ANGPT4

Summary

ANGPT4 (angiopoietin 4, HGNC:487) is a protein-coding gene on chromosome 20p13, encoding Angiopoietin-4 (Q9Y264). Binds to TEK/TIE2, modulating ANGPT1 signaling.

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin.

Source: NCBI Gene 51378 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 111 total — 12 pathogenic, 4 likely-pathogenic
• MANE Select transcript: NM_015985

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:487
Approved symbol	ANGPT4
Name	angiopoietin 4
Location	20p13
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000101280
Ensembl biotype	protein_coding
OMIM	603705
Entrez	51378

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 protein_coding

ENST00000381922, ENST00000878109

RefSeq mRNA: 2 — MANE Select: NM_015985 NM_001322809, NM_015985

CCDS: CCDS13009

Canonical transcript exons

ENST00000381922 — 9 exons

Exon	Start	End
ENSE00000655125	874284	874414
ENSE00000655126	878161	878327
ENSE00000655127	879747	879848
ENSE00000655128	881171	881286
ENSE00000655130	888318	888439
ENSE00000655133	890213	890368
ENSE00000858558	885078	885325
ENSE00001490278	869900	873120
ENSE00001490322	915906	916334

Expression profiles

Bgee: expression breadth ubiquitous, 122 present calls, max score 72.51.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2193 / max 43.1889, expressed in 80 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185993	0.2193	80

Top tissues by expression

273 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
subcutaneous adipose tissue	UBERON:0002190	72.51	gold quality
left uterine tube	UBERON:0001303	72.29	gold quality
olfactory bulb	UBERON:0002264	72.09	gold quality
type B pancreatic cell	CL:0000169	72.08	gold quality
right ovary	UBERON:0002118	71.26	gold quality
endocervix	UBERON:0000458	70.64	gold quality
omental fat pad	UBERON:0010414	68.96	gold quality
peritoneum	UBERON:0002358	68.92	gold quality
popliteal artery	UBERON:0002250	68.90	gold quality
tibial artery	UBERON:0007610	68.89	gold quality
adipose tissue of abdominal region	UBERON:0007808	68.34	gold quality
body of uterus	UBERON:0009853	68.03	gold quality
left ovary	UBERON:0002119	66.85	gold quality
ectocervix	UBERON:0012249	66.80	gold quality
diaphragm	UBERON:0001103	65.62	gold quality
adipose tissue	UBERON:0001013	64.98	gold quality
uterine cervix	UBERON:0000002	64.38	gold quality
connective tissue	UBERON:0002384	64.08	gold quality
right coronary artery	UBERON:0001625	63.87	gold quality
cervix squamous epithelium	UBERON:0006922	63.41	gold quality
secondary oocyte	CL:0000655	63.16	gold quality
ovary	UBERON:0000992	62.48	gold quality
left coronary artery	UBERON:0001626	62.13	gold quality
aorta	UBERON:0000947	62.08	gold quality
coronary artery	UBERON:0001621	62.07	gold quality
thymus	UBERON:0002370	61.91	gold quality
right lobe of thyroid gland	UBERON:0001119	61.76	gold quality
cervix epithelium	UBERON:0004801	61.48	gold quality
blood vessel layer	UBERON:0004797	61.16	gold quality
oral cavity	UBERON:0000167	61.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.14

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): GLI1, HIF1A

miRNA regulators (miRDB)

117 targeting ANGPT4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-6856-5P	100.00	65.47	1298
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4725-3P	99.96	69.53	2520
HSA-MIR-6780B-5P	99.96	69.60	2562
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-3671	99.90	73.04	3897

Literature-anchored findings (GeneRIF, showing 11)

