AGTRAP

Summary

AGTRAP (angiotensin II receptor associated protein, HGNC:13539) is a protein-coding gene on chromosome 1p36.22, encoding Type-1 angiotensin II receptor-associated protein (Q6RW13). Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation.

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Source: NCBI Gene 57085 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 53 total — 2 pathogenic, 2 likely-pathogenic
• MANE Select transcript: NM_020350

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13539
Approved symbol	AGTRAP
Name	angiotensin II receptor associated protein
Location	1p36.22
Locus type	gene with protein product
Status	Approved
Aliases	ATRAP
Ensembl gene	ENSG00000177674
Ensembl biotype	protein_coding
OMIM	608729
Entrez	57085

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 11 protein_coding, 4 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000314340, ENST00000376627, ENST00000376629, ENST00000376637, ENST00000400895, ENST00000452018, ENST00000471765, ENST00000476309, ENST00000476512, ENST00000491346, ENST00000494437, ENST00000510878, ENST00000513739, ENST00000514733, ENST00000856549, ENST00000856550, ENST00000856551, ENST00000929521

RefSeq mRNA: 5 — MANE Select: NM_020350 NM_001040194, NM_001040195, NM_001040196, NM_001040197, NM_020350

CCDS: CCDS136, CCDS30585, CCDS30586, CCDS41248, CCDS44056

Canonical transcript exons

ENST00000314340 — 5 exons

Exon	Start	End
ENSE00001901851	11750077	11750769
ENSE00001954756	11736136	11736235
ENSE00003499860	11745803	11745837
ENSE00003521575	11748415	11748610
ENSE00003637198	11747440	11747545

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 98.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.3382 / max 358.5780, expressed in 1819 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
639	40.4662	1817
638	2.3957	1379
637	1.4763	1038

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	98.55	gold quality
monocyte	CL:0000576	98.22	gold quality
leukocyte	CL:0000738	98.21	gold quality
right uterine tube	UBERON:0001302	97.84	gold quality
pancreatic ductal cell	CL:0002079	97.60	silver quality
blood	UBERON:0000178	96.63	gold quality
mucosa of stomach	UBERON:0001199	95.33	gold quality
spleen	UBERON:0002106	95.18	gold quality
right lung	UBERON:0002167	95.14	gold quality
upper lobe of left lung	UBERON:0008952	94.87	gold quality
bone marrow	UBERON:0002371	94.50	gold quality
decidua	UBERON:0002450	94.40	gold quality
upper lobe of lung	UBERON:0008948	94.25	gold quality
right adrenal gland	UBERON:0001233	94.02	gold quality
apex of heart	UBERON:0002098	93.82	gold quality
pericardium	UBERON:0002407	93.81	gold quality
body of pancreas	UBERON:0001150	93.73	gold quality
stromal cell of endometrium	CL:0002255	93.47	gold quality
right adrenal gland cortex	UBERON:0035827	93.41	gold quality
left adrenal gland	UBERON:0001234	93.37	gold quality
left adrenal gland cortex	UBERON:0035825	93.37	gold quality
right lobe of thyroid gland	UBERON:0001119	93.05	gold quality
prostate gland	UBERON:0002367	93.05	gold quality
left coronary artery	UBERON:0001626	92.91	gold quality
adrenal cortex	UBERON:0001235	92.84	gold quality
metanephros cortex	UBERON:0010533	92.81	gold quality
tibial nerve	UBERON:0001323	92.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.69	gold quality
left lobe of thyroid gland	UBERON:0001120	92.62	gold quality
coronary artery	UBERON:0001621	92.58	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-6678	yes	23.63
E-ANND-3	yes	8.30
E-CURD-84	no	429.03

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, CREM, NFKB, RUNX3, SP1, USF1, USF2

miRNA regulators (miRDB)

30 targeting AGTRAP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4715-3P	99.98	66.03	670
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-6715B-5P	99.64	69.63	1420
HSA-MIR-4269	99.55	69.89	1373
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-155-5P	99.35	70.16	1509
HSA-MIR-6744-3P	99.22	64.41	972
HSA-MIR-1911-3P	99.15	66.17	528
HSA-MIR-6768-3P	99.14	67.38	1319
HSA-MIR-4757-5P	99.12	64.51	981
HSA-MIR-661	99.09	65.94	2062
HSA-MIR-648	98.64	66.13	553
HSA-MIR-6810-5P	98.29	66.21	975
HSA-MIR-5691	98.23	67.02	1335
HSA-MIR-6805-3P	98.23	67.02	1334
HSA-MIR-4433A-3P	97.75	62.82	1435
HSA-MIR-1910-5P	97.42	66.36	844
HSA-MIR-7976	95.75	65.67	1186
HSA-MIR-324-5P	95.68	65.20	560
HSA-MIR-874-3P	95.02	65.66	806

