APPAT

Summary

APPAT (atherosclerotic plaque pathogenesis associated transcript, HGNC:56009) is a long non-coding RNA gene on chromosome 2q11.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:56009
Approved symbol	APPAT
Name	atherosclerotic plaque pathogenesis associated transcript
Location	2q11.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC092683.1
Ensembl gene	ENSG00000230606
Ensembl biotype	lncRNA
Entrez	100506123
RNAcentral	URS00007E40C8 — lncRNA, 717 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 31 — 31 lncRNA

ENST00000430893, ENST00000431244, ENST00000594050, ENST00000596026, ENST00000600957, ENST00000604397, ENST00000607984, ENST00000609751, ENST00000610408, ENST00000612970, ENST00000616716, ENST00000616719, ENST00000618277, ENST00000620023, ENST00000620051, ENST00000620272, ENST00000621982, ENST00000653793, ENST00000655509, ENST00000656384, ENST00000656798, ENST00000803744, ENST00000803745, ENST00000803746, ENST00000803747, ENST00000803748, ENST00000803749, ENST00000803750, ENST00000803751, ENST00000803752, ENST00000803753

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000430893 — 3 exons

Exon	Start	End
ENSE00001609950	97423059	97423084
ENSE00001660241	97423802	97424201
ENSE00002450440	97423177	97423272

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 98.15.

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.15	gold quality
right testis	UBERON:0004534	98.14	gold quality
right uterine tube	UBERON:0001302	97.43	gold quality
testis	UBERON:0000473	96.82	gold quality
pituitary gland	UBERON:0000007	96.32	gold quality
adenohypophysis	UBERON:0002196	95.94	gold quality
caudate nucleus	UBERON:0001873	95.91	gold quality
putamen	UBERON:0001874	95.81	gold quality
primary visual cortex	UBERON:0002436	95.56	gold quality
sural nerve	UBERON:0015488	95.52	gold quality
nucleus accumbens	UBERON:0001882	95.44	gold quality
right frontal lobe	UBERON:0002810	94.75	gold quality
hypothalamus	UBERON:0001898	94.72	gold quality
superior frontal gyrus	UBERON:0002661	94.16	gold quality
corpus callosum	UBERON:0002336	93.28	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.25	gold quality
anterior cingulate cortex	UBERON:0009835	93.22	gold quality
right hemisphere of cerebellum	UBERON:0014890	93.06	gold quality
cerebellar hemisphere	UBERON:0002245	92.97	gold quality
cerebellar cortex	UBERON:0002129	92.96	gold quality
minor salivary gland	UBERON:0001830	92.80	gold quality
cerebellum	UBERON:0002037	92.76	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.71	gold quality
endometrium	UBERON:0001295	92.67	gold quality
left ovary	UBERON:0002119	92.51	gold quality
brain	UBERON:0000955	92.25	gold quality
Ammon’s horn	UBERON:0001954	92.25	gold quality
cortical plate	UBERON:0005343	92.03	gold quality
saliva-secreting gland	UBERON:0001044	92.01	gold quality
ovary	UBERON:0000992	91.80	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	63.09
E-ANND-3	yes	7.40

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.