• the angiopoietin/Tie-2 system may participate in the angiogenic response to hypoxia in renal tissues and in tumor angiogenesis in renal carcinoma. (PMID:15198927)
• Recombinant Ang4 formed disulfide-linked dimers. Ang4 produces corneal angiogenesis extending from the limbus across the mouse cornea in vivo. Ang4 is an agonist of Tie2. (PMID:15284220)
• angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure (PMID:16790085)
• Results describe the expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumors, leiomyomas and schwannomas. (PMID:17724803)
• Linkage to 20p13 including the ANGPT4 gene in families with mixed Alzheimer disease and vascular dementia is reported. (PMID:20596041)
• Results establish the novel effects of Ang-4 on tumor angiogenesis and GBM progression and suggest that this pro-GBM effect of Ang-4 is mediated by promoting tumor angiogenesis and activating Erk1/2 kinase in GBM cells. (PMID:20823154)
• In tumor cells, only Ang-4 expression has prognostic impact in NSCLC. In NSCLC tumor stroma, Ang-4 and Ang-2 are independently associated with survival. (PMID:21603628)
• Angptl4 is a glucocorticoid-responsive mediator of fasting-induced intracellular lipolysis and stimulates cAMP signaling in adipocytes (PMID:22267746)
• acute-phase protein A1AT is a physiological regulator of angptl4, another acute-phase protein. (PMID:24760148)
• Ang-4 also promoted survival of LECs. Thus, blocking Ang-4 may prune the draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular permeability. (PMID:25977256)
• Dual functional nanoparticles containing SOX duo and ANGPT4 shRNA for osteoarthritis treatment. (PMID:30957437)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	angpt4	ENSDARG00000076787
mus_musculus	Angpt4	ENSMUSG00000027460
rattus_norvegicus	Angpt4	ENSRNOG00000005008

Paralogs (25): TNC (ENSG00000041982), FCN1 (ENSG00000085265), ANGPT2 (ENSG00000091879), FGL1 (ENSG00000104760), FN1 (ENSG00000115414), TNR (ENSG00000116147), ANGPTL1 (ENSG00000116194), TNN (ENSG00000120332), FGL2 (ENSG00000127951), FIBCD1 (ENSG00000130720), ANGPTL6 (ENSG00000130812), ANGPTL3 (ENSG00000132855), ANGPTL2 (ENSG00000136859), FCN3 (ENSG00000142748), FNDC7 (ENSG00000143107), ANGPT1 (ENSG00000154188), FCN2 (ENSG00000160339), MFAP4 (ENSG00000166482), ANGPTL4 (ENSG00000167772), TNXB (ENSG00000168477), FGG (ENSG00000171557), FGA (ENSG00000171560), FGB (ENSG00000171564), ANGPTL7 (ENSG00000171819), ANGPTL5 (ENSG00000187151)

Protein

Protein identifiers

Angiopoietin-4 — Q9Y264 (reviewed: Q9Y264)

Alternative names: Angiopoietin-3

All UniProt accessions (1): Q9Y264

UniProt curated annotations — full annotation on UniProt →

Function. Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

Subunit / interactions. Homodimer; disulfide-linked. Interacts with TEK/TIE2.

Subcellular location. Secreted.

Tissue specificity. Highly expressed in the lung with much lower levels found in other tissues.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9Y264-1	1	yes
Q9Y264-2	2

RefSeq proteins (2): NP_001309738, NP_057069* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002181	Fibrinogen_a/b/g_C_dom	Domain
IPR014716	Fibrinogen_a/b/g_C_1	Homologous_superfamily
IPR020837	Fibrinogen_CS	Conserved_site
IPR036056	Fibrinogen-like_C	Homologous_superfamily
IPR037579	FIB_ANG-like	Family
IPR057439	ANG-1/2/4	Domain

Pfam: PF00147, PF25443

UniProt features (17 total): glycosylation site 9, disulfide bond 2, signal peptide 1, chain 1, splice variant 1, sequence variant 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y264-F1	83.33	0.60

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (2): 291–320, 444–457

Glycosylation sites (9): 311, 337, 427, 96, 126, 140, 158, 247, 274

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-210993	Tie2 Signaling
R-HSA-109582	Hemostasis
R-HSA-202733	Cell surface interactions at the vascular wall

MSigDB gene sets: 151 (showing top): GOBP_REGULATION_OF_PHOSPHORYLATION, GOBP_NEGATIVE_REGULATION_OF_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_POSITIVE_REGULATION_OF_VASCULATURE_DEVELOPMENT, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, CAGCTG_AP4_Q5, GOBP_POSITIVE_REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION, REACTOME_TIE2_SIGNALING, GOBP_POSITIVE_REGULATION_OF_ENDOTHELIAL_CELL_MIGRATION, GOBP_WOUND_HEALING, GOMF_KINASE_ACTIVATOR_ACTIVITY, VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP, GOBP_BLOOD_VESSEL_ENDOTHELIAL_CELL_MIGRATION, GOBP_NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS, GOBP_CELLULAR_RESPONSE_TO_OXYGEN_LEVELS

GO Biological Process (13): angiogenesis (GO:0001525), signal transduction (GO:0007165), Notch signaling pathway (GO:0007219), blood coagulation (GO:0007596), positive regulation of endothelial cell migration (GO:0010595), negative regulation of angiogenesis (GO:0016525), negative regulation of apoptotic process (GO:0043066), positive regulation of blood vessel endothelial cell migration (GO:0043536), negative regulation of blood vessel endothelial cell migration (GO:0043537), positive regulation of angiogenesis (GO:0045766), Tie signaling pathway (GO:0048014), positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731), cellular response to hypoxia (GO:0071456)

GO Molecular Function (3): transmembrane receptor protein tyrosine kinase activator activity (GO:0030297), receptor tyrosine kinase binding (GO:0030971), receptor ligand activity (GO:0048018)

GO Cellular Component (2): extracellular region (GO:0005576), obsolete extracellular space (GO:0005615)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Cell surface interactions at the vascular wall	1
Hemostasis	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
angiogenesis	2
regulation of angiogenesis	2
blood vessel endothelial cell migration	2
regulation of blood vessel endothelial cell migration	2
signaling receptor activator activity	2
signaling receptor binding	2
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell surface receptor signaling pathway	1
hemostasis	1
wound healing	1
coagulation	1
regulation of endothelial cell migration	1
positive regulation of cell migration	1
endothelial cell migration	1
negative regulation of blood vessel morphogenesis	1
apoptotic process	1
regulation of apoptotic process	1
negative regulation of programmed cell death	1
positive regulation of endothelial cell migration	1
negative regulation of endothelial cell migration	1
positive regulation of vasculature development	1
cell surface receptor protein tyrosine kinase signaling pathway	1
positive regulation of protein phosphorylation	1
peptidyl-tyrosine phosphorylation	1
regulation of peptidyl-tyrosine phosphorylation	1
response to hypoxia	1
cellular response to stress	1
cellular response to decreased oxygen levels	1
transmembrane receptor protein tyrosine kinase activity	1
protein tyrosine kinase activator activity	1
protein tyrosine kinase binding	1
signal transduction	1
cellular anatomical structure	1

Protein interactions and networks

STRING

598 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ANGPT4	TEK	Q02763	995
ANGPT4	TIE1	P35590	942
ANGPT4	KDR	P35968	581
ANGPT4	VPS51	Q9UID3	571
ANGPT4	NTRK1	P04629	512
ANGPT4	ANGPTL1	O95841	507
ANGPT4	THBS1	P07996	492
ANGPT4	ANG	P03950	490
ANGPT4	EDNRB	P24530	464
ANGPT4	FN1	P02751	451
ANGPT4	EDNRA	P25101	449
ANGPT4	FST	P19883	435
ANGPT4	VASH1	Q7L8A9	433
ANGPT4	HSPG2	P98160	433
ANGPT4	RNASE1	P07998	431

IntAct

6 interactions, top by confidence:

A	B	Type	Score
N	CAVIN2	psi-mi:“MI:0914”(association)	0.530
ANGPT4		psi-mi:“MI:0407”(direct interaction)	0.440
ANGPT4	TEK	psi-mi:“MI:0407”(direct interaction)	0.440
P		psi-mi:“MI:0914”(association)	0.350
ANGPT4	POTEF	psi-mi:“MI:0914”(association)	0.350
MAGEA10	KANSL1L	psi-mi:“MI:0914”(association)	0.350

BioGRID (33): ANGPT4 (Reconstituted Complex), ANGPT4 (Affinity Capture-MS), ANGPT4 (Reconstituted Complex), ANGPT4 (Reconstituted Complex), KIF4A (Affinity Capture-MS), CCDC136 (Affinity Capture-MS), IFFO1 (Affinity Capture-MS), DTNBP1 (Affinity Capture-MS), LAMC1 (Affinity Capture-MS), RNF40 (Affinity Capture-MS), SNAPIN (Affinity Capture-MS), EXOC7 (Affinity Capture-MS), NID1 (Affinity Capture-MS), CEP63 (Affinity Capture-MS), NUCB2 (Affinity Capture-MS)

ESM2 similar proteins: A0A8J8, O08538, O15123, O18920, O35460, O35462, O35608, O43827, O77802, O95841, P02675, P02676, P02678, P02679, P02680, P04115, P12799, P12804, P14480, P17634, P21758, P30204, P86239, Q02020, Q08830, Q0P4P2, Q14314, Q15389, Q1RMR1, Q29RY7, Q3SZZ7, Q5EA66, Q5M8C6, Q5XK91, Q60FC1, Q640P2, Q6AX44, Q71KU9, Q86XS5, Q8K0E8

Diamond homologs: A0A8J8, A2AV25, D8VNS7, D8VNS8, D8VNS9, D8VNT0, E2IYB3, E9PV24, O00602, O08538, O15123, O18920, O35460, O35462, O35608, O43827, O70165, O70497, O75636, O77802, O93526, O95841, P02671, P02675, P02676, P02678, P02679, P02680, P04115, P06399, P10039, P12799, P12804, P14448, P14480, P17634, P19477, P21520, P22105, P24821

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
ANGPT4	up-regulates	TEK	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

111 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	12
Likely pathogenic	4
Uncertain significance	80
Likely benign	8
Benign	3

Top pathogenic / likely-pathogenic (16)

Variant ID	HGVS	Classification
146529	GRCh38/hg38 20p13(chr20:89939-1494113)x1	Pathogenic
1526676	GRCh37/hg19 20p13(chr20:61568-1823540)	Pathogenic
161074	GRCh38/hg38 20p13(chr20:89939-1852477)x1	Pathogenic
2671592	Single allele	Pathogenic
2671604	Single allele	Pathogenic
35265	GRCh38/hg38 20p13(chr20:89939-1852477)x1	Pathogenic
393750	GRCh37/hg19 20p13(chr20:121521-2073612)x1	Pathogenic
57188	GRCh38/hg38 20p13(chr20:89939-1360110)x1	Pathogenic
57307	GRCh38/hg38 20p13(chr20:89939-1028206)x3	Pathogenic
58941	GRCh38/hg38 20p13(chr20:89939-975656)x1	Pathogenic
58942	GRCh38/hg38 20p13(chr20:89939-1939218)x1	Pathogenic
58945	GRCh38/hg38 20p13(chr20:121781-2290194)x1	Pathogenic
154852	GRCh38/hg38 20p13(chr20:80106-1246891)x1	Likely pathogenic
155633	GRCh38/hg38 20p13(chr20:80927-1806080)x1	Likely pathogenic
3391837	GRCh37/hg19 20p13(chr20:61569-1091477)x1	Likely pathogenic
441596	GRCh37/hg19 20p13(chr20:61568-1651420)x1	Likely pathogenic

SpliceAI

1788 predictions. Top by Δscore:

Variant	Effect	Δscore
20:873116:CCACC:C	acceptor_gain	1.0000
20:873117:CACC:C	acceptor_gain	1.0000
20:873117:CACCC:C	acceptor_gain	1.0000
20:873119:CC:C	acceptor_gain	1.0000
20:873120:CCTGG:C	acceptor_gain	1.0000
20:878158:CACCT:C	donor_loss	1.0000
20:878159:A:AT	donor_loss	1.0000
20:878326:CC:C	acceptor_gain	1.0000
20:878327:CC:C	acceptor_gain	1.0000
20:878328:C:CC	acceptor_gain	1.0000
20:878328:CTAT:C	acceptor_loss	1.0000
20:878329:T:G	acceptor_loss	1.0000
20:879761:T:TA	donor_gain	1.0000
20:881173:T:A	donor_gain	1.0000
20:885322:CGCG:C	acceptor_gain	1.0000
20:885324:CG:C	acceptor_gain	1.0000
20:885326:C:CC	acceptor_gain	1.0000
20:888314:CCA:C	donor_loss	1.0000
20:888316:ACCT:A	donor_loss	1.0000
20:888440:C:CC	acceptor_gain	1.0000
20:888447:A:T	acceptor_gain	1.0000
20:888453:C:CT	acceptor_gain	1.0000
20:890209:TTAC:T	donor_loss	1.0000
20:890212:CCT:C	donor_loss	1.0000
20:890365:CTAG:C	acceptor_gain	1.0000
20:890369:C:CC	acceptor_gain	1.0000
20:915902:GTACC:G	donor_loss	1.0000
20:915903:TA:T	donor_loss	1.0000
20:915904:A:C	donor_loss	1.0000
20:915905:CCTT:C	donor_gain	1.0000

AlphaMissense

3308 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
20:874346:A:C	F430C	0.996
20:874345:A:C	F430L	0.995
20:874345:A:T	F430L	0.995
20:874347:A:G	F430L	0.995
20:878322:G:C	F353L	0.995
20:878322:G:T	F353L	0.995
20:878324:A:G	F353L	0.995
20:879774:A:C	F342L	0.995
20:879774:A:T	F342L	0.995
20:879776:A:G	F342L	0.995
20:879797:G:T	R335S	0.995
20:873029:C:A	W481C	0.994
20:873029:C:G	W481C	0.994
20:873113:C:A	W453C	0.994
20:873113:C:G	W453C	0.994
20:874346:A:G	F430S	0.994
20:873031:A:G	W481R	0.993
20:873031:A:T	W481R	0.993
20:879775:A:C	F342C	0.993
20:873110:A:C	F454L	0.992
20:873110:A:T	F454L	0.992
20:873112:A:G	F454L	0.992
20:873083:G:C	N463K	0.991
20:873083:G:T	N463K	0.991
20:873115:A:G	W453R	0.991
20:873115:A:T	W453R	0.991
20:874342:G:C	S431R	0.991
20:874342:G:T	S431R	0.991
20:874344:T:G	S431R	0.991
20:878323:A:C	F353C	0.991

dbSNP variants (sampled 300 via entrez): RS1000034916 (20:909610 T>G), RS1000065959 (20:907468 G>C), RS1000100866 (20:871723 G>A,C), RS1000148070 (20:907320 A>G), RS1000159103 (20:897593 T>C), RS1000323625 (20:876502 G>A), RS1000335033 (20:904826 T>C), RS1000362434 (20:892347 G>A), RS1000413301 (20:886518 G>A), RS1000423293 (20:914871 G>A,C), RS1000465265 (20:897775 C>A,T), RS1000500710 (20:875535 A>T), RS1000512088 (20:898761 C>T), RS1000513844 (20:897016 A>T), RS1000596865 (20:886863 T>C)

Disease associations

OMIM: gene MIM:603705 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST005576_7	Intracranial aneurysm	3.000000e-06
GCST006038_2	Food allergy	4.000000e-08
GCST006039_2	Peanut allergy	2.000000e-07
GCST006994_4	Logical memory (immediate recall) in Alzheimer’s disease dementia	5.000000e-07
GCST010057_9	Lung function	2.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007016	food allergy measurement
EFO:0007017	peanut allergy measurement
EFO:0004874	memory performance
EFO:0004312	vital capacity

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
bisphenol A	decreases methylation	1
ethyl-p-hydroxybenzoate	decreases expression	1
sodium arsenite	increases expression	1
tobacco tar	decreases reaction, increases expression	1
diallyl disulfide	decreases reaction, increases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
CGP 52608	affects binding, increases reaction	1
nutlin 3	affects cotreatment, increases expression	1
abrine	increases expression	1
Allergens	decreases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	affects methylation, increases methylation	1
Chelating Agents	increases expression, affects binding	1
Copper	affects binding, increases expression	1
Dactinomycin	affects cotreatment, increases expression	1
Diazinon	increases methylation	1
Diethylhexyl Phthalate	decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression, decreases expression	1
Nicotine	increases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Aflatoxin B1	increases methylation	1
Zinc Sulfate	increases expression	1
Okadaic Acid	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.