APTR

Summary

APTR (Alu-mediated CDKN1A/p21 transcriptional regulator, HGNC:44173) is a long non-coding RNA gene on chromosome 7q11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44173
Approved symbol	APTR
Name	Alu-mediated CDKN1A/p21 transcriptional regulator
Location	7q11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000214293
Ensembl biotype	lncRNA
OMIM	616048
Entrez	100505854
RNAcentral	URS000075BCAA — lncRNA, 1978 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 18 lncRNA

ENST00000398043, ENST00000416650, ENST00000430801, ENST00000440088, ENST00000447009, ENST00000654794, ENST00000659053, ENST00000663454, ENST00000663654, ENST00000664660, ENST00000665948, ENST00000687769, ENST00000687850, ENST00000690779, ENST00000751173, ENST00000751174, ENST00000751175, ENST00000751176

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000398043 — 2 exons

Exon	Start	End
ENSE00004096156	77695896	77696268
ENSE00004096164	77683305	77685328

Expression profiles

Bgee: expression breadth ubiquitous, 231 present calls, max score 89.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.4710 / max 62.5457, expressed in 1737 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
84472	6.0022	1728
84471	0.4688	194

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left lobe of thyroid gland	UBERON:0001120	89.12	gold quality
right lobe of thyroid gland	UBERON:0001119	88.53	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.27	gold quality
thyroid gland	UBERON:0002046	88.25	gold quality
pancreatic ductal cell	CL:0002079	87.38	gold quality
left testis	UBERON:0004533	87.31	gold quality
right testis	UBERON:0004534	86.81	gold quality
mucosa of transverse colon	UBERON:0004991	86.47	gold quality
adenohypophysis	UBERON:0002196	85.54	gold quality
testis	UBERON:0000473	85.22	gold quality
pituitary gland	UBERON:0000007	84.36	gold quality
left ovary	UBERON:0002119	84.25	gold quality
body of stomach	UBERON:0001161	83.76	gold quality
nasal cavity mucosa	UBERON:0001826	83.69	gold quality
body of pancreas	UBERON:0001150	83.65	gold quality
right lobe of liver	UBERON:0001114	83.48	gold quality
bronchial epithelial cell	CL:0002328	83.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.27	gold quality
lower esophagus	UBERON:0013473	83.25	gold quality
right ovary	UBERON:0002118	83.14	gold quality
bronchus	UBERON:0002185	82.55	gold quality
colonic epithelium	UBERON:0000397	82.41	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.41	gold quality
lower esophagus mucosa	UBERON:0035834	82.22	gold quality
minor salivary gland	UBERON:0001830	82.19	gold quality
transverse colon	UBERON:0001157	82.18	gold quality
ventricular zone	UBERON:0003053	82.16	gold quality
pancreas	UBERON:0001264	82.09	gold quality
ovary	UBERON:0000992	82.08	gold quality
hypothalamus	UBERON:0001898	81.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• APTR associates with the promoter of CDKN1A/p21 and this association requires a complementary-Alu sequence encoded in APTR. A different module of APTR associates with and recruits the Polycomb repressive complex 2 (PRC2) to repress the p21 promote (PMID:24748121)
• Results show that portal venous levels of APTR was significantly decreased after TIPS treatment and its aberrant expression levels were positively correlated with Model for End Stage Liver Disease (MELD), portal hepatic venous pressure gradient (PHPG) in patients. Higher APTR expression in portal vein was associated with poor prognosis. (PMID:29274906)
• APTR contributed to osteosarcoma progression through repression of miR-132-3p and upregulation of YAP1 expression. (PMID:30317613)
• Down-Regulation of APTR and it’s Diagnostic Value in Papillary and Anaplastic Thyroid Cancer. (PMID:30539519)
• Expression and Significance of the Long Non-Coding RNA APTR in the Occurrence and Development of Lung Adenocarcinoma. (PMID:39462445)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.