AGAP2-AS1

Summary

AGAP2-AS1 (AGAP2 antisense RNA 1, HGNC:48633) is a long non-coding RNA gene on chromosome 12q14.1.

Biomarker of lung non-small cell carcinoma; malignant astrocytoma; and stomach cancer.

Source: NCBI Gene 100130776 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48633
Approved symbol	AGAP2-AS1
Name	AGAP2 antisense RNA 1
Location	12q14.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC100130776, PUNISHER
Ensembl gene	ENSG00000255737
Ensembl biotype	lncRNA
Entrez	100130776
RNAcentral	URS000075E9B8 — lncRNA, 1567 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000542466

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000542466 — 2 exons

Exon	Start	End
ENSE00002206204	57726271	57726378
ENSE00002208928	57726965	57728356

Expression profiles

Bgee: expression breadth ubiquitous, 157 present calls, max score 88.75.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.3972 / max 114.3323, expressed in 1271 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
126312	7.9620	1268
126313	0.4353	116

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	88.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.88	gold quality
skin of leg	UBERON:0001511	81.42	gold quality
ectocervix	UBERON:0012249	81.41	gold quality
endocervix	UBERON:0000458	81.21	gold quality
skin of abdomen	UBERON:0001416	80.74	gold quality
right coronary artery	UBERON:0001625	80.62	gold quality
adenohypophysis	UBERON:0002196	79.28	gold quality
cortical plate	UBERON:0005343	78.99	gold quality
apex of heart	UBERON:0002098	78.63	gold quality
left coronary artery	UBERON:0001626	78.46	gold quality
pituitary gland	UBERON:0000007	78.40	gold quality
esophagus mucosa	UBERON:0002469	78.34	gold quality
body of pancreas	UBERON:0001150	78.30	gold quality
zone of skin	UBERON:0000014	78.21	gold quality
omental fat pad	UBERON:0010414	78.16	gold quality
peritoneum	UBERON:0002358	78.06	gold quality
body of uterus	UBERON:0009853	77.61	gold quality
lower esophagus mucosa	UBERON:0035834	77.53	gold quality
left ovary	UBERON:0002119	76.75	gold quality
tibial artery	UBERON:0007610	76.69	gold quality
popliteal artery	UBERON:0002250	76.68	gold quality
coronary artery	UBERON:0001621	76.57	gold quality
right ovary	UBERON:0002118	76.52	gold quality
ascending aorta	UBERON:0001496	76.27	gold quality
aorta	UBERON:0000947	76.25	gold quality
adipose tissue of abdominal region	UBERON:0007808	76.20	gold quality
thoracic aorta	UBERON:0001515	76.18	gold quality
minor salivary gland	UBERON:0001830	75.79	gold quality
ganglionic eminence	UBERON:0004023	75.77	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.39

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 22)

• PUNISHER is specifically expressed in differentiated endothelial cells. PUNISHER knockdown downregulated 802 genes involved in mitosis and cell division and upregulated 831 genes involved in cell adhesion and extracellular interactions. (PMID:25739401)
• AGAP2-AS1 is a prognostic biomarker for patients with GBM, and functions as an oncogenic lncRNA to modulate GBM cell proliferation, apoptosis, migration, and invasion, which suggests that AGAP2-AS1 is potential therapeutic target for GBM. (PMID:30525219)
• AGAP2-AS1 promoted glioma cell proliferation by sponging miR-15a/b-5p to upregulate the expression of HDGF (PMID:30684575)
• Data show that RREB1-induced upregulation of AGAP2-AS1 regulates cell proliferation and migration in PC partly through suppressing ANKRD1 and ANGPTL4 by recruiting EZH2. (PMID:30814490)
• Authors show that AGAP2-AS1 was secreted outside cells by incorporation into exosomes in an hnRNPA2B1-dependent manner. More importantly, co-culture AGAP2-AS1-containing exosomes with sensitive cells reduced the trastuzumab-induced cell death, and silencing of AGAP2-AS1 from exosomes reversed this effect. (PMID:30910994)
• AGAP2-AS1 overexpression led to downregulation of MEG3, while MEG3 overexpression failed to affect AGAP2-AS1. AGAP2-AS1 overexpression promoted proliferation of OC cells, while MEG3 overexpression inhibited proliferation of OC cells. (PMID:31233485)
• Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype. (PMID:32150333)
• LncRNA AGAP2-AS1 augments cell viability and mobility, and confers gemcitabine resistance by inhibiting miR-497 in colorectal cancer. (PMID:32202509)
• Long non-coding RNA AGAP2-AS1 accelerates cell proliferation, migration, invasion and the EMT process in colorectal cancer via regulating the miR-4,668-3p/SRSF1 axis. (PMID:32639657)
• SP1 induced long non-coding RNA AGAP2-AS1 promotes cholangiocarcinoma proliferation via silencing of CDKN1A. (PMID:33522895)
• M2 macrophage-derived exosomal long non-coding RNA AGAP2-AS1 enhances radiotherapy immunity in lung cancer by reducing microRNA-296 and elevating NOTCH2. (PMID:33972506)
• AGAP2-AS1/miR-628-5p/FOXP2 feedback loop facilitates the growth of prostate cancer via activating WNT pathway. (PMID:34255057)
• Long non-coding RNA AGAP2-AS1 is up regulated in colorectal cancer. (PMID:34308771)
• E2F4-induced AGAP2-AS1 up-regulation accelerates the progression of colorectal cancer via miR-182-5p/CFL1 axis. (PMID:34838479)
• N(6)-methyladenosine-modified long non-coding RNA AGAP2-AS1 promotes psoriasis pathogenesis via miR-424-5p/AKT3 axis. (PMID:34930676)
• Long non-coding RNA AGAP2-AS1 promotes cell proliferation and invasion through regulating miR-193a-3p/LOXL4 axis in laryngeal squamous cell carcinoma. (PMID:35113007)
• Role of lncRNA AGAP2-AS1 in Breast Cancer Cell Resistance to Apoptosis by the Regulation of MTA1 Promoter Activity. (PMID:35369814)
• The lncRNA Punisher Regulates Apoptosis and Mitochondrial Homeostasis of Vascular Smooth Muscle Cells via Targeting miR-664a-5p and OPA1. (PMID:35663194)
• PUNISHER rs12318065 C>A transversion: a putative somatic driver mutation for poor prognosis in colon cancer. (PMID:35670784)
• AGAP2-AS1: An Indispensable lncRNA in Tumors. (PMID:35708074)
• EIF4A3 stabilizes the expression of lncRNA AGAP2-AS1 to activate cancer-associated fibroblasts via MyD88/NF-kappab signaling. (PMID:36541122)
• Long Non-Coding RNA AGAP2-AS1: A Comprehensive Overview on Its Biological Functions and Clinical Significances in Human Cancers. (PMID:39124865)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.