ADTRP

Summary

ADTRP (androgen dependent TFPI regulating protein, HGNC:21214) is a protein-coding gene on chromosome 6p24.1, encoding Androgen-dependent TFPI-regulating protein (Q96IZ2). Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids.

Enables hydrolase activity. Involved in several processes, including cell migration involved in sprouting angiogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; and negative regulation of secretion by cell. Located in caveola and cell surface.

Source: NCBI Gene 84830 — RefSeq curated summary.

At a glance

• GWAS associations: 22
• Clinical variants (ClinVar): 57 total — 12 pathogenic
• MANE Select transcript: NM_032744

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21214
Approved symbol	ADTRP
Name	androgen dependent TFPI regulating protein
Location	6p24.1
Locus type	gene with protein product
Status	Approved
Aliases	dJ413H6.1, AIG1L
Ensembl gene	ENSG00000111863
Ensembl biotype	protein_coding
OMIM	614348
Entrez	84830

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 6 protein_coding, 3 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000229583, ENST00000379415, ENST00000414691, ENST00000485323, ENST00000503285, ENST00000505099, ENST00000506810, ENST00000512139, ENST00000513651, ENST00000514824, ENST00000894491

RefSeq mRNA: 2 — MANE Select: NM_032744 NM_001143948, NM_032744

CCDS: CCDS4521, CCDS47374

Canonical transcript exons

ENST00000414691 — 6 exons

Exon	Start	End
ENSE00001844667	11778607	11778803
ENSE00001858441	11713523	11714512
ENSE00003477093	11723349	11723500
ENSE00003519109	11768249	11768383
ENSE00003590997	11766274	11766375
ENSE00003784748	11735568	11735683

Expression profiles

Bgee: expression breadth ubiquitous, 228 present calls, max score 98.00.

FANTOM5 (CAGE): breadth broad, TPM avg 5.4894 / max 337.7836, expressed in 329 samples.

FANTOM5 promoters (16 alternative TSS)

Promoter ID	TPM avg	Samples expressed
71767	3.2331	176
71766	0.7254	101
71749	0.6036	66
71751	0.2165	51
71752	0.1707	46
71750	0.1396	43
71768	0.0816	55
71770	0.0754	36
71772	0.0640	14
71769	0.0478	26

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.00	gold quality
mucosa of transverse colon	UBERON:0004991	97.84	gold quality
jejunal mucosa	UBERON:0000399	97.56	gold quality
pigmented layer of retina	UBERON:0001782	97.55	gold quality
colonic mucosa	UBERON:0000317	96.57	gold quality
rectum	UBERON:0001052	96.44	gold quality
mucosa of sigmoid colon	UBERON:0004993	95.99	gold quality
male germ cell	CL:0000015	94.78	gold quality
upper leg skin	UBERON:0004262	94.33	gold quality
ileal mucosa	UBERON:0000331	93.03	gold quality
duodenum	UBERON:0002114	92.99	gold quality
seminal vesicle	UBERON:0000998	90.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	89.55	gold quality
mammalian vulva	UBERON:0000997	89.49	gold quality
small intestine	UBERON:0002108	88.65	gold quality
skin of abdomen	UBERON:0001416	88.34	gold quality
corpus epididymis	UBERON:0004359	88.29	gold quality
transverse colon	UBERON:0001157	87.91	gold quality
left testis	UBERON:0004533	86.98	gold quality
palpebral conjunctiva	UBERON:0001812	86.73	gold quality
right testis	UBERON:0004534	86.58	gold quality
zone of skin	UBERON:0000014	85.53	gold quality
buccal mucosa cell	CL:0002336	85.21	gold quality
testis	UBERON:0000473	85.19	gold quality
skin of leg	UBERON:0001511	84.62	gold quality
vermiform appendix	UBERON:0001154	84.18	gold quality
cartilage tissue	UBERON:0002418	83.68	gold quality
caecum	UBERON:0001153	83.22	gold quality
colonic epithelium	UBERON:0000397	82.71	gold quality
body of stomach	UBERON:0001161	82.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.83

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

2 targets.

