ALKBH3-AS1

Summary

ALKBH3-AS1 (ALKBH3 antisense RNA 1, HGNC:48670) is a long non-coding RNA gene on chromosome 11p11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48670
Approved symbol	ALKBH3-AS1
Name	ALKBH3 antisense RNA 1
Location	11p11.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000244926
Ensembl biotype	lncRNA
Entrez	100507300
RNAcentral	URS000075AA52 — lncRNA, 1931 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 lncRNA

ENST00000499194, ENST00000527960, ENST00000528285, ENST00000534287, ENST00000664150, ENST00000719958, ENST00000719959

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000499194 — 6 exons

Exon	Start	End
ENSE00001964351	43920874	43920926
ENSE00001966598	43916669	43916921
ENSE00001972073	43919586	43919662
ENSE00001973834	43912263	43912484
ENSE00001982798	43909292	43910513
ENSE00001985684	43920386	43920464

Expression profiles

Bgee: expression breadth ubiquitous, 158 present calls, max score 85.80.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0051 / max 5.4130, expressed in 3 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119426	0.0051	3

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.80	gold quality
sperm	CL:0000019	79.06	silver quality
right testis	UBERON:0004534	74.44	gold quality
left testis	UBERON:0004533	73.99	gold quality
bone marrow cell	CL:0002092	73.53	silver quality
testis	UBERON:0000473	71.57	gold quality
sural nerve	UBERON:0015488	68.64	gold quality
stromal cell of endometrium	CL:0002255	67.68	gold quality
hindlimb stylopod muscle	UBERON:0004252	65.76	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	65.28	gold quality
ventricular zone	UBERON:0003053	64.37	gold quality
mucosa of transverse colon	UBERON:0004991	64.23	gold quality
ganglionic eminence	UBERON:0004023	63.79	gold quality
cortical plate	UBERON:0005343	63.74	gold quality
granulocyte	CL:0000094	63.36	gold quality
cerebellar hemisphere	UBERON:0002245	62.12	gold quality
cerebellar cortex	UBERON:0002129	62.00	gold quality
muscle of leg	UBERON:0001383	61.85	gold quality
gastrocnemius	UBERON:0001388	61.62	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.48	gold quality
apex of heart	UBERON:0002098	61.16	gold quality
islet of Langerhans	UBERON:0000006	60.88	gold quality
cerebellum	UBERON:0002037	60.66	gold quality
body of uterus	UBERON:0009853	59.92	gold quality
right ovary	UBERON:0002118	59.78	gold quality
calcaneal tendon	UBERON:0003701	59.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	59.37	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	59.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	59.28	gold quality
lower esophagus	UBERON:0013473	59.27	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.70

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA ALKBH3-AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion. (PMID:36098205)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.