AQP10

Summary

AQP10 (aquaporin 10, HGNC:16029) is a protein-coding gene on chromosome 1q21.3, encoding Aquaporin-10 (Q96PS8). Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient.

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea.

Source: NCBI Gene 89872 — RefSeq curated summary.

At a glance

• GWAS associations: 9
• Clinical variants (ClinVar): 30 total — 1 likely-pathogenic
• MANE Select transcript: NM_080429

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16029
Approved symbol	AQP10
Name	aquaporin 10
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000143595
Ensembl biotype	protein_coding
OMIM	606578
Entrez	89872

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000324978, ENST00000355197, ENST00000484864, ENST00000908289

RefSeq mRNA: 1 — MANE Select: NM_080429 NM_080429

CCDS: CCDS1065

Canonical transcript exons

ENST00000324978 — 6 exons

Exon	Start	End
ENSE00001174192	154321933	154322059
ENSE00001174203	154321093	154321260
ENSE00001317145	154323589	154323806
ENSE00001401376	154324282	154325325
ENSE00003514644	154323241	154323359
ENSE00003678643	154322982	154323119

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 99.26.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5338 / max 125.7734, expressed in 113 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5486	0.2994	77
5485	0.2344	64

Top tissues by expression

212 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
jejunal mucosa	UBERON:0000399	99.26	gold quality
duodenum	UBERON:0002114	93.45	gold quality
monocyte	CL:0000576	83.37	gold quality
leukocyte	CL:0000738	82.45	gold quality
jejunum	UBERON:0002115	73.00	gold quality
right uterine tube	UBERON:0001302	71.34	gold quality
granulocyte	CL:0000094	71.27	gold quality
blood	UBERON:0000178	64.68	gold quality
right lung	UBERON:0002167	61.26	gold quality
oocyte	CL:0000023	57.85	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	53.99	gold quality
bone marrow cell	CL:0002092	50.94	gold quality
fallopian tube	UBERON:0003889	49.83	gold quality
spleen	UBERON:0002106	48.77	gold quality
upper lobe of left lung	UBERON:0008952	48.67	gold quality
upper lobe of lung	UBERON:0008948	47.64	gold quality
nasal cavity mucosa	UBERON:0001826	47.07	gold quality
bone marrow	UBERON:0002371	45.85	gold quality
islet of Langerhans	UBERON:0000006	45.11	gold quality
lung	UBERON:0002048	45.03	gold quality
middle temporal gyrus	UBERON:0002771	44.26	gold quality
vermiform appendix	UBERON:0001154	44.16	gold quality
heart left ventricle	UBERON:0002084	43.82	gold quality
cardiac ventricle	UBERON:0002082	43.69	gold quality
amniotic fluid	UBERON:0000173	43.64	gold quality
gall bladder	UBERON:0002110	43.38	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
right atrium auricular region	UBERON:0006631	43.32	silver quality
cardiac atrium	UBERON:0002081	43.24	silver quality
caecum	UBERON:0001153	43.12	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

18 targeting AQP10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-6757-3P	99.63	66.88	1089
HSA-MIR-3128	99.50	67.85	1258
HSA-MIR-7515	99.31	68.22	1795
HSA-MIR-4795-5P	99.11	66.90	876
HSA-MIR-6868-5P	99.06	65.69	1284
HSA-MIR-3154	98.94	66.55	1455
HSA-MIR-320A-5P	98.88	66.75	1248
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-4266	98.53	67.29	1035
HSA-MIR-1248	98.47	67.54	1314
HSA-MIR-6804-5P	98.39	65.77	1084
HSA-MIR-8078	98.32	65.73	361
HSA-MIR-4799-3P	97.78	65.97	893
HSA-MIR-6865-3P	97.54	64.67	684
HSA-MIR-4720-5P	97.46	65.67	893
HSA-MIR-5588-5P	97.46	65.70	913
HSA-MIR-6732-5P	93.97	64.65	422

Literature-anchored findings (GeneRIF, showing 10)