Literature-anchored findings (GeneRIF, showing 17)

• cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein (PMID:11733189)
• isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells (PMID:14559250)
• mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. (PMID:14985364)
• CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology (PMID:15668245)
• Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. (PMID:19805740)
• Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. (PMID:20018811)
• CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes (PMID:20541774)
• the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. (PMID:21423001)
• The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). (PMID:21728994)
• ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. (PMID:23902639)
• A role for AT1 receptor-associated proteins in blood pressure regulation (PMID:25562590)
• Leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocyte inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of non-communicable diseases. (PMID:29407599)
• There was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to diabetic nephropathy (DN) in the Malay Indonesian population. (PMID:30630996)
• Angiotensin II type 1 receptor-associated protein deficiency attenuates sirtuin1 expression in an immortalised human renal proximal tubule cell line. (PMID:31719572)
• The pathophysiological role of angiotensin receptor-binding protein in hypertension and kidney diseases: Oshima Award Address 2019. (PMID:32112267)
• S-adenosylmethionine upregulates the angiotensin receptor-binding protein ATRAP via the methylation of HuR in NAFLD. (PMID:33753727)
• USF1-ATRAP-PBX3 Axis Promote Breast Cancer Glycolysis and Malignant Phenotype by Activating AKT/mTOR Signaling. (PMID:35414770)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	agtrap	ENSDARG00000077082
mus_musculus	Agtrap	ENSMUSG00000029007
rattus_norvegicus	Agtrap	ENSRNOG00000008619
drosophila_melanogaster	CG32638	FBGN0052638

Protein

Protein identifiers

Type-1 angiotensin II receptor-associated protein — Q6RW13 (reviewed: Q6RW13)

Alternative names: AT1 receptor-associated protein

All UniProt accessions (4): Q6RW13, D6RB40, D6RBK6, X6R9H3

UniProt curated annotations — full annotation on UniProt →

Function. Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.

Subunit / interactions. Interacts with RACK1, and with the C-terminal region of AGTR1.

Subcellular location. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cytoplasmic vesicle membrane.

Tissue specificity. Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.

Isoforms (5)

UniProt ID	Names	Canonical?
Q6RW13-1	1	yes
Q6RW13-2	2
Q6RW13-3	3
Q6RW13-5	5
Q6RW13-4	4

RefSeq proteins (5): NP_001035284, NP_001035285, NP_001035286, NP_001035287, NP_065083* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009436	AGTRAP	Family

Pfam: PF06396

UniProt features (22 total): modified residue 5, topological domain 4, splice variant 4, transmembrane region 3, sequence conflict 2, region of interest 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6RW13-F1	80.97	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (5): 126, 127, 135, 138, 153

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6802952	Signaling by BRAF and RAF1 fusions
R-HSA-1643685	Disease
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6802957	Oncogenic MAPK signaling

MSigDB gene sets: 151 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_RESPONSE_TO_ANGIOTENSIN, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, FOSTER_TOLERANT_MACROPHAGE_DN, GOBP_CELLULAR_RESPONSE_TO_HORMONE_STIMULUS, GOBP_RESPONSE_TO_OXYGEN_LEVELS, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS, GOBP_RESPONSE_TO_OXYGEN_CONTAINING_COMPOUND, LIAO_METASTASIS, GOBP_CELLULAR_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_RESPONSE_TO_HORMONE, GOBP_RESPONSE_TO_ABIOTIC_STIMULUS, GOMF_PEPTIDE_RECEPTOR_ACTIVITY

GO Biological Process (3): response to hypoxia (GO:0001666), regulation of blood pressure (GO:0008217), angiotensin-activated signaling pathway (GO:0038166)

GO Molecular Function (3): angiotensin type II receptor activity (GO:0004945), identical protein binding (GO:0042802), protein binding (GO:0005515)

GO Cellular Component (9): Golgi membrane (GO:0000139), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), cell cortex (GO:0005938), cytoplasmic vesicle membrane (GO:0030659), endoplasmic reticulum (GO:0005783), membrane (GO:0016020), cytoplasmic vesicle (GO:0031410)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Oncogenic MAPK signaling	1
Disease	1
Diseases of signal transduction by growth factor receptors and second messengers	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	4
endomembrane system	2
intracellular membrane-bounded organelle	2
cell periphery	2
response to stress	1
response to decreased oxygen levels	1
blood circulation	1
regulation of biological quality	1
G protein-coupled receptor signaling pathway	1
cellular response to angiotensin	1
angiotensin receptor activity	1
protein binding	1
binding	1
Golgi apparatus	1
bounding membrane of organelle	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
vesicle membrane	1
cytoplasmic vesicle	1
cellular anatomical structure	1
intracellular vesicle	1

