ADGRL4

Summary

ADGRL4 (adhesion G protein-coupled receptor L4, HGNC:20822) is a protein-coding gene on chromosome 1p31.1, encoding Adhesion G protein-coupled receptor L4 (Q9HBW9). Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasmic vesicle. Predicted to be active in plasma membrane. Biomarker of glioblastoma and hypertrophic cardiomyopathy.

Source: NCBI Gene 64123 — RefSeq curated summary.

At a glance

• GWAS associations: 34
• Clinical variants (ClinVar): 129 total
• Druggable target: yes
• MANE Select transcript: NM_022159

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20822
Approved symbol	ADGRL4
Name	adhesion G protein-coupled receptor L4
Location	1p31.1
Locus type	gene with protein product
Status	Approved
Aliases	ETL
Ensembl gene	ENSG00000162618
Ensembl biotype	protein_coding
OMIM	616419
Entrez	64123

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 16 protein_coding, 4 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000370742, ENST00000401034, ENST00000640664, ENST00000655029, ENST00000656204, ENST00000656300, ENST00000656841, ENST00000659100, ENST00000659463, ENST00000659905, ENST00000661030, ENST00000661361, ENST00000662530, ENST00000662640, ENST00000662895, ENST00000664452, ENST00000671209, ENST00000870761, ENST00000870762, ENST00000870763, ENST00000954023, ENST00000954024, ENST00000954025

RefSeq mRNA: 1 — MANE Select: NM_022159 NM_022159

CCDS: CCDS41352

Canonical transcript exons

ENST00000370742 — 15 exons

Exon	Start	End
ENSE00001066948	78917634	78917700
ENSE00001066955	78893098	78893189
ENSE00001066961	78891524	78891692
ENSE00001453511	78889764	78891216
ENSE00001604519	79005070	79005219
ENSE00001605048	78920183	78920386
ENSE00001614417	78938100	78938279
ENSE00001633254	78926886	78927091
ENSE00001651406	78946274	78946426
ENSE00001664982	78937807	78937990
ENSE00001685557	78936295	78936411
ENSE00001687024	78921613	78921786
ENSE00001764197	78917830	78918050
ENSE00001886600	79006633	79006730
ENSE00003887835	78939188	78939258

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 97.25.

FANTOM5 (CAGE): breadth broad, TPM avg 10.8128 / max 351.0348, expressed in 836 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
12921	9.2387	795
12923	0.8564	392
12922	0.5165	278
12925	0.1483	59
12924	0.0528	22

Top tissues by expression

278 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pericardium	UBERON:0002407	97.25	gold quality
visceral pleura	UBERON:0002401	97.18	gold quality
parietal pleura	UBERON:0002400	97.17	gold quality
pleura	UBERON:0000977	96.85	gold quality
subcutaneous adipose tissue	UBERON:0002190	96.75	gold quality
omental fat pad	UBERON:0010414	96.56	gold quality
peritoneum	UBERON:0002358	96.53	gold quality
adipose tissue of abdominal region	UBERON:0007808	96.50	gold quality
adipose tissue	UBERON:0001013	96.18	gold quality
connective tissue	UBERON:0002384	95.54	gold quality
calcaneal tendon	UBERON:0003701	94.12	gold quality
smooth muscle tissue	UBERON:0001135	91.87	gold quality
lower lobe of lung	UBERON:0008949	91.53	gold quality
gall bladder	UBERON:0002110	91.40	gold quality
vena cava	UBERON:0004087	91.35	gold quality
mammary gland	UBERON:0001911	90.83	gold quality
thoracic mammary gland	UBERON:0005200	90.83	gold quality
spleen	UBERON:0002106	90.29	gold quality
heart right ventricle	UBERON:0002080	89.89	gold quality
choroid plexus epithelium	UBERON:0003911	89.77	gold quality
right lung	UBERON:0002167	89.76	gold quality
right lobe of thyroid gland	UBERON:0001119	89.41	gold quality
skin of hip	UBERON:0001554	89.06	gold quality
periodontal ligament	UBERON:0008266	88.97	gold quality
colonic epithelium	UBERON:0000397	88.91	gold quality
left lobe of thyroid gland	UBERON:0001120	88.90	gold quality
layer of synovial tissue	UBERON:0007616	88.90	gold quality
upper lobe of lung	UBERON:0008948	88.79	gold quality
tendon	UBERON:0000043	88.69	gold quality
upper lobe of left lung	UBERON:0008952	88.60	gold quality

Single-cell (SCXA)

Detected in 25 experiment(s), a significant marker in 25.

Experiment	Marker?	Max mean expression
E-MTAB-8142	yes	1262.14
E-CURD-7	yes	1096.54
E-ENAD-21	yes	1050.25
E-HCAD-15	yes	654.32
E-ENAD-27	yes	642.85
E-MTAB-5061	yes	468.19
E-CURD-126	yes	377.05
E-MTAB-10287	yes	81.17
E-GEOD-135922	yes	47.03
E-HCAD-11	yes	47.00
E-GEOD-134144	yes	46.09
E-MTAB-10553	yes	45.68
E-HCAD-1	yes	40.94
E-HCAD-10	yes	39.13
E-MTAB-6701	yes	36.98

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

84 targeting ADGRL4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-589-3P	99.91	69.62	2088
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-139-5P	99.80	69.50	1399

Literature-anchored findings (GeneRIF, showing 13)

• Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders. (PMID:18519829)
• Results of this study strongly suggests that associative analysis was able to accurately identify ELTD1 as a putative glioma-associated biomarker (PMID:23096411)
• Two of these (D1S0818i-ELTD1 and D6S0035i-MAPK14) remain associated following application of Bonferroni’s correction and multivariate analysis. (PMID:23474535)
• Results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation. (PMID:23871637)
• miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle. (PMID:26449464)
• High ELTD1 expression is associated with glioma. (PMID:27416955)
• ELTD1 facilitates glioma proliferation, migration and invasion by activating JAK/STAT3/HIF-1alpha signaling axis. (PMID:31554859)
• Adhesion G protein-coupled receptor, ELTD1, is a potential therapeutic target for retinoblastoma migration and invasion. (PMID:33430814)
• Elevated expression of the adhesion GPCR ADGRL4/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. (PMID:33893326)
• ELTD1 deletion reduces vascular abnormality and improves T-cell recruitment after PD-1 blockade in glioma. (PMID:34347079)
• ADGRL4/ELTD1 Expression in Breast Cancer Cells Induces Vascular Normalization and Immune Suppression. (PMID:34348993)
• ELTD1 promotes invasion and metastasis by activating MMP2 in colorectal cancer. (PMID:34421349)
• ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype. (PMID:34681953)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	adgrl4	ENSDARG00000013653
mus_musculus	Adgrl4	ENSMUSG00000039167
rattus_norvegicus	Adgrl4	ENSRNOG00000033940

Paralogs (42): CALCR (ENSG00000004948), GIPR (ENSG00000010310), ADGRA2 (ENSG00000020181), CALCRL (ENSG00000064989), GLP2R (ENSG00000065325), ADGRF5 (ENSG00000069122), ADGRL1 (ENSG00000072071), ADCYAP1R1 (ENSG00000078549), SCTR (ENSG00000080293), VIPR2 (ENSG00000106018), CRHR2 (ENSG00000106113), GHRHR (ENSG00000106128), ADGRD1 (ENSG00000111452), GLP1R (ENSG00000112164), ADGRG6 (ENSG00000112414), VIPR1 (ENSG00000114812), ADGRL2 (ENSG00000117114), CRHR1 (ENSG00000120088), ADGRB2 (ENSG00000121753), ADGRE5 (ENSG00000123146), ADGRE2 (ENSG00000127507), ADGRE3 (ENSG00000131355), ADGRB3 (ENSG00000135298), PTH2R (ENSG00000144407), ADGRG7 (ENSG00000144820), ADGRL3 (ENSG00000150471), ADGRA3 (ENSG00000152990), ADGRF1 (ENSG00000153292), ADGRF4 (ENSG00000153294), ADGRG4 (ENSG00000156920), ADGRG5 (ENSG00000159618), PTH1R (ENSG00000160801), EVA1C (ENSG00000166979), ADGRF3 (ENSG00000173567), ADGRG2 (ENSG00000173698), ADGRE1 (ENSG00000174837), ADGRD2 (ENSG00000180264), ADGRB1 (ENSG00000181790), ADGRG3 (ENSG00000182885), ADGRA1 (ENSG00000197177)

Protein

Protein identifiers

Adhesion G protein-coupled receptor L4 — Q9HBW9 (reviewed: Q9HBW9)

Alternative names: EGF, latrophilin and seven transmembrane domain-containing protein 1, EGF-TM7-latrophilin-related protein

All UniProt accessions (10): A0A1W2PP07, Q9HBW9, A0A590UJ41, A0A590UJN9, A0A590UJS7, A0A590UJU5, A0A590UJX8, A0A590UK74, A0A590UK90, B1AR72

UniProt curated annotations — full annotation on UniProt →

Function. Endothelial orphan receptor that acts as a key regulator of angiogenesis.

