AP3M2

Summary

AP3M2 (adaptor related protein complex 3 subunit mu 2, HGNC:570) is a protein-coding gene on chromosome 8p11.21, encoding AP-3 complex subunit mu-2 (P53677). Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated.

This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 3 (AP-3), which belongs to the adaptor complexes medium subunits family. The AP-3 complex plays a role in protein trafficking to lysosomes and specialized organelles. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Source: NCBI Gene 10947 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 62 total — 1 pathogenic
• MANE Select transcript: NM_006803

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:570
Approved symbol	AP3M2
Name	adaptor related protein complex 3 subunit mu 2
Location	8p11.21
Locus type	gene with protein product
Status	Approved
Aliases	CLA20, AP47B
Ensembl gene	ENSG00000070718
Ensembl biotype	protein_coding
OMIM	610469
Entrez	10947

Gene structure

Transcript identifiers

Ensembl transcripts: 20 — 12 protein_coding, 3 nonsense_mediated_decay, 3 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000396926, ENST00000517499, ENST00000517865, ENST00000517922, ENST00000517969, ENST00000518421, ENST00000520685, ENST00000520689, ENST00000521235, ENST00000521280, ENST00000521899, ENST00000522288, ENST00000522320, ENST00000522606, ENST00000523249, ENST00000530375, ENST00000858465, ENST00000913686, ENST00000913687, ENST00000943124

RefSeq mRNA: 2 — MANE Select: NM_006803 NM_001134296, NM_006803

CCDS: CCDS6125

Canonical transcript exons

ENST00000396926 — 9 exons

Exon	Start	End
ENSE00001192655	42167164	42167371
ENSE00001192674	42154616	42154960
ENSE00001526776	42168961	42171183
ENSE00002098792	42153063	42153105
ENSE00003473813	42165427	42165560
ENSE00003482889	42165071	42165156
ENSE00003513595	42162281	42162418
ENSE00003515576	42167666	42167810
ENSE00003590579	42157941	42158112

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 97.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 13.7001 / max 132.9119, expressed in 1753 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
88671	13.6581	1752
88672	0.0420	14

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	97.60	gold quality
middle temporal gyrus	UBERON:0002771	97.16	gold quality
Brodmann (1909) area 23	UBERON:0013554	95.97	gold quality
secondary oocyte	CL:0000655	94.47	gold quality
Brodmann (1909) area 10	UBERON:0013541	94.21	gold quality
frontal pole	UBERON:0002795	93.67	gold quality
prefrontal cortex	UBERON:0000451	92.93	gold quality
Brodmann (1909) area 46	UBERON:0006483	92.75	gold quality
cranial nerve II	UBERON:0000941	92.65	gold quality
oocyte	CL:0000023	92.19	gold quality
primary visual cortex	UBERON:0002436	92.01	gold quality
orbitofrontal cortex	UBERON:0004167	92.01	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.86	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.77	gold quality
frontal cortex	UBERON:0001870	91.60	gold quality
frontal lobe	UBERON:0016525	91.60	gold quality
neocortex	UBERON:0001950	91.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.23	gold quality
superior frontal gyrus	UBERON:0002661	91.16	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.79	gold quality
cerebral cortex	UBERON:0000956	90.74	gold quality
cingulate cortex	UBERON:0003027	90.57	gold quality
right frontal lobe	UBERON:0002810	90.56	gold quality
anterior cingulate cortex	UBERON:0009835	90.54	gold quality
pons	UBERON:0000988	90.53	gold quality
cortical plate	UBERON:0005343	90.25	gold quality
hypothalamus	UBERON:0001898	90.19	gold quality
entorhinal cortex	UBERON:0002728	90.16	gold quality
middle frontal gyrus	UBERON:0002702	89.94	gold quality
telencephalon	UBERON:0001893	89.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.51

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

79 targeting AP3M2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-3686	99.90	70.53	2432
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-205-5P	99.81	70.05	1557
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-623	99.76	68.16	1170
HSA-MIR-6733-5P	99.74	67.94	2759
HSA-MIR-3059-5P	99.70	69.93	2491

Literature-anchored findings (GeneRIF, showing 1)

• some AP3M2 mutations still remain candidates for unmapped disorders including epilepsy, febrile seizure, and other neuronal developmental disorders associated with functional abnormalities of GABAergic transmission (PMID:17293072)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	ap3m2	ENSDARG00000016128
mus_musculus	Ap3m2	ENSMUSG00000031539
rattus_norvegicus	Ap3m2	ENSRNOG00000018650
drosophila_melanogaster	cm	FBGN0000330

Paralogs (7): AP1M1 (ENSG00000072958), AP1M2 (ENSG00000129354), STON2 (ENSG00000140022), AP2M1 (ENSG00000161203), AP3M1 (ENSG00000185009), AP4M1 (ENSG00000221838), STON1 (ENSG00000243244)

Protein

Protein identifiers

AP-3 complex subunit mu-2 — P53677 (reviewed: P53677)

Alternative names: Adaptor-related protein complex 3 subunit mu-2, Clathrin assembly protein assembly protein complex 3 mu-2 medium chain, Clathrin coat assembly protein AP47 homolog 2, Clathrin coat-associated protein AP47 homolog 2, Golgi adaptor AP-1 47 kDa protein homolog 2, HA1 47 kDa subunit homolog 2, Mu3B-adaptin, P47B

All UniProt accessions (10): P53677, A0A1D5RMS9, A0A384NYL6, E5RGF3, E5RI83, E5RJ52, E7ER80, H0YAY4, H0YBA0, H0YBM0

UniProt curated annotations — full annotation on UniProt →

Function. Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Subunit / interactions. AP-3 associates with the BLOC-1 complex. Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2).

Subcellular location. Golgi apparatus. Cytoplasmic vesicle membrane.

Similarity. Belongs to the adaptor complexes medium subunit family.

Isoforms (2)

UniProt ID	Names	Canonical?
P53677-1	1	yes
P53677-2	2

RefSeq proteins (2): NP_001127768, NP_006794* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001392	Clathrin_mu	Family
IPR011012	Longin-like_dom_sf	Homologous_superfamily
IPR018240	Clathrin_mu_CS	Conserved_site
IPR022775	AP_mu_sigma_su	Domain
IPR028565	MHD	Domain
IPR036168	AP2_Mu_C_sf	Homologous_superfamily
IPR050431	Adaptor_comp_med_subunit	Family

Pfam: PF00928, PF01217

UniProt features (4 total): splice variant 2, chain 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P53677-F1	93.07	0.82

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 303 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, GOBP_SYNAPTIC_VESICLE_LOCALIZATION, BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_AXO_DENDRITIC_TRANSPORT, GOBP_VESICLE_LOCALIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, FISCHER_G1_S_CELL_CYCLE, GOBP_VESICLE_ORGANIZATION, GOBP_SYNAPTIC_VESICLE_CYTOSKELETAL_TRANSPORT, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, DACOSTA_UV_RESPONSE_VIA_ERCC3_UP, GOBP_VACUOLAR_TRANSPORT, KEGG_LYSOSOME, GOBP_VESICLE_MEDIATED_TRANSPORT

GO Biological Process (10): intracellular protein transport (GO:0006886), endocytosis (GO:0006897), anterograde axonal transport (GO:0008089), synaptic vesicle coating (GO:0016183), clathrin-coated vesicle cargo loading, AP-3-mediated (GO:0035654), synaptic vesicle recycling (GO:0036465), anterograde synaptic vesicle transport (GO:0048490), protein transport (GO:0015031), vesicle-mediated transport (GO:0016192), synaptic vesicle endocytosis (GO:0048488)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (14): early endosome (GO:0005769), Golgi apparatus (GO:0005794), synaptic vesicle (GO:0008021), AP-type membrane coat adaptor complex (GO:0030119), AP-3 adaptor complex (GO:0030123), clathrin adaptor complex (GO:0030131), cytoplasmic vesicle membrane (GO:0030659), cytoplasmic vesicle (GO:0031410), glutamatergic synapse (GO:0098978), GABA-ergic synapse (GO:0098982), axon cytoplasm (GO:1904115), cytoplasm (GO:0005737), endomembrane system (GO:0012505), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transport	3
cellular anatomical structure	3
intracellular protein localization	2
cytoplasm	2
AP-type membrane coat adaptor complex	2
synapse	2
protein transport	1
intracellular transport	1
vesicle budding from membrane	1
membrane invagination	1
vesicle-mediated transport	1
import into cell	1
axonal transport	1
axon cytoplasm	1
vesicle coat assembly	1
synaptic vesicle budding from presynaptic endocytic zone membrane	1
clathrin-coated vesicle cargo loading	1
establishment of localization in cell	1
synaptic vesicle cycle	1
anterograde axonal transport	1
synaptic vesicle transport along microtubule	1
establishment of protein localization	1
cellular process	1
synaptic vesicle recycling	1
presynaptic endocytosis	1
binding	1
endosome	1
endomembrane system	1
intracellular membrane-bounded organelle	1
exocytic vesicle	1
presynapse	1
membrane coat	1
membrane protein complex	1
clathrin coat	1
vesicle membrane	1
cytoplasmic vesicle	1
intracellular vesicle	1
axon	1
neuron projection cytoplasm	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

