APOA1-AS

Summary

APOA1-AS (APOA1 antisense RNA, HGNC:40079) is a long non-coding RNA gene on chromosome 11q23.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40079
Approved symbol	APOA1-AS
Name	APOA1 antisense RNA
Location	11q23.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235910
Ensembl biotype	lncRNA
OMIM	620112
Entrez	104326055
RNAcentral	URS00005069DC — lncRNA, 563 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000444200, ENST00000669664

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000444200 — 2 exons

Exon	Start	End
ENSE00004123728	116855290	116856210
ENSE00004123729	116836117	116836239

Expression profiles

Bgee: expression breadth ubiquitous, 131 present calls, max score 79.11.

Top tissues by expression

131 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	79.11	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.01	gold quality
colonic epithelium	UBERON:0000397	73.02	gold quality
sural nerve	UBERON:0015488	70.43	gold quality
bone marrow cell	CL:0002092	69.89	silver quality
liver	UBERON:0002107	67.31	gold quality
cortical plate	UBERON:0005343	66.11	gold quality
ventricular zone	UBERON:0003053	65.31	gold quality
skeletal muscle tissue	UBERON:0001134	64.44	gold quality
duodenum	UBERON:0002114	63.71	gold quality
adrenal tissue	UBERON:0018303	63.03	gold quality
ganglionic eminence	UBERON:0004023	62.76	gold quality
right lobe of liver	UBERON:0001114	62.65	gold quality
bone marrow	UBERON:0002371	62.30	gold quality
tibial nerve	UBERON:0001323	61.59	gold quality
calcaneal tendon	UBERON:0003701	61.11	gold quality
left lobe of thyroid gland	UBERON:0001120	60.61	gold quality
thyroid gland	UBERON:0002046	60.19	gold quality
blood	UBERON:0000178	60.18	gold quality
left ovary	UBERON:0002119	59.98	gold quality
prefrontal cortex	UBERON:0000451	59.97	gold quality
ovary	UBERON:0000992	59.78	gold quality
right lobe of thyroid gland	UBERON:0001119	59.43	gold quality
tonsil	UBERON:0002372	59.06	gold quality
stromal cell of endometrium	CL:0002255	58.87	gold quality
popliteal artery	UBERON:0002250	58.71	gold quality
tibial artery	UBERON:0007610	58.65	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	58.40	gold quality
heart left ventricle	UBERON:0002084	58.26	gold quality
myometrium	UBERON:0001296	58.22	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	5728.94
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• ANRIL, NOS3-AS, and APOA1-AS may have roles in development of atherosclerosis in systemic lupus erythematosus (SLE) (PMID:30128915)
• KCNQ1OT1, HIF1A-AS2 and APOA1-AS are promising novel biomarkers for diagnosis of coronary artery disease (PMID:30941792)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.