APPBP2-DT

Summary

APPBP2-DT (APPBP2 divergent transcript, HGNC:55423) is a long non-coding RNA gene on chromosome 17q23.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:55423
Approved symbol	APPBP2-DT
Name	APPBP2 divergent transcript
Location	17q23.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259349
Ensembl biotype	lncRNA
Entrez	120017341
RNAcentral	URS0002A1625F — lncRNA, 1956 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 lncRNA

ENST00000558027, ENST00000559739, ENST00000691821, ENST00000844193, ENST00000844194

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558027 — 3 exons

Exon	Start	End
ENSE00002542299	60550737	60550798
ENSE00002552622	60526299	60526501
ENSE00002568615	60548408	60548695

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 85.57.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	85.57	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.05	gold quality
right testis	UBERON:0004534	69.55	gold quality
left testis	UBERON:0004533	68.54	gold quality
testis	UBERON:0000473	68.28	gold quality
ventricular zone	UBERON:0003053	67.53	gold quality
ganglionic eminence	UBERON:0004023	65.99	gold quality
right uterine tube	UBERON:0001302	64.91	gold quality
cortex of kidney	UBERON:0001225	62.69	gold quality
endometrium	UBERON:0001295	62.22	gold quality
adult mammalian kidney	UBERON:0000082	62.05	gold quality
kidney	UBERON:0002113	61.73	gold quality
metanephros cortex	UBERON:0010533	61.32	gold quality
placenta	UBERON:0001987	60.76	gold quality
stromal cell of endometrium	CL:0002255	59.69	gold quality
gall bladder	UBERON:0002110	59.50	gold quality
lymph node	UBERON:0000029	58.66	gold quality
apex of heart	UBERON:0002098	58.35	gold quality
duodenum	UBERON:0002114	58.19	gold quality
islet of Langerhans	UBERON:0000006	58.07	gold quality
left adrenal gland	UBERON:0001234	58.07	gold quality
tonsil	UBERON:0002372	58.06	gold quality
right lobe of thyroid gland	UBERON:0001119	57.82	gold quality
adrenal gland	UBERON:0002369	57.79	gold quality
thyroid gland	UBERON:0002046	57.54	gold quality
right adrenal gland	UBERON:0001233	57.51	gold quality
right adrenal gland cortex	UBERON:0035827	57.51	gold quality
left lobe of thyroid gland	UBERON:0001120	57.48	gold quality
cortical plate	UBERON:0005343	57.22	gold quality
smooth muscle tissue	UBERON:0001135	57.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.56

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.