◎ Sugi Atlas

Atlas / Gene / AKR1B15

AKR1B15

gene
On this page

Summary

AKR1B15 (aldo-keto reductase family 1 member B15, HGNC:37281) is a protein-coding gene on chromosome 7q33, encoding Aldo-keto reductase family 1 member B15 (C9JRZ8). Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds.

Enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity. Predicted to be involved in estrogen biosynthetic process. Located in cytosol and mitochondrion.

Source: NCBI Gene 441282 — RefSeq curated summary.

At a glance

  • GWAS associations: 2
  • Clinical variants (ClinVar): 76 total
  • MANE Select transcript: NM_001080538

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:37281
Approved symbolAKR1B15
Namealdo-keto reductase family 1 member B15
Location7q33
Locus typegene with protein product
StatusApproved
Ensembl geneENSG00000227471
Ensembl biotypeprotein_coding
OMIM616336
Entrez441282

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 retained_intron

ENST00000423958, ENST00000457545, ENST00000467156, ENST00000652743

RefSeq mRNA: 3 — MANE Select: NM_001080538 NM_001080538, NM_001367820, NM_001367821

CCDS: CCDS47715, CCDS94205

Canonical transcript exons

ENST00000457545 — 12 exons

ExonStartEnd
ENSE00001653107134556736134556859
ENSE00001673699134564598134564769
ENSE00001684793134549110134549249
ENSE00001704980134571604134571681
ENSE00001743890134577704134577786
ENSE00001774315134569413134569529
ENSE00002456786134575821134575927
ENSE00002462394134575420134575542
ENSE00002468691134576963134577046
ENSE00002521002134576349134576430
ENSE00003542726134568158134568325
ENSE00003844463134579507134579869

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 81.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2554 / max 24.2956, expressed in 86 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter IDTPM avgSamples expressed
812610.237975
812620.01748

Top tissues by expression

122 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047381.01gold quality
duodenumUBERON:000211479.93gold quality
gastrocnemiusUBERON:000138879.82gold quality
hindlimb stylopod muscleUBERON:000425279.33gold quality
muscle of legUBERON:000138378.15gold quality
mucosa of transverse colonUBERON:000499176.26gold quality
skeletal muscle tissueUBERON:000113475.56gold quality
esophagus mucosaUBERON:000246970.23gold quality
gall bladderUBERON:000211069.87gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099169.77gold quality
muscle tissueUBERON:000238567.73gold quality
placentaUBERON:000198766.91gold quality
body of stomachUBERON:000116166.84gold quality
vaginaUBERON:000099664.71gold quality
stomachUBERON:000094563.86gold quality
urinary bladderUBERON:000125563.05gold quality
islet of LangerhansUBERON:000000662.59gold quality
minor salivary glandUBERON:000183058.72gold quality
saliva-secreting glandUBERON:000104457.80gold quality
transverse colonUBERON:000115757.64gold quality
small intestineUBERON:000210856.92gold quality
fundus of stomachUBERON:000116055.94gold quality
esophagusUBERON:000104355.90gold quality
lower esophagus mucosaUBERON:003583455.47gold quality
small intestine Peyer’s patchUBERON:000345455.41gold quality
subcutaneous adipose tissueUBERON:000219054.89gold quality
rectumUBERON:000105254.75gold quality
left coronary arteryUBERON:000162654.03gold quality
skin of abdomenUBERON:000141654.01gold quality
thoracic mammary glandUBERON:000520053.85gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes7.98

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): AP1, AR, CEBPG, FOS, JUN, JUND, NR1H4, NR1I2, NR1I3, NR5A1, SP1

miRNA regulators (miRDB)

26 targeting AKR1B15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-314899.9775.066478
HSA-MIR-467999.7669.191229
HSA-MIR-6885-3P99.7570.363187
HSA-MIR-4804-3P99.6567.78866
HSA-MIR-1211799.5067.57868
HSA-MIR-216A-5P99.5068.021288
HSA-MIR-5584-3P99.2368.791351
HSA-MIR-510099.1167.521098
HSA-MIR-1288-5P98.8567.01734
HSA-MIR-5000-3P98.7965.631251
HSA-MIR-548Q98.7165.35563
HSA-MIR-4733-3P98.3565.20994
HSA-MIR-3689A-5P98.3570.121049
HSA-MIR-3689B-5P98.3570.121049
HSA-MIR-3689E98.3570.121049
HSA-MIR-3689F98.3570.081052
HSA-MIR-4436A98.0564.831140
HSA-MIR-4700-3P97.7468.641014
HSA-MIR-6511A-3P97.6066.61713
HSA-MIR-6511B-3P97.6066.61713
HSA-MIR-5196-3P97.5765.98979
HSA-MIR-3663-5P97.0164.84713
HSA-MIR-383-5P96.8667.55820
HSA-MIR-433095.4466.39993
HSA-MIR-1238-5P94.8267.52493
HSA-MIR-4758-5P94.8267.06499