Target	Regulation
MIA3	Activation
TFPI	Activation

miRNA regulators (miRDB)

46 targeting ADTRP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-548D-3P	99.87	70.67	4362
HSA-MIR-548BB-3P	99.86	70.58	4354
HSA-MIR-548AC	99.84	70.77	4351
HSA-MIR-548H-3P	99.84	70.80	4349
HSA-MIR-548Z	99.84	70.80	4349
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-4659A-3P	99.80	72.62	4248
HSA-MIR-4659B-3P	99.80	72.62	4248
HSA-MIR-6817-3P	99.79	68.35	2126
HSA-MIR-513C-5P	99.50	68.42	1730
HSA-MIR-514B-5P	99.50	68.19	1766
HSA-MIR-6165	99.44	67.12	1389
HSA-MIR-183-3P	99.41	69.41	1598
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-4667-3P	99.26	65.45	1608
HSA-MIR-3978	99.24	68.39	2201
HSA-MIR-122B-3P	99.21	68.90	1333
HSA-MIR-21-3P	99.21	68.95	1312

Literature-anchored findings (GeneRIF, showing 14)

• This study confirms ADTRP expression and colocalization with TFPI and caveolin-1 in endothelial cell. (PMID:21868574)
• The single nucleotide polymorphism rs6903956 within the ADTRP gene on chromosome 6p24.1 is significantly associated with coronary artery disease in different ethnic groups of the Singaporean population. (PMID:23337689)
• ADTRP polymorphism is associated with the development of coronary atherosclerosis. (PMID:24573017)
• Activation of PPARG increases the expression of C6ORF105 in human macrophages and atherosclerotic lesions. (PMID:25595457)
• SNP rs6903956 associated with asymptomatic hyperuricemia susceptibility in Han Chinese (PMID:25928384)
• association of ADTRP with the pathogenesis of early-onset CAD (PMID:26375920)
• These results indicate that AIG1 and ADTRP are founding members of an evolutionarily conserved class of transmembrane threonine hydrolases involved in bioactive lipid metabolism. (PMID:27018888)
• ADTRP increases the number of S phase cells during cell cycle. (PMID:27235449)
• ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. (PMID:28341552)
• These data suggest that one molecular mechanism by which androgen confers protection against coronary artery disease is stimulation of ADTRP expression. (PMID:28645652)
• Data identify POU1F1 as a transcription factor that regulates TFPI transcription in response to ADTRP, and link POU1F1 variants to risk of CAD for the first time. (PMID:32445923)
• Detection of ADTRP in circulation and its role as a novel biomarker for coronary artery disease. (PMID:32790694)
• GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through preferential interaction with the G allele. (PMID:33856550)
• Androgen-dependent tissue factor pathway inhibitor regulating protein: a review of its peripheral actions and association with cardiometabolic diseases. (PMID:34797389)

Cross-species orthologs

10 orthologs

Organism	Symbol	Gene ID
danio_rerio	adtrp	ENSDARG00000086114
mus_musculus	Adtrp	ENSMUSG00000058022
rattus_norvegicus	Adtrp	ENSRNOG00000014481
drosophila_melanogaster	CG11601	FBGN0031244
drosophila_melanogaster	CG3625	FBGN0031245
drosophila_melanogaster	CG6149	FBGN0036158
caenorhabditis_elegans		WBGENE00007068
caenorhabditis_elegans		WBGENE00007994
caenorhabditis_elegans		WBGENE00007995
caenorhabditis_elegans		WBGENE00304175

Paralogs (1): AIG1 (ENSG00000146416)

Protein

Protein identifiers

Androgen-dependent TFPI-regulating protein — Q96IZ2 (reviewed: Q96IZ2)

Alternative names: Fatty acid esters of hydroxy fatty acids hydrolase ADTRP

All UniProt accessions (5): Q96IZ2, D6R9A9, D6RDG9, H0Y9P4, H0YAA5

UniProt curated annotations — full annotation on UniProt →

Function. Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids. Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids. Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro).

