AKAP8L

Summary

AKAP8L (A-kinase anchoring protein 8 like, HGNC:29857) is a protein-coding gene on chromosome 19p13.12, encoding A-kinase anchor protein 8-like (Q9ULX6). Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9.

Enables histone deacetylase binding activity and lamin binding activity. Involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in chromatin; cytoplasm; and nuclear lumen. Part of ribonucleoprotein complex.

Source: NCBI Gene 26993 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 115 total
• Druggable target: yes
• MANE Select transcript: NM_014371

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29857
Approved symbol	AKAP8L
Name	A-kinase anchoring protein 8 like
Location	19p13.12
Locus type	gene with protein product
Status	Approved
Aliases	NAKAP95, HAP95
Ensembl gene	ENSG00000011243
Ensembl biotype	protein_coding
OMIM	609475
Entrez	26993

Gene structure

Transcript identifiers

Ensembl transcripts: 44 — 18 retained_intron, 12 protein_coding, 10 nonsense_mediated_decay, 4 protein_coding_CDS_not_defined

ENST00000397410, ENST00000593845, ENST00000594594, ENST00000594893, ENST00000595067, ENST00000595087, ENST00000595136, ENST00000595465, ENST00000595879, ENST00000596195, ENST00000596213, ENST00000596750, ENST00000597994, ENST00000598292, ENST00000599137, ENST00000599488, ENST00000600065, ENST00000600247, ENST00000601147, ENST00000609519, ENST00000679634, ENST00000679638, ENST00000680017, ENST00000680103, ENST00000680302, ENST00000680303, ENST00000680323, ENST00000680363, ENST00000680642, ENST00000680649, ENST00000680703, ENST00000680774, ENST00000680803, ENST00000680865, ENST00000680957, ENST00000681170, ENST00000681405, ENST00000681459, ENST00000681744, ENST00000885826, ENST00000885827, ENST00000964225, ENST00000964226, ENST00000964227

RefSeq mRNA: 2 — MANE Select: NM_014371 NM_001291478, NM_014371

CCDS: CCDS46005, CCDS77249

Canonical transcript exons

ENST00000397410 — 14 exons

Exon	Start	End
ENSE00003487431	15380050	15380430
ENSE00003506012	15397714	15397855
ENSE00003547549	15404010	15404042
ENSE00003567904	15397520	15397625
ENSE00003568503	15403475	15403715
ENSE00003575529	15401150	15401603
ENSE00003606649	15380517	15380612
ENSE00003607658	15410520	15410594
ENSE00003668730	15397150	15397280
ENSE00003693521	15418911	15418988
ENSE00003703289	15399302	15399410
ENSE00003705303	15400295	15400358
ENSE00003707414	15400794	15400864
ENSE00003710027	15400947	15401043

Expression profiles

Bgee: expression breadth ubiquitous, 270 present calls, max score 99.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.5300 / max 679.9277, expressed in 1820 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
179743	37.3552	1817
179742	7.1412	1728
179741	0.0279	5
179740	0.0057	3

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	99.12	gold quality
right uterine tube	UBERON:0001302	98.94	gold quality
cerebellar hemisphere	UBERON:0002245	98.84	gold quality
cerebellar cortex	UBERON:0002129	98.61	gold quality
right lobe of thyroid gland	UBERON:0001119	98.51	gold quality
adenohypophysis	UBERON:0002196	98.50	gold quality
left lobe of thyroid gland	UBERON:0001120	98.47	gold quality
metanephros cortex	UBERON:0010533	98.43	gold quality
sural nerve	UBERON:0015488	98.38	gold quality
right testis	UBERON:0004534	98.24	gold quality
left testis	UBERON:0004533	98.18	gold quality
right adrenal gland cortex	UBERON:0035827	98.14	gold quality
right adrenal gland	UBERON:0001233	98.07	gold quality
mucosa of stomach	UBERON:0001199	97.98	gold quality
left adrenal gland cortex	UBERON:0035825	97.94	gold quality
endocervix	UBERON:0000458	97.92	gold quality
left adrenal gland	UBERON:0001234	97.85	gold quality
tibial nerve	UBERON:0001323	97.82	gold quality
ventricular zone	UBERON:0003053	97.67	gold quality
granulocyte	CL:0000094	97.66	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.60	gold quality
apex of heart	UBERON:0002098	97.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.53	gold quality
right ovary	UBERON:0002118	97.49	gold quality
left ovary	UBERON:0002119	97.46	gold quality
body of uterus	UBERON:0009853	97.42	gold quality
right frontal lobe	UBERON:0002810	97.41	gold quality
right lung	UBERON:0002167	97.40	gold quality
cortical plate	UBERON:0005343	97.35	gold quality
pituitary gland	UBERON:0000007	97.33	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.42