Protein interactions and networks

STRING

806 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AGTRAP	AGTR1	P30556	974
AGTRAP	AGT	P01019	851
AGTRAP	CAMLG	P49069	843
AGTRAP	CHRM3	P20309	715
AGTRAP	BDKRB1	P46663	648
AGTRAP	BDKRB2	P30411	612
AGTRAP	ARAP1	Q96P48	610
AGTRAP	PITPNC1	Q9UKF7	602
AGTRAP	BST2	Q10589	584
AGTRAP	CLCN6	P51797	571
AGTRAP	RACK1	P25388	549
AGTRAP	NFATC2	Q13469	548
AGTRAP	REN	P00797	478
AGTRAP	ADRB2	P07550	465
AGTRAP	PPIB	P23284	452

IntAct

263 interactions, top by confidence:

A	B	Type	Score
AGTRAP	PITPNC1	psi-mi:“MI:0915”(physical association)	0.760
PITPNC1	AGTRAP	psi-mi:“MI:0915”(physical association)	0.760
AGTRAP	PDHX	psi-mi:“MI:0915”(physical association)	0.740
SSX5	AGTRAP	psi-mi:“MI:0915”(physical association)	0.740
AGTRAP	PTPN9	psi-mi:“MI:0915”(physical association)	0.740
SYT16	AGTRAP	psi-mi:“MI:0915”(physical association)	0.740
AGTRAP	SPG21	psi-mi:“MI:0915”(physical association)	0.740
PDHX	AGTRAP	psi-mi:“MI:0915”(physical association)	0.740
AGTRAP	SSX5	psi-mi:“MI:0915”(physical association)	0.740
SPG21	AGTRAP	psi-mi:“MI:0915”(physical association)	0.740
AGTRAP	SYT16	psi-mi:“MI:0915”(physical association)	0.740
PTPN9	AGTRAP	psi-mi:“MI:0915”(physical association)	0.740
AGTRAP	ARFIP2	psi-mi:“MI:0915”(physical association)	0.670
MYG1	AGTRAP	psi-mi:“MI:0915”(physical association)	0.670
AGTRAP	HSCB	psi-mi:“MI:0915”(physical association)	0.670
AGTRAP	COQ8A	psi-mi:“MI:0915”(physical association)	0.670
ACSF2	AGTRAP	psi-mi:“MI:0915”(physical association)	0.670
AGTRAP	MCEE	psi-mi:“MI:0915”(physical association)	0.670
ARFIP2	AGTRAP	psi-mi:“MI:0915”(physical association)	0.670

BioGRID (246): AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid), AGTRAP (Two-hybrid)

ESM2 similar proteins: A2VE58, A3KQ86, A6H7B0, A7E3W5, A8MWL6, B2RZ87, O43759, O43760, O43761, O54980, O55100, O55101, O76735, O95473, P07825, P08247, P0DI73, P20488, P22831, P47987, P79826, Q08AU7, Q08DL4, Q28793, Q2YDD6, Q5EBF8, Q5R703, Q5RER2, Q5XGR0, Q5XIT3, Q5YJC1, Q62277, Q62876, Q642A2, Q6RW13, Q7JYV2, Q7TQJ1, Q8BGN8, Q8R191, Q8TBG9

Diamond homologs: Q5EBF8, Q5RER2, Q642A2, Q6RW13, Q9WVK0

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

53 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	2
Likely pathogenic	2
Uncertain significance	30
Likely benign	10
Benign	0

Top pathogenic / likely-pathogenic (4)

Variant ID	HGVS	Classification
146535	GRCh38/hg38 1p36.23-36.22(chr1:8283694-12470133)x1	Pathogenic
3063399	GRCh37/hg19 1p36.31-36.21(chr1:6330828-12910774)x1	Pathogenic
443150	GRCh37/hg19 1p36.22-36.21(chr1:10722725-14267773)x1	Likely pathogenic
814053	GRCh37/hg19 1p36.22(chr1:9852396-11909475)x1	Likely pathogenic

SpliceAI

1145 predictions. Top by Δscore:

Variant	Effect	Δscore
1:11747541:GCATG:G	donor_gain	1.0000
1:11748409:TTGCA:T	acceptor_loss	1.0000
1:11748410:TGCAG:T	acceptor_loss	1.0000
1:11748411:GCA:G	acceptor_loss	1.0000
1:11748412:CAG:C	acceptor_loss	1.0000
1:11748413:A:AG	acceptor_gain	1.0000
1:11748413:A:T	acceptor_loss	1.0000
1:11748414:G:A	acceptor_loss	1.0000
1:11748414:G:GT	acceptor_gain	1.0000
1:11748414:GT:G	acceptor_gain	1.0000
1:11748414:GTT:G	acceptor_gain	1.0000
1:11748414:GTTT:G	acceptor_gain	1.0000
1:11748414:GTTTC:G	acceptor_gain	1.0000
1:11748579:G:GT	donor_gain	1.0000
1:11750060:T:G	acceptor_gain	1.0000
1:11736197:GCC:G	donor_gain	0.9900
1:11736274:G:GT	donor_gain	0.9900
1:11747542:CATGG:C	donor_loss	0.9900
1:11747545:GGTGA:G	donor_loss	0.9900
1:11747546:G:A	donor_loss	0.9900
1:11747547:T:A	donor_loss	0.9900
1:11748587:GGG:G	donor_gain	0.9900
1:11748588:GGG:G	donor_gain	0.9900
1:11750073:CTAGG:C	acceptor_loss	0.9900
1:11750074:TA:T	acceptor_loss	0.9900
1:11750075:A:G	acceptor_loss	0.9900
1:11750076:G:GA	acceptor_loss	0.9900
1:11746123:T:A	acceptor_gain	0.9800
1:11747546:G:GG	donor_gain	0.9800
1:11748588:GG:G	donor_gain	0.9800

AlphaMissense

1025 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:11748463:A:C	S73R	0.990
1:11748465:C:A	S73R	0.990
1:11748465:C:G	S73R	0.990
1:11748529:A:C	S95R	0.989
1:11748531:C:A	S95R	0.989
1:11748531:C:G	S95R	0.989
1:11747504:T:A	W43R	0.988
1:11747504:T:C	W43R	0.988
1:11748449:A:T	D68V	0.988
1:11748449:A:C	D68A	0.987
1:11745821:T:A	W16R	0.986
1:11745821:T:C	W16R	0.986
1:11747507:G:C	A44P	0.986
1:11748543:G:C	K99N	0.986
1:11748543:G:T	K99N	0.986
1:11747498:G:C	G41R	0.985
1:11747479:C:A	N34K	0.983
1:11747479:C:G	N34K	0.983
1:11747441:G:C	G22R	0.982
1:11747493:C:A	A39D	0.982
1:11747499:G:A	G41D	0.981
1:11747508:C:A	A44D	0.981
1:11748448:G:C	D68H	0.981
1:11748424:G:C	G60R	0.979
1:11748553:T:C	C103R	0.976
1:11748505:T:C	F87L	0.975
1:11748507:T:A	F87L	0.975
1:11748507:T:G	F87L	0.975
1:11748448:G:T	D68Y	0.972
1:11748425:G:A	G60D	0.970

dbSNP variants (sampled 300 via entrez): RS1000148201 (1:11739766 G>A), RS1000175147 (1:11745213 C>T), RS1000218063 (1:11751211 C>T), RS1000272543 (1:11737842 C>G,T), RS1000365655 (1:11749544 G>C), RS1000403382 (1:11750915 C>T), RS1000427707 (1:11744046 T>A,G), RS1000575859 (1:11739056 T>A), RS1000706557 (1:11738150 T>C,G), RS1001008593 (1:11739409 G>C), RS1001266741 (1:11739415 G>A), RS1001349203 (1:11744726 C>G,T), RS1001573008 (1:11750376 G>A,T), RS1001607951 (1:11743670 G>A), RS1001759706 (1:11749034 G>T)

Disease associations

OMIM: gene MIM:608729 | disease phenotypes: MIM:612201

GenCC curated gene-disease

Mondo (1): atrial fibrillation, familial, 6 (MONDO:0012816)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST000395_2	Systolic blood pressure	2.000000e-13
GCST010654_5	Arterial stiffness (brachial-femoral pulse wave velocity)	1.000000e-06
GCST90002380_74	Basophil percentage of white cells	7.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0006335	systolic blood pressure
EFO:0004517	arterial stiffness measurement
EFO:0007992	basophil percentage of leukocytes

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C567400	Atrial Fibrillation, Familial, 6 (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

40 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression	3
Plant Extracts	decreases reaction, increases expression, increases reaction, decreases activity	2
Aflatoxin B1	affects expression, decreases methylation	2
GSK-J4	decreases expression	1
bufotalin	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
glycidyl methacrylate	decreases expression	1
tris(2-butoxyethyl) phosphate	affects expression	1
sodium arsenite	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
K 7174	decreases expression	1
jinfukang	affects cotreatment, increases expression	1
(+)-JQ1 compound	decreases expression	1
MT19c compound	decreases expression	1
gnetin C	decreases activity	1
Bortezomib	decreases expression	1
Resveratrol	decreases activity	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Coumestrol	increases expression	1
Diuron	decreases expression	1
Dust	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Flavonoids	increases expression, increases reaction, decreases reaction	1
Formaldehyde	increases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Ivermectin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.