Literature-anchored findings (GeneRIF, showing 5)

  • AKR1B15 and Akr1b16 genes are expressed as functional proteins in human and murine tissues (PMID:21276782)
  • Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients (PMID:22277967)
  • human sperm possess an aldo-keto reductase on their membrane surface and are thus enzymatically protected against reactive aldehyde species both in the male and female reproductive tract (PMID:22970857)
  • AKR1B15.2 localizes to the cytosol and displays no enzymatic activity with the substrates tested. (PMID:25577493)
  • Amino acid substitutions clustered in loops A and C result in a smaller more hydrophobic and more rigid active site in AKR1B15 compared with the AKR1B10 pocket, consistent with distinct substrate specificity and narrower inhibitor selectivity for AKR1B15. (PMID:26222439)

Cross-species orthologs

23 orthologs

OrganismSymbolGene ID
danio_reriozgc:110366ENSDARG00000004167
danio_rerioakr1a1aENSDARG00000035257
danio_reriozgc:110782ENSDARG00000044544
danio_reriozgc:101765ENSDARG00000054934
danio_reriozgc:56622ENSDARG00000099728
drosophila_melanogasterCG10863FBGN0027552
drosophila_melanogasterCG9436FBGN0033101
drosophila_melanogasterCG12766FBGN0035476
drosophila_melanogasterCG6083FBGN0036183
drosophila_melanogasterCG10638FBGN0036290
drosophila_melanogasterCG18547FBGN0037973
drosophila_melanogasterCG3397FBGN0037975
drosophila_melanogasterARYFBGN0058064
caenorhabditis_elegansWBGENE00003176
caenorhabditis_elegansWBGENE00009980
caenorhabditis_elegansWBGENE00009981
caenorhabditis_elegansWBGENE00012722
caenorhabditis_elegansWBGENE00012723
caenorhabditis_elegansWBGENE00015307
caenorhabditis_elegansWBGENE00015564
caenorhabditis_elegansWBGENE00015565
caenorhabditis_elegansWBGENE00016985
caenorhabditis_elegansWBGENE00022887

Paralogs (16): AKR7A2 (ENSG00000053371), KCNAB2 (ENSG00000069424), AKR1B1 (ENSG00000085662), AKR1A1 (ENSG00000117448), AKR1D1 (ENSG00000122787), AKR1C2 (ENSG00000151632), AKR7A3 (ENSG00000162482), AKR1E2 (ENSG00000165568), KCNAB1 (ENSG00000169282), KCNAB3 (ENSG00000170049), AKR1C1 (ENSG00000187134), AKR1C3 (ENSG00000196139), AKR1B10 (ENSG00000198074), AKR1C4 (ENSG00000198610), AKR7L (ENSG00000211454), AKR1C8 (ENSG00000264006)

Protein

Protein identifiers

Aldo-keto reductase family 1 member B15 — C9JRZ8 (reviewed: C9JRZ8)

Alternative names: Estradiol 17-beta-dehydrogenase AKR1B15, Farnesol dehydrogenase, Testosterone 17beta-dehydrogenase

All UniProt accessions (1): C9JRZ8

UniProt curated annotations — full annotation on UniProt →

Function. Catalyzes the NADPH-dependent reduction of a variety of carbonyl substrates, like aromatic aldehydes, alkenals, ketones and alpha-dicarbonyl compounds. In addition, catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Displays strong enzymatic activity toward all-trans-retinal and 9-cis-retinal. May play a physiological role in retinoid metabolism. No oxidoreductase activity observed with the tested substrates.

Subunit / interactions. Monomer.

Subcellular location. Mitochondrion Cytoplasm. Cytosol.