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1

Literature-anchored findings (GeneRIF, showing 9)

• Results indicate that in vitro, the interaction between HA95 and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 rather than by CDK1- or PKC-mediated phosphorylation of LAP2beta (PMID:12950172)
• NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD (PMID:16391387)
• Nuclear PKA C subunit co-locates with HA95 in splicing factor compartments and regulates pre-mRNA splicing, possibly through a cAMP-independent mechanism. (PMID:17594903)
• These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. (PMID:18313049)
• Gene dosage at 19p13.12, and AKAP8 and/or AKAP8L in particular, play an important role in modulation of head size and may contribute to autism risk. (PMID:26076356)
• A-kinase anchoring protein 8L interacts with mTORC1 and promotes cell growth. (PMID:32312749)
• Novel prognostic model predicts overall survival in colon cancer based on RNA splicing regulation gene expression. (PMID:35792657)
• AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA. (PMID:36522343)
• Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer. (PMID:37683130)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	akap8l	ENSDARG00000099635
mus_musculus	Akap8l	ENSMUSG00000002625
rattus_norvegicus	Akap8l	ENSRNOG00000006355

Paralogs (2): AKAP8 (ENSG00000105127), ZNF326 (ENSG00000162664)

Protein

Protein identifiers

A-kinase anchor protein 8-like — Q9ULX6 (reviewed: Q9ULX6)

Alternative names: Helicase A-binding protein 95, Homologous to AKAP95 protein, Neighbor of A-kinase-anchoring protein 95

All UniProt accessions (14): Q9ULX6, A0A7P0T847, A0A7P0T8N3, A0A7P0T9N5, A0A7P0TAD3, A0A7P0TAE3, A0A7P0TAJ5, A0A7P0TBP0, M0QYT7, M0R008, M0R010, M0R1L5, M0R1Y5, V9GZ50

UniProt curated annotations — full annotation on UniProt →

Function. Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at ‘Ser-10’ of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing. (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.

Subunit / interactions. Interacts (via N-terminus) with DHX9 (via RGG region). Interacts with TMPO isoform Beta, PRPF40A, RNF43, lamin-B. Interacts with HDAC3; increased during mitosis. Interacts with EBV EBNA-LP. Interacts with HIV-1 reverse transcriptase/ribonuclease H.

Subcellular location. Nucleus. Nucleus matrix. Nucleus speckle. PML body. Cytoplasm.

Tissue specificity. Ubiquitously expressed. Expressed in the brain cortex (at protein level).

Post-translational modifications. Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.

Similarity. Belongs to the AKAP95 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9ULX6-1	1	yes
Q9ULX6-2	2

RefSeq proteins (2): NP_001278407, NP_055186* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007071	AKAP95	Family
IPR034736	ZF_C2H2_AKAP95	Domain

Pfam: PF04988

UniProt features (34 total): modified residue 11, compositionally biased region 7, sequence conflict 5, region of interest 3, short sequence motif 3, zinc finger region 2, chain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9ULX6-F1	55.46	0.13

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (11): 208, 208, 217, 237, 247, 257, 267, 283, 292, 297, 552

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9772755	Formation of WDR5-containing histone-modifying complexes
R-HSA-212165	Epigenetic regulation of gene expression
R-HSA-74160	Gene expression (Transcription)
R-HSA-9917777	Epigenetic regulation by WDR5-containing histone modifying complexes

MSigDB gene sets: 190 (showing top): GOBP_CHROMOSOME_ORGANIZATION, MODULE_255, YAO_HOXA10_TARGETS_VIA_PROGESTERONE_UP, BROWNE_HCMV_INFECTION_8HR_UP, GOBP_MEMBRANE_DISASSEMBLY, GOBP_CELL_CYCLE_PHASE_TRANSITION, MODULE_317, BROWNE_HCMV_INFECTION_16HR_UP, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1, GOBP_CHROMOSOME_CONDENSATION, GOBP_REGULATION_OF_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOBP_NUCLEAR_TRANSPORT, GOBP_ORGANELLE_FISSION, GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT, BLALOCK_ALZHEIMERS_DISEASE_UP

GO Biological Process (7): mRNA processing (GO:0006397), mitotic chromosome condensation (GO:0007076), RNA splicing (GO:0008380), regulation of mRNA export from nucleus (GO:0010793), cell cycle G2/M phase transition (GO:0044839), positive regulation of transcription by RNA polymerase II (GO:0045944), nuclear membrane disassembly (GO:0051081)

