AFF2-IT1

Summary

AFF2-IT1 (AFF2 intronic transcript 1, HGNC:41334) is a long non-coding RNA gene on chromosome Xq28.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41334
Approved symbol	AFF2-IT1
Name	AFF2 intronic transcript 1
Location	Xq28
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000223516
Ensembl biotype	lncRNA
Entrez	100874269
RNAcentral	URS00025D6F3A — lncRNA, 520 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000435346

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000435346 — 2 exons

Exon	Start	End
ENSE00001694552	148546878	148547166
ENSE00001738018	148547244	148547397

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 77.90.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	77.90	gold quality
bone marrow	UBERON:0002371	66.90	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.28	gold quality
calcaneal tendon	UBERON:0003701	63.81	gold quality
lymph node	UBERON:0000029	61.86	gold quality
colonic epithelium	UBERON:0000397	60.29	silver quality
tonsil	UBERON:0002372	60.14	gold quality
endometrium	UBERON:0001295	57.96	silver quality
adrenal tissue	UBERON:0018303	57.24	gold quality
prostate gland	UBERON:0002367	53.48	gold quality
blood	UBERON:0000178	52.75	gold quality
right hemisphere of cerebellum	UBERON:0014890	50.17	gold quality
monocyte	CL:0000576	49.98	silver quality
left adrenal gland cortex	UBERON:0035825	49.97	gold quality
kidney	UBERON:0002113	49.15	silver quality
lung	UBERON:0002048	49.00	silver quality
intestine	UBERON:0000160	48.86	silver quality
omental fat pad	UBERON:0010414	48.66	gold quality
corpus callosum	UBERON:0002336	48.13	silver quality
cerebellar cortex	UBERON:0002129	48.03	silver quality
cerebellar hemisphere	UBERON:0002245	47.84	silver quality
esophagogastric junction muscularis propria	UBERON:0035841	47.61	gold quality
tibial artery	UBERON:0007610	47.47	gold quality
multicellular organism	UBERON:0000468	47.42	gold quality
heart	UBERON:0000948	47.31	gold quality
left ovary	UBERON:0002119	46.60	gold quality
brain	UBERON:0000955	46.18	silver quality
thyroid gland	UBERON:0002046	45.71	silver quality
ascending aorta	UBERON:0001496	45.64	silver quality
body of stomach	UBERON:0001161	45.41	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.