3P | 99.22 | 68.84 | 1843 |
| HSA-MIR-892C-5P | 99.16 | 70.56 | 2116 |
| HSA-MIR-371A-5P | 99.08 | 66.51 | 1914 |
| HSA-MIR-6074 | 98.89 | 69.64 | 2187 |
| HSA-MIR-412-3P | 98.86 | 66.89 | 712 |
| HSA-MIR-6754-3P | 98.84 | 66.60 | 889 |
| HSA-MIR-599 | 98.32 | 66.99 | 1037 |
| HSA-MIR-12120 | 98.05 | 68.44 | 1768 |
Literature-anchored findings (GeneRIF, showing 2)
- An expressed in-frame TRK-fused gene-G-protein-coupled receptor GPR128 is identified in healthy individuals and in patients with myeloproliferative neoplasms. (PMID:19797732)
- Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells. (PMID:38786015)
Cross-species orthologs
4 orthologs
| Organism | Symbol | Gene ID |
|---|---|---|
| danio_rerio | adgrg7.2 | ENSDARG00000071085 |
| danio_rerio | adgrg7.1 | ENSDARG00000071088 |
| mus_musculus | Adgrg7 | ENSMUSG00000022755 |
| rattus_norvegicus | Adgrg7 | ENSRNOG00000001634 |
Paralogs (42): CALCR (ENSG00000004948), GIPR (ENSG00000010310), ADGRA2 (ENSG00000020181), CALCRL (ENSG00000064989), GLP2R (ENSG00000065325), ADGRF5 (ENSG00000069122), ADGRL1 (ENSG00000072071), ADCYAP1R1 (ENSG00000078549), SCTR (ENSG00000080293), VIPR2 (ENSG00000106018), CRHR2 (ENSG00000106113), GHRHR (ENSG00000106128), ADGRD1 (ENSG00000111452), GLP1R (ENSG00000112164), ADGRG6 (ENSG00000112414), VIPR1 (ENSG00000114812), ADGRL2 (ENSG00000117114), CRHR1 (ENSG00000120088), ADGRB2 (ENSG00000121753), ADGRE5 (ENSG00000123146), ADGRE2 (ENSG00000127507), ADGRE3 (ENSG00000131355), ADGRB3 (ENSG00000135298), PTH2R (ENSG00000144407), ADGRL3 (ENSG00000150471), ADGRA3 (ENSG00000152990), ADGRF1 (ENSG00000153292), ADGRF4 (ENSG00000153294), ADGRG4 (ENSG00000156920), ADGRG5 (ENSG00000159618), PTH1R (ENSG00000160801), ADGRL4 (ENSG00000162618), EVA1C (ENSG00000166979), ADGRF3 (ENSG00000173567), ADGRG2 (ENSG00000173698), ADGRE1 (ENSG00000174837), ADGRD2 (ENSG00000180264), ADGRB1 (ENSG00000181790), ADGRG3 (ENSG00000182885), ADGRA1 (ENSG00000197177)
Protein
Protein identifiers
Adhesion G-protein coupled receptor G7 — Q96K78 (reviewed: Q96K78)
Alternative names: G-protein coupled receptor 128
All UniProt accessions (2): Q96K78, E9PHI0
UniProt curated annotations — full annotation on UniProt →
Function. Orphan receptor.
Subcellular location. Membrane.
Similarity. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
RefSeq proteins (2): NP_001295291, NP_116176* (*=MANE)
Domains & families (InterPro)
| ID | Name | Type |
|---|---|---|
| IPR000203 | GPS | Conserved_site |
| IPR000832 | GPCR_2_secretin-like | Family |
| IPR017981 | GPCR_2-like_7TM | Domain |
| IPR046338 | GAIN_dom_sf | Homologous_superfamily |
| IPR047938 | GPR128_7tmB2 | Domain |
| IPR053066 | ADGR_G7 | Family |
| IPR053984 | GPR128_N | Domain |
| IPR053985 | GPR128_GAIN_subdom_A | Domain |
| IPR053986 | GPR128_GAIN_subdom_B | Domain |
| IPR057244 | GAIN_B | Domain |
Pfam: PF00002, PF01825, PF22257, PF22259, PF22261
UniProt features (34 total): glycosylation site 10, topological domain 8, transmembrane region 7, sequence variant 3, disulfide bond 2, signal peptide 1, chain 1, domain 1, region of interest 1
Structure
Experimental structures (PDB)
0 structures.
