AFDN-DT

Summary

AFDN-DT (AFDN divergent transcript, HGNC:21236) is a long non-coding RNA gene on chromosome 6q27.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:21236
Approved symbol	AFDN-DT
Name	AFDN divergent transcript
Location	6q27
Locus type	RNA, long non-coding
Status	Approved
Aliases	HGC6.4, dJ431P23.3, XBP1SBM
Ensembl gene	ENSG00000198221
Ensembl biotype	lncRNA
Entrez	653483
RNAcentral	URS000075BCEE — lncRNA, 2311 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 110 — 110 lncRNA

ENST00000366822, ENST00000417244, ENST00000425438, ENST00000495520, ENST00000663809, ENST00000669546, ENST00000685931, ENST00000686435, ENST00000686823, ENST00000687268, ENST00000688535, ENST00000689959, ENST00000692751, ENST00000693058, ENST00000693293, ENST00000701075, ENST00000701277, ENST00000715776, ENST00000794546, ENST00000794547, ENST00000794548, ENST00000794549, ENST00000794550, ENST00000794551, ENST00000794552, ENST00000794553, ENST00000794554, ENST00000794555, ENST00000794556, ENST00000794557, ENST00000794558, ENST00000794559, ENST00000794560, ENST00000794561, ENST00000794562, ENST00000794563, ENST00000794564, ENST00000794565, ENST00000794566, ENST00000794567, ENST00000794568, ENST00000794569, ENST00000794570, ENST00000794571, ENST00000794572, ENST00000794573, ENST00000794574, ENST00000794575, ENST00000794576, ENST00000794577, ENST00000794578, ENST00000794579, ENST00000794580, ENST00000794581, ENST00000794582, ENST00000794583, ENST00000794584, ENST00000794585, ENST00000794586, ENST00000794587, ENST00000794588, ENST00000794589, ENST00000794590, ENST00000794591, ENST00000794592, ENST00000794593, ENST00000794594, ENST00000794595, ENST00000794596, ENST00000794597, ENST00000794598, ENST00000794599, ENST00000794600, ENST00000794601, ENST00000794602, ENST00000794603, ENST00000794604, ENST00000794605, ENST00000794606, ENST00000794607, ENST00000794608, ENST00000794609, ENST00000794610, ENST00000794611, ENST00000794612, ENST00000794613, ENST00000794614, ENST00000794615, ENST00000794616, ENST00000794617, ENST00000794618, ENST00000794619, ENST00000794620, ENST00000794621, ENST00000794622, ENST00000794623, ENST00000794624, ENST00000794625, ENST00000794626, ENST00000794627, ENST00000794628, ENST00000794629, ENST00000794630, ENST00000794631, ENST00000794632, ENST00000794633, ENST00000794634, ENST00000794635, ENST00000794636, ENST00000794637

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000366822 — 3 exons

Exon	Start	End
ENSE00002163345	167790947	167791093
ENSE00004178475	167796609	167796876
ENSE00004178492	167786195	167787607

Expression profiles

Bgee: expression breadth ubiquitous, 199 present calls, max score 90.66.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0610 / max 10.0521, expressed in 32 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
76720	0.3262	139
76719	0.0399	20
76718	0.0211	11

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	90.66	gold quality
ganglionic eminence	UBERON:0004023	88.92	gold quality
buccal mucosa cell	CL:0002336	87.25	gold quality
right uterine tube	UBERON:0001302	83.32	gold quality
lower esophagus mucosa	UBERON:0035834	81.20	gold quality
embryo	UBERON:0000922	79.45	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.42	gold quality
ventricular zone	UBERON:0003053	76.90	gold quality
tibia	UBERON:0000979	76.53	gold quality
endothelial cell	CL:0000115	76.36	silver quality
colonic epithelium	UBERON:0000397	74.65	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	73.72	gold quality
minor salivary gland	UBERON:0001830	73.70	gold quality
saliva-secreting gland	UBERON:0001044	71.25	gold quality
esophagus mucosa	UBERON:0002469	70.76	gold quality
spinal cord	UBERON:0002240	70.35	gold quality
jejunal mucosa	UBERON:0000399	70.12	gold quality
body of pancreas	UBERON:0001150	69.99	gold quality
sperm	CL:0000019	69.72	silver quality
mouth mucosa	UBERON:0003729	69.71	gold quality
right lobe of liver	UBERON:0001114	66.52	gold quality
bronchial epithelial cell	CL:0002328	65.87	gold quality
esophagus squamous epithelium	UBERON:0006920	65.82	gold quality
germinal epithelium of ovary	UBERON:0001304	65.56	gold quality
apex of heart	UBERON:0002098	64.99	gold quality
metanephros cortex	UBERON:0010533	64.90	gold quality
left testis	UBERON:0004533	64.86	gold quality
hindlimb stylopod muscle	UBERON:0004252	64.69	gold quality
pancreas	UBERON:0001264	64.64	gold quality
pigmented layer of retina	UBERON:0001782	64.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Tumour suppressive long non-coding RNA AFDN-DT inhibits gastric cancer invasion via transcriptional regulation. (PMID:31981317)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.