ADIRF-AS1

Summary

ADIRF-AS1 (ADIRF antisense RNA 1, HGNC:45127) is a long non-coding RNA gene on chromosome 10q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45127
Approved symbol	ADIRF-AS1
Name	ADIRF antisense RNA 1
Location	10q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000272734
Ensembl biotype	lncRNA
Entrez	100133190
RNAcentral	URS000212321C — lncRNA, 1998 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 lncRNA, 1 retained_intron

ENST00000418273, ENST00000440490, ENST00000609111, ENST00000609170, ENST00000725869, ENST00000725870

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418273 — 3 exons

Exon	Start	End
ENSE00001597214	86969263	86971311
ENSE00001745966	86965740	86966237
ENSE00001776156	86969042	86969121

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 93.70.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.2449 / max 75.2944, expressed in 1013 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110424	2.2449	1013

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of leg	UBERON:0001511	93.70	gold quality
skin of abdomen	UBERON:0001416	93.19	gold quality
left testis	UBERON:0004533	91.29	gold quality
tibial artery	UBERON:0007610	91.15	gold quality
popliteal artery	UBERON:0002250	91.13	gold quality
right testis	UBERON:0004534	90.99	gold quality
mucosa of stomach	UBERON:0001199	90.78	gold quality
right uterine tube	UBERON:0001302	89.68	gold quality
zone of skin	UBERON:0000014	89.60	gold quality
left ovary	UBERON:0002119	88.78	gold quality
sural nerve	UBERON:0015488	88.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.54	gold quality
tibial nerve	UBERON:0001323	88.50	gold quality
aorta	UBERON:0000947	87.97	gold quality
left lobe of thyroid gland	UBERON:0001120	87.80	gold quality
right lung	UBERON:0002167	87.71	gold quality
right adrenal gland cortex	UBERON:0035827	87.24	gold quality
testis	UBERON:0000473	87.00	gold quality
ectocervix	UBERON:0012249	86.99	gold quality
thyroid gland	UBERON:0002046	86.86	gold quality
right adrenal gland	UBERON:0001233	86.76	gold quality
tibialis anterior	UBERON:0001385	86.73	silver quality
right ovary	UBERON:0002118	86.47	gold quality
left adrenal gland cortex	UBERON:0035825	86.23	gold quality
descending thoracic aorta	UBERON:0002345	85.98	gold quality
left uterine tube	UBERON:0001303	85.83	gold quality
endocervix	UBERON:0000458	85.63	gold quality
body of uterus	UBERON:0009853	85.47	gold quality
left adrenal gland	UBERON:0001234	84.69	gold quality
right lobe of thyroid gland	UBERON:0001119	84.51	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	11799.53
E-ANND-3	yes	25.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761. (PMID:35030964)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.