AFTPH

Summary

AFTPH (aftiphilin, HGNC:25951) is a protein-coding gene on chromosome 2p14, encoding Aftiphilin (Q6ULP2). Component of clathrin-coated vesicles.

Enables clathrin binding activity. Predicted to be involved in intracellular transport. Located in Golgi apparatus; cytosol; and nucleoplasm. Part of AP-1 adaptor complex.

Source: NCBI Gene 54812 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 155 total
• MANE Select transcript: NM_203437

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25951
Approved symbol	AFTPH
Name	aftiphilin
Location	2p14
Locus type	gene with protein product
Status	Approved
Aliases	MGC33965, FLJ20080, FLJ23793, Nbla10388
Ensembl gene	ENSG00000119844
Ensembl biotype	protein_coding
OMIM	619628
Entrez	54812

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 19 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000238856, ENST00000409183, ENST00000409933, ENST00000487769, ENST00000498706, ENST00000695864, ENST00000695865, ENST00000695866, ENST00000695867, ENST00000695868, ENST00000695869, ENST00000695960, ENST00000880238, ENST00000880239, ENST00000880240, ENST00000880241, ENST00000880242, ENST00000880243, ENST00000880244, ENST00000920107, ENST00000920108, ENST00000942373, ENST00000942374

RefSeq mRNA: 10 — MANE Select: NM_203437 NM_001002243, NM_001375969, NM_001375970, NM_001375971, NM_001375972, NM_001375973, NM_001394995, NM_001394996, NM_017657, NM_203437

CCDS: CCDS1878, CCDS46303, CCDS92767, CCDS92768, CCDS92769, CCDS92770, CCDS92771

Canonical transcript exons

ENST00000409933 — 10 exons

Exon	Start	End
ENSE00000810183	64579486	64579546
ENSE00001587108	64591888	64593005
ENSE00003488799	64572946	64573068
ENSE00003496930	64585422	64585545
ENSE00003506130	64569092	64569218
ENSE00003544540	64567562	64567713
ENSE00003614120	64551443	64553409
ENSE00003718530	64569623	64569679
ENSE00003965278	64581190	64581273
ENSE00003965634	64524328	64524612

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 97.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.3247 / max 346.4255, expressed in 1642 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
20589	3.8963	1365
20588	2.0494	941
20590	1.4515	511
20592	0.5042	254
20591	0.4233	151

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	97.48	gold quality
male germ cell	CL:0000015	97.36	gold quality
sperm	CL:0000019	97.36	gold quality
buccal mucosa cell	CL:0002336	97.29	gold quality
cardia of stomach	UBERON:0001162	96.74	gold quality
epithelium of nasopharynx	UBERON:0001951	96.67	gold quality
cerebellar vermis	UBERON:0004720	96.65	gold quality
ileal mucosa	UBERON:0000331	96.59	gold quality
type B pancreatic cell	CL:0000169	96.49	gold quality
pylorus	UBERON:0001166	96.42	gold quality
parotid gland	UBERON:0001831	96.36	gold quality
olfactory bulb	UBERON:0002264	96.31	silver quality
oviduct epithelium	UBERON:0004804	96.17	gold quality
nasal cavity epithelium	UBERON:0005384	96.11	gold quality
tongue squamous epithelium	UBERON:0006919	95.85	gold quality
nipple	UBERON:0002030	95.79	gold quality
superior surface of tongue	UBERON:0007371	95.26	gold quality
pharyngeal mucosa	UBERON:0000355	95.13	gold quality
upper arm skin	UBERON:0004263	94.98	gold quality
diaphragm	UBERON:0001103	94.92	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.82	gold quality
islet of Langerhans	UBERON:0000006	94.73	gold quality
trachea	UBERON:0003126	94.71	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.61	gold quality
bronchus	UBERON:0002185	94.59	gold quality
mucosa of urinary bladder	UBERON:0001259	94.57	gold quality
epithelium of bronchus	UBERON:0002031	94.57	gold quality
leukocyte	CL:0000738	94.54	gold quality
mononuclear cell	CL:0000842	94.54	gold quality
monocyte	CL:0000576	94.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.03

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

124 targeting AFTPH, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-4753-3P	99.90	71.03	3786

Literature-anchored findings (GeneRIF, showing 3)

• the aftiphilin/p200/gamma-synergin complex facilitates AP-1 function (PMID:15758025)
• Data show that by recruiting aftiphilin/gamma-synergin in addition to clathrin, AP-1 coordinates formation of Weibel-Palade bodies with their acquisition of a regulated secretory phenotype. (PMID:18815278)
• Expression profiles and prognostic significance of AFTPH in different tumors. (PMID:33090728)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	aftpha	ENSDARG00000069249
danio_rerio	aftphb	ENSDARG00000071347
mus_musculus	Aftph	ENSMUSG00000049659
rattus_norvegicus	Aftph	ENSRNOG00000005411
caenorhabditis_elegans		WBGENE00021561

