ADPGK-AS1

Summary

ADPGK-AS1 (ADPGK antisense RNA 1, HGNC:44144) is a long non-coding RNA gene on chromosome 15q24.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44144
Approved symbol	ADPGK-AS1
Name	ADPGK antisense RNA 1
Location	15q24.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000260898
Ensembl biotype	lncRNA
Entrez	100287559
RNAcentral	URS00004A7F77 — lncRNA, 2730 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000563592, ENST00000566745, ENST00000670622, ENST00000733802, ENST00000733803, ENST00000733804, ENST00000733805, ENST00000733806, ENST00000733807, ENST00000733808

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000563592 — 3 exons

Exon	Start	End
ENSE00002611248	72787422	72787593
ENSE00002621762	72782835	72785196
ENSE00002629328	72798004	72798199

Expression profiles

Bgee: expression breadth ubiquitous, 127 present calls, max score 78.07.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6077 / max 171.6274, expressed in 264 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
147589	0.8947	221
147590	0.7130	182

Top tissues by expression

127 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.07	gold quality
bone marrow cell	CL:0002092	71.38	gold quality
granulocyte	CL:0000094	71.23	gold quality
bone marrow	UBERON:0002371	70.66	gold quality
monocyte	CL:0000576	68.63	gold quality
leukocyte	CL:0000738	68.07	gold quality
right testis	UBERON:0004534	67.22	gold quality
testis	UBERON:0000473	66.68	gold quality
left testis	UBERON:0004533	66.33	gold quality
skeletal muscle tissue	UBERON:0001134	64.85	silver quality
anterior cingulate cortex	UBERON:0009835	62.17	gold quality
cortical plate	UBERON:0005343	61.97	gold quality
ganglionic eminence	UBERON:0004023	61.87	gold quality
putamen	UBERON:0001874	61.79	gold quality
sural nerve	UBERON:0015488	60.99	gold quality
nucleus accumbens	UBERON:0001882	60.61	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.55	gold quality
primary visual cortex	UBERON:0002436	59.88	gold quality
caudate nucleus	UBERON:0001873	59.69	gold quality
cerebral cortex	UBERON:0000956	59.25	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.99	silver quality
prefrontal cortex	UBERON:0000451	58.87	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.55	gold quality
frontal cortex	UBERON:0001870	58.48	gold quality
right frontal lobe	UBERON:0002810	58.27	gold quality
blood	UBERON:0000178	58.12	gold quality
amygdala	UBERON:0001876	58.12	gold quality
temporal lobe	UBERON:0001871	58.01	gold quality
brain	UBERON:0000955	57.12	gold quality
hypothalamus	UBERON:0001898	56.62	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	5.71
E-ANND-3	no	1.55

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• MiR-205-5p was low-expressed while ZEB1 and ADPGK-AS1 were high-expressed in pancreatic cancer (PC) tissues and cells. ADPGK-AS1 could directly target miR-205-5p and miR-205-5p could directly target ZEB1 3’UTR. MiR-205-5p expression negatively correlated with proliferation, migration and invasion, and positively correlated with apoptosis rate of PC cells, while ZEB1 and ADPGK-AS1 had an inversed effect. (PMID:29667486)
• ADPGK-AS1 promotes gastric cancer (GC) progression and is associated with GC prognosis. DPGK-AS1 sponges miR-3196 to deregulate KDM1B in GC. (PMID:30944080)
• LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma. (PMID:31696461)
• ADPGK-AS1 long noncoding RNA switches macrophage metabolic and phenotypic state to promote lung cancer growth. (PMID:37545364)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.