GO Molecular Function (10): DNA binding (GO:0003677), RNA binding (GO:0003723), lamin binding (GO:0005521), zinc ion binding (GO:0008270), DEAD/H-box RNA helicase binding (GO:0017151), protein kinase A regulatory subunit binding (GO:0034237), histone deacetylase binding (GO:0042826), protein binding (GO:0005515), kinase activity (GO:0016301), metal ion binding (GO:0046872)

GO Cellular Component (8): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytoplasm (GO:0005737), nuclear matrix (GO:0016363), PML body (GO:0016605), nuclear speck (GO:0016607), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Epigenetic regulation by WDR5-containing histone modifying complexes	1
Gene expression (Transcription)	1
Epigenetic regulation of gene expression	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
RNA processing	2
nucleic acid binding	2
enzyme binding	2
nuclear lumen	2
mRNA metabolic process	1
mitotic sister chromatid segregation	1
mitotic cell cycle	1
chromosome condensation	1
mitotic cell cycle process	1
mRNA export from nucleus	1
regulation of RNA export from nucleus	1
regulation of ribonucleoprotein complex localization	1
cell cycle phase transition	1
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
positive regulation of DNA-templated transcription	1
membrane disassembly	1
nuclear membrane organization	1
protein binding	1
transition metal ion binding	1
protein kinase A binding	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
cation binding	1
chromosome	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
nuclear body	1
nuclear ribonucleoprotein granule	1
protein-containing complex	1

Protein interactions and networks

STRING

1204 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AKAP8L	RNF43	Q68DV7	934
AKAP8L	DHX9	Q08211	873
AKAP8L	PRPF40A	O75400	779
AKAP8L	EMD	P50402	757
AKAP8L	HTT	P42858	713
AKAP8L	HAX1	O00165	605
AKAP8L	MYOM2	P54296	594
AKAP8L	NXF1	Q9UBU9	543
AKAP8L	NONO	P30807	532
AKAP8L	AKAP8	O43823	521
AKAP8L	SFPQ	P23246	509
AKAP8L	HDAC1	Q13547	485
AKAP8L	HSPA4	P34932	450
AKAP8L	AKAP17A	Q02040	442
AKAP8L	NCOR1	O75376	433

IntAct

333 interactions, top by confidence:

A	B	Type	Score
IFT27	IFT56	psi-mi:“MI:0914”(association)	0.690
HDAC3	AKAP8	psi-mi:“MI:0914”(association)	0.650
AKAP8	HDAC3	psi-mi:“MI:0403”(colocalization)	0.650
AKAP8L	HDAC3	psi-mi:“MI:0915”(physical association)	0.610
HDAC3	AKAP8L	psi-mi:“MI:0915”(physical association)	0.610
AKAP8L	CTA1	psi-mi:“MI:0915”(physical association)	0.560
FRS3	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
TYK2	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
ZNF785	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
MPLKIP	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
ZIC1	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
PKN1	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
FAM222B	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
PATZ1	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560
ENKD1	AKAP8L	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (294): AKAP8L (Affinity Capture-RNA), AKAP8L (Affinity Capture-RNA), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS), AKAP8L (Affinity Capture-MS)

ESM2 similar proteins: A0A0R4IZ84, A2CEZ5, A2RV70, D3YXK2, F1MJM0, O15047, O43823, O60293, O88291, O88453, P41073, P43243, P43244, P61129, P61406, P78332, P97868, Q08D57, Q14151, Q15424, Q1LY77, Q28F29, Q2HJG4, Q3TLH4, Q498L2, Q5BKZ1, Q5F3P8, Q5R452, Q5RAK6, Q5RCA4, Q5U236, Q5VK71, Q5ZJ02, Q63014, Q66HC1, Q66J90, Q7YZA2, Q7Z6E9, Q80YR5, Q86US8

Diamond homologs: A2CEZ5, A2RV70, F1MJM0, O43823, O88291, Q28F29, Q5BKZ1, Q5RCA4, Q5VK71, Q5ZJ02, Q63014, Q9DBR0, Q9R0L7, Q9ULX6

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
AKAP8L	up-regulates	mRNA_nuclear_export
AKAP8L	“up-regulates activity”	DHX9	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

115 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	94
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

2868 predictions. Top by Δscore:

Variant	Effect	Δscore
19:15380511:CCTCA:C	donor_loss	1.0000
19:15380512:CTCAC:C	donor_loss	1.0000
19:15380513:TCA:T	donor_loss	1.0000
19:15380514:CACCT:C	donor_loss	1.0000
19:15380516:C:CA	donor_loss	1.0000
19:15380608:ATGAG:A	acceptor_gain	1.0000
19:15380609:TGAG:T	acceptor_gain	1.0000
19:15380613:C:CC	acceptor_gain	1.0000
19:15397145:CTCA:C	donor_loss	1.0000
19:15397146:TCA:T	donor_loss	1.0000
19:15397147:CA:C	donor_loss	1.0000
19:15397148:A:AC	donor_gain	1.0000
19:15397148:AC:A	donor_gain	1.0000
19:15397148:ACC:A	donor_gain	1.0000
19:15397149:C:CC	donor_gain	1.0000
19:15397149:CC:C	donor_gain	1.0000
19:15397149:CCC:C	donor_gain	1.0000
19:15397149:CCCT:C	donor_gain	1.0000
19:15397149:CCCTG:C	donor_gain	1.0000
19:15397276:AATTT:A	acceptor_gain	1.0000
19:15397277:ATTT:A	acceptor_gain	1.0000
19:15397278:TTT:T	acceptor_gain	1.0000
19:15397278:TTTCT:T	acceptor_loss	1.0000
19:15397279:TT:T	acceptor_gain	1.0000
19:15397280:TCTG:T	acceptor_loss	1.0000
19:15397281:C:CA	acceptor_loss	1.0000
19:15397281:C:CC	acceptor_gain	1.0000
19:15397282:T:G	acceptor_loss	1.0000
19:15397516:TCA:T	donor_loss	1.0000
19:15397517:CACCC:C	donor_loss	1.0000

AlphaMissense

4280 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:15380416:G:C	F549L	1.000
19:15380416:G:T	F549L	1.000
19:15380418:A:G	F549L	1.000
19:15380521:A:G	L543P	1.000
19:15380533:A:G	L539P	1.000
19:15380560:A:G	L530P	1.000
19:15380560:A:T	L530H	1.000
19:15380563:A:C	I529S	1.000
19:15380563:A:G	I529T	1.000
19:15380563:A:T	I529N	1.000
19:15380565:A:C	S528R	1.000
19:15380565:A:T	S528R	1.000
19:15380567:T:G	S528R	1.000
19:15380572:G:T	A526D	1.000
19:15380573:C:G	A526P	1.000
19:15380592:C:A	K519N	1.000
19:15380592:C:G	K519N	1.000
19:15380597:A:G	S518P	1.000
19:15397154:C:G	R511P	1.000
19:15397165:G:C	H507Q	1.000
19:15397165:G:T	H507Q	1.000
19:15397167:G:C	H507D	1.000
19:15397183:A:C	H501Q	1.000
19:15397183:A:T	H501Q	1.000
19:15397185:G:C	H501D	1.000
19:15397185:G:T	H501N	1.000
19:15397214:A:T	I491N	1.000
19:15397220:A:G	L489P	1.000
19:15397225:G:C	C487W	1.000
19:15397226:C:A	C487F	1.000

dbSNP variants (sampled 300 via entrez): RS1000006524 (19:15390289 C>T), RS1000076362 (19:15408840 C>T), RS1000207351 (19:15380443 G>T), RS1000285549 (19:15390114 TA>T,TAA), RS1000377937 (19:15419374 C>T), RS1000407446 (19:15419191 G>A), RS1000503386 (19:15391216 TTTG>T), RS1000572338 (19:15389983 C>G), RS1000628408 (19:15415451 T>A), RS1000725278 (19:15397906 A>G), RS1000782953 (19:15396469 T>G), RS1000835224 (19:15396167 C>A,T), RS1000907276 (19:15420679 G>A,C), RS1000922626 (19:15415219 A>C), RS1001011102 (19:15385091 C>A)

Disease associations

OMIM: gene MIM:609475 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90002403_282	Red blood cell count	3.000000e-15

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066358 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.80	Kd	1590	nM	CHEMBL5653589
5.76	ED50	1729	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2147830: Binding affinity to human AKAP8L incubated for 45 mins by Kinobead based pull down assay	kd	1.5897	uM

CTD chemical–gene interactions

48 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, increases expression, affects cotreatment, decreases expression	4
sodium arsenite	affects cotreatment, increases abundance, increases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression, increases expression	2
aristolochic acid I	increases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
deoxynivalenol	increases expression	1
trichostatin A	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
methacrylaldehyde	increases expression, increases abundance, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
deguelin	increases expression	1
monomethylarsonous acid	increases expression	1
K 7174	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
abrine	increases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
bisphenol AF	increases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Vorinostat	decreases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Air Pollutants	increases abundance, increases expression, affects cotreatment	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5650872	Binding	Binding affinity to human AKAP8L incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.