ALMS1-IT1

Summary

ALMS1-IT1 (ALMS1 intronic transcript 1, HGNC:41305) is a long non-coding RNA gene on chromosome 2p13.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41305
Approved symbol	ALMS1-IT1
Name	ALMS1 intronic transcript 1
Location	2p13.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230002
Ensembl biotype	lncRNA
Entrez	100874291
RNAcentral	URS000075CB55 — lncRNA, 1766 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000441587

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000441587 — 2 exons

Exon	Start	End
ENSE00001609206	73456764	73457326
ENSE00001752358	73457941	73459482

Expression profiles

Bgee: expression breadth ubiquitous, 167 present calls, max score 92.16.

Top tissues by expression

240 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	92.16	gold quality
secondary oocyte	CL:0000655	92.01	gold quality
oocyte	CL:0000023	91.47	gold quality
oviduct epithelium	UBERON:0004804	75.37	silver quality
colonic epithelium	UBERON:0000397	72.80	gold quality
bone marrow cell	CL:0002092	71.40	silver quality
cartilage tissue	UBERON:0002418	71.29	gold quality
calcaneal tendon	UBERON:0003701	70.50	gold quality
sural nerve	UBERON:0015488	69.88	gold quality
tendon	UBERON:0000043	66.05	gold quality
ventricular zone	UBERON:0003053	65.27	gold quality
monocyte	CL:0000576	64.25	gold quality
left ovary	UBERON:0002119	63.99	gold quality
tendon of biceps brachii	UBERON:0008188	63.76	silver quality
leukocyte	CL:0000738	63.68	gold quality
tibial nerve	UBERON:0001323	63.39	gold quality
ovary	UBERON:0000992	63.17	gold quality
right ovary	UBERON:0002118	63.03	gold quality
ectocervix	UBERON:0012249	61.30	gold quality
popliteal artery	UBERON:0002250	61.05	gold quality
tibial artery	UBERON:0007610	61.02	gold quality
right lung	UBERON:0002167	60.98	gold quality
ganglionic eminence	UBERON:0004023	60.64	gold quality
aorta	UBERON:0000947	60.57	gold quality
ascending aorta	UBERON:0001496	60.51	gold quality
thoracic aorta	UBERON:0001515	60.12	gold quality
uterine cervix	UBERON:0000002	59.64	gold quality
bone marrow	UBERON:0002371	59.50	gold quality
endocervix	UBERON:0000458	58.91	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• The lncRNA ALMS1-IT1 may promote malignant progression of lung adenocarcinoma via AVL9-mediated activation of the cyclin-dependent kinase pathway. (PMID:33683834)
• LncRNA ALMS1-IT1 is a novel prognostic biomarker and correlated with immune infiltrates in colon adenocarcinoma. (PMID:36281164)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.