• Results suggest that AQP10 represents a new member of aquaglyceroporins functionally as well as structurally. (PMID:12084581)
• AQP10 with an insertion of 475 nt was localized in the capillary endothelium in villi of the small intestine and the isoform without the insertion localized in the gastro-entero-pancrestic endocrine cells. (PMID:15898950)
• differential polarity and selective targeting of AQP3 and AQP10 in the intestinal epithelial cells is influenced by amino acid signal motifs. (PMID:18678926)
• study unveiled the uniquely dual functional characteristic of hAQP10 as a carrier/channel for solute transport, providing a novel insight into its operation mechanism, which would help further elucidate its physiological role (PMID:21691092)
• the presence of at least one glycosylated protein within each tetramer is sufficient to convey an enhanced structural stability to the remaining hAQP10 protomers of the tetramer. (PMID:21733844)
• Aquaporin-10 is expressed exclusively in the adipocytes, which is particularly important for the maintenance of normal or low glycerol contents inside the adipocyte, thus protecting humans from obesity. (PMID:23382902)
• the human aquaglyceroporins, i.e., AQP3, AQP7, AQP9 and AQP10 can act as silicon transporters in both Xenopus laevis oocytes and HEK-293 cells. (PMID:26313002)
• Expression of CXCL4 and aquaporin 3 and 10 mRNAs in middle ear effusion is associated with the pathophysiology of otitis media with effusion. (PMID:26810286)
• in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. (PMID:30420639)
• The role of water coordination in the pH-dependent gating of hAQP10. (PMID:34699768)

Cross-species orthologs

11 orthologs

Organism	Symbol	Gene ID
danio_rerio	aqp10a	ENSDARG00000007086
danio_rerio	aqp10b	ENSDARG00000058678
danio_rerio	aqp8a.2	ENSDARG00000071592
danio_rerio	aqp8b	ENSDARG00000089749
rattus_norvegicus	Aqp10	ENSRNOG00000069352
drosophila_melanogaster	Drip	FBGN0015872
drosophila_melanogaster	Eglp1	FBGN0034882
drosophila_melanogaster	Eglp2	FBGN0034883
drosophila_melanogaster	Eglp3	FBGN0034884
drosophila_melanogaster	Eglp4	FBGN0034885
caenorhabditis_elegans		WBGENE00000170

Paralogs (11): AQP6 (ENSG00000086159), AQP8 (ENSG00000103375), AQP9 (ENSG00000103569), MIP (ENSG00000135517), AQP5 (ENSG00000161798), AQP7 (ENSG00000165269), AQP3 (ENSG00000165272), AQP2 (ENSG00000167580), AQP4 (ENSG00000171885), AQP1 (ENSG00000240583), AQP7B (ENSG00000259916)

Protein

Protein identifiers

Aquaporin-10 — Q96PS8 (reviewed: Q96PS8)

Alternative names: Aquaglyceroporin-10, Small intestine aquaporin

All UniProt accessions (1): Q96PS8

UniProt curated annotations — full annotation on UniProt →

Function. Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Among aquaglyceroporins, it exhibits a unique pH-gated glycerol transport activity, being more active at acidic pH. It most likely plays a central role in the efflux of glycerol formed during triglyceride hydrolysis in adipocytes and in glycerol uptake by enterocytes, as both processes occur and are stimulated at acidic pH.

Subunit / interactions. Homotetramer; each monomer provides an independent glycerol/water pore.

Subcellular location. Apical cell membrane. Cell membrane. Lipid droplet.

Tissue specificity. Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum. Detected in subcutaneous adipose tissue.

Post-translational modifications. N-glycosylation at Asn-133 increases the stability of the protein but has no effect on its activity.

Activity regulation. Glycerol transport is regulated by pH, with the porin being permeable to glycerol at pH 5.5 but not at pH 7.4. Water permeability, however, is not influenced by pH.

Domain organisation. Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Miscellaneous. In vitro, it can transport the dietary compounds erythritol and xylitol.

Similarity. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96PS8-1	1	yes
Q96PS8-2	2

RefSeq proteins (1): NP_536354* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000425	MIP	Family
IPR022357	MIP_CS	Conserved_site
IPR023271	Aquaporin-like	Homologous_superfamily
IPR026252	Aquaporin_10	Family
IPR050363	MIP/Aquaporin	Family

Pfam: PF00230

Catalyzed reactions (Rhea), 3 shown:

• H2O(in) = H2O(out) (RHEA:29667)
• glycerol(in) = glycerol(out) (RHEA:29675)
• urea(in) = urea(out) (RHEA:32799)

UniProt features (51 total): helix 13, topological domain 9, mutagenesis site 8, transmembrane region 6, turn 3, intramembrane region 2, short sequence motif 2, glycosylation site 2, sequence variant 2, chain 1, site 1, splice variant 1, strand 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6F7H	X-RAY DIFFRACTION	2.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96PS8-F1	91.22	0.84

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 80 (ph-sensor)

Glycosylation sites (2): 128, 133

Mutagenesis-validated functional residues (8):

Position	Phenotype
27	loss of glycerol channel activity.
73	increased glycerol channel activity at acidic ph.
73	loss of glycerol channel activity.
77	decreased glycerol channel activity.
80	loss of glycerol channel activity.
85	decreased glycerol channel activity.
94	loss of glycerol channel activity.
133	abolishes n-glycosylation.

