APP-DT

Summary

APP-DT (APP divergent transcript, HGNC:55075) is a long non-coding RNA gene on chromosome 21q21.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55075
Approved symbol	APP-DT
Name	APP divergent transcript
Location	21q21.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000273492
Ensembl biotype	lncRNA
Entrez	118568803
RNAcentral	URS00026A24B3 — lncRNA, 1986 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000608591, ENST00000609365, ENST00000664668, ENST00000717650, ENST00000717651, ENST00000717652, ENST00000717653, ENST00000735791, ENST00000735792, ENST00000735793, ENST00000735794, ENST00000735795

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000608591 — 3 exons

Exon	Start	End
ENSE00003704546	26170871	26171052
ENSE00003705072	26214745	26214861
ENSE00003708938	26215702	26217381

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 75.04.

FANTOM5 (CAGE): breadth broad, TPM avg 0.9007 / max 231.6339, expressed in 222 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
188687	0.4886	186
188688	0.4121	46

Top tissues by expression

217 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	75.04	silver quality
nucleus accumbens	UBERON:0001882	73.53	gold quality
prefrontal cortex	UBERON:0000451	71.36	gold quality
anterior cingulate cortex	UBERON:0009835	71.14	gold quality
cerebellar cortex	UBERON:0002129	71.05	gold quality
cerebellar hemisphere	UBERON:0002245	70.96	gold quality
cerebellum	UBERON:0002037	70.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.28	gold quality
superficial temporal artery	UBERON:0001614	69.93	gold quality
amygdala	UBERON:0001876	69.69	gold quality
buccal mucosa cell	CL:0002336	68.97	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.93	gold quality
right frontal lobe	UBERON:0002810	68.74	gold quality
neocortex	UBERON:0001950	68.65	gold quality
endothelial cell	CL:0000115	68.63	gold quality
hypothalamus	UBERON:0001898	68.56	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.36	gold quality
frontal cortex	UBERON:0001870	68.35	gold quality
caudate nucleus	UBERON:0001873	68.23	gold quality
putamen	UBERON:0001874	68.02	gold quality
cerebral cortex	UBERON:0000956	67.08	gold quality
cortical plate	UBERON:0005343	67.03	gold quality
brain	UBERON:0000955	66.55	gold quality
forebrain	UBERON:0001890	66.37	gold quality
primary visual cortex	UBERON:0002436	66.12	gold quality
temporal lobe	UBERON:0001871	65.79	gold quality
substantia nigra	UBERON:0002038	65.11	gold quality
Ammon’s horn	UBERON:0001954	64.71	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	64.34	silver quality
islet of Langerhans	UBERON:0000006	64.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.60

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.