Tissue specificity. Widely expressed. Expressed at highest levels in steroid-sensitive tissues, such as placenta, testis and adipose tissue.

Activity regulation. Inhibited by the inhibitor JF0064.

Miscellaneous. Has no counterpart in murine species.

Similarity. Belongs to the aldo/keto reductase family.

Isoforms (2)

UniProt IDNamesCanonical?
C9JRZ8-11, AKR1B15.1yes
C9JRZ8-22, AKR1B15.2

RefSeq proteins (3): NP_001074007, NP_001354749, NP_001354750 (=MANE)

Domains & families (InterPro)

IDNameType
IPR018170Aldo/ket_reductase_CSConserved_site
IPR020471AKRFamily
IPR023210NADP_OxRdtase_domDomain
IPR036812NAD(P)_OxRdtase_dom_sfHomologous_superfamily

Pfam: PF00248

Enzyme classification (BRENDA):

  • EC 1.1.1.36 — acetoacetyl-CoA reductase (BRENDA: 31 organisms, 72 substrates, 26 inhibitors, 49 Km, 19 kcat entries)
  • EC 1.1.1.62 — 17beta-estradiol 17-dehydrogenase (BRENDA: 20 organisms, 283 substrates, 790 inhibitors, 95 Km, 44 kcat entries)

Substrate kinetics (BRENDA)

51 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

SubstrateKm (mM)Measurements
ACETOACETYL-COA0.002–0.7416
ESTRADIOL-17BETA0.0008–0.02514
ESTRONE—10
NADP+0.0001–99
17BETA-ESTRADIOL0.0006–0.0827
NADPH0.0003–0.167
ESTRADIOL0.0036–0.1186
NADPH0.018–0.04435
TESTOSTERONE0.0071–0.2634
(3R)-3-HYDROXYDECANOYL-COA0.0054–0.00583
(3R)-HYDROXYHEXADECANOYL-COA0.024–0.0253
NADH0.0077–0.43
DEHYDROEPIANDROSTERONE0.0172–0.05983
(3R)-HYDROXYBUTYRYL-COA0.0552
NADP+0.031–0.062

Catalyzed reactions (Rhea), 12 shown:

  • allyl alcohol + NADP(+) = acrolein + NADPH + H(+) (RHEA:12168)
  • (2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + NADPH + H(+) (RHEA:14697)
  • testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH + H(+) (RHEA:14981)
  • 17beta-estradiol + NADP(+) = estrone + NADPH + H(+) (RHEA:24616)
  • all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+) (RHEA:25033)
  • acetoin + NADP(+) = diacetyl + NADPH + H(+) (RHEA:35607)
  • 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+) (RHEA:42120)
  • androsterone + NADPH + H(+) = 5alpha-androstane-3alpha,17beta-diol + NADP(+) (RHEA:42156)
  • 3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+) (RHEA:46628)
  • nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+) (RHEA:50616)
  • 9-cis-retinol + NADP(+) = 9-cis-retinal + NADPH + H(+) (RHEA:54916)
  • (E)-4-hydroxynon-2-en-1-ol + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+) (RHEA:58416)

UniProt features (13 total): binding site 7, modified residue 2, chain 1, active site 1, splice variant 1, site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-C9JRZ8-F197.710.99

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 49 (proton donor); 78 (lowers pka of active site tyr)

Ligand- & substrate-binding residues (7): 20–22; 44; 111; 160–161; 184; 210–217; 261–273

Post-translational modifications (2): 125, 263

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

IDPathway
R-HSA-193144Estrogen biosynthesis
R-HSA-1430728Metabolism
R-HSA-196071Metabolism of steroid hormones
R-HSA-556833Metabolism of lipids
R-HSA-8957322Metabolism of steroids

MSigDB gene sets: 108 (showing top): GOBP_REGULATION_OF_HORMONE_LEVELS, GOBP_RETINOL_METABOLIC_PROCESS, GOMF_STEROID_DEHYDROGENASE_ACTIVITY_ACTING_ON_THE_CH_OH_GROUP_OF_DONORS_NAD_OR_NADP_AS_ACCEPTOR, GOBP_HORMONE_BIOSYNTHETIC_PROCESS, GOBP_STEROID_BIOSYNTHETIC_PROCESS, GOBP_LIPID_METABOLIC_PROCESS, GOBP_LIPID_BIOSYNTHETIC_PROCESS, GOBP_ESTROGEN_BIOSYNTHETIC_PROCESS, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS, GOBP_ISOPRENOID_METABOLIC_PROCESS, GOBP_PRIMARY_ALCOHOL_METABOLIC_PROCESS, GOBP_ESTROGEN_METABOLIC_PROCESS, GOBP_STEROID_METABOLIC_PROCESS, GOBP_ALCOHOL_METABOLIC_PROCESS, GOCC_MITOCHONDRIAL_MATRIX