Predicted structure (AlphaFold)
| Model | pLDDT | Fraction very-high |
|---|---|---|
| AF-Q96K78-F1 | 80.48 | 0.42 |
Functional residue map
Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.
Disulfide bonds (2): 383–410, 398–412
Glycosylation sites (10): 82, 159, 178, 191, 247, 261, 312, 316, 387, 413
Function
Pathways and Gene Ontology
Reactome pathways
0 pathways
MSigDB gene sets: 32 (showing top):
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GSE13522_WT_VS_IFNG_KO_SKIN_DN, chr3q12, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MIKKELSEN_MEF_ICP_WITH_H3K27ME3, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_UP, DIDO1_TARGET_GENES, ZNF2_TARGET_GENES, MIR1297, MIR12120, GSE10463_CD40L_AND_VA347_VS_CD40L_IN_DC_DN, MIR4762_5P, MIR4646_5P
GO Biological Process (3): cell surface receptor signaling pathway (GO:0007166), G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)
GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), transmembrane signaling receptor activity (GO:0004888), protein binding (GO:0005515)
GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)
GO top-level categories
Rollup of top GO terms by namespace:
| Category | Terms |
|---|---|
| signal transduction | 2 |
| G protein-coupled receptor activity | 1 |
| cell communication | 1 |
| cellular process | 1 |
| signaling | 1 |
| regulation of cellular process | 1 |
| cellular response to stimulus | 1 |
| transmembrane signaling receptor activity | 1 |
| G protein-coupled receptor signaling pathway | 1 |
| signaling receptor activity | 1 |
| binding | 1 |
| membrane | 1 |
| cell periphery | 1 |
| cellular anatomical structure | 1 |
Protein interactions and networks
STRING
510 interactions, top by confidence (×1000):
| Protein A | Protein B | Partner UniProt | Score |
|---|---|---|---|
| ADGRG7 | ADGRA1 | Q86SQ6 | 603 |
| ADGRG7 | RNF25 | Q96BH1 | 442 |
| ADGRG7 | TMEM244 | Q5VVB8 | 398 |
| ADGRG7 | USF3 | Q68DE3 | 375 |
| ADGRG7 | NTRK1 | P04629 | 370 |
| ADGRG7 | CAPN12 | Q6ZSI9 | 370 |
| ADGRG7 | ADGRG4 | Q8IZF6 | 367 |
| ADGRG7 | OR51M1 | Q9H341 | 354 |
| ADGRG7 | ARL17B | I3L3L1 | 352 |
| ADGRG7 | ARHGAP20 | Q9P2F6 | 344 |
| ADGRG7 | FAM221A | A4D161 | 335 |
| ADGRG7 | ADGRG5 | Q8IZF4 | 314 |
| ADGRG7 | OR2T29 | Q8NH02 | 314 |
| ADGRG7 | DPYS | Q14117 | 310 |
| ADGRG7 | ADGRA3 | Q8IWK6 | 306 |
IntAct
17 interactions, top by confidence:
| A | B | Type | Score |
|---|---|---|---|
| ADGRG7 | LDLRAD1 | psi-mi:“MI:0915”(physical association) | 0.780 |
| LDLRAD1 | ADGRG7 | psi-mi:“MI:0915”(physical association) | 0.780 |
| ADGRG7 | psi-mi:“MI:0915”(physical association) | 0.560 | |
| ADGRG7 | psi-mi:“MI:0915”(physical association) | 0.560 | |
| ADGRG7 | VAPA | psi-mi:“MI:0915”(physical association) | 0.560 |
| ADGRG7 | SORT1 | psi-mi:“MI:0915”(physical association) | 0.560 |
| ADGRG7 | LDLRAD1 | psi-mi:“MI:0915”(physical association) | 0.000 |
| ADGRG7 | VAPA | psi-mi:“MI:0915”(physical association) | 0.000 |
| ADGRG7 | SORT1 | psi-mi:“MI:0915”(physical association) | 0.000 |
BioGRID (6): GPR128 (Two-hybrid), LDLRAD1 (Two-hybrid), GPR128 (Two-hybrid), GPR128 (Two-hybrid), GPR128 (Two-hybrid), LDLRAD1 (Two-hybrid)
ESM2 similar proteins: A7E2Z9, A8K7I4, B7ZSK1, C6KFA3, P07911, P15396, P17301, P19218, P52787, P53710, Q14CN2, Q16819, Q1WIM2, Q2TU62, Q5T601, Q5VV43, Q5Y4N8, Q61549, Q62469, Q62929, Q66IR0, Q6DJ83, Q6F3F9, Q6PT52, Q6Q473, Q6QMG1, Q6YHK3, Q70VB1, Q862Z3, Q86SQ4, Q8BGZ8, Q8BLQ9, Q8BM96, Q8CJ11, Q8CJ12, Q8IZP9, Q8K4Z6, Q8N3J6, Q8TCW7, Q91X17
Diamond homologs: A6QLU6, B7ZCC9, C6KFA3, G5ECX0, O88917, O88923, O95490, O97817, O97827, O97831, P05451, P43137, P48960, Q14246, Q2Q421, Q2Q426, Q5R7Y0, Q5T601, Q5Y4N8, Q61549, Q6QNK2, Q7SY09, Q80T32, Q80TS3, Q86SQ3, Q86SQ4, Q8CJ11, Q8CJ12, Q8IZF6, Q8IZP9, Q8SQA4, Q8VEC3, Q91ZE5, Q923X1, Q96K78, Q9BY15, Q9ESC1, Q9HAR2, Q9HBW9, Q9UHX3
SIGNOR signaling
0 interactions.