Subcellular location. Cell membrane.

Tissue specificity. Expressed in cultured endothelial cells and in placenta.

Activity regulation. Inhibited by N-hydroxyhydantoin carbamate JJH260 and beta-lactone KC01.

Induction. By androgens.

Similarity. Belongs to the AIG1 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q96IZ2-1	1	yes
Q96IZ2-2	2
Q96IZ2-3	3

RefSeq proteins (2): NP_001137420, NP_116133* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR006838	ADTRP_AIG1	Family

Pfam: PF04750

Catalyzed reactions (Rhea), 12 shown:

• 9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+) (RHEA:52048)
• 9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+) (RHEA:52052)
• 12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+) (RHEA:52056)
• 12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+) (RHEA:52060)
• 13-(9Z-octadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+) (RHEA:52064)
• 9-(9Z-hexadecenoyloxy)-octadecanoate + H2O = (9Z)-hexadecenoate + 9-hydroxy-octadecanoate + H(+) (RHEA:52068)
• 12-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-hexadecenoate + H(+) (RHEA:52072)
• 13-(9Z-hexadecenoyloxy)-octadecanoate + H2O = 13-hydroxy-octadecanoate + (9Z)-hexadecenoate + H(+) (RHEA:52076)
• 12-octadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + octadecanoate + H(+) (RHEA:52080)
• 13-octadecanoyloxy-octadecanoate + H2O = 13-hydroxy-octadecanoate + octadecanoate + H(+) (RHEA:52084)
• 9-octadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + octadecanoate + H(+) (RHEA:52096)
• 5-(9Z-octadecenoyloxy)-octadecanoate + H2O = 5-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+) (RHEA:52100)

UniProt features (21 total): topological domain 7, transmembrane region 6, site 2, splice variant 2, mutagenesis site 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96IZ2-F1	90.99	0.82

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 47 (important for catalytic activity); 131 (important for catalytic activity)

Mutagenesis-validated functional residues (2):

Position	Phenotype
47	loss of hydrolase activity.
131	loss of hydrolase activity.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (13): cell migration involved in sprouting angiogenesis (GO:0002042), negative regulation of leukocyte migration (GO:0002686), negative regulation of extracellular matrix constituent secretion (GO:0003332), positive regulation of gene expression (GO:0010628), negative regulation of blood coagulation (GO:0030195), long-chain fatty acid catabolic process (GO:0042758), negative regulation of protein secretion (GO:0050709), positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897), cellular response to steroid hormone stimulus (GO:0071383), cellular response to oxidised low-density lipoprotein particle stimulus (GO:0140052), negative regulation of leukocyte cell-cell adhesion (GO:1903038), negative regulation of lymphocyte migration (GO:2000402), lipid metabolic process (GO:0006629)

GO Molecular Function (2): hydrolase activity (GO:0016787), protein binding (GO:0005515)

GO Cellular Component (5): caveola (GO:0005901), cell surface (GO:0009986), endomembrane system (GO:0012505), membrane (GO:0016020), plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
negative regulation of secretion by cell	2
sprouting angiogenesis	1
blood vessel endothelial cell migration	1
negative regulation of immune system process	1
regulation of leukocyte migration	1
negative regulation of cell migration	1
leukocyte migration	1
regulation of extracellular matrix constituent secretion	1
extracellular matrix constituent secretion	1
negative regulation of extracellular matrix organization	1
gene expression	1
regulation of gene expression	1
positive regulation of macromolecule biosynthetic process	1
blood coagulation	1
regulation of blood coagulation	1
negative regulation of coagulation	1
negative regulation of wound healing	1
negative regulation of hemostasis	1
long-chain fatty acid metabolic process	1
fatty acid catabolic process	1
protein secretion	1
regulation of protein secretion	1
negative regulation of protein transport	1
phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1
positive regulation of intracellular signal transduction	1
cellular response to hormone stimulus	1
response to steroid hormone	1
cellular response to lipid	1
cellular response to low-density lipoprotein particle stimulus	1
leukocyte cell-cell adhesion	1
negative regulation of cell-cell adhesion	1
regulation of leukocyte cell-cell adhesion	1
negative regulation of mononuclear cell migration	1
lymphocyte migration	1
regulation of lymphocyte migration	1
primary metabolic process	1
catalytic activity	1
binding	1

