ADORA2A-AS1

Summary

ADORA2A-AS1 (ADORA2A antisense RNA 1, HGNC:37122) is a long non-coding RNA gene on chromosome 22q11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37122
Approved symbol	ADORA2A-AS1
Name	ADORA2A antisense RNA 1
Location	22q11.23
Locus type	RNA, long non-coding
Status	Approved
Aliases	FLJ34651, hLinfRNA1
Ensembl gene	ENSG00000178803
Ensembl biotype	lncRNA
Entrez	646023
RNAcentral	URS00008E39D5 — lncRNA, 2052 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 15 lncRNA

ENST00000326341, ENST00000412790, ENST00000427813, ENST00000650766, ENST00000720893, ENST00000720894, ENST00000720895, ENST00000720896, ENST00000720897, ENST00000720898, ENST00000720899, ENST00000720900, ENST00000720901, ENST00000720902, ENST00000720903

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000326341 — 7 exons

Exon	Start	End
ENSE00001248991	24430897	24431562
ENSE00001425133	24429206	24430364
ENSE00001618254	24471768	24471895
ENSE00001628564	24494690	24494800
ENSE00001725037	24474983	24475153
ENSE00001796475	24441992	24442140
ENSE00002037662	24432262	24432434

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 88.64.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1346 / max 29.0545, expressed in 31 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
193373	0.1074	27
193372	0.0213	10
193362	0.0059	4

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right lobe of liver	UBERON:0001114	88.64	gold quality
liver	UBERON:0002107	82.05	gold quality
left testis	UBERON:0004533	82.05	gold quality
right testis	UBERON:0004534	81.77	gold quality
testis	UBERON:0000473	79.20	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.85	gold quality
bone marrow cell	CL:0002092	75.58	gold quality
jejunal mucosa	UBERON:0000399	75.26	gold quality
adult mammalian kidney	UBERON:0000082	72.91	gold quality
colonic epithelium	UBERON:0000397	71.30	silver quality
kidney	UBERON:0002113	68.59	gold quality
sperm	CL:0000019	67.69	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	67.21	gold quality
metanephros cortex	UBERON:0010533	66.27	gold quality
cortex of kidney	UBERON:0001225	66.08	gold quality
sural nerve	UBERON:0015488	63.68	silver quality
right atrium auricular region	UBERON:0006631	63.54	gold quality
cardiac atrium	UBERON:0002081	62.68	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.27	gold quality
cortical plate	UBERON:0005343	61.38	gold quality
cerebellar cortex	UBERON:0002129	61.25	gold quality
cerebellar hemisphere	UBERON:0002245	61.20	gold quality
ventricular zone	UBERON:0003053	61.16	gold quality
blood	UBERON:0000178	60.46	gold quality
cerebellum	UBERON:0002037	59.94	gold quality
jejunum	UBERON:0002115	59.57	silver quality
cerebellar vermis	UBERON:0004720	59.50	gold quality
ganglionic eminence	UBERON:0004023	59.38	gold quality
vermiform appendix	UBERON:0001154	58.88	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.97

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• C22orf45 is a novel human-specific protein-coding gene. (PMID:19726446)
• Knockdown of ADORA2A antisense RNA 1 inhibits cell proliferation and enhances imatinib sensitivity in chronic myeloid leukemia. (PMID:35034552)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.