APCDD1L-DT

Summary

APCDD1L-DT (APCDD1L divergent transcript, HGNC:27152) is a long non-coding RNA gene on chromosome 20q13.32.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27152
Approved symbol	APCDD1L-DT
Name	APCDD1L divergent transcript
Location	20q13.32
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000231290
Ensembl biotype	lncRNA
Entrez	149773
RNAcentral	URS000075A519 — lncRNA, 2099 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 38 — 37 lncRNA, 1 retained_intron

ENST00000420279, ENST00000424205, ENST00000427140, ENST00000427794, ENST00000439558, ENST00000445984, ENST00000447767, ENST00000448374, ENST00000661476, ENST00000701694, ENST00000733472, ENST00000733473, ENST00000733474, ENST00000733475, ENST00000733476, ENST00000733477, ENST00000733478, ENST00000733479, ENST00000733480, ENST00000733481, ENST00000733482, ENST00000733483, ENST00000733484, ENST00000733485, ENST00000733486, ENST00000733487, ENST00000733488, ENST00000733489, ENST00000733490, ENST00000733491, ENST00000733492, ENST00000733493, ENST00000733494, ENST00000733495, ENST00000733496, ENST00000733497, ENST00000733498, ENST00000733499

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000420279 — 6 exons

Exon	Start	End
ENSE00001594593	58519504	58519599
ENSE00001621878	58515499	58515740
ENSE00001729214	58523169	58523281
ENSE00001730979	58523714	58523806
ENSE00001782068	58547812	58547928
ENSE00004064852	58573576	58573885

Expression profiles

Bgee: expression breadth ubiquitous, 148 present calls, max score 89.43.

FANTOM5 (CAGE): breadth broad, TPM avg 3.9236 / max 363.7967, expressed in 596 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
185504	3.7140	592
185505	0.2097	62

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
islet of Langerhans	UBERON:0000006	89.43	gold quality
minor salivary gland	UBERON:0001830	80.23	gold quality
saliva-secreting gland	UBERON:0001044	77.99	gold quality
stromal cell of endometrium	CL:0002255	77.60	gold quality
buccal mucosa cell	CL:0002336	77.52	silver quality
mouth mucosa	UBERON:0003729	77.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.05	gold quality
bone marrow cell	CL:0002092	70.78	silver quality
adult mammalian kidney	UBERON:0000082	70.72	gold quality
pancreas	UBERON:0001264	68.32	gold quality
colonic epithelium	UBERON:0000397	68.19	silver quality
skin of abdomen	UBERON:0001416	67.47	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	67.45	gold quality
tonsil	UBERON:0002372	67.37	gold quality
hindlimb stylopod muscle	UBERON:0004252	67.13	gold quality
parotid gland	UBERON:0001831	65.67	gold quality
skin of leg	UBERON:0001511	65.57	gold quality
gingival epithelium	UBERON:0001949	64.06	gold quality
kidney	UBERON:0002113	63.91	gold quality
calcaneal tendon	UBERON:0003701	63.57	gold quality
zone of skin	UBERON:0000014	63.38	gold quality
metanephros cortex	UBERON:0010533	62.67	gold quality
descending thoracic aorta	UBERON:0002345	62.60	gold quality
cortex of kidney	UBERON:0001225	61.88	gold quality
smooth muscle tissue	UBERON:0001135	61.40	gold quality
germinal epithelium of ovary	UBERON:0001304	60.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	60.60	gold quality
ganglionic eminence	UBERON:0004023	60.54	gold quality
thoracic aorta	UBERON:0001515	60.26	gold quality
ascending aorta	UBERON:0001496	60.22	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	44.06
E-ANND-3	yes	5.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• A total of 2,041 significant the differentially expressed lncRNAs were identified in Lung squamous cell carcinoma (LUSC) samples. RP5-821D11.7 (co-expressed with PCNA), APCDD1L-AS1 (co-expressed with SEMA5A, SEMA6D, ADAMTSL1, ADAMTS6, SLIT3 and TNC) and RP11-277P12.9 (co-expressed with WNT2B) may be important lncRNAs associated with the prognosis of LUSC. (PMID:29568882)
• Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis. (PMID:34546854)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.