Protein interactions and networks

STRING

446 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ADTRP	ZNF202	O95125	618
ADTRP	TFPI	P10646	519
ADTRP	TTC32	Q5I0X7	507
ADTRP	MIA3	Q5JRA6	506
ADTRP	SCN3B	Q9NY72	504
ADTRP	STK32B	Q9NY57	497
ADTRP	TRMO	Q9BU70	495
ADTRP	TBX10	O75333	493
ADTRP	EVC2	Q86UK5	492
ADTRP	STX18	Q9P2W9	492
ADTRP	CRMP1	Q14194	491
ADTRP	HEMGN	Q9BXL5	491
ADTRP	WNT11	O96014	490
ADTRP	SATB2	Q9UPW6	469
ADTRP	ADH1C	P00326	466

IntAct

11 interactions, top by confidence:

A	B	Type	Score
CMTM7	ADTRP	psi-mi:“MI:0915”(physical association)	0.560
TMED8	ADTRP	psi-mi:“MI:0915”(physical association)	0.560
ADTRP	CREB3	psi-mi:“MI:0915”(physical association)	0.370
ADTRP	VTN	psi-mi:“MI:0915”(physical association)	0.370
ADTRP	S100B	psi-mi:“MI:0915”(physical association)	0.370
CREB3	ADTRP	psi-mi:“MI:0915”(physical association)	0.370
TMED8	ADTRP	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (6): ADTRP (Two-hybrid), ADTRP (Two-hybrid), ADTRP (Two-hybrid), CMTM7 (Two-hybrid), ADTRP (Affinity Capture-MS), VTN (Two-hybrid)

ESM2 similar proteins: A0JNC4, A1L3X0, A6ZSP9, B4QVX4, D4ADY9, G5ED45, G5EEE5, I1MSF2, O13752, O35949, O59735, P25358, P38703, P39540, P40319, P49191, Q03574, Q20300, Q20303, Q4D321, Q4D5J7, Q4DHY2, Q4DHY3, Q4DUK4, Q4DUK7, Q4QJ85, Q54CJ4, Q54TC9, Q555E8, Q57UP6, Q57UP7, Q57UP8, Q57X51, Q5GKZ7, Q5M828, Q60534, Q7Z139, Q86JM5, Q8C138, Q96IZ2

Diamond homologs: Q5M828, Q60534, Q8C138, Q96IZ2, Q9D8B1, Q9NVV5

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	12
Likely pathogenic	0
Uncertain significance	33
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (12)

Variant ID	HGVS	Classification
154343	GRCh38/hg38 6p24.2-23(chr6:10601499-13987316)x1	Pathogenic
154368	GRCh38/hg38 6p25.2-22.3(chr6:2862640-16697788)x1	Pathogenic
155267	GRCh38/hg38 6p25.3-23(chr6:152634-14417003)x3	Pathogenic
155715	GRCh38/hg38 6p25.3-23(chr6:156974-13855925)x1	Pathogenic
1810398	GRCh37/hg19 6p25.3-22.3(chr6:820000-21700000)x3	Pathogenic
253430	GRCh37/hg19 6p25.1-22.3(chr6:5354402-17950079)x1	Pathogenic
2684439	GRCh37/hg19 6p25.3-22.3(chr6:156975-15478095)x3	Pathogenic
560067	Single allele	Pathogenic
563139	GRCh37/hg19 6p25.3-23(chr6:156974-13502033)x3	Pathogenic
563140	GRCh37/hg19 6p25.3-22.3(chr6:156974-21955964)x3	Pathogenic
58124	GRCh38/hg38 6p25.3-22.3(chr6:106431-18360595)x3	Pathogenic
687409	GRCh37/hg19 6p25.3-22.3(chr6:156974-23221621)x3	Pathogenic

