AHI1-DT

Summary

AHI1-DT (AHI1 divergent transcript, HGNC:32526) is a long non-coding RNA gene on chromosome 6q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32526
Approved symbol	AHI1-DT
Name	AHI1 divergent transcript
Location	6q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231028
Ensembl biotype	lncRNA
Entrez	100131814
RNAcentral	URS000075A820 — lncRNA, 1666 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 66 — 66 lncRNA

ENST00000421378, ENST00000436554, ENST00000438618, ENST00000579057, ENST00000579339, ENST00000579944, ENST00000580741, ENST00000653664, ENST00000655302, ENST00000655480, ENST00000658067, ENST00000662332, ENST00000664629, ENST00000664883, ENST00000666467, ENST00000684828, ENST00000685995, ENST00000686835, ENST00000689196, ENST00000690121, ENST00000690403, ENST00000690910, ENST00000691507, ENST00000692483, ENST00000702072, ENST00000808294, ENST00000808295, ENST00000808296, ENST00000808297, ENST00000808298, ENST00000808299, ENST00000808300, ENST00000808301, ENST00000808302, ENST00000808303, ENST00000808304, ENST00000808305, ENST00000808306, ENST00000808307, ENST00000808308, ENST00000808309, ENST00000808310, ENST00000808311, ENST00000808312, ENST00000808313, ENST00000808314, ENST00000808315, ENST00000808316, ENST00000808317, ENST00000808318, ENST00000808319, ENST00000808320, ENST00000808321, ENST00000808322, ENST00000808323, ENST00000808324, ENST00000808325, ENST00000808326, ENST00000808327, ENST00000808328, ENST00000808329, ENST00000808330, ENST00000808331, ENST00000808332, ENST00000808333, ENST00000808334

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000421378 — 4 exons

Exon	Start	End
ENSE00001629726	135672294	135672429
ENSE00001742117	135642193	135642276
ENSE00002721754	135497803	135498000
ENSE00002729416	135689623	135690838

Expression profiles

Bgee: expression breadth ubiquitous, 165 present calls, max score 85.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.3604 / max 57.7389, expressed in 1022 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
69933	1.1931	629
69934	1.1674	575

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	85.48	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.03	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.33	gold quality
left testis	UBERON:0004533	81.75	gold quality
right testis	UBERON:0004534	81.59	gold quality
testis	UBERON:0000473	79.40	gold quality
calcaneal tendon	UBERON:0003701	78.78	gold quality
islet of Langerhans	UBERON:0000006	77.62	gold quality
adenohypophysis	UBERON:0002196	77.14	gold quality
left lobe of thyroid gland	UBERON:0001120	75.59	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.51	gold quality
pituitary gland	UBERON:0000007	75.39	gold quality
right lobe of thyroid gland	UBERON:0001119	75.25	gold quality
thyroid gland	UBERON:0002046	75.17	gold quality
adrenal tissue	UBERON:0018303	73.31	gold quality
metanephros cortex	UBERON:0010533	72.56	gold quality
sural nerve	UBERON:0015488	72.08	gold quality
bone marrow cell	CL:0002092	71.67	silver quality
pancreas	UBERON:0001264	71.08	gold quality
right adrenal gland cortex	UBERON:0035827	71.08	gold quality
colonic epithelium	UBERON:0000397	70.31	gold quality
right adrenal gland	UBERON:0001233	70.29	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.88	gold quality
left adrenal gland	UBERON:0001234	69.86	gold quality
left adrenal gland cortex	UBERON:0035825	69.86	gold quality
body of pancreas	UBERON:0001150	68.96	gold quality
adrenal gland	UBERON:0002369	68.74	gold quality
adult mammalian kidney	UBERON:0000082	68.61	gold quality
adrenal cortex	UBERON:0001235	68.04	gold quality
left ovary	UBERON:0002119	67.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.82

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• There was no significant difference in brain expression of C6orf217 between patients and controls and no genotypic effect. (PMID:20452750)
• Results show that LINC00271 expression was significantly downregulated in papillary thyroid cancer (PTC) and suggest that LINC00271 is a possible suppressor gene in PTC. (PMID:27833134)
• LINC00271 is downregulated in adrenocortical carcinoma (ACC) and associated with prognosis - patients with low LINC00271 expression survived a shorter time than patients with high expression. Low LINC00271 expression was positively associated with WNT signaling, cell cycle, and chromosome segregation pathways commonly dysregulated in ACC. Results suggest that LINC00271 may be a prognostic marker in ACC. (PMID:31522749)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.