Disease & clinical
Clinical variants and AI predictions
ClinVar
146 variants total. Per-class counts are floors (≥ shown; pagination cap):
| Classification | Count (floor) |
|---|---|
| Pathogenic | 0 |
| Likely pathogenic | 0 |
| Uncertain significance | 118 |
| Likely benign | 12 |
| Benign | 4 |
Top pathogenic / likely-pathogenic (0)
SpliceAI
2227 predictions. Top by Δscore:
| Variant | Effect | Δscore |
|---|---|---|
| 3:100629694:GAC:G | donor_gain | 1.0000 |
| 3:100637296:TGGCA:T | acceptor_loss | 1.0000 |
| 3:100637297:GGCA:G | acceptor_loss | 1.0000 |
| 3:100637298:GCAG:G | acceptor_loss | 1.0000 |
| 3:100637299:CA:C | acceptor_loss | 1.0000 |
| 3:100637300:A:AG | acceptor_gain | 1.0000 |
| 3:100637300:AGG:A | acceptor_loss | 1.0000 |
| 3:100637301:G:GC | acceptor_gain | 1.0000 |
| 3:100637400:AACG:A | donor_loss | 1.0000 |
| 3:100637401:AC:A | donor_gain | 1.0000 |
| 3:100637401:ACG:A | donor_loss | 1.0000 |
| 3:100637402:CGT:C | donor_loss | 1.0000 |
| 3:100637403:G:GC | donor_loss | 1.0000 |
| 3:100637403:G:GG | donor_gain | 1.0000 |
| 3:100637404:TAA:T | donor_loss | 1.0000 |
| 3:100645940:TATA:T | acceptor_loss | 1.0000 |
| 3:100645941:ATAG:A | acceptor_loss | 1.0000 |
| 3:100645942:T:G | acceptor_gain | 1.0000 |
| 3:100645943:A:AG | acceptor_gain | 1.0000 |
| 3:100645943:AGATT:A | acceptor_loss | 1.0000 |
| 3:100645944:G:GA | acceptor_gain | 1.0000 |
| 3:100646107:AGGT:A | donor_loss | 1.0000 |
| 3:100646108:GGTG:G | donor_loss | 1.0000 |
| 3:100646109:G:GG | donor_gain | 1.0000 |
| 3:100646109:GT:G | donor_loss | 1.0000 |
| 3:100646567:A:AG | acceptor_gain | 1.0000 |
| 3:100646568:G:GA | acceptor_gain | 1.0000 |
| 3:100646568:GTAC:G | acceptor_gain | 1.0000 |
| 3:100646568:GTACA:G | acceptor_gain | 1.0000 |
| 3:100646601:T:G | acceptor_gain | 1.0000 |
AlphaMissense
5234 scored. Top likely-pathogenic:
| Variant | Protein change | am_pathogenicity |
|---|---|---|
| 3:100629702:T:A | C74S | 0.997 |
| 3:100629703:G:C | C74S | 0.997 |
| 3:100646637:G:C | W393C | 0.997 |
| 3:100646637:G:T | W393C | 0.997 |
| 3:100629702:T:C | C74R | 0.994 |
| 3:100629669:T:A | C63S | 0.993 |
| 3:100629670:G:C | C63S | 0.993 |
| 3:100629704:T:G | C74W | 0.991 |
| 3:100633291:T:A | C121S | 0.990 |
| 3:100633292:G:C | C121S | 0.990 |
| 3:100633293:C:G | C121W | 0.990 |
| 3:100669019:T:A | W684R | 0.990 |
| 3:100669019:T:C | W684R | 0.990 |
| 3:100629636:T:A | C52S | 0.989 |
| 3:100629637:G:C | C52S | 0.989 |
| 3:100629669:T:C | C63R | 0.989 |
| 3:100646635:T:A | W393R | 0.989 |
| 3:100646635:T:C | W393R | 0.989 |
| 3:100629703:G:T | C74F | 0.988 |
| 3:100646650:T:A | C398S | 0.988 |
| 3:100646651:G:C | C398S | 0.988 |