SpliceAI

1042 predictions. Top by Δscore:

Variant	Effect	Δscore
6:11735567:CCGG:C	donor_gain	1.0000
6:11735680:TGTG:T	acceptor_gain	1.0000
6:11766371:ACAAA:A	acceptor_gain	1.0000
6:11766372:CAAA:C	acceptor_gain	1.0000
6:11766372:CAAAC:C	acceptor_gain	1.0000
6:11766373:AAA:A	acceptor_gain	1.0000
6:11766374:AA:A	acceptor_gain	1.0000
6:11766375:ACT:A	acceptor_loss	1.0000
6:11766376:C:CC	acceptor_gain	1.0000
6:11766376:CTG:C	acceptor_loss	1.0000
6:11766383:A:AC	acceptor_gain	1.0000
6:11766383:A:C	acceptor_gain	1.0000
6:11768242:AACTT:A	donor_loss	1.0000
6:11768243:ACTT:A	donor_loss	1.0000
6:11768244:CTTAC:C	donor_loss	1.0000
6:11768245:TTACC:T	donor_loss	1.0000
6:11768246:TA:T	donor_loss	1.0000
6:11768247:ACCGT:A	donor_loss	1.0000
6:11735566:A:AC	donor_gain	0.9900
6:11735567:C:CC	donor_gain	0.9900
6:11735679:GTGTG:G	acceptor_gain	0.9900
6:11735680:TGTGC:T	acceptor_loss	0.9900
6:11735681:GTG:G	acceptor_gain	0.9900
6:11735682:TG:T	acceptor_gain	0.9900
6:11735683:GC:G	acceptor_loss	0.9900
6:11735684:C:CA	acceptor_loss	0.9900
6:11735684:C:CC	acceptor_gain	0.9900
6:11735685:T:A	acceptor_loss	0.9900
6:11766267:CACT:C	donor_loss	0.9900
6:11766268:ACTC:A	donor_loss	0.9900

AlphaMissense

1499 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:11766358:G:C	F102L	0.986
6:11766358:G:T	F102L	0.986
6:11766360:A:G	F102L	0.986
6:11778714:A:G	W16R	0.955
6:11778714:A:T	W16R	0.955
6:11766291:A:G	W125R	0.945
6:11766291:A:T	W125R	0.945
6:11723407:G:C	S200R	0.944
6:11723407:G:T	S200R	0.944
6:11723409:T:G	S200R	0.944
6:11723469:A:G	W180R	0.939
6:11723469:A:T	W180R	0.939
6:11766346:A:C	F106L	0.939
6:11766346:A:T	F106L	0.939
6:11766348:A:G	F106L	0.939
6:11766357:A:G	W103R	0.938
6:11766357:A:T	W103R	0.938
6:11768276:G:C	F87L	0.936
6:11768276:G:T	F87L	0.936
6:11768278:A:G	F87L	0.936
6:11723467:C:A	W180C	0.928
6:11723467:C:G	W180C	0.928
6:11768353:A:G	C62R	0.923
6:11778610:A:C	N50K	0.919
6:11778610:A:T	N50K	0.919
6:11766283:A:C	N127K	0.910
6:11766283:A:T	N127K	0.910
6:11735681:G:C	H131Q	0.901
6:11735681:G:T	H131Q	0.901
6:11768366:G:C	F57L	0.901

dbSNP variants (sampled 300 via entrez): RS1000099334 (6:11746190 A>C), RS1000102807 (6:11769441 A>T), RS1000116663 (6:11775315 C>T), RS1000133498 (6:11733657 C>T), RS1000162337 (6:11766161 G>A), RS1000224151 (6:11751362 C>A), RS1000373428 (6:11771512 G>A), RS1000379496 (6:11777836 T>C), RS1000387182 (6:11757441 G>A,C), RS1000400676 (6:11733886 C>A,T), RS1000483371 (6:11721344 C>G), RS1000525960 (6:11738186 A>C), RS1000578546 (6:11737884 C>A), RS1000624676 (6:11765871 T>G), RS1000634864 (6:11779779 A>G)