GO Biological Process (3): estrogen biosynthetic process (GO:0006703), lipid metabolic process (GO:0006629), retinol metabolic process (GO:0042572)

GO Molecular Function (9): aldose reductase (NADPH) activity (GO:0004032), estradiol 17-beta-dehydrogenase [NAD(P)+] activity (GO:0004303), oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616), testosterone dehydrogenase (NADP+) activity (GO:0047045), allyl-alcohol dehydrogenase activity (GO:0047655), farnesol dehydrogenase activity (GO:0047886), all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650), protein binding (GO:0005515), oxidoreductase activity (GO:0016491)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), cytosol (GO:0005829), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-4 pathways:

CategoryPathways
Metabolism of steroid hormones1
Metabolism of steroids1
Metabolism1
Metabolism of lipids1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
alcohol dehydrogenase (NADP+) activity2
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor2
cytoplasm2
cellular anatomical structure2
estrogen metabolic process1
hormone biosynthetic process1
steroid hormone biosynthetic process1
primary metabolic process1
retinoid metabolic process1
primary alcohol metabolic process1
hormone metabolic process1
olefinic compound metabolic process1
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor1
oxidoreductase activity, acting on CH-OH group of donors1
17-beta-hydroxysteroid dehydrogenase (NADP+) activity1
retinol metabolic process1
binding1
catalytic activity1
intracellular membrane-bounded organelle1
mitochondrion1
intracellular organelle lumen1
intracellular anatomical structure1

Protein interactions and networks

STRING

932 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
AKR1B15AKR7A2O43488518
AKR1B15UBXN8O00124483
AKR1B15GIN1Q9NXP7481
AKR1B15AKR7A3O95154464
AKR1B15KCNAB3O43448419
AKR1B15CTSEP14091395
AKR1B15CTXND1A0A1B0GTU2395
AKR1B15CNBPP20694393
AKR1B15COBLO75128356
AKR1B15ALDH3A2P51648353
AKR1B15ALDH3A1P30838353
AKR1B15ALDH3B1P43353353
AKR1B15KCNAB1Q14722346
AKR1B15KCNAB2Q13303326
AKR1B15ZNF506Q5JVG8322

IntAct

5 interactions, top by confidence:

ABTypeScore
AKR1B10POTEFpsi-mi:“MI:0914”(association)0.530
AKR1B10AKR1B15psi-mi:“MI:0915”(physical association)0.500
AKR1B1AKR1B15psi-mi:“MI:0915”(physical association)0.400
ATG16L1ESYT2psi-mi:“MI:0914”(association)0.350

BioGRID (20): AKR1B15 (Affinity Capture-MS), AKR1B15 (Affinity Capture-MS), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Co-fractionation), AKR1B15 (Affinity Capture-MS), AKR1B15 (Affinity Capture-MS), AKR1B15 (Two-hybrid), AKR1B15 (Affinity Capture-MS)

ESM2 similar proteins: C9JRZ8, M9PF61, O08782, O14088, O60218, O70473, O80944, O94735, P02532, P07943, P0DXG9, P0DXH7, P14550, P15121, P15122, P16116, P17264, P21300, P28475, P31210, P31867, P38715, P45376, P45377, P47137, P50578, P51635, P51857, P78736, P80276, P82125, Q0PGJ6, Q28FD1, Q3ZCJ2, Q54NZ7, Q568L5, Q5R5D5, Q5RJP0, Q5U1Y4, Q5ZK84

Diamond homologs: A0A1D5XGW0, A0A1X9QHJ0, A0A2P1GIY9, A0A9E7S518, A0A9E7S5B9, B4F9A4, B9VRJ2, C9JRZ8, D3ZF77, E7C196, H9JTG9, M9PF61, O08782, O32210, O34678, O49133, O60218, O70473, O80944, P02532, P05980, P07943, P0DKI7, P0DXG9, P0DXH7, P14065, P14550, P15121, P15122, P16116, P17264, P17516, P21300, P23457, P23901, P26690, P28475, P31867, P42330, P45376