Paralogs (1): CLBA1 (ENSG00000140104)

Protein

Protein identifiers

Aftiphilin — Q6ULP2 (reviewed: Q6ULP2)

All UniProt accessions (8): A0A0U1RR74, A0A8Q3SI61, A0A8Q3SI81, A0A8Q3SIA4, A0A8Q3WKU6, A0A8Q3WM48, B8ZZI9, Q6ULP2

UniProt curated annotations — full annotation on UniProt →

Function. Component of clathrin-coated vesicles. Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.

Subunit / interactions. Self-associates. Interacts with GGA1 (via GAE domain). Interacts with GGA3 (via GAE domain), AP1G1 (via GAE domain) and AP1G2 (via GAE domain). Component of the aftiphilin/p200/gamma-synergin complex, at least composed of AFTPH/aftiphilin, HEATR5B/p200a and SYNRG/gamma-synergin, which plays a role in the AP1G1/AP-1-mediated protein trafficking from early to recycling endosomes. Within the complex interacts with HEATR5B/p200a and SYNRG/gamma-synergin; the interactions are direct. Interacts with AP1G1/AP-1; the interaction is required to recruit AFTPH/aftiphilin to the perinuclear region of the cell. Interacts with CLTCL1/Clathrin.

Subcellular location. Cytoplasm. Perinuclear region. Cytoplasmic vesicle. Clathrin-coated vesicle.

Domain organisation. The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself.

Miscellaneous. May be due to intron retention.

Isoforms (5)

UniProt ID	Names	Canonical?
Q6ULP2-1	1	yes
Q6ULP2-6	2
Q6ULP2-7	3
Q6ULP2-8	4
Q6ULP2-9	5

RefSeq proteins (10): NP_001002243, NP_001362898, NP_001362899, NP_001362900, NP_001362901, NP_001362902, NP_001381924, NP_001381925, NP_060127, NP_982261* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029205	Clathrin-bd	Domain
IPR046359	Aftin-like	Family

Pfam: PF15045

UniProt features (34 total): region of interest 7, short sequence motif 5, sequence conflict 5, compositionally biased region 4, modified residue 4, splice variant 4, sequence variant 3, chain 1, mutagenesis site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ULP2-F1	46.36	0.00

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (4): 151, 395, 518, 617

Mutagenesis-validated functional residues (1):

Position	Phenotype
716–718	abolishes the interaction with cltcl1/clathrin.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 172 (showing top): chr2p14, GOCC_TRANS_GOLGI_NETWORK, GOCC_COATED_VESICLE, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, GOCC_GOLGI_ASSOCIATED_VESICLE, GOCC_VESICLE_COAT, MARIADASON_REGULATED_BY_HISTONE_ACETYLATION_UP, GOCC_CLATHRIN_COATED_VESICLE, GOCC_TRANS_GOLGI_NETWORK_TRANSPORT_VESICLE_MEMBRANE, GOCC_GOLGI_ASSOCIATED_VESICLE_MEMBRANE, GOCC_CLATHRIN_COAT, GOCC_CLATHRIN_VESICLE_COAT, MARSON_BOUND_BY_FOXP3_STIMULATED, GOCC_CLATHRIN_COATED_VESICLE_MEMBRANE, GOCC_MEMBRANE_PROTEIN_COMPLEX

GO Biological Process (2): protein transport (GO:0015031), intracellular transport (GO:0046907)

GO Molecular Function (2): clathrin binding (GO:0030276), protein binding (GO:0005515)

GO Cellular Component (9): nucleoplasm (GO:0005654), Golgi apparatus (GO:0005794), cytosol (GO:0005829), AP-1 adaptor complex (GO:0030121), trans-Golgi network membrane (GO:0032588), perinuclear region of cytoplasm (GO:0048471), cytoplasm (GO:0005737), clathrin-coated vesicle (GO:0030136), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	4
transport	2
intracellular anatomical structure	2
intracellular protein localization	1
establishment of protein localization	1
cellular localization	1
establishment of localization in cell	1
protein binding	1
binding	1
nuclear lumen	1
endomembrane system	1
intracellular membrane-bounded organelle	1
clathrin coat of trans-Golgi network vesicle	1
clathrin adaptor complex	1
trans-Golgi network	1
organelle membrane	1
coated vesicle	1
intracellular vesicle	1

Protein interactions and networks

STRING

726 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AFTPH	SYNRG	Q9UMZ2	693
AFTPH	AP1G2	O75843	546
AFTPH	CPNE1	Q99829	527
AFTPH	STXBP2	Q15833	480
AFTPH	INAFM1	C9JVW0	464
AFTPH	SERTAD2	Q14140	406
AFTPH	NUDCD1	Q96RS6	392
AFTPH	CAAP1	Q9H8G2	391
AFTPH	TBC1D22B	Q9NU19	391
AFTPH	SCYL2	Q6P3W7	371
AFTPH	HEATR5B	Q9P2D3	370
AFTPH	NTSR1	P30989	366
AFTPH	DCAF5	Q96JK2	350
AFTPH	SFT2D2	O95562	349
AFTPH	FAM216A	Q8WUB2	348
AFTPH	TULP4	Q9NRJ4	348

IntAct

48 interactions, top by confidence:

A	B	Type	Score
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
AP1S2	AP1G1	psi-mi:“MI:0914”(association)	0.670
AP1S2	AP1G1	psi-mi:“MI:0914”(association)	0.660
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
CLTB	PIK3C2A	psi-mi:“MI:0914”(association)	0.530
AFTPH	SYNRG	psi-mi:“MI:0915”(physical association)	0.500
PEX14	AFTPH	psi-mi:“MI:0407”(direct interaction)	0.440
AP2B1	AFTPH	psi-mi:“MI:0407”(direct interaction)	0.440
MAP1LC3B	AFTPH	psi-mi:“MI:0407”(direct interaction)	0.440
STAT5B	AFTPH	psi-mi:“MI:0915”(physical association)	0.370
AFTPH	rep	psi-mi:“MI:0915”(physical association)	0.370
UBE3A	AFTPH	psi-mi:“MI:0915”(physical association)	0.370
Csk	FRYL	psi-mi:“MI:0914”(association)	0.350
AP1S2	SLC43A3	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.350
AP1M2	AP1G1	psi-mi:“MI:0914”(association)	0.350
ARHGAP18	CLTB	psi-mi:“MI:0914”(association)	0.350
CLTA	CLTB	psi-mi:“MI:0914”(association)	0.350
TUBA1B	SLAIN2	psi-mi:“MI:0914”(association)	0.350
TUBB4B	TUBA1B	psi-mi:“MI:0914”(association)	0.350

BioGRID (79): AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AFTPH (Synthetic Lethality), AFTPH (Proximity Label-MS), AFTPH (Affinity Capture-MS), AFTPH (Affinity Capture-MS), AP1G1 (Reconstituted Complex), CLTC (Reconstituted Complex)

ESM2 similar proteins: A0A1B0GTU1, A0P8Z5, A2A870, A4IGN8, B0KYV5, D3ZUI5, F1LR10, O00515, O46385, O75128, O75152, O75410, P0DQW0, P42167, P57016, Q4KLH6, Q5NBX1, Q5RDC1, Q5REG6, Q5SV85, Q5U5Q9, Q5ZIB2, Q5ZJJ1, Q61029, Q62733, Q641Q2, Q6INC4, Q6NZF1, Q6PGL7, Q6ULP2, Q6WKZ4, Q6Y685, Q6ZQ03, Q6ZQ06, Q6ZSR9, Q80WT5, Q80X08, Q86UE4, Q8BJ05, Q8K4L3

Diamond homologs: Q6ULP2, Q80WT5, Q8BHN9, Q17QP7, Q5RJN9, Q96F83

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 42 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	6	122.8×	2e-10
The role of Nef in HIV-1 replication and disease pathogenesis	6	122.8×	2e-10
Lysosome Vesicle Biogenesis	7	73.7×	2e-10
Host Interactions of HIV factors	6	65.0×	7e-09
Golgi Associated Vesicle Biogenesis	7	45.2×	3e-09
trans-Golgi Network Vesicle Budding	5	40.9×	2e-06
Translocation of SLC2A4 (GLUT4) to the plasma membrane	6	29.9×	7e-07
MHC class II antigen presentation	9	25.9×	1e-09

GO biological processes:

GO term	Partners	Fold	FDR
synaptic vesicle endocytosis	5	60.0×	3e-06
intracellular protein transport	10	18.0×	4e-08
vesicle-mediated transport	6	16.1×	8e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

155 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	128
Likely benign	6
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1493 predictions. Top by Δscore:

Variant	Effect	Δscore
2:64551441:A:C	acceptor_loss	1.0000
2:64551442:G:GC	acceptor_loss	1.0000
2:64551442:GGT:G	acceptor_gain	1.0000
2:64567554:T:TA	acceptor_gain	1.0000
2:64567561:GACA:G	acceptor_gain	1.0000
2:64567710:GTGG:G	donor_gain	1.0000
2:64567711:TGG:T	donor_gain	1.0000
2:64567712:GG:G	donor_gain	1.0000
2:64567712:GGG:G	donor_gain	1.0000
2:64567713:GG:G	donor_gain	1.0000
2:64567713:GGT:G	donor_loss	1.0000
2:64567714:G:GC	donor_loss	1.0000
2:64567714:G:GG	donor_gain	1.0000
2:64567715:T:G	donor_loss	1.0000
2:64569219:G:GG	donor_gain	1.0000
2:64569223:GTTT:G	donor_gain	1.0000
2:64569610:A:AG	acceptor_gain	1.0000
2:64569610:AAC:A	acceptor_gain	1.0000
2:64569610:AACGT:A	acceptor_gain	1.0000
2:64569611:A:G	acceptor_gain	1.0000
2:64569612:C:CA	acceptor_gain	1.0000
2:64569612:C:G	acceptor_gain	1.0000
2:64572944:AG:A	acceptor_gain	1.0000
2:64572945:GG:G	acceptor_gain	1.0000
2:64572945:GGGT:G	acceptor_gain	1.0000
2:64573064:TCCAG:T	donor_loss	1.0000
2:64573065:CCAGG:C	donor_loss	1.0000
2:64573066:CAGG:C	donor_loss	1.0000
2:64573067:AGG:A	donor_loss	1.0000
2:64573068:GG:G	donor_loss	1.0000

AlphaMissense

6239 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:64579513:T:A	W808R	1.000
2:64579513:T:C	W808R	1.000
2:64579515:G:C	W808C	1.000
2:64579515:G:T	W808C	1.000
2:64569156:T:A	W718R	0.999
2:64569156:T:C	W718R	0.999
2:64572953:T:C	L760S	0.999
2:64579507:T:C	F806L	0.999
2:64579509:T:A	F806L	0.999
2:64579509:T:G	F806L	0.999
2:64579529:T:C	L813P	0.999
2:64591977:T:C	L918S	0.999
2:64591982:T:C	F920L	0.999
2:64591983:T:C	F920S	0.999
2:64591984:C:A	F920L	0.999
2:64591984:C:G	F920L	0.999
2:64569158:G:C	W718C	0.998
2:64569158:G:T	W718C	0.998
2:64569184:T:C	L727P	0.998
2:64569187:T:C	L728S	0.998
2:64569202:T:A	I733K	0.998
2:64569211:G:C	R736P	0.998
2:64569660:C:A	P751H	0.998
2:64569660:C:G	P751R	0.998
2:64569665:T:G	Y753D	0.998
2:64569669:C:A	A754E	0.998
2:64569678:T:C	L757S	0.998
2:64579508:T:C	F806S	0.998
2:64579508:T:G	F806C	0.998
2:64579529:T:A	L813H	0.998

dbSNP variants (sampled 300 via entrez): RS1000019309 (2:64530083 G>C), RS1000053713 (2:64580532 T>A,C), RS1000062885 (2:64560071 C>G), RS1000101717 (2:64525598 T>G), RS1000113001 (2:64526007 A>G), RS1000134198 (2:64534467 CTTATAG>C), RS1000154603 (2:64568457 C>A,T), RS1000156790 (2:64544724 G>A), RS1000162191 (2:64576931 A>C,G), RS1000215924 (2:64541589 T>A), RS1000225395 (2:64566784 A>G), RS1000248676 (2:64541261 G>T), RS1000329305 (2:64562513 C>A,T), RS1000351309 (2:64581713 T>C,G), RS1000382342 (2:64555770 A>G)

Disease associations

OMIM: gene MIM:619628 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005851_16	Delirium	1.000000e-06
GCST008836_1	Lung adenocarcinoma	2.000000e-08
GCST009391_27	Metabolite levels	3.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0010350	cholesteryl ester 22:6 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	increases expression, affects cotreatment, increases methylation	2
Arsenic Trioxide	decreases response to substance, increases expression	2
Tretinoin	increases expression	2
Valproic Acid	affects expression, increases expression	2
aristolochic acid I	decreases expression	1
GSK-J4	increases expression	1
FR900359	affects phosphorylation	1
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
bisphenol A	affects cotreatment, affects methylation, increases methylation	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
coumarin	increases phosphorylation	1
1-nitropyrene	increases expression	1
K 7174	increases expression	1
abrine	increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
Resveratrol	decreases expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, affects methylation, increases methylation	1
Arsenic	decreases expression, increases abundance	1
Vehicle Emissions	affects expression, increases abundance	1
Benzo(a)pyrene	decreases methylation	1
Caffeine	affects phosphorylation	1
Cannabidiol	increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SB89	HAP1 AFTPH (-) 1	Cancer cell line	Male
CVCL_SB90	HAP1 AFTPH (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.