Subunit / interactions. Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

Subcellular location. Cell membrane.

Tissue specificity. Detected in the majority of epithelial cells in tumor and normal tissues. Expressed also in human umbilical vein endothelial cells.

Post-translational modifications. Glycosylated. Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

Domain organisation. The transmembrane domain is not required for cleavage, but it is required for dimer formation.

Induction. Up-regulated in tumor endothelial cells. Up-regulated by DLL4.

Similarity. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.

RefSeq proteins (1): NP_071442* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000152	EGF-type_Asp/Asn_hydroxyl_site	PTM
IPR000203	GPS	Conserved_site
IPR000742	EGF	Domain
IPR000832	GPCR_2_secretin-like	Family
IPR001881	EGF-like_Ca-bd_dom	Domain
IPR017981	GPCR_2-like_7TM	Domain
IPR017983	GPCR_2_secretin-like_CS	Conserved_site
IPR018097	EGF_Ca-bd_CS	Conserved_site
IPR032471	AGRL2-4_GAIN_subdom_A	Domain
IPR046338	GAIN_dom_sf	Homologous_superfamily
IPR049883	NOTCH1_EGF-like	Domain
IPR057244	GAIN_B	Domain

Pfam: PF00002, PF01825, PF07645, PF16489

UniProt features (42 total): glycosylation site 9, topological domain 8, disulfide bond 8, transmembrane region 7, domain 3, sequence variant 3, signal peptide 1, chain 1, region of interest 1, site 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
9QXL	ELECTRON MICROSCOPY	3.14

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HBW9-F1	81.09	0.27

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 406–407 (cleavage; by autolysis)

Disulfide bonds (8): 22–33, 27–42, 44–56, 62–75, 69–84, 86–107, 370–401, 389–403

Glycosylation sites (9): 21, 64, 74, 127, 177, 188, 249, 381, 395

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 126 (showing top): GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP, PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_UP, CUI_TCF21_TARGETS_2_DN, BOQUEST_STEM_CELL_DN, SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_UP, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, SENESE_HDAC1_AND_HDAC2_TARGETS_UP, MODULE_470, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, WONG_ADULT_TISSUE_STEM_MODULE, FIGUEROA_AML_METHYLATION_CLUSTER_6_DN, CHYLA_CBFA2T3_TARGETS_UP, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, PRC2_EED_DN.V1_UP

GO Biological Process (3): cell surface receptor signaling pathway (GO:0007166), G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)

GO Molecular Function (3): G protein-coupled receptor activity (GO:0004930), calcium ion binding (GO:0005509), transmembrane signaling receptor activity (GO:0004888)

GO Cellular Component (3): plasma membrane (GO:0005886), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
signal transduction	2
G protein-coupled receptor activity	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
metal ion binding	1
signaling receptor activity	1
membrane	1
cell periphery	1
cellular anatomical structure	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

930 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ADGRL4	EDNRA	P25101	575
ADGRL4	SCT	P09683	561
ADGRL4	DLL4	Q9NR61	555
ADGRL4	EDNRB	P24530	552
ADGRL4	PTGFR	P43088	480
ADGRL4	MIGA1	Q8NAN2	475
ADGRL4	MYCT1	Q8N699	462
ADGRL4	ANKRD29	Q8N6D5	455
ADGRL4	EMCN	Q9ULC0	454
ADGRL4	IFI44	Q8TCB0	438
ADGRL4	TEX9	Q8N6V9	404
ADGRL4	EDN1	P05305	400
ADGRL4	ZZZ3	Q8IYH5	400
ADGRL4	CCDC117	Q8IWD4	390
ADGRL4	C10orf88	Q9H8K7	382

IntAct

2 interactions, top by confidence:

A	B	Type	Score
	NPC1	psi-mi:“MI:0914”(association)	0.350

BioGRID (2): ELTD1 (Synthetic Lethality), ELTD1 (Affinity Capture-Western)