| 3:100646713:G:C | A419P | 0.988 |
| 3:100655082:T:A | W543R | 0.988 |
| 3:100655082:T:C | W543R | 0.988 |
| 3:100629689:G:C | W69C | 0.987 |
| 3:100629689:G:T | W69C | 0.987 |
| 3:100629703:G:A | C74Y | 0.987 |
| 3:100646616:G:C | W386C | 0.987 |
| 3:100646616:G:T | W386C | 0.987 |
| 3:100629675:T:A | C65S | 0.986 |
dbSNP variants (sampled 300 via entrez): RS1000004829 (3:100642986 T>C), RS1000028992 (3:100692017 A>G), RS1000032965 (3:100616989 T>A,C), RS1000038121 (3:100626690 T>C), RS1000057429 (3:100670061 C>G), RS1000077932 (3:100668284 G>A), RS1000190252 (3:100653010 G>A,T), RS1000204635 (3:100614739 C>A,G), RS1000253296 (3:100624515 G>T), RS1000283046 (3:100663369 A>T), RS1000315068 (3:100620275 A>G), RS1000329827 (3:100647497 A>T), RS1000394156 (3:100674471 A>G), RS1000464792 (3:100659130 T>G), RS1000473406 (3:100615023 C>T)
Disease associations
OMIM: gene MIM:612307 | disease phenotypes: MIM:189800
GenCC curated gene-disease
Mondo (1): preeclampsia (MONDO:0005081)
Orphanet (1): Preeclampsia (Orphanet:275555)
HPO phenotypes
0 total (0 of 0 shown, HPO-id order):
GWAS associations
1 associations (top):
| Study | Trait | p-value |
|---|---|---|
| GCST010002_434 | Refractive error | 5.000000e-25 |
MeSH disease descriptors (1)
| Descriptor | Name | Tree numbers |
|---|---|---|
| D011225 | Pre-Eclampsia | C12.050.703.395.249 |
Drugs & pharmacology
Drug and pharmacology data
Is drug target: no
PharmGKB: 1 entry (VIP=true, CPIC=false)
PharmGKB variants
1 variants.
| Variant | Genes | Level | Score | #Clin annots | Drugs |
|---|---|---|---|---|---|
| rs117308378 | ADGRG7 | 0.00 | 0 |
GtoPdb / IUPHAR curated pharmacology
(IUPHAR/BPS Guide to Pharmacology — expert-curated)
Target class: gpcr — Adhesion Class GPCRs
CTD chemical–gene interactions
12 total (human), top 12 by PubMed support.
| Chemical | Actions (top 5) | PubMed papers |
|---|---|---|
| Benzo(a)pyrene | decreases expression, increases methylation | 2 |
| methyleugenol | decreases expression | 1 |
| quercitrin | increases expression | 1 |
| S-(1,2-dichlorovinyl)cysteine | affects response to substance, increases expression, affects cotreatment | 1 |
| CGP 52608 | affects binding, increases reaction | 1 |
| theaflavin-3,3’-digallate | affects expression | 1 |
| Cadmium | decreases expression | 1 |
| Lipopolysaccharides | affects response to substance, increases expression, affects cotreatment | 1 |
| N-Nitrosopyrrolidine | decreases expression | 1 |
| Valproic Acid | decreases methylation | 1 |
| Aflatoxin B1 | increases methylation | 1 |
| Okadaic Acid | decreases expression | 1 |
Clinical trials (associated diseases)
300 trials via MONDO — disease-level, not drug-specific.