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-432047	Passive transport by Aquaporins
R-HSA-382551	Transport of small molecules
R-HSA-445717	Aquaporin-mediated transport

MSigDB gene sets: 67 (showing top): GOBP_CARBOHYDRATE_TRANSPORT, GOBP_PROTEIN_HOMOTETRAMERIZATION, GOBP_ORGANIC_HYDROXY_COMPOUND_TRANSPORT, GOBP_WATER_TRANSPORT, GOBP_POLYOL_TRANSMEMBRANE_TRANSPORT, GOBP_ONE_CARBON_COMPOUND_TRANSPORT, GOCC_APICAL_PLASMA_MEMBRANE, GOBP_PROTEIN_HOMOOLIGOMERIZATION, GOBP_RESPONSE_TO_TOXIC_SUBSTANCE, GOBP_PROTEIN_TETRAMERIZATION, GOBP_TRANSMEMBRANE_TRANSPORT, GOBP_FLUID_TRANSPORT, chr1q21, GOCC_APICAL_PART_OF_CELL, GOCC_PLASMA_MEMBRANE_REGION

GO Biological Process (6): water transport (GO:0006833), response to toxic substance (GO:0009636), glycerol transmembrane transport (GO:0015793), protein homotetramerization (GO:0051289), transmembrane transport (GO:0055085), urea transmembrane transport (GO:0071918)

GO Molecular Function (5): urea transmembrane transporter activity (GO:0015204), water channel activity (GO:0015250), glycerol channel activity (GO:0015254), protein binding (GO:0005515), channel activity (GO:0015267)

GO Cellular Component (5): lipid droplet (GO:0005811), plasma membrane (GO:0005886), basolateral plasma membrane (GO:0016323), apical plasma membrane (GO:0016324), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Aquaporin-mediated transport	1
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
channel activity	2
plasma membrane region	2
fluid transport	1
response to chemical	1
polyol transmembrane transport	1
carbohydrate transmembrane transport	1
protein homooligomerization	1
protein tetramerization	1
transport	1
cellular process	1
urea transport	1
transmembrane transport	1
transmembrane transporter activity	1
urea transmembrane transport	1
water transmembrane transporter activity	1
glycerol transmembrane transporter activity	1
binding	1
passive transmembrane transporter activity	1
intracellular membraneless organelle	1
membrane	1
cell periphery	1
basal plasma membrane	1
apical part of cell	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2351 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
AQP10	AQP12A	Q8IXF9	891
AQP10	AQP8	O94778	889
AQP10	MIP	P30301	889
AQP10	AQP11	Q8NBQ7	888
AQP10	AQP6	Q13520	886
AQP10	AQP5	P55064	812
AQP10	AQP12B	A6NM10	545
AQP10	AQP7	O14520	437
AQP10	AQP3	Q92482	420
AQP10	SERTM2	A0A1B0GWG4	397
AQP10	AQP2	P41181	396
AQP10	ARRDC3	Q96B67	371
AQP10	ALDH18A1	P54886	360
AQP10	GK2	Q14410	353
AQP10	RNF175	Q8N4F7	353

IntAct

59 interactions, top by confidence:

A	B	Type	Score
AQP10	SAR1A	psi-mi:“MI:0915”(physical association)	0.560
PGRMC2	AQP10	psi-mi:“MI:0915”(physical association)	0.560
CREB3L1	AQP10	psi-mi:“MI:0915”(physical association)	0.560
PLP1	AQP10	psi-mi:“MI:0915”(physical association)	0.560
MGST3	AQP10	psi-mi:“MI:0915”(physical association)	0.560
NEMP1	AQP10	psi-mi:“MI:0915”(physical association)	0.560
AQP10	ERGIC3	psi-mi:“MI:0915”(physical association)	0.560
CISD2	AQP10	psi-mi:“MI:0915”(physical association)	0.560
AQP10	SCN3B	psi-mi:“MI:0915”(physical association)	0.560
GPR37L1	AQP10	psi-mi:“MI:0915”(physical association)	0.560
GPR152	AQP10	psi-mi:“MI:0915”(physical association)	0.560
SYT2	AQP10	psi-mi:“MI:0915”(physical association)	0.560
AQP10	CYBC1	psi-mi:“MI:0915”(physical association)	0.560
AQP10	TMEM167B	psi-mi:“MI:0915”(physical association)	0.560
SSMEM1	AQP10	psi-mi:“MI:0915”(physical association)	0.560
AQP10	LYVE1	psi-mi:“MI:0915”(physical association)	0.560
KIR2DL3	AQP10	psi-mi:“MI:0915”(physical association)	0.560
ARL13B	AQP10	psi-mi:“MI:0915”(physical association)	0.560
PVR	AQP10	psi-mi:“MI:0915”(physical association)	0.560
KLHL22	TRAV18	psi-mi:“MI:0914”(association)	0.350
AQP10	PGRMC2	psi-mi:“MI:0915”(physical association)	0.000
AQP10	CREB3L1	psi-mi:“MI:0915”(physical association)	0.000
AQP10	NEMP1	psi-mi:“MI:0915”(physical association)	0.000
AQP10	ERGIC3	psi-mi:“MI:0915”(physical association)	0.000
AQP10	CISD2	psi-mi:“MI:0915”(physical association)	0.000
AQP10	SCN3B	psi-mi:“MI:0915”(physical association)	0.000
AQP10	GPR37L1	psi-mi:“MI:0915”(physical association)	0.000
AQP10	GPR152	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (21): AQP10 (Two-hybrid), AQP10 (Two-hybrid), AQP10 (Two-hybrid), AQP10 (Two-hybrid), AQP10 (Two-hybrid), AQP10 (Two-hybrid), AQP10 (Two-hybrid), SYT2 (Two-hybrid), CISD2 (Two-hybrid), CREB3L1 (Two-hybrid), PGRMC2 (Two-hybrid), SSMEM1 (Two-hybrid), SCN3B (Two-hybrid), TMEM194A (Two-hybrid), ARL13B (Two-hybrid)

ESM2 similar proteins: A0A075B734, A1L272, A2IBY8, A8W649, A9Y006, D4A7H1, E7EXX2, F7B113, O14520, O35454, O54794, O62735, O94956, P34080, P35525, P41181, P47862, P47863, P47864, P51789, P51797, P56402, P56403, P79099, Q06495, Q06496, Q08DE6, Q4R691, Q5PQL3, Q62052, Q866S3, Q8BLV3, Q8BXB6, Q8BZ00, Q8IVB4, Q8K078, Q8MIQ9, Q8R2N1, Q8TCT8, Q921R8

Diamond homologs: A0A075B734, A0A384JPP3, A0A384JSZ0, A9Y006, B0D4E4, B0D4J9, B0D4K0, B0DLE4, B1VB61, F9USY3, F9UTW9, F9UUB3, G5CTF9, G5CTG0, G5CTG1, G5CTG4, G5CTG5, G5CTG6, G5CTG7, I1CR68, I1CS06, I1RHJ1, I1RIY3, I1Z8E7, I1Z8E8, I1Z8E9, I1Z8F0, I3W9F7, O14520, O43315, O54794, O62735, O77697, O77714, O77722, O77740, P0A3Q7, P0A3Q8, P0AER0, P0AER1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

30 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	27
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
493594	GRCh37/hg19 1q21.3-23.1(chr1:153751465-156660462)x3	Likely pathogenic

SpliceAI

685 predictions. Top by Δscore:

Variant	Effect	Δscore
1:154322047:G:GA	donor_gain	1.0000
1:154322056:TCAG:T	donor_loss	1.0000
1:154322057:CAGG:C	donor_loss	1.0000
1:154322058:AGG:A	donor_loss	1.0000
1:154322060:G:GA	donor_loss	1.0000
1:154322061:T:G	donor_loss	1.0000
1:154323130:G:T	donor_gain	1.0000
1:154323138:G:GT	donor_gain	1.0000
1:154323239:A:AC	acceptor_loss	1.0000
1:154323239:A:AG	acceptor_gain	1.0000
1:154323239:AGAT:A	acceptor_gain	1.0000
1:154323240:G:GT	acceptor_gain	1.0000
1:154323240:GA:G	acceptor_gain	1.0000
1:154323240:GAT:G	acceptor_gain	1.0000
1:154323240:GATG:G	acceptor_gain	1.0000
1:154323356:TCAGG:T	donor_loss	1.0000
1:154323357:CAGG:C	donor_loss	1.0000
1:154323358:AGG:A	donor_loss	1.0000
1:154323360:G:GG	donor_gain	1.0000
1:154321929:GC:G	acceptor_gain	0.9900
1:154321929:GCA:G	acceptor_gain	0.9900
1:154321929:GCAGC:G	acceptor_gain	0.9900
1:154321931:A:AG	acceptor_gain	0.9900
1:154321932:G:GG	acceptor_gain	0.9900
1:154322046:TGGTA:T	donor_gain	0.9900
1:154322970:T:A	acceptor_gain	0.9900
1:154323095:G:GT	donor_gain	0.9900
1:154323129:G:GT	donor_gain	0.9900
1:154323139:G:T	donor_gain	0.9900
1:154323240:GATGC:G	acceptor_gain	0.9900