ESM2 similar proteins: A6QP74, O08893, O35659, O97148, P23811, P25107, P25117, P30082, P30083, P30988, P32214, P32215, P32241, P32301, P35000, P35464, P41586, P41587, P41588, P43220, P49190, P70205, P70555, P79222, P83120, Q09460, Q0P4Y4, Q16602, Q28992, Q29627, Q5FWI2, Q60755, Q63118, Q68EK2, Q7ZXS8, Q8AXU4, Q8WN93, Q90308, Q91085, Q91V95

Diamond homologs: A6QLU6, C0HL12, D4A3T6, E9Q4J9, G5ECX0, G5EDW2, O14514, O35161, O60242, O88278, O88917, O88923, O94910, O95490, O97817, O97827, O97831, P30083, P48960, Q14246, Q2Q421, Q2Q426, Q3UHD1, Q54MC6, Q58Y75, Q59I63, Q5T601, Q5Y4N8, Q61549, Q6F3F9, Q6QNK2, Q7SY09, Q7Z7M1, Q80T32, Q80TR1, Q80TS3, Q80ZF8, Q86SQ3, Q86SQ4, Q8IZF2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

129 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	106
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2480 predictions. Top by Δscore:

Variant	Effect	Δscore
1:78891217:C:CC	acceptor_gain	1.0000
1:78891217:CTAA:C	acceptor_loss	1.0000
1:78891218:T:A	acceptor_loss	1.0000
1:78891562:T:TA	donor_gain	1.0000
1:78891563:C:A	donor_gain	1.0000
1:78891564:C:A	donor_gain	1.0000
1:78917825:CTTA:C	donor_loss	1.0000
1:78917827:TA:T	donor_loss	1.0000
1:78917828:A:AC	donor_gain	1.0000
1:78917828:ACAC:A	donor_loss	1.0000
1:78917829:C:CG	donor_gain	1.0000
1:78917829:CA:C	donor_gain	1.0000
1:78917829:CACT:C	donor_gain	1.0000
1:78917829:CACTT:C	donor_gain	1.0000
1:78918046:AAGAG:A	acceptor_gain	1.0000
1:78918047:AGAG:A	acceptor_gain	1.0000
1:78918048:GAG:G	acceptor_gain	1.0000
1:78918048:GAGCT:G	acceptor_loss	1.0000
1:78918049:AG:A	acceptor_gain	1.0000
1:78918049:AGCTA:A	acceptor_loss	1.0000
1:78918050:GCTAG:G	acceptor_loss	1.0000
1:78918051:C:CC	acceptor_gain	1.0000
1:78918051:CTAGA:C	acceptor_loss	1.0000
1:78918059:C:CT	acceptor_gain	1.0000
1:78918060:A:T	acceptor_gain	1.0000
1:78938094:A:AC	donor_gain	1.0000
1:78938095:C:CC	donor_gain	1.0000
1:78938096:TTA:T	donor_loss	1.0000
1:78938097:TA:T	donor_loss	1.0000
1:78938098:A:AC	donor_gain	1.0000

AlphaMissense

4563 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:78891643:A:G	W631R	1.000
1:78891643:A:T	W631R	1.000
1:78917993:A:G	W507R	1.000
1:78917993:A:T	W507R	1.000
1:78891565:C:A	G657W	0.999
1:78891565:C:G	G657R	0.999
1:78891565:C:T	G657R	0.999
1:78891587:G:C	F649L	0.999
1:78891587:G:T	F649L	0.999
1:78891589:A:G	F649L	0.999
1:78893184:A:C	N585K	0.999
1:78893184:A:T	N585K	0.999
1:78917661:A:C	F574L	0.999
1:78917661:A:T	F574L	0.999
1:78917663:A:G	F574L	0.999
1:78917664:A:C	S573R	0.999
1:78917664:A:T	S573R	0.999
1:78917666:T:G	S573R	0.999
1:78917694:C:A	W563C	0.999
1:78917694:C:G	W563C	0.999
1:78917696:A:G	W563R	0.999
1:78917696:A:T	W563R	0.999
1:78917699:A:G	C562R	0.999
1:78917890:G:C	P541R	0.999
1:78917890:G:T	P541Q	0.999
1:78917892:G:C	S540R	0.999
1:78917892:G:T	S540R	0.999
1:78917894:T:G	S540R	0.999
1:78917902:C:T	G537D	0.999
1:78917968:A:G	L515P	0.999

dbSNP variants (sampled 300 via entrez): RS1000010971 (1:78901233 T>A), RS1000093521 (1:78980527 T>C), RS1000097858 (1:78932948 A>T), RS1000113063 (1:79000908 C>A), RS1000118557 (1:78963583 T>A), RS1000143808 (1:78984218 T>A), RS1000150551 (1:78935803 A>C), RS1000181936 (1:78923389 C>T), RS1000198781 (1:78974686 T>C), RS1000203982 (1:78895267 G>A), RS1000233555 (1:78953388 G>C), RS1000292984 (1:78968840 G>A,C), RS1000312197 (1:78907046 A>C,G,T), RS1000350607 (1:78968675 G>A,T), RS1000372134 (1:78929878 G>A,T)

Disease associations

OMIM: gene MIM:616419 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

34 associations (top):

Study	Trait	p-value
GCST001166_6	Aging (time to event)	4.000000e-06
GCST001877_8	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)	4.000000e-06
GCST002829_2	Urate levels in overweight individuals	9.000000e-06
GCST002987_15	Stroke	7.000000e-07
GCST003659_7	Modified Stumvoll Insulin Sensitivity Index (BMI interaction)	8.000000e-09
GCST004001_9	Bipolar disorder or attention deficit hyperactivity disorder	4.000000e-07
GCST004002_5	Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder	2.000000e-06
GCST004613_51	Sum neutrophil eosinophil counts	2.000000e-11
GCST004614_113	Granulocyte count	3.000000e-11
GCST004620_1	Sum basophil neutrophil counts	4.000000e-10
GCST004626_60	Myeloid white cell count	1.000000e-11
GCST004629_9	Neutrophil count	3.000000e-10
GCST004632_90	Lymphocyte percentage of white cells	7.000000e-09
GCST005212_14	Asthma	5.000000e-06
GCST006606_5	Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count)	2.000000e-11
GCST006609_6	Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count)	8.000000e-06
GCST006904_14	Cerebral amyloid deposition (PET imaging)	8.000000e-06
GCST007576_154	Chronotype	3.000000e-10
GCST010396_39	Gut microbiota (bacterial taxa, hurdle binary method)	4.000000e-06
GCST011741_72	LDL cholesterol levels in HIV infection	4.000000e-06
GCST011741_8	LDL cholesterol levels in HIV infection	4.000000e-06
GCST90000025_930	Appendicular lean mass	2.000000e-09
GCST90002381_577	Eosinophil count	5.000000e-17
GCST90002383_327	Hematocrit	2.000000e-12
GCST90002384_2	Hemoglobin	2.000000e-09
GCST90002388_649	Lymphocyte count	1.000000e-11
GCST90002389_57	Lymphocyte percentage of white cells	4.000000e-27
GCST90002393_34	Monocyte count	5.000000e-12
GCST90002395_309	Mean platelet volume	5.000000e-09
GCST90002398_486	Neutrophil count	3.000000e-23

EFO canonical traits (23, from GWAS)

EFO ID	Trait name
EFO:0022597	aging
EFO:0004531	urate measurement
EFO:0004340	body mass index
EFO:0004471	insulin sensitivity measurement
EFO:0004833	neutrophil count
EFO:0004842	eosinophil count
EFO:0007987	granulocyte count
EFO:0005090	basophil count
EFO:0007993	lymphocyte percentage of leukocytes
EFO:0004653	response to TNF antagonist
EFO:0005413	joint damage measurement
EFO:0007707	cerebral amyloid deposition measurement
EFO:0008328	chronotype measurement
EFO:0007874	gut microbiome measurement
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0004980	appendicular lean mass
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement
EFO:0004587	lymphocyte count
EFO:0005091	monocyte count
EFO:0007990	neutrophil percentage of leukocytes
EFO:0004305	erythrocyte count
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523920 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Adhesion Class GPCRs

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	7
bisphenol A	affects cotreatment, decreases methylation, increases expression	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
methylmercuric chloride	increases expression	1
ethyl-p-hydroxybenzoate	increases expression	1
trichostatin A	increases expression	1
cobaltous chloride	decreases expression	1
brequinar	increases expression	1
perfluorooctane sulfonic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases methylation	1
Sunitinib	decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Carbamazepine	affects expression	1
Diethylhexyl Phthalate	increases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, increases expression	1
Thiram	increases expression	1
Tretinoin	increases expression	1
Zinc	decreases expression	1
Sodium Selenite	increases expression	1
Particulate Matter	increases abundance, decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883367	Binding	PRESTO-Tango GPCRome screening (ELTD1)	Data for DCP probe UCSF924

Cellosaurus cell lines

1 cell lines: 1 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A8ZW	FAHZUe001-A	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.