860 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AP3M2	AP3D1	O14617	839
AP3M2	GSTM1	P09488	711
AP3M2	AP3S1	Q92572	657
AP3M2	AP3B1	O00203	562
AP3M2	AP3B2	Q13367	529
AP3M2	AP1S1	P61966	485
AP3M2	ZNF398	Q8TD17	445
AP3M2	RABGGTA	Q92696	397
AP3M2	AP3S2	P59780	387
AP3M2	BLOC1S6	Q9UL45	384
AP3M2	SMIM12	Q96EX1	382
AP3M2	UBE2C	O00762	381
AP3M2	LRRC40	Q9H9A6	366
AP3M2	DUSP13B	Q9UII6	358
AP3M2	BEND7	Q8N7W2	353

IntAct

27 interactions, top by confidence:

A	B	Type	Score
AP3M1	AP3B1	psi-mi:“MI:0914”(association)	0.640
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.640
TUBA4A	TXNDC9	psi-mi:“MI:0914”(association)	0.640
AP3M2	AP3B1	psi-mi:“MI:0914”(association)	0.530
AP3S1	AP3B1	psi-mi:“MI:0914”(association)	0.530
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.530
EPB41L3	AP3B1	psi-mi:“MI:0914”(association)	0.530
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
LYPD4	DPYSL4	psi-mi:“MI:0914”(association)	0.350
CAMKV	AP3B1	psi-mi:“MI:0914”(association)	0.350
EDA	AP3B1	psi-mi:“MI:0914”(association)	0.350
IQCF1	TBC1D4	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
KLRC1	METTL15	psi-mi:“MI:0914”(association)	0.350
PLCD3	AP3B1	psi-mi:“MI:0914”(association)	0.350
LYPD4	PIK3C2A	psi-mi:“MI:0914”(association)	0.350
TCEAL9	DIRAS1	psi-mi:“MI:0914”(association)	0.350
DHDH	ZNF185	psi-mi:“MI:0914”(association)	0.350
TUBB	VWA8	psi-mi:“MI:0914”(association)	0.350

BioGRID (41): AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3B1 (Affinity Capture-MS), AP3S2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3D1 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), MEOX2 (Two-hybrid), AP3M2 (Affinity Capture-MS), AP3M2 (Affinity Capture-MS), AP3S2 (Affinity Capture-MS)

ESM2 similar proteins: A2RV18, A4IG72, A7MB11, B8APQ0, D3ZAA9, E2RED8, E9PY46, F4I562, O00189, O43304, O89043, P33611, P47795, P47823, P53676, P53677, P53678, Q0J649, Q10QS7, Q13144, Q14168, Q14181, Q24K11, Q29RY8, Q2PWT8, Q3UR70, Q499N2, Q4R6Q7, Q58D13, Q5E9X5, Q5R478, Q5ZMP7, Q64350, Q8BJ63, Q8CHW4, Q8R2R9, Q8WUH2, Q93Y22, Q96RY7, Q9D0T2

Diamond homologs: F4I562, P47795, P53676, P53677, P53678, Q00776, Q24K11, Q5R478, Q5ZMP7, Q8R2R9, Q9GPF1, Q9HFE5, Q9JKC8, Q9Y2T2, D3ZRP6, P35585, P35602, P38700, Q2KJ81, Q32Q06, Q3SYW1, Q54HS9, Q9BXS5, Q9WVP1, Q9Y6Q5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
AP3M2	“form complex”	“Neuronal AP-3”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 26 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Membrane Trafficking	5	11.6×	1e-03
Vesicle-mediated transport	5	10.9×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

62 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	48
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
687703	GRCh37/hg19 8p11.21(chr8:41761813-42107108)x1	Pathogenic

SpliceAI

1810 predictions. Top by Δscore:

Variant	Effect	Δscore
8:42155967:A:AG	acceptor_gain	1.0000
8:42158108:CACAG:C	donor_loss	1.0000
8:42158109:ACAGG:A	donor_loss	1.0000
8:42158110:CAGGT:C	donor_loss	1.0000
8:42158111:AGGTA:A	donor_loss	1.0000
8:42158114:T:G	donor_loss	1.0000
8:42165415:T:TA	acceptor_gain	1.0000
8:42165558:GAA:G	donor_gain	1.0000
8:42165561:G:GG	donor_gain	1.0000
8:42167162:A:AG	acceptor_gain	1.0000
8:42167162:AGTCT:A	acceptor_gain	1.0000
8:42167163:G:GA	acceptor_gain	1.0000
8:42167163:GT:G	acceptor_gain	1.0000
8:42167163:GTCT:G	acceptor_gain	1.0000
8:42167163:GTCTG:G	acceptor_gain	1.0000
8:42167279:G:GT	donor_gain	1.0000
8:42169040:G:GT	donor_gain	1.0000
8:42169040:G:T	donor_gain	1.0000
8:42169064:G:GT	donor_gain	1.0000
8:42169080:G:T	donor_gain	1.0000
8:42153104:AG:A	donor_loss	0.9900
8:42153105:GGTGA:G	donor_loss	0.9900
8:42153106:GT:G	donor_loss	0.9900
8:42153107:T:G	donor_loss	0.9900
8:42154614:A:AG	acceptor_gain	0.9900
8:42154615:G:GG	acceptor_gain	0.9900
8:42154615:GA:G	acceptor_gain	0.9900
8:42155968:A:G	acceptor_gain	0.9900
8:42157936:ATCAG:A	acceptor_gain	0.9900
8:42157937:T:G	acceptor_gain	0.9900

AlphaMissense

2763 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:42162334:T:A	W167R	1.000
8:42162334:T:C	W167R	1.000
8:42165097:G:A	G204R	1.000
8:42165097:G:C	G204R	1.000
8:42165097:G:T	G204W	1.000
8:42165098:G:A	G204E	1.000
8:42165140:T:C	L218P	1.000
8:42165467:T:A	V237D	1.000
8:42167675:T:A	W341R	1.000
8:42167675:T:C	W341R	1.000
8:42158017:T:C	L117P	0.999
8:42158026:G:A	G120D	0.999
8:42158056:T:C	L130P	0.999
8:42158095:T:A	V143D	0.999
8:42162336:G:C	W167C	0.999
8:42162336:G:T	W167C	0.999
8:42162338:G:C	R168P	0.999
8:42162371:C:A	A179D	0.999
8:42162389:A:T	E185V	0.999
8:42162400:G:C	A189P	0.999
8:42165122:T:C	L212P	0.999
8:42165134:C:A	P216Q	0.999
8:42165146:T:C	L220P	0.999
8:42165463:T:C	C236R	0.999
8:42165464:G:A	C236Y	0.999
8:42165465:T:G	C236W	0.999
8:42165481:T:A	W242R	0.999
8:42165481:T:C	W242R	0.999
8:42165512:C:A	P252H	0.999
8:42165512:C:G	P252R	0.999

dbSNP variants (sampled 300 via entrez): RS1000094092 (8:42165220 A>C,T), RS1000140452 (8:42165702 G>A), RS1000249424 (8:42163986 C>G), RS1000330404 (8:42151795 A>G,T), RS1000359130 (8:42153087 C>G,T), RS1000372924 (8:42152908 C>T), RS1000443093 (8:42164844 G>A), RS1000578318 (8:42153676 A>G,T), RS1000635156 (8:42169067 G>A,T), RS1000883960 (8:42170890 G>A,C), RS1001050183 (8:42152038 T>A), RS1001149095 (8:42163943 G>T), RS1001298824 (8:42157757 T>C), RS1001313185 (8:42156906 C>G), RS1001332055 (8:42170287 C>T)

Disease associations

OMIM: gene MIM:610469 | disease phenotypes: MIM:615592

GenCC curated gene-disease

Mondo (1): severe combined immunodeficiency due to IKK2 deficiency (MONDO:0014267)

Orphanet (1): Combined immunodeficiency due to IKBKB deficiency (Orphanet:397787)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006988_102	Blond vs. brown/black hair color	2.000000e-10

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0003924	hair color

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, affects cotreatment, increases expression	3
Valproic Acid	affects cotreatment, increases expression, decreases methylation	3
sodium arsenite	decreases expression, increases expression	2
Acetaminophen	increases expression	2
Benzo(a)pyrene	decreases methylation, increases expression	2
Nickel	increases expression	2
Cyclosporine	increases expression, increases methylation	2
alpha phellandrene	increases expression	1
bisphenol A	affects cotreatment, increases methylation	1
di-n-butylphosphoric acid	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Decitabine	affects expression	1
Sunitinib	increases expression	1
Fulvestrant	affects cotreatment, increases methylation	1
Air Pollutants, Occupational	affects expression	1
Benzene	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Progesterone	affects cotreatment, decreases expression	1
Quercetin	increases expression	1
Tretinoin	decreases expression	1
Tunicamycin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.