AlphaMissense

1905 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:154323741:C:A	N214K	0.993
1:154323741:C:G	N214K	0.993
1:154322995:T:A	N82K	0.992
1:154322995:T:G	N82K	0.992
1:154323306:T:C	F146L	0.992
1:154323308:T:A	F146L	0.992
1:154323308:T:G	F146L	0.992
1:154323789:G:C	W230C	0.986
1:154323789:G:T	W230C	0.986
1:154323787:T:A	W230R	0.984
1:154323787:T:C	W230R	0.984
1:154323006:C:T	S86F	0.983
1:154323752:A:C	D218A	0.982
1:154323802:T:C	F235L	0.982
1:154323804:C:A	F235L	0.982
1:154323804:C:G	F235L	0.982
1:154323763:C:A	R222S	0.981
1:154323751:G:C	D218H	0.980
1:154324301:T:A	W243R	0.978
1:154324301:T:C	W243R	0.978
1:154323752:A:G	D218G	0.977
1:154324295:T:A	W241R	0.977
1:154324295:T:C	W241R	0.977
1:154323752:A:T	D218V	0.975
1:154323682:G:A	G195R	0.974
1:154323682:G:C	G195R	0.974
1:154323006:C:A	S86Y	0.973
1:154323090:C:A	A114D	0.973
1:154323307:T:G	F146C	0.973
1:154323683:G:A	G195E	0.972

dbSNP variants (sampled 300 via entrez): RS1000026795 (1:154324217 G>A,T), RS1000381897 (1:154324344 C>A,T), RS1001530885 (1:154324832 T>C), RS1001658320 (1:154323282 G>A), RS1001834412 (1:154325274 G>A), RS1001995122 (1:154321654 A>G), RS1002361824 (1:154321413 C>T), RS1003671850 (1:154320059 T>A,C), RS1004151454 (1:154325337 G>A), RS1004457626 (1:154325463 C>A), RS1006163511 (1:154321786 C>A), RS1006503510 (1:154320234 A>ACTAGAGGT), RS1008692475 (1:154325538 C>A,G), RS1009096596 (1:154324230 G>A), RS1010060209 (1:154324795 C>T)

Disease associations

OMIM: gene MIM:606578 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

9 associations (top):

Study	Trait	p-value
GCST004602_16	Mean corpuscular volume	2.000000e-10
GCST004630_13	Mean corpuscular hemoglobin	9.000000e-10
GCST005989_3	Serum total protein levels	5.000000e-09
GCST005990_38	Non-albumin protein levels	1.000000e-12
GCST008103_125	Bipolar disorder	2.000000e-06
GCST011038_5	Parkinson’s disease progression (motor)	5.000000e-06
GCST90002390_18	Mean corpuscular hemoglobin	2.000000e-14
GCST90002392_285	Mean corpuscular volume	6.000000e-16
GCST90002404_426	Red cell distribution width	2.000000e-13

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0008336	disease progression measurement
EFO:0009188	Red cell distribution width

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: other ic — Aquaporins

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic	decreases expression, increases abundance, increases reaction, increases transport	2
Mercury	affects activity, decreases activity	2
triphenyl phosphate	affects expression	1
1,6-hexamethylene diisocyanate	affects expression	1
trimellitic anhydride	affects expression	1
sodium arsenite	increases reaction, decreases expression, increases abundance	1
ammonium hexachloroplatinate	affects expression	1
arsenic pentoxide	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	increases expression	1
Benzo(a)pyrene	decreases methylation	1
Calcitriol	increases abundance, increases reaction, decreases expression	1
Folic Acid	decreases expression	1
Glycerol	increases uptake	1
Hydralazine	increases expression, affects cotreatment	1
Tobacco Smoke Pollution	decreases expression	1
Tretinoin	decreases expression	1
Triclosan	decreases expression	1
Urea	increases uptake	1
Valproic Acid	affects cotreatment, increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.