| Trial | Phase | Status | Title |
|---|---|---|---|
| NCT00117546 | PHASE4 | UNKNOWN | Cardiovascular and Autonomic Reactivity in Women With a History of Pre-eclampsia |
| NCT00567957 | PHASE4 | UNKNOWN | Remifentanil for General Anesthesia in Preeclamptics |
| NCT01030627 | PHASE4 | COMPLETED | Treatment Approaches to Preeclampsia |
| NCT01352234 | PHASE4 | COMPLETED | Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia |
| NCT01361425 | PHASE4 | UNKNOWN | Anti-Hypertensive Treatment In Stable Pregnant Women With Severe Pre-Eclampsia (Metildopape) |
| NCT01729468 | PHASE4 | COMPLETED | Prevention of Pre-eclampsia and SGA by Low-Dose Aspirin in Nulliparous Women With Abnormal First-trimester Uterine Artery Dopplers |
| NCT01761916 | PHASE4 | COMPLETED | Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure |
| NCT01912677 | PHASE4 | COMPLETED | Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy |
| NCT02025426 | PHASE4 | TERMINATED | Phenylephrine Versus Ephedrine in Pre-eclampsia |
| NCT02091401 | PHASE4 | COMPLETED | A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen |
| NCT02163655 | PHASE4 | COMPLETED | Diuretics for Postpartum High Blood Pressure in Preeclampsia |
| NCT02338687 | PHASE4 | COMPLETED | Low Dose Calcium to Prevent Preeclampsia |
| NCT02396030 | PHASE4 | TERMINATED | Different Schemes of Magnesium Sulfate for Preeclampsia |
| NCT02531490 | PHASE4 | UNKNOWN | Early Vascular Adjustments During Hypertensive Pregnancy |
| NCT02699827 | PHASE4 | COMPLETED | Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia |
| NCT02835339 | PHASE4 | COMPLETED | Magnesium Sulfate in Obese Preeclamptics |
| NCT02891174 | PHASE4 | COMPLETED | The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy |
| NCT02911701 | PHASE4 | COMPLETED | Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features |
| NCT03171480 | PHASE4 | COMPLETED | Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia |
| NCT03233880 | PHASE4 | UNKNOWN | Impact of Antichlamydial Treatment on the Rate of Preeclampsia |
| NCT03237000 | PHASE4 | UNKNOWN | Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preeclamptic Patients |
| NCT03506724 | PHASE4 | COMPLETED | Response to Anti-hypertensives in Pregnant and Postpartum Patients |
| NCT03674606 | PHASE4 | COMPLETED | Trial of Early Screening Test for Pre-eclampsia and Growth Restriction |
| NCT03735433 | PHASE4 | TERMINATED | The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia |
| NCT03824119 | PHASE4 | UNKNOWN | Postpartum NSAIDS and Maternal Hypertension |
| NCT04051567 | PHASE4 | UNKNOWN | Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies |
| NCT04077853 | PHASE4 | COMPLETED | Progesterone in Expectantly Managed Early-onset Preeclampsia |
| NCT04158830 | PHASE4 | WITHDRAWN | Aspirin (ASA) Therapy and Preeclampsia Prevention |
| NCT04424693 | PHASE4 | UNKNOWN | Comparing the Incidence of Preeclampsia Between Pregnant Women Receiving Tdap Vaccinations at Week 28 or at Week 36 |
| NCT04631627 | PHASE4 | UNKNOWN | Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort |
| NCT04656665 | PHASE4 | UNKNOWN | The Effectiveness of Aspirin on Preventing Pre-eclampsia |
| NCT04797949 | PHASE4 | WITHDRAWN | Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia |
| NCT04908982 | PHASE4 | UNKNOWN | Aspirin for the Prevention of Preeclampsia in Women With Stage 1 Hypertension |
| NCT05221164 | PHASE4 | UNKNOWN | 162 mg of Aspirin for Prevention of Preeclampsia |
| NCT05294952 | PHASE4 | UNKNOWN | co Ihibtory Receptor in Preeclampsia |
| NCT05514847 | PHASE4 | ACTIVE_NOT_RECRUITING | Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients |
| NCT05586373 | PHASE4 | COMPLETED | Ibuprofen vs Dipyrone After C-section in Preeclampsia |
| NCT06069102 | PHASE4 | COMPLETED | Optimal Blood Pressure Treatment Thresholds Postpartum |
| NCT06107335 | PHASE4 | NOT_YET_RECRUITING | Effect of Albumin Versus Routine Care on Hemodynamic Response and Stability in Patients With Preeclampsia Guided by a Non-invasive Hemodynamic Monitoring System During Cesarean Delivery With Spinal Anesthesia |
| NCT06281665 | PHASE4 | RECRUITING | Treatment With Aspirin After Preeclampsia: TAP Trial |
Related Atlas pages
- Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): preeclampsia