AIRN

Summary

AIRN (antisense of IGF2R non-protein coding RNA, HGNC:34515) is a long non-coding RNA gene on chromosome 6q25.3.

Both spliced and un-spliced long non-coding RNAs are transcribed from this gene. This gene overlaps on the opposite strand the second intron of the insulin-like growth factor 2 receptor gene; a CpG island associated with the second intron denotes an active promoter that drives the expression of this gene. The related mouse gene is responsible for silencing the insulin-like growth factor 2 receptor gene and flanking genes in the imprinted gene cluster of mice. This gene may be expressed in Wilms tumors.

Source: NCBI Gene 100271873 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:34515
Approved symbol	AIRN
Name	antisense of IGF2R non-protein coding RNA
Location	6q25.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	AIR, NCRNA00088, IGF2RAS, IGF2R-AS1
Ensembl gene	ENSG00000268257
Ensembl biotype	lncRNA
OMIM	604893
Entrez	100271873
RNAcentral	URS000041E62F — lncRNA, 1489 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000601203, ENST00000609176, ENST00000796971, ENST00000796972, ENST00000796973

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000601203 — 1 exons

Exon	Start	End
ENSE00003162982	160003291	160007664

Expression profiles

Bgee: expression breadth broad, 65 present calls, max score 85.17.

Top tissues by expression

65 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.17	gold quality
bone marrow cell	CL:0002092	66.26	silver quality
colon	UBERON:0001155	62.74	silver quality
cortical plate	UBERON:0005343	62.07	silver quality
ovary	UBERON:0000992	60.41	silver quality
thyroid gland	UBERON:0002046	59.40	silver quality
blood	UBERON:0000178	57.12	gold quality
thoracic mammary gland	UBERON:0005200	57.02	silver quality
urinary bladder	UBERON:0001255	56.11	silver quality
small intestine	UBERON:0002108	55.33	silver quality
hindlimb stylopod muscle	UBERON:0004252	55.31	silver quality
liver	UBERON:0002107	55.28	silver quality
lung	UBERON:0002048	53.59	silver quality
prefrontal cortex	UBERON:0000451	52.11	gold quality
adrenal tissue	UBERON:0018303	51.75	gold quality
intestine	UBERON:0000160	51.26	silver quality
calcaneal tendon	UBERON:0003701	50.61	silver quality
heart left ventricle	UBERON:0002084	49.15	silver quality
primary visual cortex	UBERON:0002436	49.05	gold quality
monocyte	CL:0000576	48.92	silver quality
cortex of kidney	UBERON:0001225	48.45	silver quality
frontal cortex	UBERON:0001870	48.19	silver quality
multicellular organism	UBERON:0000468	47.80	gold quality
endometrium	UBERON:0001295	47.11	silver quality
superior frontal gyrus	UBERON:0002661	46.67	silver quality
adrenal gland	UBERON:0002369	46.51	gold quality
cerebral cortex	UBERON:0000956	45.70	silver quality
heart	UBERON:0000948	45.68	silver quality
gastrocnemius	UBERON:0001388	45.56	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	45.09	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.86

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): USF1, USF2

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA AIRN influences the proliferation and apoptosis of hepatocellular carcinoma cells by regulating STAT1 ubiquitination. (PMID:33759138)
• LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway. (PMID:36171606)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.