APRG1

Summary

APRG1 (APRG1 tumor suppressor candidate, HGNC:24082) is a long non-coding RNA gene on chromosome 3p22.2.

Predicted to be located in membrane.

Source: NCBI Gene 339883 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24082
Approved symbol	APRG1
Name	APRG1 tumor suppressor candidate
Location	3p22.2
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000198590
Ensembl biotype	lncRNA
OMIM	611429
Entrez	339883
RNAcentral	URS000227830B — lncRNA, 1530 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000328376, ENST00000332506, ENST00000425564, ENST00000425932, ENST00000426078, ENST00000452017, ENST00000466204, ENST00000481400, ENST00000654228, ENST00000654714, ENST00000661769, ENST00000662797, ENST00000665000, ENST00000669217

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000328376 — 6 exons

Exon	Start	End
ENSE00001301109	37411138	37411309
ENSE00001316631	37417253	37417492
ENSE00001537668	37417019	37417142
ENSE00001537682	37399162	37399659
ENSE00001749192	37416554	37416724
ENSE00003755972	37434844	37435497

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 81.57.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2795 / max 14.3536, expressed in 140 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
36066	0.2795	140

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	81.57	gold quality
bone marrow cell	CL:0002092	80.41	gold quality
calcaneal tendon	UBERON:0003701	79.44	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.19	gold quality
bone marrow	UBERON:0002371	75.98	gold quality
skin of leg	UBERON:0001511	75.53	gold quality
skeletal muscle tissue	UBERON:0001134	74.57	gold quality
zone of skin	UBERON:0000014	74.44	gold quality
mucosa of stomach	UBERON:0001199	73.21	gold quality
skin of abdomen	UBERON:0001416	72.96	gold quality
lower esophagus mucosa	UBERON:0035834	71.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	70.85	gold quality
cerebellar cortex	UBERON:0002129	70.73	gold quality
cerebellar hemisphere	UBERON:0002245	70.73	gold quality
cerebellum	UBERON:0002037	70.70	gold quality
tonsil	UBERON:0002372	70.70	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	70.50	gold quality
right lung	UBERON:0002167	70.29	gold quality
colonic epithelium	UBERON:0000397	69.75	gold quality
muscle tissue	UBERON:0002385	69.74	gold quality
right hemisphere of cerebellum	UBERON:0014890	69.73	gold quality
body of pancreas	UBERON:0001150	69.46	gold quality
uterine cervix	UBERON:0000002	68.92	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.85	gold quality
minor salivary gland	UBERON:0001830	68.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.68	gold quality
thoracic mammary gland	UBERON:0005200	68.64	gold quality
saliva-secreting gland	UBERON:0001044	68.39	gold quality
muscle of leg	UBERON:0001383	67.79	gold quality
ectocervix	UBERON:0012249	67.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• There is a trend for APRG1 transcription to be low in malignant tissues and lower still in those patients who develop progressive disease, also between gr I and gr III tumors. Results suggestive of APRG1 acting as a tumour suppressor gene. (PMID:16187228)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.