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

76 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance56
Likely benign4
Benign3

Top pathogenic / likely-pathogenic (0)

SpliceAI

1919 predictions. Top by Δscore:

VariantEffectΔscore
7:134549248:AGG:Adonor_loss1.0000
7:134549250:G:Adonor_loss1.0000
7:134549250:G:GGdonor_gain1.0000
7:134549251:T:Adonor_loss1.0000
7:134568153:TTCA:Tacceptor_loss1.0000
7:134568154:TCA:Tacceptor_loss1.0000
7:134568155:CA:Cacceptor_loss1.0000
7:134568156:A:ACacceptor_loss1.0000
7:134568156:A:AGacceptor_gain1.0000
7:134568157:G:GCacceptor_gain1.0000
7:134568157:GT:Gacceptor_gain1.0000
7:134568157:GTC:Gacceptor_gain1.0000
7:134568157:GTCT:Gacceptor_gain1.0000
7:134568157:GTCTC:Gacceptor_gain1.0000
7:134568372:G:GTdonor_gain1.0000
7:134575541:AG:Adonor_loss1.0000
7:134575542:GG:Gdonor_loss1.0000
7:134575543:G:GCdonor_loss1.0000
7:134576343:CCCTA:Cacceptor_loss1.0000
7:134576344:CCTAG:Cacceptor_loss1.0000
7:134576345:CTAG:Cacceptor_loss1.0000
7:134576346:TA:Tacceptor_loss1.0000
7:134576347:A:AGacceptor_gain1.0000
7:134576347:AG:Aacceptor_gain1.0000
7:134576347:AGG:Aacceptor_gain1.0000
7:134576347:AGGG:Aacceptor_loss1.0000
7:134576348:G:GTacceptor_gain1.0000
7:134576348:GG:Gacceptor_gain1.0000
7:134576348:GGG:Gacceptor_gain1.0000
7:134576348:GGGCC:Gacceptor_gain1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000158376 (7:134563413 T>C), RS1000469036 (7:134561671 C>T), RS1000507347 (7:134551708 A>C), RS1000525326 (7:134571216 G>A), RS1000623721 (7:134566383 T>G), RS1000783040 (7:134556647 T>C), RS1000800411 (7:134561495 C>T), RS1000878995 (7:134547363 A>C), RS1001007358 (7:134552233 C>T), RS1001169637 (7:134550866 G>A), RS1001232148 (7:134571020 C>A), RS1001432388 (7:134551009 C>T), RS1001520136 (7:134561166 T>A), RS1001593564 (7:134561398 G>C), RS1001736231 (7:134556015 A>T)

Disease associations

OMIM: gene MIM:616336 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

StudyTraitp-value
GCST000785_19Longevity1.000000e-06
GCST012191_9Body mass index and systolic blood pressure (bivariate analysis)6.000000e-06

EFO canonical traits (2, from GWAS)

EFO IDTrait name
EFO:0004340body mass index
EFO:0006335systolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

ChemicalActions (top 5)PubMed papers
Benzo(a)pyreneincreases methylation, increases expression3
sodium arseniteincreases expression2
afuresertibincreases expression1
methyleugenolincreases expression1
4-nitrobenzaldehydeincreases metabolic processing1
S-(1,2-dichlorovinyl)cysteineaffects cotreatment, increases expression1
2-palmitoylglycerolincreases expression1
abrineincreases expression1
quinocetonedecreases expression1
jinfukangaffects cotreatment, increases expression1
3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic aciddecreases expression1
NSC668394increases expression1
Temozolomidedecreases expression1
Troglitazoneincreases expression1
Arsenicaffects methylation1
Cisplatinincreases expression, affects cotreatment1
Cytarabinedecreases expression1
Glyceraldehydeincreases metabolic processing1
Lipopolysaccharidesaffects cotreatment, increases expression1
N-Nitrosopyrrolidineincreases expression1
Tobacco Smoke Pollutionincreases expression1
Urethanedecreases expression1
Aflatoxin B1increases methylation1
Okadaic Acidincreases expression1
Copper Sulfateincreases expression1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.4
BioBTree
v2.0.2

Sources 75

This page pulls from 75 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot