ANKRD44

Summary

ANKRD44 (ankyrin repeat domain 44, HGNC:25259) is a protein-coding gene on chromosome 2q33.1, encoding Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B (Q8N8A2). Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 156 total — 7 pathogenic, 1 likely-pathogenic
• Druggable target: yes
• MANE Select transcript: NM_001195144

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25259
Approved symbol	ANKRD44
Name	ankyrin repeat domain 44
Location	2q33.1
Locus type	gene with protein product
Status	Approved
Aliases	PP6-ARS-B
Ensembl gene	ENSG00000065413
Ensembl biotype	protein_coding
OMIM	620861
Entrez	91526

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 9 protein_coding, 3 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000282272, ENST00000328737, ENST00000409153, ENST00000409919, ENST00000422886, ENST00000424317, ENST00000443014, ENST00000447713, ENST00000463879, ENST00000473081, ENST00000477852, ENST00000486006, ENST00000647377, ENST00000871701

RefSeq mRNA: 5 — MANE Select: NM_001195144 NM_001195144, NM_001367495, NM_001367496, NM_001367497, NM_153697

CCDS: CCDS33355, CCDS74619, CCDS92920

Canonical transcript exons

ENST00000282272 — 28 exons

Exon	Start	End
ENSE00001700541	196986662	196989649
ENSE00003795682	197310578	197310780
ENSE00003801238	196995379	196995461
ENSE00003801352	197008944	197009031
ENSE00003801758	197081645	197081725
ENSE00003802097	197125837	197126037
ENSE00003803379	197110766	197110844
ENSE00003803555	197086680	197086748
ENSE00003804682	197121332	197121544
ENSE00003805035	197005694	197005910
ENSE00003805191	197083369	197083509
ENSE00003805328	197078703	197078814
ENSE00003805439	197001753	197001840
ENSE00003806807	197136592	197136662
ENSE00003808023	196993583	196993674
ENSE00003808060	197088711	197088774
ENSE00003809168	196998337	196998419
ENSE00003809427	197000419	197000502
ENSE00003809535	197007806	197007923
ENSE00003810210	197099816	197099930
ENSE00003810251	196998907	196999052
ENSE00003810298	197013511	197013712
ENSE00003810373	197025196	197025267
ENSE00003810618	197187023	197187106
ENSE00003810691	197089950	197090032
ENSE00003810828	197147027	197147105
ENSE00003811241	197125381	197125468
ENSE00003811307	197122650	197122792

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 97.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.8023 / max 443.4716, expressed in 1322 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
33064	7.7540	821
33063	4.0174	939
33066	1.6520	479
33065	1.1783	344
202527	0.1302	61
33060	0.0703	31

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	97.09	gold quality
leukocyte	CL:0000738	96.80	gold quality
bone marrow cell	CL:0002092	95.50	gold quality
epithelial cell of pancreas	CL:0000083	95.13	gold quality
blood	UBERON:0000178	94.90	gold quality
thymus	UBERON:0002370	94.51	gold quality
vermiform appendix	UBERON:0001154	94.16	gold quality
lymph node	UBERON:0000029	94.02	gold quality
epithelium of nasopharynx	UBERON:0001951	93.93	gold quality
superficial temporal artery	UBERON:0001614	93.87	gold quality
visceral pleura	UBERON:0002401	93.66	gold quality
corpus callosum	UBERON:0002336	92.73	gold quality
bone marrow	UBERON:0002371	92.21	gold quality
tonsil	UBERON:0002372	91.75	gold quality
right coronary artery	UBERON:0001625	91.31	gold quality
granulocyte	CL:0000094	90.97	gold quality
caecum	UBERON:0001153	90.73	gold quality
calcaneal tendon	UBERON:0003701	90.53	gold quality
sural nerve	UBERON:0015488	90.24	gold quality
right lung	UBERON:0002167	89.89	gold quality
lower lobe of lung	UBERON:0008949	89.77	gold quality
colonic epithelium	UBERON:0000397	89.46	gold quality
spleen	UBERON:0002106	89.39	gold quality
lung	UBERON:0002048	89.35	gold quality
amniotic fluid	UBERON:0000173	89.29	gold quality
parietal pleura	UBERON:0002400	89.23	gold quality
cortical plate	UBERON:0005343	89.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	89.07	gold quality
lower esophagus	UBERON:0013473	88.99	gold quality
mucosa of paranasal sinus	UBERON:0005030	88.74	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 10.

Experiment	Marker?	Max mean expression
E-ANND-2	yes	4073.04
E-GEOD-131882	yes	1496.83
E-GEOD-180759	yes	1358.26
E-CURD-119	yes	1015.60
E-MTAB-11268	yes	667.78
E-HCAD-35	yes	37.44
E-MTAB-6678	yes	34.80
E-ANND-3	yes	23.54
E-CURD-122	yes	21.10
E-HCAD-25	yes	18.41

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

27 targeting ANKRD44, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-3156-3P	99.76	66.72	939
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-4284	99.36	65.25	1293
HSA-MIR-6507-5P	99.36	70.46	2524
HSA-MIR-329-5P	99.27	68.11	1597
HSA-MIR-10522-5P	99.26	68.50	2087
HSA-MIR-181A-2-3P	98.91	67.60	1168
HSA-MIR-619-3P	98.38	65.58	693
HSA-MIR-490-3P	97.79	65.54	606
HSA-MIR-127-5P	97.78	67.64	869
HSA-MIR-215-3P	97.02	68.01	1209
HSA-MIR-3152-5P	96.98	66.88	819
HSA-MIR-4471	95.11	66.84	755
HSA-MIR-8059	95.11	66.30	646
HSA-MIR-4301	95.00	65.22	554

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	ankrd44	ENSDARG00000026028
mus_musculus	Ankrd44	ENSMUSG00000052331
rattus_norvegicus	Ankrd44	ENSRNOG00000021384

Paralogs (3): ANKRD52 (ENSG00000139645), ANKRD55 (ENSG00000164512), ANKRD28 (ENSG00000206560)

Protein

Protein identifiers

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B — Q8N8A2 (reviewed: Q8N8A2)

Alternative names: Ankyrin repeat domain-containing protein 44

All UniProt accessions (6): Q8N8A2, A0A2R8Y7Y4, C9JY51, F8WBW3, H7C209, H7C4A0

UniProt curated annotations — full annotation on UniProt →

Function. Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Subunit / interactions. Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.

Isoforms (5)

UniProt ID	Names	Canonical?
Q8N8A2-1	1	yes
Q8N8A2-2	2
Q8N8A2-3	3
Q8N8A2-4	4
Q8N8A2-5	5

RefSeq proteins (5): NP_001182073, NP_001354424, NP_001354425, NP_001354426, NP_710181 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002110	Ankyrin_rpt	Repeat
IPR036770	Ankyrin_rpt-contain_sf	Homologous_superfamily

Pfam: PF00023, PF12796, PF13637

UniProt features (40 total): repeat 28, splice variant 7, sequence conflict 4, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N8A2-F1	90.57	0.80

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 243 (showing top): ZHAN_MULTIPLE_MYELOMA_PR_DN, GATA1_02, BERNARD_PPAPDC1B_TARGETS_UP, ZHENG_BOUND_BY_FOXP3, ZHENG_FOXP3_TARGETS_IN_T_LYMPHOCYTE_DN, PASQUALUCCI_LYMPHOMA_BY_GC_STAGE_DN, WANG_SMARCE1_TARGETS_UP, MODULE_358, JOHNSTONE_PARVB_TARGETS_3_DN, MODULE_525, GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN, KATSANOU_ELAVL1_TARGETS_UP, GCNP_SHH_UP_EARLY.V1_DN, WINTER_HYPOXIA_DN, HMGA1_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1

Protein interactions and networks

STRING

1518 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
ANKRD44	PPP6R1	Q9UPN7	774
ANKRD44	PPP6R2	O75170	713
ANKRD44	PPP6R3	Q5H9R7	695
ANKRD44	PPP6C	O00743	688
ANKRD44	RFTN2	Q52LD8	479
ANKRD44	OR6C74	A6NCV1	418
ANKRD44	PLCL1	Q15111	379
ANKRD44	ANKRD28	O15084	364
ANKRD44	ANKRD52	Q8NB46	360
ANKRD44	C7orf57	Q8NEG2	353
ANKRD44	ZNF223	Q9UK11	348
ANKRD44	BOLL	Q8N9W6	339
ANKRD44	TPPP2	P59282	318
ANKRD44	FGD6	Q6ZV73	314
ANKRD44	OR10J5	Q8NHC4	314

IntAct

54 interactions, top by confidence:

A	B	Type	Score
PPP6R1	PPP6C	psi-mi:“MI:0914”(association)	0.920
PPP6C	ANKRD28	psi-mi:“MI:0914”(association)	0.870
ANKRD28	PPP6C	psi-mi:“MI:0914”(association)	0.870
PPP6R1	ANKRD44	psi-mi:“MI:0914”(association)	0.800
ANKRD44	PPP6C	psi-mi:“MI:0914”(association)	0.790
ANKRD44	ANKRD28	psi-mi:“MI:0914”(association)	0.710
ANKRD44	WWP2	psi-mi:“MI:0915”(physical association)	0.670
WWP2	ANKRD44	psi-mi:“MI:0915”(physical association)	0.670
USP10	ANKRD28	psi-mi:“MI:0914”(association)	0.610
ANKRD44	USP6	psi-mi:“MI:0407”(direct interaction)	0.570
ANKRD44	USP6	psi-mi:“MI:0915”(physical association)	0.570
ANKRD44	USP6	psi-mi:“MI:0403”(colocalization)	0.570
SDCBP	TARS3	psi-mi:“MI:0914”(association)	0.530
MOB1A	PPP6C	psi-mi:“MI:2364”(proximity)	0.420
Ppp6r3	PPP6C	psi-mi:“MI:2364”(proximity)	0.420
KRTAP4-12	ANKRD44	psi-mi:“MI:0915”(physical association)	0.370
ANKRD44	USP6	psi-mi:“MI:0915”(physical association)	0.370
ANKRD44		psi-mi:“MI:0915”(physical association)	0.370
Ppp6r1	PPP6C	psi-mi:“MI:0914”(association)	0.350
Ppp6c	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
HIF1AN	CNOT1	psi-mi:“MI:0914”(association)	0.350
ORF48	ANKRD28	psi-mi:“MI:0914”(association)	0.350
PLK1	ERCC6L	psi-mi:“MI:0914”(association)	0.350

BioGRID (97): ANKRD44 (Two-hybrid), ANKRD44 (Affinity Capture-RNA), ANKRD28 (Affinity Capture-MS), NOTCH1 (Affinity Capture-MS), NOTCH2 (Affinity Capture-MS), NOTCH3 (Affinity Capture-MS), PPP6R2 (Affinity Capture-MS), ANKFY1 (Affinity Capture-MS), PPP6R1 (Affinity Capture-MS), PPP6R3 (Affinity Capture-MS), HIF1AN (Affinity Capture-MS), MTCL1 (Affinity Capture-MS), PPP6C (Affinity Capture-MS), CDKN2C (Affinity Capture-MS), ANKRD44 (Affinity Capture-MS)

ESM2 similar proteins: A2AS55, B2RXR6, O15084, O75832, P0C927, Q08DV6, Q0P5B9, Q29RM5, Q2TB02, Q3SX45, Q495B1, Q499M5, Q4V890, Q502K3, Q505D1, Q53RE8, Q5F478, Q5RFS1, Q5U2S6, Q5ZLC8, Q6GPE5, Q6P6B7, Q6P9Z4, Q70X92, Q7T3P8, Q810B6, Q8BTI7, Q8C0T1, Q8C6Y6, Q8K0L0, Q8N8A2, Q8NB46, Q8NI38, Q8WXH4, Q91ZT8, Q96AX9, Q96DX5, Q96NS5, Q96Q27, Q9BSK4

Diamond homologs: A2AQH4, A2AS55, A6QR20, O04251, O75762, O90760, P25963, Q10311, Q1RJM6, Q24145, Q499M5, Q4JHE0, Q5H9F3, Q6RI86, Q70X92, Q86WC6, Q8BLA8, Q8N8A2, Q8R3P9, Q9BQI6, Q9J4Z4, Q9WV72, Q9Y575, Q9Z2F6, A2ARS0, B2RXR6, C9JTQ0, L7XCU0, L7XDS4, O15084, O89019, P25799, Q00653, Q18297, Q2TB02, Q3EC11, Q3KP44, Q3SX00, Q4ULZ2, Q502K3

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

156 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	7
Likely pathogenic	1
Uncertain significance	126
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (8)

Variant ID	HGVS	Classification
154446	GRCh38/hg38 2q33.1(chr2:197125460-199741748)x1	Pathogenic
253668	GRCh37/hg19 2q32.3-33.1(chr2:196581377-200947041)x1	Pathogenic
394652	GRCh37/hg19 2q32.3-33.1(chr2:194581315-201752422)x1	Pathogenic
562673	GRCh37/hg19 2q32.3-33.1(chr2:193537927-202027736)x1	Pathogenic
562676	GRCh37/hg19 2q32.2-33.1(chr2:191750202-202297376)x1	Pathogenic
57395	GRCh38/hg38 2q32.3-33.1(chr2:194515159-198545937)x1	Pathogenic
689171	GRCh37/hg19 2q32.3-33.1(chr2:195786723-200531127)x1	Pathogenic
3067112	NM_001195144.2(ANKRD44):c.1317-1308T>C	Likely pathogenic

SpliceAI

6283 predictions. Top by Δscore:

Variant	Effect	Δscore
2:196992772:C:CC	donor_gain	1.0000
2:196993672:GGT:G	acceptor_gain	1.0000
2:196993673:GTC:G	acceptor_loss	1.0000
2:196993674:TC:T	acceptor_loss	1.0000
2:196993675:C:CC	acceptor_gain	1.0000
2:196995377:A:AC	donor_gain	1.0000
2:196995378:C:CC	donor_gain	1.0000
2:196995378:CGT:C	donor_gain	1.0000
2:196998075:C:CT	donor_gain	1.0000
2:196998076:T:TT	donor_gain	1.0000
2:196998116:T:TA	donor_gain	1.0000
2:196998332:CATA:C	donor_gain	1.0000
2:196998335:A:AC	donor_gain	1.0000
2:196998336:C:CC	donor_gain	1.0000
2:196998336:CTTTA:C	donor_gain	1.0000
2:196998337:TTTAC:T	donor_gain	1.0000
2:196998338:TTACT:T	donor_gain	1.0000
2:196998341:C:CT	donor_gain	1.0000
2:196998342:T:TT	donor_gain	1.0000
2:196998376:AT:A	donor_gain	1.0000
2:196998377:T:C	donor_gain	1.0000
2:196998902:CATA:C	donor_loss	1.0000
2:196998903:ATAC:A	donor_loss	1.0000
2:196998905:A:AC	donor_gain	1.0000
2:196998905:AC:A	donor_gain	1.0000
2:196998906:C:CC	donor_gain	1.0000
2:196998906:C:CT	donor_loss	1.0000
2:196998906:CC:C	donor_gain	1.0000
2:196998906:CCCA:C	donor_gain	1.0000
2:196998956:C:A	donor_gain	1.0000

AlphaMissense

6551 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:197013579:A:G	L619P	1.000
2:197099879:G:T	A346D	1.000
2:197110794:G:C	F319L	1.000
2:197110794:G:T	F319L	1.000
2:197110796:A:G	F319L	1.000
2:197110801:C:A	G317V	1.000
2:197110801:C:T	G317E	1.000
2:197110810:G:T	A314D	1.000
2:197125871:G:T	A143D	1.000
2:197125877:C:G	R141P	1.000
2:197125880:C:T	G140E	1.000
2:197125886:C:G	R138P	1.000
2:197125889:T:A	D137V	1.000
2:197125890:C:A	D137Y	1.000
2:197125890:C:G	D137H	1.000
2:197125970:G:C	P110R	1.000
2:197125970:G:T	P110H	1.000
2:197125978:C:A	W107C	1.000
2:197125978:C:G	W107C	1.000
2:197125980:A:G	W107R	1.000
2:197125980:A:T	W107R	1.000
2:197125988:T:A	D104V	1.000
2:197125989:C:G	D104H	1.000
2:197125990:C:A	R103S	1.000
2:197125990:C:G	R103S	1.000
2:197125991:C:A	R103M	1.000
2:197125991:C:G	R103T	1.000
2:197126006:G:T	A98D	1.000
2:197126021:A:G	L93S	1.000
2:197136614:C:G	R80P	1.000

dbSNP variants (sampled 300 via entrez): RS1000003559 (2:197291399 A>G,T), RS1000005099 (2:197073567 C>T), RS1000005430 (2:197028758 G>A), RS1000014166 (2:197248016 C>G), RS1000016250 (2:197038186 T>C), RS1000031658 (2:197209422 G>A), RS1000048374 (2:197118635 G>A,C), RS1000048628 (2:197031258 C>T), RS1000066462 (2:197247655 T>C), RS1000080452 (2:197135930 C>T), RS1000083372 (2:197209644 T>C), RS1000095962 (2:197163832 T>C), RS1000106460 (2:196977563 A>T), RS1000114604 (2:197079981 A>C), RS1000120053 (2:197305248 G>A)

Disease associations

OMIM: gene MIM:620861 | disease phenotypes: MIM:617268

GenCC curated gene-disease

Mondo (1): neurodevelopmental disorder with hypotonia, seizures, and absent language (MONDO:0014995)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST002539_41	Schizophrenia	2.000000e-11
GCST002666_1	Interferon alpha levels in systemic lupus erythematosus	1.000000e-06
GCST002666_8	Interferon alpha levels in systemic lupus erythematosus	5.000000e-06
GCST003683_4	Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy)	5.000000e-08
GCST004521_180	Autism spectrum disorder or schizophrenia	3.000000e-11
GCST006803_21	Schizophrenia	4.000000e-13
GCST007565_1	Morning person	8.000000e-21
GCST010698_25	Subcortical volume (min-P)	2.000000e-08
GCST010699_24	Brain morphology (min-P)	1.000000e-09
GCST010700_25	Cortical thickness (MOSTest)	2.000000e-10
GCST010701_25	Cortical surface area (MOSTest)	2.000000e-37
GCST010702_65	Subcortical volume (MOSTest)	1.000000e-11
GCST010703_197	Brain morphology (MOSTest)	1.000000e-11

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0006517	interferon alpha measurement
EFO:0008328	chronotype measurement
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4105772 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

41 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression	7
sodium arsenite	increases expression	2
entinostat	decreases expression, affects cotreatment	2
Benzo(a)pyrene	affects methylation, decreases expression	2
Nickel	increases expression	2
Tretinoin	increases expression	2
aristolochic acid I	decreases expression	1
methylmercuric chloride	decreases expression	1
pirinixic acid	affects binding, increases activity, increases expression	1
bisphenol A	affects methylation	1
lead acetate	increases expression	1
arsenite	increases methylation	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
2-palmitoylglycerol	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression, increases expression	1
dorsomorphin	affects cotreatment, decreases expression, increases expression	1
jinfukang	decreases expression, affects cotreatment	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Acetaminophen	decreases expression	1
Cadmium	increases abundance, increases expression	1
Cisplatin	decreases expression, affects cotreatment	1
Formaldehyde	decreases expression	1
Hydralazine	affects cotreatment, increases expression	1
Hydrogen Peroxide	increases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression, affects cotreatment	1
Methotrexate	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4012572	Binding	Binding affinity to serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B in human INA-6 cells after 3 hrs by nanoLC-MS/MS method	Ugi Reaction-Derived α-Acyl Aminocarboxamides Bind to Phosphatidylinositol 3-Kinase-Related Kinases, Inhibit HSF1-Dependent Heat Shock Response, and Induce Apoptosis in Multiple Myeloma Cells. — J Med Chem

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SC56	HAP1 ANKRD44 (-) 1	Cancer cell line	Male
CVCL_SC57	HAP1 ANKRD44 (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.