Disease associations

OMIM: gene MIM:614348 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

22 associations (top):

Study	Trait	p-value
GCST001082_1	Orofacial clefts (maternal alcohol consumption interaction)	4.000000e-08
GCST002200_1	Anxiety and major depressive disorder	8.000000e-06
GCST003390_10	Thrombosis	4.000000e-07
GCST003518_55	Daytime sleep phenotypes	1.000000e-06
GCST005951_152	Body mass index	2.000000e-09
GCST006665_5	Social science traits (pleiotropy) (HIPO component 1)	4.000000e-08
GCST006923_10	Loneliness	3.000000e-09
GCST006924_12	Loneliness (MTAG)	9.000000e-09
GCST008551_23	Simvastatin-induced myopathy	9.000000e-06
GCST009306_10	Spatial processing	5.000000e-06
GCST010002_48	Refractive error	3.000000e-08
GCST010243_151	Apolipoprotein B levels	1.000000e-08
GCST010796_730	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-09
GCST010796_731	Electrocardiogram morphology (amplitude at temporal datapoints)	2.000000e-08
GCST010796_732	Electrocardiogram morphology (amplitude at temporal datapoints)	7.000000e-09
GCST010796_733	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST010796_734	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-08
GCST010796_735	Electrocardiogram morphology (amplitude at temporal datapoints)	8.000000e-09
GCST010796_736	Electrocardiogram morphology (amplitude at temporal datapoints)	5.000000e-09
GCST010796_737	Electrocardiogram morphology (amplitude at temporal datapoints)	3.000000e-08
GCST010796_738	Electrocardiogram morphology (amplitude at temporal datapoints)	1.000000e-08
GCST010796_739	Electrocardiogram morphology (amplitude at temporal datapoints)	4.000000e-08

EFO canonical traits (11, from GWAS)

EFO ID	Trait name
EFO:0003959	cleft lip
EFO:0003907	deep vein thrombosis
EFO:0007828	daytime rest measurement
EFO:0004340	body mass index
EFO:0007006	depressive symptom measurement
EFO:0007660	neuroticism measurement
EFO:0007869	wellbeing measurement
EFO:0007865	loneliness measurement
EFO:0008354	cognitive function measurement
EFO:0004615	apolipoprotein B measurement
EFO:0004327	electrocardiography

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PubChem BioAssay actives

2 with measured affinity, of 2 total; 2 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
(6Z)-6-(2-oxo-4-tridecyloxetan-3-ylidene)hexanamide	1801987: Gel-based ABPP Assay from Article 10.1038/nchembio.2051: “AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.”	ic50	1.3000	uM
[7-[4-(dimethylamino)benzoyl]-1,3-dioxo-5,6,8,8a-tetrahydroimidazo[1,5-a]pyrazin-2-yl] 4-[2-(4-chlorophenyl)ethyl]piperidine-1-carboxylate	1801987: Gel-based ABPP Assay from Article 10.1038/nchembio.2051: “AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.”	ic50	8.5000	uM

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
(+)-JQ1 compound	decreases expression	2
Benzo(a)pyrene	decreases expression, increases methylation	2
Valproic Acid	decreases expression, decreases methylation, increases expression	2
Cadmium Chloride	increases expression	2
propionaldehyde	increases expression	1
bisphenol A	decreases methylation, affects cotreatment	1
cobaltous chloride	decreases expression	1
butyraldehyde	increases expression	1
tobacco tar	decreases reaction, increases expression	1
diallyl disulfide	decreases reaction, increases expression	1
hydroquinone	increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
di-n-butylphosphoric acid	affects expression	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
abrine	increases expression	1
NSC 689534	affects binding, increases expression	1
theaflavin-3,3’-digallate	affects expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Air Pollutants	increases abundance, increases expression	1
Copper	increases expression, affects binding	1
Drugs, Chinese Herbal	increases expression	1
Formaldehyde	increases expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Nicotine	increases expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Isotretinoin	decreases expression	1
Cyclosporine	decreases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.